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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Sustainable Animal Nutrition: Impacts on Physiology, Health, and Production

edited by

Christos Eliopoulos

and

Dimitrios Arapoglou

submission deadline 30 Apr 2026 | Viewed by 226 | Submission Open

Keywords: animal nutrition; alternative feedstuffs; physiology; gut health; nutrient metabolism; immune function; animal performance; sustainable livestock production

(This special issue belongs to the Section Animal Science)

Rumen Microbiome and Fermentation Function Research

edited by

Xingzhou Tian

submission deadline 30 Apr 2026 | Viewed by 219 | Submission Open

Keywords: rumen; in vivo; in vitro; microbe; fermentation; multi-omics

(This special issue belongs to the Section Animal Science)

Developmental Programming in Cats and Dogs

edited by

Franck Péron

Virginie Gaillard

and Sylvie Chastant

submission deadline 30 Apr 2026 | Viewed by 194 | Submission Open

Keywords: dog; cat; growth; health; prevention; development; susceptibility; environment; risk factors; nutrition; neutering

(This special issue belongs to the Section Animal Science)

Novel Diagnostics and Therapeutics for Ophthalmic Diseases

edited by

Chris H. L. Lim

submission deadline 30 Apr 2026 | Viewed by 187 | Submission Open

Keywords: clinical ophthalmology; ophthalmic innovations; diagnostic technologies; therapeutic advancements; surgical techniques; disparity in global eye health; personalized medicine

(This special issue belongs to the Section Medical Research)

15th Anniversary of Life—Emerging Plant-Based Materials and Bioactive Compounds in Biomedical Applications

edited by

Stefania Lamponi

submission deadline 30 Apr 2026 | Viewed by 187 | Submission Open

Keywords: plant-derived materials; bioactive compounds; phytochemicals; biomedical applications; natural products; plant-based polymers; drug delivery; tissue engineering

(This special issue belongs to the Section Plant Science)

Behavioral Manifestations and Neural Regulation of Movements

edited by

Luca Puce

and

Nicola Luigi Bragazzi

submission deadline 30 Apr 2026 | Viewed by 175 | Submission Open

Keywords: motor control; movement behavior; sensorimotor integration; neurophysiology; emotion and movement; cognitive-motor interaction; temperament; neurotechnology; rehabilitation; performance

(This special issue belongs to the Section Physiology and Pathology)

Genetic Drivers in Endocrine Disorders: From Rare Variants to Aggressive Malignancies

edited by

Sorina Schipor

Mihai Constantin Ceausu

and

Mihai Publik

submission deadline 30 Apr 2026 | Viewed by 160 | Submission Open

Keywords: endocrine tumors; rare variants; somatic variants; next-generation sequencing; molecular pathology; differentially expressed genes; aggressive tumor phenotype; novel genetic tests

(This special issue belongs to the Section Genetics and Genomics)

Cortical Development and Neurotransmission

edited by Christine Hohmann and Joanne Berger-Sweeney

submission deadline 30 Apr 2026 | Viewed by 148 | Submission Open

Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism

(This special issue belongs to the Section Medical Research)

Advances in Tissue Engineering in Reproduction

edited by

Rodrigo Da Silva Nunes Barreto

submission deadline 30 Apr 2026 | Viewed by 144 | Submission Open

Keywords: translational regenerative medicine; bioengineered scaffolds; organoids and organ-on-a-chip; in vitro models; extracellular matrix on reproduction and regeneration

(This special issue belongs to the Section Animal Science)

Research and Management of Endocrine Tumors

edited by

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Apr 2026 | Viewed by 131 | Submission Open

Keywords: thyroid cancer; papillary thyroid cancer; anaplastic thyroid cancer; radioiodine; multiple kinase and angiogenetic factor inhibitors; adrenal cancer; pituitary adenomas

(This special issue belongs to the Section Medical Research)

Diabetes, Microbiome, and Inflammation: Mechanisms and Therapeutic Perspectives

edited by

Gratiela Pircalabioru

and

Octavian Savu

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: diabetes mellitus; microbiome; microbiota metabolites; metabolic disease; dysbiosis

(This special issue belongs to the Section Medical Research)

Advances in Disease Mechanisms and Treatment Innovations in Rhinology and Allergy

edited by

Chien-Chia Huang

submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open

Keywords: sinonasal disorder ; chronic rhinosinusitis ; rhinitis ; empty nose syndrome ; nasal septal deviation ; obstructive sleep apnea ; sinonasal tumor ; skull base surgery ; pediatric otorhinolaryngology

(This special issue belongs to the Section Medical Research)

Current Challenges in Prognostic Assessment and Intervention Strategies in Acute and Critical Care

edited by

Hidetaka Onda

submission deadline 30 Apr 2026 | Viewed by 117 | Submission Open

Keywords: acute and critical care; prognostic assessment; biomarkers; therapeutic strategies; sepsis; trauma; cardiac arrest; respiratory failure/ARDS; neurocritical care; implementation; patient-centered outcomes keyword

(This special issue belongs to the Section Medical Research)

Research on the Pathogenesis and Association of Diabetes and Metabolic Syndrome

edited by Gwo-Ping Jong

submission deadline 30 Apr 2026 | Viewed by 108 | Submission Open

Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; coronary artery disease; endothelial dysfunction; stroke; hypertension; peripheric arterial disease; metabolic dysfunction; hyperlipidemia

(This special issue belongs to the Section Physiology and Pathology)

Novel Biomarkers for Lymphoma Diagnosis and Prognosis: Translating Research into Practice

edited by Dominic Kaddu-Mulindwa

submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open

Keywords: lymphoma; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); molecular profiling; tumor microenvironment; epigenetic markers; predictive diagnostics

(This special issue belongs to the Section Physiology and Pathology)

Targeting DEK and TGF-β Signaling in Gynecologic Disease and Cancer: Diagnostic and Therapeutic Perspectives

edited by

Hung-Chi Cheng

and Anastasia Tsigkou

submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open

Keywords: DEK oncogene; TGF-β signaling; cervical cancer; endometriosis; uterine myomas; cancer biomarkers; epithelial– mesenchymal transition (EMT); SMAD2/3 phosphorylation; LY364947; targeted therapy

(This special issue belongs to the Section Medical Research)

Decoding Helicobacter pylori: Genetic Secrets, Flagellar Motility, and Biofilm Mechanisms

edited by Xiaolin Liu and Shuai Hu

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: virulence genes; motility; flagella; biofilm; antibiotic resistance; colonization; Helicobacter pylori

(This special issue belongs to the Section Microbiology)

Ultrasound-Guided Interventions and Advances in Musculoskeletal Disorders

edited by Chih-Ya Chang

submission deadline 5 May 2026 | Viewed by 151 | Submission Open

Keywords: ultrasound-guided interventions; regenerative medicine; platelet-rich plasma (PRP); musculoskeletal disorders; shoulder and knee osteoarthritis; peripheral nerve injuries

(This special issue belongs to the Section Medical Research)

Exploration of Gene Regulation and Therapeutic Targets in Refractory Cancers

edited by Wei-Chieh Huang

submission deadline 6 May 2026 | Viewed by 91 | Submission Open

Keywords: refractory cancers; gene regulation; targeted therapy; drug resistance

(This special issue belongs to the Section Medical Research)

Melatonin Signaling: Therapeutic Implications and Molecular Mechanisms

edited by

Yen-Sung Huang

and

Chia-Chao Wu

submission deadline 15 May 2026 | Viewed by 834 | Submission Open

Keywords: melatonin; AANAT; HIOMT; MTNR1A; MTNR1B; circadian rhythms

(This special issue belongs to the Section Physiology and Pathology)

Recent Advances in Crop Genetics and Breeding: 2nd Edition

edited by

Tianxiao Chen

Xiangjin Wei

Baohua Feng

and Long Chen

submission deadline 15 May 2026 | Viewed by 118 | Submission Open

Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection

(This special issue belongs to the Section Plant Science)

Microvascular Dynamics: Insights and Applications

edited by

Aristotle G. Koutsiaris

and Friedrich Jung

submission deadline 18 May 2026 | 6 articles | Viewed by 16979 | Submission Open

Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical

(This special issue belongs to the Section Physiology and Pathology)

Cancer Epidemiology

edited by Daniela-Cristina Stefan and Honoré K. Mitonga

submission deadline 18 May 2026 | 8 articles | Viewed by 12834 | Submission Open

Keywords: cancer disparities; specific populations; methodological advances; cancer trends; cancer causes; prevention strategies

(This special issue belongs to the Section Epidemiology)

Vestibular Disorders: Pathogenesis and Modern Diagnostic Approaches

edited by Kazimierz Niemczyk and Agnieszka Jasińska-Nowacka

submission deadline 18 May 2026 | Viewed by 104 | Submission Open

Keywords: vestibular disorders; Mé niè re’ s disease; vestibular migraine; vertigo; perilymph; endolymph

(This special issue belongs to the Section Medical Research)

Emerging Applications of Nanobiotechnology in Medicine and Health

edited by Roshanak Khandanlou

submission deadline 19 May 2026 | 2 articles | Viewed by 1542 | Submission Open

Keywords: nanobiotechnology; targeted drug-delivery; tissue engineering; cancer treatment; regenerative medicine; medical applications

(This special issue belongs to the Section Medical Research)

Wildlife Shifts: Species, Space, and Survival

edited by Nikolay D. Natchev

submission deadline 19 May 2026 | Viewed by 100 | Submission Open

Keywords: ecological transitions; behavior; adaptation; organisms; habitat specifics

(This special issue belongs to the Section Animal Science)

Environmental Contaminants: Impacts on Reproduction and Embryonic Development

edited by

Elena Maria Scalisi

submission deadline 20 May 2026 | 1 articles | Viewed by 1135 | Submission Open

Keywords: environmental contaminants; embryonic development; fertility; toxicity; chemicals

(This special issue belongs to the Section Reproductive and Developmental Biology)

Diagnosis and Management of Maternal Medical Diseases in Pregnancy: Current Practice and Future Perspectives

edited by

Alexandra Arvanitaki

and

Ioannis Tsakiridis

submission deadline 20 May 2026 | Viewed by 153 | Submission Open

Keywords: maternal medical disease; maternal cardiac disease; maternal thyroid disease; gestational diabetes; gestational hypertension; pre-eclampsia; diagnosis; management; maternal and fetal outcomes

(This special issue belongs to the Section Medical Research)

Clinical and Radiological Perspectives in Rhinosinusal Pathology

edited by

Alin Horatiu Nedelcu

Ancuta Lupu

and

Vasile Valeriu Lupu

submission deadline 20 May 2026 | Viewed by 84 | Submission Open

Keywords: chronic rhinosinusitis; CBCT; CT; acute rhinosinusitis; maxillary rhinosinusitis; ethmoidal air cells variants; maxillary sinus; Haller cells; Onodi cells; concha bullosa; Agger nasi cells

(This special issue belongs to the Section Medical Research)

Advances in Cardiac Arrhythmias: Mechanisms, Diagnostics and Therapeutics

edited by

Paschalis Karakasis

submission deadline 22 May 2026 | 1 articles | Viewed by 2621 | Submission Open

Keywords: cardiac electrophysiology; arrhythmias; inherited channelopathies

(This special issue belongs to the Section Medical Research)

From Animal Models to Clinical Innovations: Translating Research into Medicine

edited by

Mihaela-Claudia Spataru

and

Manuela Ciocoiu

submission deadline 22 May 2026 | 2 articles | Viewed by 1389 | Submission Open

Keywords: animal models; animal research; biomedical research; ethics of animal experimentation; experimentation on animals; interspecies differences; translational medicine; human clinical medicine

(This special issue belongs to the Section Animal Science)

Progress and Challenges in Emerging Therapies for Alzheimer’s Disease and Its Comorbidities

edited by

Gabriela Dumitrița Stanciu

submission deadline 22 May 2026 | Viewed by 77 | Submission Open

Keywords: Alzheimer’ s disease; emerging therapies/novel treatments; multimorbidity/comorbidities; translational research; cognitive decline; drug development; innovative approaches

(This special issue belongs to the Section Medical Research)

Advanced Cardiovascular Imaging in Heart Failure and Cardio-Oncology: From Early Detection to Personalized Prognosis

edited by

Carla Contaldi

and

Paolo Calabrò

submission deadline 22 May 2026 | Viewed by 69 | Submission Open

Keywords: advanced cardiovascular imaging; heart failure; cardio-oncology; global longitudinal strain; cardiac magnetic resonance; PET/CT imaging; artificial intelligence; risk stratification; cardiotoxicity; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Nutritional Supplementation, Body Composition and Performance in Athletes

edited by

Bojan Knap

submission deadline 25 May 2026 | 2 articles | Viewed by 23197 | Submission Open

Keywords: optimal macro and micronutrients in exercise; plant-based food in sports nutrition; beetroot as ergogenic aid; body mass composition and nutrition practice; phase angle as VO2 max predictor; RED syndrome low and high energetic availability in sports praxis

(This special issue belongs to the Section Physiology and Pathology)

Current Advances in Diagnosis and Treatment of Sepsis

edited by Chih-Huang Li

submission deadline 25 May 2026 | 5 articles | Viewed by 12126 | Submission Open

Keywords: sepsis; biomarkers; prediction; immunotherapy; AI model

(This special issue belongs to the Section Medical Research)

Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health

edited by

Thomas Tsiampalis

and Matina Kouvari

submission deadline 25 May 2026 | 1 articles | Viewed by 9633 | Submission Open

Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors

(This special issue belongs to the Section Epidemiology)

Animal Nutritional Physiology: Effects of Feed Additives on Livestock Products

edited by

Anna Arczewska-Włosek

and Katarzyna Poltowicz

submission deadline 25 May 2026 | Viewed by 1072 | Submission Open

Keywords: feed additives; animal health; animal performance; animal-derived products; animal nutritional physiology

(This special issue belongs to the Section Physiology and Pathology)

Molecular Signatures and Biomarkers in Human Diseases

edited by Manuela Montanaro and Alfonso Baldi

submission deadline 25 May 2026 | Viewed by 74 | Submission Open

Keywords: biomarkers; therapeutic biomarkers; circulating biomarkers; molecular signatures; molecular imaging; precision medicine; targeted therapies; technological innovations

(This special issue belongs to the Section Medical Research)

Coronary Artery Disease: Pathophysiological Mechanisms, Imaging Modalities and Therapeutic Implications

edited by

Michele Russo

and Filippo Luca Gurgoglione

submission deadline 26 May 2026 | 5 articles | Viewed by 21587 | Submission Open

Keywords: coronary artery disease; coronary atherosclerosis; atherosclerotic plaque progression; coronary imaging; cardiovascular risk factors and coronary atherosclerosis-associated diseases

(This special issue belongs to the Section Medical Research)

Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment

edited by

Eliza Elena Cintezǎ

and

Ştefana Moisǎ

submission deadline 26 May 2026 | 3 articles | Viewed by 5015 | Submission Open

Keywords: congenital heart disease; cardiovascular imaging; minimally invasive interventions; fetal cardiology; transcatheter therapies; artificial intelligence in cardiology; 3D echocardiography; cardiac MRI; personalized medicine; genetic heart disorders; heart failure in children; robotic-assisted surgery; cardiovascular biomarkers; electrophysiology in pediatrics; innovative surgical techniques; early diagnosis of heart disease; emerging therapies in cardiology

(This special issue belongs to the Section Medical Research)

Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases

edited by

John Ong

submission deadline 26 May 2026 | 1 articles | Viewed by 2037 | Submission Open

Keywords: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease

(This special issue belongs to the Section Medical Research)

Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice: 2nd Edition

edited by Ralitsa Robeva

submission deadline 27 May 2026 | Viewed by 156 | Submission Open

Keywords: PCOS; hypothalamic amenorrhea; congenital adrenal hyperplasia; hypogonadotropic hypogonadism; premature ovarian insufficiency (POI)

(This special issue belongs to the Section Physiology and Pathology)

Advanced Research in Exercise Medicine

edited by

Ai-Lun Yang

submission deadline 28 May 2026 | 3 articles | Viewed by 16106 | Submission Open

Keywords: exercise and chronic disease; cardiovascular dysfunction/disease; metabolic syndrome; aging; athletic training; sports medicine; rehabilitation

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease

edited by

Marcin Kosmalski

and Monika Różycka-Kosmalska

submission deadline 28 May 2026 | 7 articles | Viewed by 13118 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension

(This special issue belongs to the Section Medical Research)

Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases

edited by

Doina-Adina Todea

Anca-Diana Maierean

and

Damiana-Maria Vulturar

submission deadline 28 May 2026 | 4 articles | Viewed by 3623 | Submission Open

Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; thoracic surgery

(This special issue belongs to the Section Medical Research)

Diagnosis and Treatment of Orthopedic Diseases: Advancing Arthroscopy

edited by

Dimitrios A. Flevas

and

Ioannis Gkiatas

submission deadline 28 May 2026 | 2 articles | Viewed by 2924 | Submission Open

Keywords: arthroscopy; knee; hip; shoulder; arthroscopic surgery

(This special issue belongs to the Section Medical Research)

Microglia, Behavior, and Sex Differences: Neuroimmune Mechanisms in Development and Disease

edited by Irene García Domínguez and Elena Aguado-Domínguez

submission deadline 28 May 2026 | Viewed by 100 | Submission Open

Keywords: microglia; neuroinflammation; sex differences; neurodevelopment; behavior; neuroimmune mechanisms; brain disorders

(This special issue belongs to the Section Physiology and Pathology)

The 15th Anniversary of Life—Alternatives to RNA World

edited by

Doron Lancet

and Amit Kahana

submission deadline 29 May 2026 | Viewed by 578 | Submission Open

Keywords: supramolecular; lipid; assembly; protocell; compositional; information; spontaneous; catalytic; network; reproduction; species; Darwinian; evolution; origin; life

(This special issue belongs to the Section Origin of Life)

Musculoskeletal Disorders: Integrative Insights into Pathophysiology, Therapeutic Strategies, and Rehabilitation

edited by

Carmelo Pirri

submission deadline 30 May 2026 | Viewed by 190 | Submission Open

Keywords: musculoskeletal disorders; high-resolution imaging; biomarkers; ultrasound-guided therapy; regenerative medicine; personalized rehabilitation; wearable sensors; translational musculoskeletal research

(This special issue belongs to the Section Medical Research)

The Role of Natural Products in Disease Treatment

edited by

Bruce Chi-Kang Tsai

submission deadline 30 May 2026 | Viewed by 162 | Submission Open

Keywords: natural products; bioactive compounds; functional foods and nutraceuticals; disease prevention and treatment

(This special issue belongs to the Section Plant Science)

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