Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare
edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura
submission deadline 15 Mar 2026 | 5 articles | Viewed by 8957 | Submission Open
Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19
(This special issue belongs to the Section Pharmaceutical Science)
Evolutionary and Conservation Genetics: 3rd Edition
edited by and Ilenia Azzena
submission deadline 15 Mar 2026 | 4 articles | Viewed by 8346 | Submission Open
Keywords: evolutionary genetics; population genetics; conservation genetics; phylogeography; phylogenetics; phylodynamics; molecular taxonomy
(This special issue belongs to the Section Evolutionary Biology)
Organ Predilection of Certain Gastrointestinal Diseases—Pathophysiology, Diagnosis and Management
edited by
submission deadline 15 Mar 2026 | 1 articles | Viewed by 2504 | Submission Open
Keywords: disease predilection in gastrointestinal tract; esophagus with certain diseases; stomach with certain diseases; duodenum with certain diseases; jejunum with certain diseases; ileum with certain diseases; colorectum with certain diseases
(This special issue belongs to the Section Physiology and Pathology)
2nd Edition—Food Microbiological Contamination submission deadline 16 Mar 2026 | 1 articles | Viewed by 311 | Submission Open
Keywords: food safety; food microbiology; foodborne pathogens; food spoilage; food quality; food contamination; microbiological hazards; natural antimicrobials
(This special issue belongs to the Section Microbiology)
Advances in Substance Abuse and Addiction—2nd Edition
edited by , and Chieh-Liang Huang
submission deadline 18 Mar 2026 | 1 articles | Viewed by 1028 | Submission Open
Keywords: addiction medicine; opioid pharmacology; substance abuse; addictive disorder intervention
(This special issue belongs to the Section Pharmaceutical Science)
Non-Valvular Atrial Fibrillation and Acute Stroke: Prevention and Management
edited by Luca Masotti
submission deadline 18 Mar 2026 | 1 articles | Viewed by 999 | Submission Open
Keywords: atrial fibrillation; acute ischemic stroke; intracerebral hemorrhage; direct oral anticoagulants; vitamin K antagonists; reversal therapy; tenecteplase; alteplase; intravenous thrombolysis; mechanical thrombectomy; left atrial appendage occlusion; embolic stroke of undetermined source; ECG monitoring
(This special issue belongs to the Section Medical Research)
New Insights Into Artificial Intelligence in Medical Imaging
edited by , , and Salvatore Lavalle
submission deadline 20 Mar 2026 | 3 articles | Viewed by 12395 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; image analysis; precision medicine; image-guided interventions; decision support systems
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition submission deadline 20 Mar 2026 | 3 articles | Viewed by 8369 | Submission Open
Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery
(This special issue belongs to the Section Physiology and Pathology)
Towards Resilient Seas: Marine Biodiversity and Ecological Functioning in a Changing Ocean
edited by and Dorka Cobián-Rojas
submission deadline 20 Mar 2026 | Viewed by 451 | Submission Open
Keywords: marine conservation; ecosystem-based management; biodiversity; climate change adaptation; restoration process; ecological connectivity
(This special issue belongs to the Section Diversity and Ecology)
Cereal Production Systems: Climate-Fertilizer-Crop Yield Dynamics submission deadline 20 Mar 2026 | 1 articles | Viewed by 393 | Submission Open
Keywords: cereals; climate; preceding crop; fertilization; grain yield; grain quality; straw yield; soil health; soil chemistry and biology; yield stability; mineral fertilizers; organic manures; tillage
(This special issue belongs to the Section Plant Science)
Bioactive Chemical Constituents of Ornamental Plants
edited by
submission deadline 20 Mar 2026 | Viewed by 71 | Submission Open
Keywords: ornamental plants; extraction technologies; structure elucidation; chemical synthesis and biosynthesis; biological investigations
(This special issue belongs to the Section Plant Science)
Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods submission deadline 24 Mar 2026 | 14 articles | Viewed by 39684 | Submission Open
Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging
(This special issue belongs to the Section Pharmaceutical Science)
Novel Therapeutics for Musculoskeletal Disorders
edited by and Giulia Letizia Mauro
submission deadline 26 Mar 2026 | 5 articles | Viewed by 4175 | Submission Open
Keywords: osteoarthritis; osteoporosis; bone; arthropathy; joint; pain; lower back pain
(This special issue belongs to the Section Medical Research)
Therapeutic Innovations from Plants and Their Bioactive Extracts
edited by and Annamária Pallag
submission deadline 26 Mar 2026 | 3 articles | Viewed by 2310 | Submission Open
Keywords: herbals; plant extracts; phytochemicals; polyphenols; anthocyanins; natural compounds isolation; herbal extract characterization; bioactive extracts preparation; oxidative stress; apoptosis; inflammation; dermatitis; psoriasis; diabetes mellitus; neurodegenerative disorders; CNS diseases; new target molecules; animal models; clinical studies
(This special issue belongs to the Section Pharmaceutical Science)
Postbiotics—Bioactive Microbial Compounds as Health-Promoting Agents submission deadline 27 Mar 2026 | 4 articles | Viewed by 7987 | Submission Open
Keywords: gut microbiota; postbiotics; prebiotics; microbiota-derived metabolites; postbiotic supplementation; postbiotics and health benefits; dysbiosis
(This special issue belongs to the Section Microbiology)
Extremophiles Breakthrough: Hot Topics and Current Issues in Their Isolation, Identification and Biotechnological Applications—2nd Edition submission deadline 27 Mar 2026 | 1 articles | Viewed by 533 | Submission Open
Keywords: astrobiology; biochemistry and molecular biology; biodiversity and ecology; biotechnology; extraterrestrial analogs; extreme environments; extremophiles; genetics; genomics; and proteomics; origin of life; phylogeny and evolution; physiology and metabolism
(This special issue belongs to the Section Microbiology)
From Stem Cells to Embryos, Congenital Anomalies and Epidemiology
edited by , Soultana Meditskou and
submission deadline 30 Mar 2026 | 9 articles | Viewed by 34947 | Submission Open
Keywords: stem cell research; human embryonic development; birth defects epidemiology; birth defects prevalence; maternal and fetal medicine; congenital anomalies prevention; ultrasound evaluation; pre-birth assessment; prenatal screening; healthcare
(This special issue belongs to the Section Epidemiology)
Innovative Perspectives in Physical Therapy and Health submission deadline 30 Mar 2026 | 9 articles | Viewed by 28608 | Submission Open
Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies
(This special issue belongs to the Section Medical Research)
Critical Issues in Intensive Care Medicine
edited by
submission deadline 30 Mar 2026 | 10 articles | Viewed by 18826 | Submission Open
Keywords: critical issues; intensive care; co-morbidities in ICUs; new technology issues in ICUs; hospital-acquired infections; end of life
(This special issue belongs to the Section Medical Research)
Advances in the Treatment of Pulmonary Hypertension and Pulmonary Embolism submission deadline 30 Mar 2026 | 5 articles | Viewed by 14305 | Submission Open
Keywords: pulmonary hypertension; pulmonary embolism; therapy; cardiac imaging; artificial intelligence
(This special issue belongs to the Section Medical Research)
Current Progress in Medical Image Segmentation
edited by
submission deadline 30 Mar 2026 | 6 articles | Viewed by 11950 | Submission Open
Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Physiological Responses of Plants Under Abiotic Stresses
edited by
submission deadline 30 Mar 2026 | 6 articles | Viewed by 9460 | Submission Open
Keywords: crops; woody plants; horticultural plants; physiological responses; abiotic stresses; photosynthesis
(This special issue belongs to the Section Plant Science)
Eye Diseases: Diagnosis and Treatment, 3rd Edition
edited by and Laura De Diego-García
submission deadline 30 Mar 2026 | 5 articles | Viewed by 9396 | Submission Open
Keywords: ocular treatment; ocular diseases; retina; anterior eye; posterior eye; ocular biomarkers
(This special issue belongs to the Section Medical Research)
From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders
edited by , and Ana Lascu
submission deadline 30 Mar 2026 | 3 articles | Viewed by 9053 | Submission Open
Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota
(This special issue belongs to the Section Physiology and Pathology)
Applications of EEG in Neural Rehabilitation: 2nd Edition submission deadline 30 Mar 2026 | 2 articles | Viewed by 8731 | Submission Open
Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Chronic Obstructive Pulmonary Disease: Clinical, Epidemiological, and Molecular Bases
edited by
submission deadline 30 Mar 2026 | 2 articles | Viewed by 4832 | Submission Open
Keywords: chronic obstructive pulmonary disease; COPD; emphysema; chronic bronchitis
(This special issue belongs to the Section Medical Research)
Gut Microbes Associating with the Host
edited by and
submission deadline 30 Mar 2026 | 2 articles | Viewed by 4720 | Submission Open
Keywords: gut microbes; microbiome; animals; nutrition
(This special issue belongs to the Section Microbiology)
Encephalitis: From Molecular Pathophysiology to Therapy
edited by Anna Tröscher and Judith Wagner
submission deadline 30 Mar 2026 | 3 articles | Viewed by 3559 | Submission Open
Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy
(This special issue belongs to the Section Physiology and Pathology)
The Other Pediatric Primary Headaches: 2nd Edition
edited by , and Giuseppe Santangelo
submission deadline 30 Mar 2026 | 2 articles | Viewed by 3447 | Submission Open
Keywords: pediatric TACs; primary pediatric headaches; pediatric tension headaches; preventive treatment; acute treatment; clinical features; children; pediatric headaches in IV 3ICHD
(This special issue belongs to the Section Medical Research)
Advances and Applications of Neuroimaging in Brain Disorder
edited by Julio Plata-Bello
submission deadline 30 Mar 2026 | 1 articles | Viewed by 3416 | Submission Open
Keywords: neuroimaging; magnetic resonance imaging; positron emission tomography; near infrared spectroscopy; brain; dementia; schizophrenia; depression; brain tumors; multiple sclerosis; autism
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Precision Medicine in Cardiovascular Diseases
edited by Brian Xiangzhi Wang
submission deadline 30 Mar 2026 | 2 articles | Viewed by 3304 | Submission Open
Keywords: genomic; cardiovascular disease; congenital; multi-omics studies; precision medicine; personalized medicine; biomarker
(This special issue belongs to the Section Genetics and Genomics)
Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions
edited by
submission deadline 30 Mar 2026 | 1 articles | Viewed by 3240 | Submission Open
Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs
(This special issue belongs to the Section Pharmaceutical Science)
Microvascular and Macrovascular Response in Healthy and Critically Ill
edited by Andrius Pranskunas and
submission deadline 30 Mar 2026 | 3 articles | Viewed by 2918 | Submission Open
Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation
(This special issue belongs to the Section Physiology and Pathology)
Effects of Exercise Training on Muscle Function—2nd Edition
edited by and
submission deadline 30 Mar 2026 | 2 articles | Viewed by 416 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Biological Insights into Drug Safety for Vulnerable Populations submission deadline 30 Mar 2026 | Viewed by 354 | Submission Open
Keywords: drug safety; vulnerable populations; pharmacotherapy; drug metabolism and efficacy; pediatric medication safety; drug pharmacokinetics and pharmacodynamics
(This special issue belongs to the Section Pharmaceutical Science)
Recent Advances in Non-Invasive Diagnosis Based on Volatile Metabolites
edited by Kiran Sankar Maiti
submission deadline 30 Mar 2026 | Viewed by 318 | Submission Open
Keywords: volatile metabolites; breath analysis; headspace analysis; biofluids; non-invasive; diagnosis
(This special issue belongs to the Section Medical Research)
Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure submission deadline 30 Mar 2026 | Viewed by 78 | Submission Open
Keywords: heart failure; biomarkers; molecular mechanisms
(This special issue belongs to the Section Physiology and Pathology)
Advances in the Structure and Function of Microbial Communities
edited by and
submission deadline 31 Mar 2026 | 4 articles | Viewed by 9423 | Submission Open
Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability
(This special issue belongs to the Section Microbiology)
New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease: 2nd Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 4982 | Submission Open
Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain
(This special issue belongs to the Section Medical Research)
Vision Science and Optometry: 2nd Edition submission deadline 31 Mar 2026 | 5 articles | Viewed by 4550 | Submission Open
Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior pole; circadian light
(This special issue belongs to the Section Medical Research)
Advanced Machine Learning for Disease Prediction and Prevention
edited by and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 4072 | Submission Open
Keywords: advanced machine learning; disease prediction; disease prevention; biomedical data integration; multimodal data; explainable AI (XAI); AI Interpretability; algorithmic fairness; bias mitigation; predictive modeling; healthcare analytics; risk stratification; early disease detection; clinical decision support; computational health; public health informatics; AI ethics in healthcare; medical AI validation; health data science; personalized medicine
(This special issue belongs to the Section Medical Research)
Enhancements in Screening Pathways for Early Detection of Lung Cancer submission deadline 31 Mar 2026 | 2 articles | Viewed by 3890 | Submission Open
Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence
(This special issue belongs to the Section Medical Research)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges: 2nd Edition submission deadline 31 Mar 2026 | 2 articles | Viewed by 3099 | Submission Open
Keywords: hyperlipidemia; neuropathy; nephropathy; retinopathy; psychological effects; epigenetic imprinting; molecular profiling; glucose control; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
New Insights into Athlete Physiology submission deadline 31 Mar 2026 | 1 articles | Viewed by 2856 | Submission Open
Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship
(This special issue belongs to the Section Physiology and Pathology)
Allergies and Allergic Diseases—Perspectives in Diagnosis and Management: 2nd Edition
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 2125 | Submission Open
Keywords: allergy; anaphylaxis; cross-allergies; IgE; exercise-induced anaphylaxis; component-resolved diagnosis
(This special issue belongs to the Section Medical Research)
Space Medicine Advancements: From Human Health to Biomedical System Design
edited by and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 2108 | Submission Open
Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations
(This special issue belongs to the Section Medical Research)
From Vessel to Muscle—an Integrative Approach to Ischemic Heart Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 1765 | Submission Open
Keywords: ischemic heart disease; atherosclerotic plaque features; microvascular dysfunction; coronary vasospasm; percutaneous transluminal coronary angioplasty; coronary artery bypass grafting; cardiac magnetic resonance imaging; coronary computed tomography angiography
(This special issue belongs to the Section Physiology and Pathology)
Innovation and Translation in Cardiovascular Interventions
edited by Jacek Bil
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1706 | Submission Open
Keywords: cardiovascular interventions; innovation; translational research; interventional cardiology; structural heart disease; device development; percutaneous therapy; imaging guidance; physiology-guided intervention; drug– device combination; artificial intelligence; digital health; bioresorbable scaffolds; clinical translation; cardiovascular technology
(This special issue belongs to the Section Medical Research)
The Contribution of Neurogenetics in Disentangling the Pathophysiology of Neurodegenerative Diseases
edited by , Michele Salemi and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1679 | Submission Open
Keywords: neurodegenerative diseases; translational neurogenetics; early diagnosis; prevention; therapies; clinical practice; advanced genetic techniques; outcome measures
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment—4th Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 982 | Submission Open
Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steatohepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases
(This special issue belongs to the Section Physiology and Pathology)
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