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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Compulsive Disorder: Understanding of the Pathophysiology and Therapeutic Implications

edited by

Donatella Marazziti

submission deadline 31 Jul 2026 | 1 articles | Viewed by 703 | Submission Open

Keywords: obsessive– compulsive disorder; compulsivity; cortico-striato-thalamo cortical circuits; cognitive inflexibility; glutamatergic modulation; neuroimmune mechanisms; neuromodulation; deep brain stimulation; precision psychiatry

(This special issue belongs to the Section Physiology and Pathology)

Precision Oncology Through Diagnostic Imaging and Theranostics

edited by

Wensi Tao

, Luyuan Li and Yu-Ping Yang

submission deadline 31 Jul 2026 | 1 articles | Viewed by 538 | Submission Open

Keywords: cancer imaging; molecular imaging; theranostics; nanomedicine; imaging biomarkers; precision oncology

(This special issue belongs to the Section Medical Research)

Anti-Inflammatory and Natural Products

edited by

Chi-Su Yoon

submission deadline 31 Jul 2026 | Viewed by 300 | Submission Open

Keywords: anti-inflammation; macrophage; mechanism study; in vivo/in vitro model; natural products; natural products-derived compound

(This special issue belongs to the Section Pharmaceutical Science)

Novel Insights for Spinal Pain Management: From Physical Therapies to Ultrasound-Guided Procedures

edited by

Ke-Vin Chang

and

Vincenzo Ricci

submission deadline 31 Jul 2026 | Viewed by 264 | Submission Open

Keywords: spine; pain; physical therapies; rehabilitation; ultrasound; procedures

(This special issue belongs to the Section Medical Research)

Building the Future of Veterinary Medicine: Foundational Data in Physiology and Pathology

edited by Bokyeong Ryu

submission deadline 31 Jul 2026 | Viewed by 221 | Submission Open

Keywords: veterinary physiology; veterinary pathology; veterinary database; multimodal evidence

(This special issue belongs to the Section Animal Science)

Black Holes in Atrial Fibrillation Therapy

edited by Roberto Cemin

submission deadline 31 Jul 2026 | Viewed by 202 | Submission Open

Keywords: atrial fibrillation; clinical guidelines; stroke prevention; oral anticoagulation; CHA2DS2-Va Score; catheter ablation; left atrial appendage closure; personalized medicine

(This special issue belongs to the Section Medical Research)

Molecular Mechanisms and Immune Regulation in Animal Diseases

edited by

Dagmara Winiarczyk

submission deadline 31 Jul 2026 | Viewed by 184 | Submission Open

Keywords: proteomics; animal diseases; mucosal immunity; biomarkers; host– pathogen interactions; immunoregulation; mass spectrometry; comparative medicine; veterinary proteomics; systems biology

(This special issue belongs to the Section Animal Science)

Genetic Regulation Mechanisms of Crop Salt–Alkali Tolerance

edited by

Zhenyuan Pan

submission deadline 31 Jul 2026 | Viewed by 165 | Submission Open

Keywords: crops; salt tolerance; genome; transcriptome; yield traits; genetic regulation mechanisms

(This special issue belongs to the Section Plant Science)

Metabolic Dysfunction and Cardiovascular Risk: From Molecular Mechanisms to Therapeutic Strategies

edited by

Chrysoula Boutari

submission deadline 31 Jul 2026 | Viewed by 156 | Submission Open

Keywords: metabolic dysfunction; obesity; dyslipidemia; MASLD/MASH; cardiovascular risk

(This special issue belongs to the Section Medical Research)

Prevention and Control of Post-Radiotherapy Complications in Head and Neck Cancer

edited by Sung-Chan Shin

submission deadline 31 Jul 2026 | Viewed by 150 | Submission Open

Keywords: head and neck cancer; radiotherapy complications; post-radiation toxicity; radiation-induced injury; prevention and management; oral and pharyngeal toxicity; salivary gland dysfunction; osteoradionecrosis; functional rehabilitation; biomarkers and prediction models

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Plant Post-Transcriptional Regulation

edited by Haihui Fu

submission deadline 1 Aug 2026 | Viewed by 192 | Submission Open

Keywords: plant; post-transcriptional regulation; environmental adaptation; growth and development

(This special issue belongs to the Section Plant Science)

Skin Models and 3D Tissue: Fungal Infections and Antifungals

edited by Marisa Meloni,

Salvatore Prete

and Antonio Del Prete

submission deadline 5 Aug 2026 | Viewed by 188 | Submission Open

Keywords: mycosis; 3D tissue in vitro models; clinical and non clinical models; antifungal therapy

(This special issue belongs to the Section Microbiology)

Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition

edited by

Alin Laurentiu Tatu

submission deadline 18 Aug 2026 | 5 articles | Viewed by 15534 | Submission Open

Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery

(This special issue belongs to the Section Physiology and Pathology)

Advances in Geriatric Medicine: Risk Assessment, Biomarkers, and Management Strategies

edited by

Nadya Kagansky

and Yochai Levy

submission deadline 18 Aug 2026 | 3 articles | Viewed by 7785 | Submission Open

Keywords: geriatric risk assessment; biomarkers in aging; personalized geriatric care

(This special issue belongs to the Section Medical Research)

Biomarkers, Neuromodulation and Neuroregulation for Diagnosis and Treatment of Brain Disorders

edited by

Ciprian Ionuț Băcilă

and

Mihnea Costin Manea

submission deadline 18 Aug 2026 | Viewed by 161 | Submission Open

Keywords: neural circuit dysfunction; brain disorders; biomarkers; neuroplasticity; neuromodulation; neuroregulation; multimodal biomarker integration; systems neuroscience approaches

(This special issue belongs to the Section Medical Research)

Challenges and Innovations in Biomaterials for Tissue Engineering

edited by

Fei Fan

, Donny Hanjaya-Putra and Loan Bui

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1066 | Submission Open

Keywords: hydrogels; nanoparticles; extracellular matrix; microfluidics; bio-responsive; tissue engineering; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Recent Advances in Head and Neck Disorders

edited by

Cosmin Ioan Faur

and Maximilian Dindelegan

submission deadline 20 Aug 2026 | Viewed by 238 | Submission Open

Keywords: molecular pathology; biomedical technology; systems biology

(This special issue belongs to the Section Medical Research)

Spotlight on Cardiovascular Physiology and Related Diseases: Impact of Sex Differences

edited by

Helena Lenasi

submission deadline 21 Aug 2026 | Viewed by 196 | Submission Open

Keywords: cardiovascular physiology; microcirculation; endothelium; oxidative stress; sex differences; mathematical algorithms for biological signal analysis; metabolic diseases; hyperglycemia

(This special issue belongs to the Section Medical Research)

Advances in Vascular Health and Metabolism—2nd Edition

edited by Ana Blazquez-Medela

submission deadline 26 Aug 2026 | Viewed by 145 | Submission Open

Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease

(This special issue belongs to the Section Medical Research)

Nutrition, Metabolism and Fitness: Exploring Dietary Effects on Exercise Physiology

edited by

Jesús Gustavo Ponce González

and

Daniel Velázquez Díaz

submission deadline 27 Aug 2026 | 1 articles | Viewed by 1655 | Submission Open

Keywords: exercise physiology; sports nutrition; metabolic health; diet– exercise interactions; nutritional interventions; energy metabolism; performance and recovery

(This special issue belongs to the Section Physiology and Pathology)

Oral Health and Systemic Conditions: From Biological Insights to Multidimensional Interventions

edited by

Gerson Aparecido Foratori-Junior

Carla Andreotti Damante

and

Nao Taniguchi (Nao Suzuki)

submission deadline 27 Aug 2026 | 1 articles | Viewed by 824 | Submission Open

Keywords: oral health ; periodontitis ; dental care ; tooth loss ; oral cancer ; facial esthetics ; salivary biomarkers ; systemic– oral health interactions ; non-invasive therapies ; clinical and epidemiological research

(This special issue belongs to the Section Medical Research)

Clinical Manifestations and Treatment of Autoimmune Diseases: 2nd Edition

edited by

Stelvio Tonello

and

Daniele Sola

submission deadline 28 Aug 2026 | 7 articles | Viewed by 15515 | Submission Open

Keywords: autoimmunity; immunobiology; vaccine; leucocytes; immune system

(This special issue belongs to the Section Medical Research)

Gut Health and Nutritional Strategies in Animals

edited by

Jian Ma

and Chunmei Du

submission deadline 28 Aug 2026 | 4 articles | Viewed by 2512 | Submission Open

Keywords: microbiota; barrier function; immunity; precision feeding; additives

(This special issue belongs to the Section Animal Science)

The Age of Longevity: Unpacking Biogerontology and the Future of Human Life

edited by Paweł Kordowitzki

submission deadline 28 Aug 2026 | 1 articles | Viewed by 1654 | Submission Open

Keywords: biogerontology; biological aging; longevity; healthspan extension; cellular senescence; epigenetic reprogramming; senolytics; gene editing; artificial intelligence in aging research

(This special issue belongs to the Section Physiology and Pathology)

Innovations in Tissue Reconstruction and Wound Repair

edited by Ishith Seth

submission deadline 28 Aug 2026 | 1 articles | Viewed by 388 | Submission Open

Keywords: stem cell therapy; tissue engineering; tissue reconstruction; microsurgery; wound healing; regenerative medicine; biomaterials; perforator flaps; supermicrosurgery

(This special issue belongs to the Section Medical Research)

Root–Soil–Microbe Interactions: Mechanisms and Management for Plant Performance and Ecosystem Function

edited by

Yuan Li

submission deadline 28 Aug 2026 | Viewed by 376 | Submission Open

Keywords: Root– soil– microbe interactions; Rhizosphere processes; Plant– microbe networks; Biogeochemical cycling; Microbiome-informed management

(This special issue belongs to the Section Plant Science)

Omics Approaches in Antipsychotic Pharmacology

edited by

Kyle Burghardt

submission deadline 28 Aug 2026 | Viewed by 320 | Submission Open

Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal

(This special issue belongs to the Section Pharmaceutical Science)

Microbial Diversity and Function in Aquatic Environments

edited by Xianglong Chen and

Liang Guo

submission deadline 30 Aug 2026 | 4 articles | Viewed by 8917 | Submission Open

Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches

(This special issue belongs to the Section Microbiology)

Airway Management in Emergency and Intensive Care Medicine

edited by

Prashant Nasa

and Tonny V. Veenith

submission deadline 30 Aug 2026 | 3 articles | Viewed by 8718 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Skin Diseases and Dermatologic Comorbidities

edited by Alessia Paganelli,

Emanuele Scala

and

Flavia Persechino

submission deadline 30 Aug 2026 | 4 articles | Viewed by 7882 | Submission Open

Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers

(This special issue belongs to the Section Physiology and Pathology)

Molecular Muscle Adaptations Across the Lifespan

edited by S. Kyle Travis and

Sime Versic

submission deadline 30 Aug 2026 | 1 articles | Viewed by 5614 | Submission Open

Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2205 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Global Burden of Chronic Pain: Advances and Challenges in Pain Management and Clinical Practice

edited by Saba Javed and Billy Huh

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2062 | Submission Open

Keywords: chronic pain syndrome; cancer pain syndrome; neuromodulation; intrathecal pump; opioids; nerve blocks; joint injections

(This special issue belongs to the Section Medical Research)

Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications

edited by

Chien-Hung Lin

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1877 | Submission Open

Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Eye Diseases: From Tomography to Clinical Prediction

edited by

Akio Oishi

and

Nilufer Yesilirmak

submission deadline 30 Aug 2026 | Viewed by 493 | Submission Open

Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations

edited by Manuel Gil Lozano and Marina Romaní-Pérez

submission deadline 30 Aug 2026 | Viewed by 415 | Submission Open

Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence and Machine Learning Empower Synthetic and Systems Biology: Theory, Design, Optimization and Application

edited by

Pasquale Stano

and

Jian Xu

submission deadline 30 Aug 2026 | Viewed by 276 | Submission Open

Keywords: AI (artificial intelligence); AI driven drug discovery; automated laboratory platforms; basic and applied science; bioengineering; biological exploration; biological network analysis; complex systems; computational genomics; computational modeling; data driven biology; deep learning; design automation; digital twins in biology; evolutionary design algorithms; gene editing; genetic circuit design; machine learning; metabolic engineering; multi omics integration; predictive biology; protein structure prediction; systems bioinformatics

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition

edited by

Elżbieta Janina Płuciennik

Żaneta Kałuzińska-Kołat

and

Damian Kołat

submission deadline 31 Aug 2026 | 5 articles | Viewed by 11770 | Submission Open

Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment

(This special issue belongs to the Section Medical Research)

Advances in Biomedical Frontier Technologies and Disease Diagnosis

edited by

Alexey Yaremenko

submission deadline 31 Aug 2026 | 2 articles | Viewed by 6056 | Submission Open

Keywords: nanomedicine ; biomaterials ; gene therapy ; drug delivery ; bacteriotherapy ; nanobiotechnology ; hereditary diseases ; bioinformatics ; personalized medicine ; smart biomaterials

(This special issue belongs to the Section Medical Research)

Musculoskeletal Function and Exercise Physiology: Integrative Approaches and Emerging Insights

edited by

Robert Smith

Tyler Neltner

Dimitrije Cabarkapa

and Luke Chowning

submission deadline 31 Aug 2026 | 4 articles | Viewed by 5862 | Submission Open

Keywords: resistance exercise; aerobic exercise; sport performance; neuromuscular; electromyography; muscle function; kinematics; kinetics; biomechanics; motion analysis; imaging techniques; muscle biopsy

(This special issue belongs to the Section Medical Research)

Regulation of Cellular Signaling Pathways in the Metabolic Syndrome

edited by Robert H. Newman and Danielle L. Schmitt

submission deadline 31 Aug 2026 | 4 articles | Viewed by 5504 | Submission Open

Keywords: metabolic syndrome (MetS); cellular signaling pathways; insulin signaling and resistance; nutrient-sensing pathways; inflammation and immune signaling

(This special issue belongs to the Section Physiology and Pathology)

Intensive Care Medicine: Current Concepts and Future Perspectives

edited by Shinichi Watanabe

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3822 | Submission Open

Keywords: intensive care; early mobilization; sepsis; mechanical ventilation; rehabilitation; artificial intelligence; PICS; multidisciplinary collaboration

(This special issue belongs to the Section Medical Research)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3176 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Conservation Ecology and Management of Mammalian Predators

edited by

Sándor Csányi

and

Miklós Gábor Heltai

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2456 | Submission Open

Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions

(This special issue belongs to the Section Animal Science)

Research on Glaucoma Diseases

edited by

Nicoleta Anton

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2294 | Submission Open

Keywords: glaucoma diseases; new technology; artificial intelligence in ophthalmology; gene therapy in glaucoma; new devices; artificial drainage systems

(This special issue belongs to the Section Medical Research)

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1631 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Innovations in Nuclear Medicine and Molecular Imaging

edited by

Christian Kühnel

and

Yiannis Parpottas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 924 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; theranostics; quantitative imaging; artificial intelligence; dosimetry; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition

edited by

Dan Mircea Olinic

and

Agata Stanek

submission deadline 31 Aug 2026 | 1 articles | Viewed by 738 | Submission Open

Keywords: vascular diseases; etiology; diagnosis; prognosis; therapy

(This special issue belongs to the Section Medical Research)

Research Advances in Wetland Ecology

edited by

Yuxiang Yuan

and

Yunlong Yao

submission deadline 31 Aug 2026 | Viewed by 268 | Submission Open

Keywords: wetland; restoration; function; plant; algae; lake eutrophication; interspecific relationship; biogeochemical cycling; climate change

(This special issue belongs to the Section Biodiversity, Ecology and Evolution)

Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment

edited by

Stefanos Roumeliotis

submission deadline 31 Aug 2026 | Viewed by 256 | Submission Open

Keywords: chronic kidney disease; end stage kidney disease; hemodialysis; peritoneal dialysis; mitochondria; oxidative stress; vascular calcification

(This special issue belongs to the Section Medical Research)

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