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Life
Special Issues
Inflammation and Natural Products: 2nd Edition
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Inflammation and Natural Products: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1318

Special Issue Editors

Prof. Dr. Azahara Rodríguez-Luna

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Guest Editor
Faculty of Health Sciences, Universidad Loyola Andalucía, Dos Hermanas, 41704 Sevilla, Spain
Interests: urticaria; immune-mediated skin diseases; machine learning; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Salvador González

E-Mail Website
Guest Editor
Department of Medicine and Medical Specialties, Faculty of Medicine, Alcalá de Henares University, 28805 Madrid, Spain
Interests: skin; photoprotection; skin cancer; inflammation; natural products; confocal microscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Irene García Domínguez

E-Mail
Guest Editor
Faculty of Health Sciences, Universidad Loyola Andalucía, Dos Hermanas, 41704 Sevilla, Spain
Interests: inflammation; natural products; neuro-inflammation; microalgae; microglia; behavior

Special Issue Information

Dear Colleagues,

We are pleased to announce the second edition of the Special Issue of Life, titled "Inflammation and Natural Products: 2nd Edition”.

Terrestrial and marine environments continue to be inexhaustible sources of active compounds and extracts that have been employed in medicine throughout history. The aim of this Special Issue is to compile new approaches on compounds and extracts isolated from natural products, focusing on their biological activity with an emphasis on anti-inflammatory pathways. Therefore, this Special Issue welcomes the submission of full papers, short communications, and review articles on natural products (from terrestrial or marine sources), as well as secondary metabolites from microorganisms and plants that exhibit significant anti-inflammatory activity.

This Special Issue aims to serve as a reference text for researchers and academia studying natural products and their pharmacological activities. We invite researchers working in the field of natural products and related pathways to publish their recent findings in this second edition of the Special Issue of Life.

We look forward to your contributions and are confident that this Special Issue will provide valuable information and new insights in the field of inflammation and natural products.

Prof. Dr. Azahara Rodríguez-Luna
Dr. Salvador González
Dr. Irene García Domínguez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • inflammation
  • biological activity
  • anti-inflammatory activity
  • antioxidant activity
  • anticancer potential
  • terrestrial products
  • marine products
  • phytochemistry
  • pharmacology

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Published Papers (1 paper)

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Research

15 pages, 4018 KiB  
Article
Endarachne binghamiae Extract Ameliorates Inflammatory Responses in Macrophages Through Regulation of MAPK, NF-kB and PI3K/AKT Pathways, and Prevents Acute Lung Injury in Mice
by Sang-Hoon Lee, Sang-Seop Lee, Ga-Young Lee, Seung-Yun Han, Dong-Sub Kim, Bong-Ho Lee and Yung-Choon Yoo
Life 2025, 15(1), 88; https://doi.org/10.3390/life15010088 - 13 Jan 2025
Viewed by 897
Abstract
In this study, the anti-inflammatory effect of the hot water extract of Endarachne binghamiae (EB-WE), a type of marine brown algae, was investigated in LPS-stimulated RAW 264.7 cells and an acute lung injury (ALI) mouse model induced by intranasal LPS administration. Treatment with [...] Read more.
In this study, the anti-inflammatory effect of the hot water extract of Endarachne binghamiae (EB-WE), a type of marine brown algae, was investigated in LPS-stimulated RAW 264.7 cells and an acute lung injury (ALI) mouse model induced by intranasal LPS administration. Treatment with EB-WE significantly inhibited NO and pro-inflammatory cytokine (TNF-a and IL-6) production in LPS-stimulated RAW 264.7 cells. In mRNA analysis, the expression of pro-inflammatory cytokines, COX-2, and iNOS mRNAs, was down-regulated by EB-WE treatment. The phosphorylation of MAPK, IkB, and PI3K/AKT molecules responsible for signal pathways during inflammation in LPS-stimulated macrophages was also significantly inhibited by EB-WE. In an in vivo model for ALI, oral administration of EB-WE significantly reduced the level of pro-inflammatory cytokines (TNF-a, IL-1b, and IL-6) and chemokines (MCP-1, CXC-16, CXCL1, and TARC) in serum or bronchoalveolar lavage fluid (BALF) of mice. Similarly to the results in LPS-stimulated RAW 264.7 cells, treatment with EB-WE significantly inhibited intracellular signal pathways mediated by MAPK, IkB, and PI3K/AKT in lung tissues of mice with ALI, and also decreased the expression of mRNAs of inflammatory mediators such as TNF-a, IL-6, iNOS, and COX-2. Furthermore, the inhibitory effect of EB-WE on ALI was apparently confirmed in histological examination through lung tissue staining. Taken together, it is clear that EB-WE has potential activity to effectively ameliorate the inflammatory responses in macrophages through down-regulation of MAPK, NF-kB, and PI3K/AKT activation, and suppress acute lung injury induced by LPS. These findings strongly suggest that EB-WE is a promising natural product beneficial for developing preventive treatments and cures of inflammation-related diseases. Full article
(This article belongs to the Special Issue Inflammation and Natural Products: 2nd Edition)
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