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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Treatment Options for Metastatic Non-Small Cell Lung Cancer and Gastrointestinal Cancer

edited by Lydia Meder and Anna M. Dmitrieva

submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open

Keywords: non-small cell lung cancer; gastrointestinal cancer; metastasis; molecular mechanisms; targeted therapy; immunotherapy; chemotherapy; vaccines; cancer treatment

(This special issue belongs to the Section Medical Research)

New Advances in Natural Product Research for Drug Discovery and Therapeutics

edited by

Luciana R. Tallini

and

Laura Torras-Claveria

submission deadline 31 Mar 2026 | Viewed by 62 | Submission Open

Keywords: plant extract; natural Product; biological activity; chemical profiling; drug discovery; clinical applications

(This special issue belongs to the Section Plant Science)

Fatty Liver Disease: From Molecular Mechanisms to Novel Therapeutics

edited by Stephen Malnick

submission deadline 31 Mar 2026 | Viewed by 60 | Submission Open

Keywords: fatty liver disease; metabolic-associated liver disease-MAFLD; alcoholic liver disease; non-alcoholic steatohepatitis; alcohol and COVID-19; cytokine storm; microbiome

(This special issue belongs to the Section Medical Research)

Stem Cell Biology, Tissue Formation, Cell Plasticity and Regenerative Medicine

edited by

Eustace Johnson

submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open

Keywords: stem cell biology; development and tissue formation; growth; tissue repair and regeneration; cell plasticity; model organisms and systems; clinical translation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease: 2nd Edition

edited by

Laura Patton

and

Guido Gabriele

submission deadline 31 Mar 2026 | Viewed by 50 | Submission Open

Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain

(This special issue belongs to the Section Medical Research)

Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment—4th Edition

edited by

Mariana Floria

Daniela Maria Tanase

and

Anca Trifan

submission deadline 31 Mar 2026 | Viewed by 31 | Submission Open

Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steatohepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases

(This special issue belongs to the Section Physiology and Pathology)

Back to Basics in Palaeontology: 2nd Edition

edited by Hua Stephane

submission deadline 31 Mar 2026 | Viewed by 22 | Submission Open

Keywords: fundamentals; natural history; multidisciplinarity; firsthand bibliography; actualism

(This special issue belongs to the Section Paleobiology)

Cellular Responses to Hypoxia

edited by

Arvydas Kanopka

submission deadline 31 Mar 2026 | Viewed by 18 | Submission Open

Keywords: hypoxia ; cellular responses ; molecular mechanisms ; hypoxia signaling; adaptive pathways

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Molecular Crossroads: Microbial Interactions and Metabolic Regulation in Livestock Health

edited by György Csikó and Orsolya Palócz

submission deadline 31 Mar 2026 | Viewed by 16 | Submission Open

Keywords: livestock microbiome; metabolic regulation; host– microbe interactions; animal health; nutrient metabolism; precision livestock farming

(This special issue belongs to the Section Animal Science)

Molecular Epidemiology of Animal Viral Diseases

edited by

Massimo Giangaspero

submission deadline 31 Mar 2026 | Viewed by 13 | Submission Open

Keywords: animal health; epidemiology; molecular characterization; virology

(This special issue belongs to the Section Animal Science)

Neurological Disorders: Pathophysiological Mechanisms, Translational Breakthroughs, and Therapeutic Horizons

edited by

Julius Höhne

and

Szabolcs Keri

submission deadline 31 Mar 2026 | Viewed by 9 | Submission Open

Keywords: neurological disorders; pathophysiological mechanisms; translational neuroscience; precision medicine; biomarkers; immunotherapy; digital health; brain– computer interfaces; regenerative medicine; nanomedicine

(This special issue belongs to the Section Medical Research)

Innovative Soil Amendments for Food Security: Biochar, Nanoparticles and Waste Valorization

edited by

Sami Abou Fayssal

submission deadline 10 Apr 2026 | Viewed by 40 | Submission Open

Keywords: food security; soil– plant-microbiome interactions; soil amendment; waste valorization

(This special issue belongs to the Section Plant Science)

Therapeutic Potential of Natural Products in Chronic Diseases

edited by

Yu-Chiang Hung

and Wen-Long Hu

submission deadline 10 Apr 2026 | Viewed by 29 | Submission Open

Keywords: natural products; herbs; chronic disease

(This special issue belongs to the Section Medical Research)

Innovation in Rheumatology: Advances in Diagnostics, Therapeutics and AI Applications

edited by

Arvind Nune

submission deadline 10 Apr 2026 | Viewed by 17 | Submission Open

Keywords: innovation; rheumatology; artificial intelligence (AI); new therapeutics; personalised therapy; wearable technologies; electronic health records; gene therapy; nanotechnology

(This special issue belongs to the Section Medical Research)

Metabolic Nutrition: Diet–Microbiota Interactions in Obesity and Inflammation

edited by

Catherine Chan

and

Emad Yuzbashian

submission deadline 16 Apr 2026 | Submission Open

Keywords: nutrition; dietary intake; microbiome; inflammation

(This special issue belongs to the Section Microbiology)

Brain Disease Diagnosis and Image Recognition

edited by Shumao Xu,

He Wang

and Minyan Ge

submission deadline 20 Apr 2026 | Viewed by 39 | Submission Open

Keywords: artificial intelligence; brain disease diagnosis; medical image recognition; neuroimaging; computational neuroscience; deep learning; machine learning; computer vision; signal processing; biomedical image analysis; neurodegenerative disorders; brain– computer interface; sleep disorders; sleep– wake regulation; polysomnography (PSG) analysis; circadian rhythms; sleep staging automation; REM sleep detection; insomnia biomarker identification; sleep apnea detection; neuroinflammation imaging; multimodal data fusion; explainable AI (XAI); federated learning; generative adversarial networks (GANs); edge computing for healthcare; clinical decision support systems; precision neurology; biomarker discovery; sleep-related neurodegeneration; EEG signal processing; functional MRI (fMRI); diffusion tensor imaging (DTI); Alzheimer’ s disease prediction; Parkinson’ s disease biomarkers; brain tumor segmentation; stroke lesion mapping; ethical AI in healthcare; AI-driven sleep medicine; automated sleep scoring

Bacterial Antibiotic Resistance: From Mechanisms to Strategies for Restoring Antibiotic Efficacy

edited by

Ishan Ghai

submission deadline 20 Apr 2026 | Viewed by 37 | Submission Open

Keywords: membrane transport; antibiotic resistance; pathogenic bacteria; bacterial defense; therapeutic strategies

(This special issue belongs to the Section Medical Research)

Phase Separation in Biological Regulation and Disease

edited by

Liang Wang

and Ke Liu

submission deadline 20 Apr 2026 | Viewed by 19 | Submission Open

Keywords: biomolecular condensates; liquid– liquid phase separation (LLPS); gene regulation; disease pathogenesis; aberrant phase separation

(This special issue belongs to the Section Physiology and Pathology)

Chronic Respiratory Comorbidities in Sleep-Disordered Breathing: A Holistic Approach

edited by

Antonio Fabozzi

and

Izolde Bouloukaki

submission deadline 24 Apr 2026 | Viewed by 394 | Submission Open

Keywords: sleep-disordered breathing (SDB); obstructive sleep apnoea (OSA); asthma; chronic obstructive pulmonary disease (COPD); interstitial lung diseases (ILDs); sleep physiology; pathophysiological traits; cardio-metabolic outcomes; treatment adherence and response

(This special issue belongs to the Section Physiology and Pathology)

Body Fluid-Based Biomarkers for Cognitive Impairment

edited by Wei Li

submission deadline 24 Apr 2026 | Viewed by 319 | Submission Open

Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis

(This special issue belongs to the Section Medical Research)

Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition

edited by

Cristiana Bustea

and

Delia Mirela Tit

submission deadline 24 Apr 2026 | Viewed by 71 | Submission Open

Keywords: CVDs; risk factors; prevention; treatment; novelties in research; artificial intelligence

(This special issue belongs to the Section Medical Research)

The Impact of Onconutraceutics as Potential Oncological Strategy

edited by

Antonella D'Anneo

and

Federica Affranchi

submission deadline 24 Apr 2026 | Viewed by 49 | Submission Open

Keywords: nutraceuticals; oncological therapies; onconutraceuticals; molecular pathways modulated by onconutraceuticals; chemotherapy; radiotherapy; personalized therapies; non-invasive approaches

(This special issue belongs to the Section Physiology and Pathology)

The 15th Anniversary of Life: Endothelial Glycocalyx—A Determinant of Endothelial Function and Vascular Reactivity

edited by

Ines Drenjančević

submission deadline 24 Apr 2026 | Viewed by 23 | Submission Open

Keywords: endothelial glycocalyx; cardiovascular system; oxidative stress; inflammation; nutrition

(This special issue belongs to the Section Physiology and Pathology)

Advances in Research on Phytohormones

edited by

Kincső Decsi

submission deadline 25 Apr 2026 | Viewed by 28 | Submission Open

Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses

(This special issue belongs to the Section Plant Science)

Transformative Frontiers in Mental Health Treatment: Advances in Neuropsychopharmacology

edited by

Senthil Kumaran Satyanarayanan

and

Luca Steardo

submission deadline 27 Apr 2026 | Viewed by 262 | Submission Open

Keywords: neuropsychopharmacology; mental health; novel drug therapies; biomarkers; personalized medicine; psychiatric conditions; treatment innovation; pharmacogenomics; synaptic plasticity; neuroinflammation; neuroendocrine systems

(This special issue belongs to the Section Pharmaceutical Science)

Gynecological Cancer: Etiologic, Diagnostic, Prognostic, and Therapeutic Research

edited by

Violante Di Donato

and

Tullio Golia D’Augè

submission deadline 27 Apr 2026 | Viewed by 186 | Submission Open

Keywords: gynecological cancer; chemotherapy in gynecological cancers; radiation therapy in gynecological oncology; gynecological cancer biomarkers; cancer prevention; gynecological cancer immunotherapy

(This special issue belongs to the Section Medical Research)

Clinical Update for Resuscitation Science: 2nd Edition

edited by Mitsuaki Nishikimi

submission deadline 27 Apr 2026 | Viewed by 12 | Submission Open

Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma

(This special issue belongs to the Section Medical Research)

Neurodegenerative Diseases: From Risk Factors to Treatments

edited by

Grazia D’Onofrio

submission deadline 28 Apr 2026 | Viewed by 83 | Submission Open

Keywords: immune regulation (e.g.; chronic inflammation) of NDs; cardiocerebral vascular disease and NDs; the effects of emotional and affective dimensions on cognitive reserve decline; the multidimensional screening of NDs; the interventions of NDs; gene polymorphism on the efficacy of pharmacological treatments in NDs; cognitive and functional rehabilitation for patients with NDs; technology innovation in the integrated approach to the patients with NDs

(This special issue belongs to the Section Medical Research)

Reviewing the Landscape of Psychopharmacology

edited by

Luca Steardo

submission deadline 28 Apr 2026 | Viewed by 48 | Submission Open

Keywords: psychopharmacology; mood disorders; neurobiology; drug safety; translational psychiatry

(This special issue belongs to the Section Pharmaceutical Science)

Cardiovascular–Kidney–Metabolic (CKM) Syndrome

edited by Chien Yu Lin and

Ching-Chung Hsiao

submission deadline 30 Apr 2026 | 3 articles | Viewed by 7449 | Submission Open

Keywords: cardiovascular-kidney-metabolic (CKM) syndrome; mortality; biomarkers; epidemiology; environmental pollutants; gut microbiome; oxidative stress; metabolic syndrome; coronary heart disease; chronic renal failure; cardiovascular disease; cardiorenal syndrome; metabolic disorders; heart failure; diabetes and CKD; inflammation and CKM syndrome; multi-organ interaction; translational research in CKM

(This special issue belongs to the Section Medical Research)

Musculoskeletal Pain and Disorders: Diagnosis, Treatment and Management

edited by

Antonio Stecco

and

Carmelo Pirri

submission deadline 30 Apr 2026 | 3 articles | Viewed by 6005 | Submission Open

Keywords: pain; connective tissue; musculoskeletal disorders; fascia; muscles; tendons; ligaments

(This special issue belongs to the Section Physiology and Pathology)

Advanced Heart Failure and Transplant Cardiology

edited by David Dobarro

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2506 | Submission Open

Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices

(This special issue belongs to the Section Medical Research)

Minimally Invasive Neuroendoscopy

edited by Stefan Linsler

submission deadline 30 Apr 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: spinal neuroendoscopy; spine and brain surgery; endonasal endoscopic skull base surgery; intraventricular neuroendoscopy

(This special issue belongs to the Section Medical Research)

Phytochemicals in Focus: Bioactivity, Safety, and Therapeutic Potential

edited by Naeem Khan

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: phytochemicals; antioxidant activity; antimicrobial properties; toxicity evaluation; natural products; medicinal plants and bioactivity; oxidative stress plant extracts; therapeutic potential; safety assessment; bioactive compounds

(This special issue belongs to the Section Plant Science)

Behavioral Manifestations and Neural Regulation of Movements

edited by

Luca Puce

and

Nicola Luigi Bragazzi

submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open

Keywords: motor control; movement behavior; sensorimotor integration; neurophysiology; emotion and movement; cognitive-motor interaction; temperament; neurotechnology; rehabilitation; performance

(This special issue belongs to the Section Physiology and Pathology)

15th Anniversary of Life—Emerging Plant-Based Materials and Bioactive Compounds in Biomedical Applications

edited by

Stefania Lamponi

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: plant-derived materials; bioactive compounds; phytochemicals; biomedical applications; natural products; plant-based polymers; drug delivery; tissue engineering

(This special issue belongs to the Section Plant Science)

Multi-Omics Insights into Traditional Fermented Foods: Microbial Ecology, Metabolite Profiles, and Functional Applications

edited by

Chia-Wen Hsieh

, Lan-Szu Chou, Chih-Yu Lo and

Brian Bor-Chun Weng

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: traditional fermented foods; omics analysis; fermentation biotechnology; bioactive metabolites

(This special issue belongs to the Section Microbiology)

Cortical Development and Neurotransmission

edited by Christine Hohmann and Joanne Berger-Sweeney

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism

(This special issue belongs to the Section Medical Research)

Updates in Pancreas and Colorectal Adenocarcinoma

edited by

Radu Virgil Costea

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: pancreatic and colorectal carcinoma; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Advances in Sustainable Animal Nutrition: Impacts on Physiology, Health, and Production

edited by

Christos Eliopoulos

and

Dimitrios Arapoglou

submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open

Keywords: animal nutrition; alternative feedstuffs; physiology; gut health; nutrient metabolism; immune function; animal performance; sustainable livestock production

(This special issue belongs to the Section Animal Science)

Novel Diagnostics and Therapeutics for Ophthalmic Diseases

edited by

Chris H. L. Lim

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: clinical ophthalmology; ophthalmic innovations; diagnostic technologies; therapeutic advancements; surgical techniques; disparity in global eye health; personalized medicine

(This special issue belongs to the Section Medical Research)

Developmental Programming in Cats and Dogs

edited by

Franck Péron

Virginie Gaillard

and Sylvie Chastant

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: dog; cat; growth; health; prevention; development; susceptibility; environment; risk factors; nutrition; neutering

(This special issue belongs to the Section Animal Science)

Research and Management of Endocrine Tumors

edited by

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: thyroid cancer; papillary thyroid cancer; anaplastic thyroid cancer; radioiodine; multiple kinase and angiogenetic factor inhibitors; adrenal cancer; pituitary adenomas

(This special issue belongs to the Section Medical Research)

Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition

edited by

Guillermo Cásedas

and

Francisco Les

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: phytochemicals; functional food; oxidative stress; metabolic syndrome; neuroinflammation; antioxidant; polyphenols; diabetes; inflammatory bowel disease; natural products; neurodegenerative disease

Research on the Pathogenesis and Association of Diabetes and Metabolic Syndrome

edited by Gwo-Ping Jong

submission deadline 30 Apr 2026 | Viewed by 16 | Submission Open

Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; coronary artery disease; endothelial dysfunction; stroke; hypertension; peripheric arterial disease; metabolic dysfunction; hyperlipidemia

(This special issue belongs to the Section Physiology and Pathology)

Novel Biomarkers for Lymphoma Diagnosis and Prognosis: Translating Research into Practice

edited by Dominic Kaddu-Mulindwa

submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open

Keywords: lymphoma; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); molecular profiling; tumor microenvironment; epigenetic markers; predictive diagnostics

(This special issue belongs to the Section Physiology and Pathology)

Decoding Helicobacter pylori: Genetic Secrets, Flagellar Motility, and Biofilm Mechanisms

edited by Xiaolin Liu and Shuai Hu

submission deadline 30 Apr 2026 | Viewed by 12 | Submission Open

Keywords: virulence genes; motility; flagella; biofilm; antibiotic resistance; colonization; Helicobacter pylori

(This special issue belongs to the Section Microbiology)

Research and Management in Autoimmune Rheumatic Diseases

edited by

Panagiotis Athanassiou

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: autoimmune rheumatic diseases; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; Sjogren's syndrome; biologic agents; JAK inhibitors

(This special issue belongs to the Section Medical Research)

Targeting DEK and TGF-β Signaling in Gynecologic Disease and Cancer: Diagnostic and Therapeutic Perspectives

edited by

Hung-Chi Cheng

and Anastasia Tsigkou

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: DEK oncogene; TGF-β signaling; cervical cancer; endometriosis; uterine myomas; cancer biomarkers; epithelial– mesenchymal transition (EMT); SMAD2/3 phosphorylation; LY364947; targeted therapy

(This special issue belongs to the Section Medical Research)

Rumen Microbiome and Fermentation Function Research

edited by

Xingzhou Tian

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: rumen; in vivo; in vitro; microbe; fermentation; multi-omics

(This special issue belongs to the Section Animal Science)

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