Advances in Upper Respiratory Tract Disorders and Head and Neck Cancers: From Pathophysiology to Innovative Approaches

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 July 2025) | Viewed by 5050

Special Issue Editors


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Guest Editor
Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi County 613, Taiwan
Interests: CAM; TCM; allergic rhinitis; choric rhinosinusitis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Otolaryngology Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi County, Puzi 613, Taiwan
Interests: rhinitis; sinusitis; nasal polyp; nasal irrigation; nasal spray; licorice; deep neck infection; peritonsillar abscess; nasal septal abscess; epiglottitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of upper respiratory tract disorders, such as rhinitis, rhinosinusitis, deep neck infections, and head and neck cancers, is increasing worldwide. In recent years, advances in modern medicine have led to the development of treatments for upper respiratory tract disorders and head and neck cancers. However, research on how to further improve therapeutic benefits is necessary.

Therapies for upper respiratory tract disorders include anti-inflammation medications, antibiotics, surgery, and therapies for head and neck cancers include chemotherapy, radiotherapy, and immunotherapy. There is currently a crisis to overcome in treating people for respiratory tract disorders and head and neck cancers due to the high economic cost and burden. In addition, these therapies are accompanied by several adverse effects and are restricted to clinical settings. It is pertinent to further investigate the pathophysiology of inflammation and infections in respiratory tract disorders and head and neck cancers in order to develop innovative new methods and treatments. 

For this Special Issue, we encourage submissions of studies focusing on the pathophysiology of, and novel therapeutic approaches toward, upper respiratory tract disorders and head and neck cancers. In vivo and in vitro studies, clinical trials, prospective or retrospective studies, case reports, and review articles are welcome. In addition, we encourage research exploring the molecular mechanisms behind novel therapeutic strategies for treating respiratory tract disorders and head and neck cancers.

We hope that the results presented in this Special Issue will provide meaningful and helpful information for clinicians in the management of upper respiratory tract disorders and head and neck cancers.

Dr. Pei-Rung Yang
Dr. Geng-He Chang
Guest Editors

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Keywords

  • inflammation
  • infection
  • cancer
  • respiratory tract
  • head and neck

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Published Papers (1 paper)

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Research

14 pages, 3900 KB  
Article
Nasal Irrigation with Licorice Extract for Allergic Rhinitis: A Clinical Study Evaluated by Subjective Assessments and Meridian Electrical Conductance
by Pei-Rung Yang, Yung-Hsiang Chen, Chao-Yang Chang, Bo-Cheng Rau, Yu-Ching Cheng, Yao-Hsu Yang, Ching-Yuan Wu and Geng-He Chang
Life 2025, 15(11), 1667; https://doi.org/10.3390/life15111667 - 25 Oct 2025
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Abstract
Objective: Allergic rhinitis (AR) continues to adversely affect the life quality of a substantial patient population, highlighting the necessity for enhanced treatment modalities. Our research utilized licorice extract (LE) in nasal irrigation for managing this condition, with its therapeutic efficacy gauged against [...] Read more.
Objective: Allergic rhinitis (AR) continues to adversely affect the life quality of a substantial patient population, highlighting the necessity for enhanced treatment modalities. Our research utilized licorice extract (LE) in nasal irrigation for managing this condition, with its therapeutic efficacy gauged against traditional saline nasal irrigation (SNI) through clinical trials. Additionally, the study incorporated traditional Chinese medicine (TCM) principles, measuring not just subjective symptom relief but also the objective shifts in lung meridian electrical conductance (MEC), to provide a comprehensive evaluation of the treatment’s effectiveness. Methods: Based on our previous laboratory and animal studies, we developed an LE solution and applied it through nasal irrigation to treat AR. In a one-month controlled trial, 60 patients with AR received either licorice nasal irrigation (LNI) or SNI daily. We assessed treatment efficacy by subjective questionnaire scores (Total Nasal Symptom Score [TNSS] and 22-item Sino-Nasal Outcome Test [SNOT-22]) and objective lung MEC analysis. Result: In the trial, 30 participants were randomly allocated to each group, and 28 individuals in the LNI group and 24 in the SNI group finished the study without any side effects. The LNI group had better improvements in sneezing, nasal itchiness, and rhinorrhea, along with a greater overall TNSS reduction. On the SNOT-22, the LNI group scored better across most nasal and extra-nasal symptoms, sleep, and physiological and psychosocial well-being. Participants were sorted into low, normal, and high lung MEC subgroups. After treatment, those in the LNI group normalized their lung MEC levels in both the low and high subgroups, which was not observed in the SNI group. Conclusions: LNI markedly improves symptoms in patients with AR, enhancing their quality of life. This treatment method, integrating Western and TCM practices, also normalizes abnormal lung MEC values following therapy. It offers a method of objectively validating the effectiveness of treatments based on TCM theories. Full article
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