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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Musculoskeletal Disorders: Integrative Insights into Pathophysiology, Therapeutic Strategies, and Rehabilitation

edited by

Carmelo Pirri

submission deadline 30 May 2026 | Viewed by 211 | Submission Open

Keywords: musculoskeletal disorders; high-resolution imaging; biomarkers; ultrasound-guided therapy; regenerative medicine; personalized rehabilitation; wearable sensors; translational musculoskeletal research

(This special issue belongs to the Section Medical Research)

Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition

edited by

Valentin Nicolae Varlas

submission deadline 30 May 2026 | Viewed by 165 | Submission Open

Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies

(This special issue belongs to the Section Medical Research)

New Mechanisms and Insights into Insect Silk Gland Biology and Silk Production

edited by Wenliang Qian

submission deadline 30 May 2026 | Viewed by 139 | Submission Open

Keywords: silk gland morphogenesis; liquid-to-solid phase transition; biomimetic microfluidic spinning; silk gland multi-omics; silk protein evolutionary adaptations; CRISPR

(This special issue belongs to the Section Animal Science)

Advances in Skin-Related Disease: Pathogenesis and Novel Therapeutic Strategies

edited by

Elisabetta Palazzo

and

Marika Quadri

submission deadline 31 May 2026 | 4 articles | Viewed by 15780 | Submission Open

Keywords: skin pathologies; skin cancer; eczema; acne; psoriasis; skin microbiome

(This special issue belongs to the Section Physiology and Pathology)

Prognosis and Management of Dry Eye Disease

edited by

Hugo Pena-Verdeal

Alena Furdova

and

Jacobo Garcia-Queiruga

submission deadline 31 May 2026 | 3 articles | Viewed by 9548 | Submission Open

Keywords: dry eye disease; dry eye epidemiology; dry eye management; dry eye natural course; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; artificial tear substitutes; tear film lipid layer; meibomian glands

(This special issue belongs to the Section Medical Research)

New Insights into Pediatric Rheumatic and Autoimmune Diseases

edited by

Lampros Fotis

submission deadline 31 May 2026 | 1 articles | Viewed by 4076 | Submission Open

Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis

(This special issue belongs to the Section Medical Research)

Current and Future Perspectives of Takotsubo Syndrome

edited by Luca Arcari

submission deadline 31 May 2026 | 2 articles | Viewed by 3279 | Submission Open

Keywords: takotsubo syndrome; heart failure; microvascular dysfunction; inflammation; myocardial edema; heart– brain axis; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging

(This special issue belongs to the Section Physiology and Pathology)

Recent Advances in Lymphomas

edited by Magdalena Witkowska

submission deadline 31 May 2026 | 3 articles | Viewed by 2744 | Submission Open

Keywords: lymphoma; cellular therapy; epigenetics; immunotherapy; targeted therapies

(This special issue belongs to the Section Medical Research)

Innovative Cardiovascular Interventions: From Imaging to Precision Therapies

edited by

Anastasios Apostolos

submission deadline 31 May 2026 | 1 articles | Viewed by 1439 | Submission Open

Keywords: cardiovascular diseases (CVDs); diagnostic imaging; minimally invasive interventions; precision medicine; 3D/4D imaging; gene therapy; cell-based therapies

(This special issue belongs to the Section Physiology and Pathology)

Advances in Wildlife Behavior and Biodiversity

edited by

Katarzyna Tajchman

and

Pawel Janiszewski

submission deadline 31 May 2026 | 1 articles | Viewed by 1309 | Submission Open

Keywords: behavioral abnormalities; the ability to exhibit natural behavior; reduced genetic diversity; habitat loss; extinction of species; species rehousing; coexistence

(This special issue belongs to the Section Diversity and Ecology)

Physiological, Pathological, and Clinical Effects of Exercise Training and Physical Activity

edited by Chia-Huei Lin

submission deadline 31 May 2026 | 2 articles | Viewed by 1200 | Submission Open

Keywords: exercise training; physical activity; individualized exercise prescription; physiological adaptation; chronic disease prevention; cardiovascular fitness; musculoskeletal health; neuroplasticity; metabolic syndrome; inflammation and immunity; stroke recovery; physical activity monitoring; mental health and exercise; cognitive function; aging and physical activity; sedentary behavior; physical function outcomes; patient-reported outcomes; clinical trial

(This special issue belongs to the Section Physiology and Pathology)

Harmful Algal Bloom Risk: Mechanisms, Prediction, Impacts and Mitigation

edited by Lixia Shang

submission deadline 31 May 2026 | 1 articles | Viewed by 1016 | Submission Open

Keywords: harmful algal blooms; marine risk; bloom mechanisms; prediction models; mitigation strategies; ecosystem impact

(This special issue belongs to the Section Diversity and Ecology)

Hybrid Molecules in Drug Discovery: From Antidiabetic Agents to Anticancer Therapeutics

edited by Jatinder Singh and Shreyosree Chatterjee

submission deadline 31 May 2026 | Viewed by 312 | Submission Open

Keywords: hybrid molecules; drug discovery; antidiabetic; oncology; structure— activity relationships

(This special issue belongs to the Section Pharmaceutical Science)

New Screening Methods for Diagnosis of Cardiovascular Diseases

edited by

Raluca-Ioana Stefan-van Staden

, Ruxandra Maria Ilie-Mihai and Damaris Cristina Gheorghe

submission deadline 31 May 2026 | Viewed by 265 | Submission Open

Keywords: cardiovascular diseases; biomarkers; screening methods; sensor; spectroscopic methods; chromatographic methods

(This special issue belongs to the Section Medical Research)

Artificial Intelligence and Machine Learning for Biomedical Diagnostics and Prognostics

edited by

César Byron Guevara Maldonado

Victoria López

and

Diego Fernando Riofrío Luzcando

submission deadline 31 May 2026 | Viewed by 240 | Submission Open

Keywords: artificial intelligence; machine learning; diagnostic and prognostic modeling; multimodal data integration; explainable AI

(This special issue belongs to the Section Medical Research)

Biofluid Mechanics and Medical Diagnostic Simulations

edited by

Violeta Carvalho

and

Adrian Neagu

submission deadline 31 May 2026 | Viewed by 236 | Submission Open

Keywords: biofluid mechanics; computational modeling; medical diagnostics; fluid-structure interaction; patient-specific modeling

(This special issue belongs to the Section Medical Research)

Objective Tools to Aid the Diagnosis and Treatment of Neurodevelopmental Disorders

edited by

Maria Pia Bucci

submission deadline 31 May 2026 | 1 articles | Viewed by 197 | Submission Open

Keywords: intervertion training ; eye tracker ; dyslexia ; postural sways ; reading ; ASD ; ADHD ; attention ; emotion

(This special issue belongs to the Section Medical Research)

Comorbidities of Migraine: Clinical and Research Perspectives

edited by

Claudio Tana

submission deadline 31 May 2026 | Viewed by 168 | Submission Open

Keywords: migraine; pain; headache; comorbidities; internal medicine; complex disorders

(This special issue belongs to the Section Medical Research)

Understanding Early Dysmetabolism in Adolescents: Bridging Research, Mechanisms and Clinical Management

edited by Anna Di Sessa

submission deadline 31 May 2026 | Viewed by 164 | Submission Open

Keywords: dysmetabolism; biomarkers; intervention; prevention; early diagnosis; strategies; children; adolescents

(This special issue belongs to the Section Physiology and Pathology)

Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Disorders

edited by Giovanni Tomasello

submission deadline 31 May 2026 | Viewed by 105 | Submission Open

Keywords: gut dysbiosis; gastrointestinal; probiotics; inflammatory bowel diseases

(This special issue belongs to the Section Microbiology)

Epidemiological Insights into Cardiovascular Risk and Outcomes

edited by Rui Providência

submission deadline 8 Jun 2026 | Viewed by 125 | Submission Open

Keywords: cohort study; Mendelian randomization; myocardial infarction; heart failure; stroke; atrial fibrillation; risk prediction

(This special issue belongs to the Section Epidemiology)

Agri-Food Waste Extracts: Structural and Functional Characterization

edited by

Stefania Lamponi

submission deadline 12 Jun 2026 | 1 articles | Viewed by 1106 | Submission Open

Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules

(This special issue belongs to the Section Plant Science)

Ultrasound and Anatomical Studies

edited by

Maribel Miguel-Pérez

, Ingrid Moller and

Albert Pérez-Bellmunt

submission deadline 15 Jun 2026 | Viewed by 197 | Submission Open

Keywords: ultrasound techniques; musculoskeletal system; human anatomy; medicine specialties; clinical students; ultrasound teaching

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity

edited by

Berit Hippe

submission deadline 18 Jun 2026 | 3 articles | Viewed by 9110 | Submission Open

Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components

(This special issue belongs to the Section Physiology and Pathology)

Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment

edited by

Mengliang Zhang

and Hans Hultborn

submission deadline 18 Jun 2026 | 3 articles | Viewed by 6541 | Submission Open

Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements

(This special issue belongs to the Section Medical Research)

Dive into Myopia

edited by

Chun-Fu Liu

submission deadline 19 Jun 2026 | 3 articles | Viewed by 6682 | Submission Open

Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles

(This special issue belongs to the Section Medical Research)

Lipid Metabolism Pathways: From Life to Disease

edited by

Anna Eiring

submission deadline 19 Jun 2026 | 1 articles | Viewed by 6242 | Submission Open

Keywords: lipid metabolism; lipid signaling; apoptosis; ferroptosis; autophagy; membrane dynamics; fatty acid oxidation; obesity

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 20 Jun 2026 | Viewed by 216 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

(This special issue belongs to the Section Medical Research)

Advances in Knee Biomechanics—2nd Edition

edited by Jason Shearn

submission deadline 22 Jun 2026 | Viewed by 106 | Submission Open

Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques

(This special issue belongs to the Section Physiology and Pathology)

Reconstruction of Bone Defects

edited by

Jörg Eschweiler

and

Philipp Kobbe

submission deadline 23 Jun 2026 | 8 articles | Viewed by 10809 | Submission Open

Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings

(This special issue belongs to the Section Medical Research)

Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)

edited by

Yongseek Park

submission deadline 26 Jun 2026 | 1 articles | Viewed by 8027 | Submission Open

Keywords: chronic kidney disease; vascular dysfunction; endothelial cells

(This special issue belongs to the Section Medical Research)

Advances in Anesthesia and Critical Care

edited by

Gabriele Melegari

submission deadline 26 Jun 2026 | 5 articles | Viewed by 7425 | Submission Open

Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning

(This special issue belongs to the Section Medical Research)

Advances in Dryland Agriculture Science

edited by

Liangshan Feng

and Hangyu Dong

submission deadline 26 Jun 2026 | 3 articles | Viewed by 4380 | Submission Open

Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation

(This special issue belongs to the Section Plant Science)

Feature Papers in Medical Research: 4th Edition

edited by

Christian Lehmann

submission deadline 26 Jun 2026 | 1 articles | Viewed by 634 | Submission Open

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition

edited by Paolo Scanagatta

submission deadline 26 Jun 2026 | 1 articles | Viewed by 583 | Submission Open

Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances

(This special issue belongs to the Section Medical Research)

Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine

edited by

Theodoros Rampias

and Maria Sideridou

submission deadline 26 Jun 2026 | Viewed by 110 | Submission Open

Keywords: Oxidative stress; Metabolic rewiring; Carcinogenesis; DNA repair; Cancer therapy; Heteroplasmy

(This special issue belongs to the Section Physiology and Pathology)

Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research

edited by

Young Ah Goo

and

Byoung-Kyu Cho

submission deadline 26 Jun 2026 | Viewed by 108 | Submission Open

Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research

(This special issue belongs to the Section Medical Research)

Advanced Technologies and Clinical Practice of Cancer Radiotherapy

edited by

Marcin Balcerzyk

submission deadline 26 Jun 2026 | Viewed by 87 | Submission Open

Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Leveraging the Power of Enzymes in Biotechnological Applications

edited by

Shengwei Sun

submission deadline 28 Jun 2026 | Viewed by 472 | Submission Open

Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application

Recent Advances in Physiotherapy for Musculoskeletal Disorders

edited by

Miguel Ángel Rosety-Rodríguez

and

Jorge Góngora-Rodríguez

submission deadline 30 Jun 2026 | 6 articles | Viewed by 17374 | Submission Open

Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery

(This special issue belongs to the Section Physiology and Pathology)

Effects of Exercise and Functional Interventions on Musculoskeletal Health

edited by

Seong-Gil Kim

submission deadline 30 Jun 2026 | 9 articles | Viewed by 17365 | Submission Open

Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science

(This special issue belongs to the Section Medical Research)

The Emerging Role of Microbiota in Health and Diseases

edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska

submission deadline 30 Jun 2026 | 6 articles | Viewed by 15056 | Submission Open

Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions

(This special issue belongs to the Section Microbiology)

2nd Edition—Featured Papers on the Origins of Life

edited by James R. Lyons

submission deadline 30 Jun 2026 | 7 articles | Viewed by 13368 | Submission Open

Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems

(This special issue belongs to the Section Origin of Life)

Current Advances in Lung Cancer Diagnosis and Treatment

edited by

Hakyoung Kim

, Daesik Yang and

Zhiwei Hu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10392 | Submission Open

Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers

(This special issue belongs to the Section Medical Research)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 30 Jun 2026 | 5 articles | Viewed by 9125 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Update on Microalgae Metabolites

edited by

Eduardo Jacob-Lopes

and

Leila Queiroz Zepka

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4047 | Submission Open

Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests

(This special issue belongs to the Section Microbiology)

Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies

edited by

Paolo Spinnato

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3866 | Submission Open

Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology

(This special issue belongs to the Section Medical Research)

Sialic Acid and Sialic Acid Derivatives in Biomedicine

edited by

Paola Rota

and

Marco Piccoli

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3738 | Submission Open

Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker

(This special issue belongs to the Section Physiology and Pathology)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3493 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

(This special issue belongs to the Section Physiology and Pathology)

Microalgae and Their Biotechnological Potential

edited by

Fantao Kong

, Yi Xin and Yuanxue Liang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3436 | Submission Open

Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering

(This special issue belongs to the Section Microbiology)

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