Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting Hormonal Regulation in Prostate Cancer
edited by Marília Figueira
submission deadline 30 Jan 2026 | Viewed by 329 | Submission Open
Keywords: prostate cancer; castrate resistant prostate cancer (CRPC); metastatic prostate cancer; estrogens; estrogen receptors; drug resistance
(This special issue belongs to the Section Medical Research)
New Advances in Neuroimaging and Brain Functions: 2nd Edition submission deadline 31 Jan 2026 | 4 articles | Viewed by 21196 | Submission Open
Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Pain and Therapy: Historical Perspectives and Future Directions submission deadline 31 Jan 2026 | 7 articles | Viewed by 11356 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Medical Research)
Pancreatic Cancer: Long Survivals
edited by Francesco Leonardi and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 8925 | Submission Open
Keywords: pancreatic cancer; long survival; outcome; pancreatic adenocarcinoma; long-term survival; surgical resection; chemotherapy; NGS
(This special issue belongs to the Section Physiology and Pathology)
Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition submission deadline 31 Jan 2026 | 4 articles | Viewed by 4304 | Submission Open
Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases
(This special issue belongs to the Section Physiology and Pathology)
Microbiome–Gut–Brain Connections: New Windows into Health and Disease
edited by and Qi Su
submission deadline 31 Jan 2026 | 3 articles | Viewed by 2883 | Submission Open
Keywords: gut microbes; gut– brain axis; neuroscience
(This special issue belongs to the Section Microbiology)
Prevention, Diagnosis, and Treatment of Gestational Diseases
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 2684 | Submission Open
Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications
(This special issue belongs to the Section Medical Research)
Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2443 | Submission Open
Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites
(This special issue belongs to the Section Medical Research)
Advances in the Rehabilitation of Stroke
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1807 | Submission Open
Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation
(This special issue belongs to the Section Medical Research)
Recent Advances in Valve Therapy: Clinical and Molecular Perspectives
edited by , Konstantinos Toutouzas and Constantina Aggeli
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1763 | Submission Open
Keywords: transcatheter aortic valve implantation (TAVI); valve-in-valve; long-term outcomes; aortic stenosis; molecular mechanisms in valve disease; structural heart disease
(This special issue belongs to the Section Medical Research)
Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1752 | Submission Open
Keywords: microplastics; nanomaterials; environmental toxicology; oxidative stress; physiological function
(This special issue belongs to the Section Physiology and Pathology)
Advances in Cardiac Arrest: Prognostic Performance and Management
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1455 | Submission Open
Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine
(This special issue belongs to the Section Medical Research)
Plant–Soil Interactions Under Global Change
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1081 | Submission Open
Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development
(This special issue belongs to the Section Plant Science)
Pig Microbiota Metabolism and Intestinal Health
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1025 | Submission Open
Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health
(This special issue belongs to the Section Animal Science)
Intracerebral Hemorrhage: Advances and Perspectives
edited by Ane Claudia Fernandes Nunes
submission deadline 31 Jan 2026 | 1 articles | Viewed by 973 | Submission Open
Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood– brain barrier; small vessel disease
(This special issue belongs to the Section Physiology and Pathology)
New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders
edited by Mihai Lazar
submission deadline 31 Jan 2026 | 1 articles | Viewed by 814 | Submission Open
Keywords: pneumonia pathophysiology; lung fibrosis; coagulation disorders; thromboinflammation; immune dysregulation; diagnostic biomarkers; translational medicine
(This special issue belongs to the Section Physiology and Pathology)
Advances in Emergency and Critical Care Medicine
edited by
submission deadline 31 Jan 2026 | Viewed by 631 | Submission Open
Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly
(This special issue belongs to the Section Medical Research)
Parasite Detection, Control Strategies and Risk Factors Related to Reproductive Health in Livestock submission deadline 31 Jan 2026 | Viewed by 505 | Submission Open
Keywords: livestock; parasite control; reproductive health; management
(This special issue belongs to the Section Animal Science)
The Biological Impacts of Fetal Alcohol Exposure
edited by Kelly J. Huffman
submission deadline 31 Jan 2026 | 1 articles | Viewed by 484 | Submission Open
Keywords: fetal alcohol spectrum disorders; fetal alcohol syndrome; brain development; behavioral development; prenatal exposure
(This special issue belongs to the Section Reproductive and Developmental Biology)
Brain Health for All Ages: Leave No One Behind
edited by and Dilani Wijeratne
submission deadline 31 Jan 2026 | 1 articles | Viewed by 463 | Submission Open
Keywords: brain health; neurology; neurological syndromes
(This special issue belongs to the Section Medical Research)
Cell Asymmetry and Polarity: Guiding Cellular Behavior and Development: Second Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 267 | Submission Open
Keywords: cell asymmetry; cell polarity; tissue morphogenesis; planar cell polarity (PCP) pathway; Wnt pathway; therapeutic implications
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Liver Disease: Pathogenesis, Diagnosis, and Treatments
edited by Hsien-Hui Chung
submission deadline 31 Jan 2026 | Viewed by 203 | Submission Open
Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies
(This special issue belongs to the Section Medical Research)
The Role of Mitochondrial Function in Cancer and Diseases and Therapeutic Explorations
edited by and
submission deadline 31 Jan 2026 | Viewed by 155 | Submission Open
Keywords: cancer metabolism; mitochondrial DNA (mtDNA) mutations; oxidative stress; mitophagy and autophagy; mitochondria-targeted therapy; metabolic reprograming; mitochondrial dynamics (fusion and fission); redox biology
(This special issue belongs to the Section Physiology and Pathology)
Advances in Imaging for Female Patients: Breast and Gynecological Diagnostics
edited by Silvia Gigli, Emanuele David and Giacomo Bonito
submission deadline 31 Jan 2026 | Viewed by 151 | Submission Open
Keywords: breast cancer; breast screening; gynecological cancer; mammography; CEM; ultrasound; MRI; PET/TC; radiomics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Microbial Biotechnology and Biomanufacturing submission deadline 31 Jan 2026 | Viewed by 149 | Submission Open
Keywords: synthetic biology tools; microbial biomanufacturing; future foods; bulk chemicals; plant natural products
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Chemical Evolutionary Pathways to Origins of Life
edited by and Christian Seitz
submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open
Keywords: origin of life; metabolism-first; early Earth; iron– sulfur world; chemical evolution  ; cellularization; surface catalysis; pioneer organism
(This special issue belongs to the Section Origin of Life)
Transformative Technologies in Liver Transplantation submission deadline 31 Jan 2026 | Viewed by 125 | Submission Open
Keywords: liver; transplant; liver surgery; machine perfusion; radiomics; nanotechnology; 3D printing; gene editing
Current Updates on Equidae Breeding and Genetics submission deadline 31 Jan 2026 | Viewed by 102 | Submission Open
Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule
(This special issue belongs to the Section Animal Science)
Cancer Genetics and Genomics: From Structure to Therapy
edited by Luca Járomi and Gellért Gerencsér
submission deadline 31 Jan 2026 | Viewed by 93 | Submission Open
Keywords: epigenetics; cancer therapy; multidrug resistance (MDR); accumulation; biomarkers
(This special issue belongs to the Section Genetics and Genomics)
Advanced Machine Learning for Bio-Signal Processing and Health Monitoring
edited by
submission deadline 31 Jan 2026 | Viewed by 80 | Submission Open
Keywords: brain– computer interface (BCI); electroencephalogram (EEG); machine learning; biomedical signal processing; brain computer interface; health monitoring
(This special issue belongs to the Section Medical Research)
Mechanisms and Ecology of Migration and Homing
edited by Hynek Burda
submission deadline 1 Feb 2026 | Viewed by 98 | Submission Open
Keywords: migration; homing; navigation; spatial orientation; magnetoreception; cognitive maps; seasonality; spatial memory
(This special issue belongs to the Section Diversity and Ecology)
Advances in Endoscopic, Surgical, and Interventional Radiological Management of Gastrointestinal Diseases
edited by
submission deadline 6 Feb 2026 | 3 articles | Viewed by 7128 | Submission Open
Keywords: gastrointestinal disease; endoscopic cystogastrostomy; endoscopic biliary prosthesis; endoscopic pancreatic prosthesis; endoscopic necrosectomy; esophagectomy; gastrectomy; bowel resection; colectomy; pancreatectomy; hepatectomy; liver transplantation; gastroenterology; surgery; interventional radiology
(This special issue belongs to the Section Medical Research)
Genetics, Breeding and Reproduction of Honeybees: Second Edition
edited by
submission deadline 9 Feb 2026 | 2 articles | Viewed by 3884 | Submission Open
Keywords: phenomics; genetics; genomics; functional genomics; metabolomics; functional genes identification; genetics editing; genome selection; genetic evaluation; hybrid breeding; egg-laying; honey production; queen breeding; varroa resistance
(This special issue belongs to the Section Animal Science)
Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans
edited by
submission deadline 13 Feb 2026 | 5 articles | Viewed by 4268 | Submission Open
Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; transcranial Doppler measurement; EEG; lifestyle
(This special issue belongs to the Section Physiology and Pathology)
Pain Epidemiology
edited by
submission deadline 14 Feb 2026 | Viewed by 141 | Submission Open
Keywords: pain epidemiology; chronic pain; neuropathic pain; nociplastic pain; headache; migraine; orofacial pain; low back pain
(This special issue belongs to the Section Epidemiology)
Prebiotic Chemistry: The Molecular Origins of Life
edited by
submission deadline 15 Feb 2026 | Viewed by 359 | Submission Open
Keywords: astrobiology; astrochemistry; biochemistry; computational modelling; geochemistry; metabolic pathways; lipid formation; peptide synthesis; photochemistry; radiation chemistry; RNA world; self-assembly; systems chemistry
(This special issue belongs to the Section Origin of Life)
Microbiome Dynamics: Advancing Therapeutic Development in Health and Disease
edited by , Sukyung Kim and
submission deadline 16 Feb 2026 | Viewed by 134 | Submission Open
Keywords: next-generation probiotics (NGPs); microbiome-based therapeutics; metagenomics and multi-omics integration; microbial biomarkers; short-chain fatty acids (SCFAs); artificial human microbiome simulators; GMP-scale production; clinical translation
(This special issue belongs to the Section Microbiology)
Omics Approaches in Antipsychotic Pharmacology
edited by
submission deadline 18 Feb 2026 | Viewed by 74 | Submission Open
Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal
(This special issue belongs to the Section Pharmaceutical Science)
Current Challenges in Human Space Flight submission deadline 20 Feb 2026 | 4 articles | Viewed by 13073 | Submission Open
Keywords: cognition; microgravity; sleep; stress; Martian and lunar dust; neural stem cells and progenitors
(This special issue belongs to the Section Astrobiology)
Musculoskeletal Function and Exercise Physiology: Integrative Approaches and Emerging Insights
edited by , , and Luke Chowning
submission deadline 20 Feb 2026 | Viewed by 134 | Submission Open
Keywords: resistance exercise; aerobic exercise; sport performance; neuromuscular; electromyography; muscle function; kinematics; kinetics; biomechanics; motion analysis; imaging techniques; muscle biopsy
(This special issue belongs to the Section Medical Research)
Mucopolysaccharidosis-Plus: From Molecular Defects to Therapeutic Strategies
edited by Zuzanna Cyske
submission deadline 20 Feb 2026 | Viewed by 62 | Submission Open
Keywords: mucopolysaccharidosis; mucopolysaccharidosis-plus syndrome; MPSPS; VPS33A; therapy; patomechanism; diagnostic; patients’ care
(This special issue belongs to the Section Medical Research)
Diagnosis, Treatment and Prognosis of Prostate Cancer
edited by and Jesús Moreno Sierra
submission deadline 25 Feb 2026 | 1 articles | Viewed by 904 | Submission Open
Keywords: active surveillance; hormonal treatment; personalized medicine; prostate cancer; robotic surgery; targeted therapy
(This special issue belongs to the Section Medical Research)
Nutrition, Exercise and Stress
edited by Maleah Holland-Winkler
submission deadline 25 Feb 2026 | Viewed by 459 | Submission Open
Keywords: nutrition; exercise; stress
(This special issue belongs to the Section Physiology and Pathology)
Gynecology Update: Modern Diagnostic Approaches and Innovative Therapies
edited by Szabolcs Várbíró, , Richárd Tóth and Balázs Lintner
submission deadline 26 Feb 2026 | 3 articles | Viewed by 2005 | Submission Open
Keywords: gynecologic oncology; endocrinology; reproductive medicine; fertility preservation; prevention; women’ s health innovation; quality of life; personalized therapy
(This special issue belongs to the Section Medical Research)
Conservative Management of Chronic Disease—2nd Edition
edited by
submission deadline 26 Feb 2026 | Viewed by 220 | Submission Open
Keywords: chronic disease; conservative management; trial protocol; clinical research; interventions
(This special issue belongs to the Section Medical Research)
Skin Aging and Dermatosis
edited by Edwin Lephart and Zoe D. Draelos
submission deadline 26 Feb 2026 | Viewed by 145 | Submission Open
Keywords: skin aging; chronological dermal aging; photo-aging; hormone therapy; menopause; estrogen-deficient skin; dermatosis; skin conditions
(This special issue belongs to the Section Medical Research)
Biomechanics of Aging submission deadline 26 Feb 2026 | Viewed by 138 | Submission Open
Keywords: aging; biomechanics; musculoskeletal; gait; balance; falls; exercise; assistive devices
(This special issue belongs to the Section Physiology and Pathology)
The Link Between Food Safety and Microbiology
edited by
submission deadline 26 Feb 2026 | Viewed by 134 | Submission Open
Keywords: food safety; food microbiology; beneficial microbes; food preservation; food safety enhancement
(This special issue belongs to the Section Microbiology)
Oral Health: Microbial Dynamics and Antibiotic Stewardship
edited by Kristina Peroš
submission deadline 26 Feb 2026 | Viewed by 82 | Submission Open
Keywords: oral health; oral microbiota; microbial dynamics; antibiotic stewardship
(This special issue belongs to the Section Microbiology)
Pharmacological Advances in Anticancer, Antiparasitic, and Immunomodulatory Therapies
edited by Cássio Santana Meira and Vinicius Pinto Costa Rocha
submission deadline 26 Feb 2026 | Viewed by 72 | Submission Open
Keywords: anticancer drugs; antiparasitic agents; immunomodulatory therapy; drug development
(This special issue belongs to the Section Pharmaceutical Science)
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