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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Treatment of Pulmonary Hypertension and Pulmonary Embolism

edited by

Egidio Imbalzano

and

Marco Vatrano

submission deadline 30 Mar 2026 | 5 articles | Viewed by 18588 | Submission Open

Keywords: pulmonary hypertension; pulmonary embolism; therapy; cardiac imaging; artificial intelligence

(This special issue belongs to the Section Medical Research)

Current Progress in Medical Image Segmentation

edited by

Krishna Chaitanya

submission deadline 30 Mar 2026 | 6 articles | Viewed by 14033 | Submission Open

Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Physiological Responses of Plants Under Abiotic Stresses

edited by

Dawei Shi

submission deadline 30 Mar 2026 | 7 articles | Viewed by 12361 | Submission Open

Keywords: crops; woody plants; horticultural plants; physiological responses; abiotic stresses; photosynthesis

(This special issue belongs to the Section Plant Science)

From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders

edited by

Doina Georgescu

Felix Bratosin

and Ana Lascu

submission deadline 30 Mar 2026 | 4 articles | Viewed by 12280 | Submission Open

Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota

(This special issue belongs to the Section Physiology and Pathology)

Eye Diseases: Diagnosis and Treatment, 3rd Edition

edited by

Alba Martín-Gil

and Laura De Diego-García

submission deadline 30 Mar 2026 | 6 articles | Viewed by 11354 | Submission Open

Keywords: ocular treatment; ocular diseases; retina; anterior eye; posterior eye; ocular biomarkers

(This special issue belongs to the Section Medical Research)

Applications of EEG in Neural Rehabilitation: 2nd Edition

edited by

Rubén Pérez-Elvira

Jorge Bosch-Bayard

Alessandra Anzolin

and

Giuseppe Augusto Chiarenza

submission deadline 30 Mar 2026 | 2 articles | Viewed by 9448 | Submission Open

Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Chronic Obstructive Pulmonary Disease: Clinical, Epidemiological, and Molecular Bases

edited by

Josef Yayan

submission deadline 30 Mar 2026 | 2 articles | Viewed by 6396 | Submission Open

Keywords: chronic obstructive pulmonary disease; COPD; emphysema; chronic bronchitis

(This special issue belongs to the Section Medical Research)

Gut Microbes Associating with the Host

edited by

Jianmin Chai

and

Kun Li

submission deadline 30 Mar 2026 | 2 articles | Viewed by 5980 | Submission Open

Keywords: gut microbes; microbiome; animals; nutrition

(This special issue belongs to the Section Microbiology)

Encephalitis: From Molecular Pathophysiology to Therapy

edited by Anna Tröscher and Judith Wagner

submission deadline 30 Mar 2026 | 3 articles | Viewed by 4563 | Submission Open

Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Physiology and Pathology)

The Other Pediatric Primary Headaches: 2nd Edition

edited by

Vincenzo Raieli

Vittorio Sciruicchio

and Giuseppe Santangelo

submission deadline 30 Mar 2026 | 2 articles | Viewed by 4262 | Submission Open

Keywords: pediatric TACs; primary pediatric headaches; pediatric tension headaches; preventive treatment; acute treatment; clinical features; children; pediatric headaches in IV 3ICHD

(This special issue belongs to the Section Medical Research)

Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions

edited by

Josipa Bukić

submission deadline 30 Mar 2026 | 1 articles | Viewed by 4059 | Submission Open

Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs

(This special issue belongs to the Section Pharmaceutical Science)

Advances and Applications of Neuroimaging in Brain Disorder

edited by Julio Plata-Bello

submission deadline 30 Mar 2026 | 1 articles | Viewed by 4032 | Submission Open

Keywords: neuroimaging; magnetic resonance imaging; positron emission tomography; near infrared spectroscopy; brain; dementia; schizophrenia; depression; brain tumors; multiple sclerosis; autism

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Precision Medicine in Cardiovascular Diseases

edited by Brian Xiangzhi Wang

submission deadline 30 Mar 2026 | 2 articles | Viewed by 3807 | Submission Open

Keywords: genomic; cardiovascular disease; congenital; multi-omics studies; precision medicine; personalized medicine; biomarker

(This special issue belongs to the Section Genetics and Genomics)

Microvascular and Macrovascular Response in Healthy and Critically Ill

edited by Andrius Pranskunas and

Marius Brazaitis

submission deadline 30 Mar 2026 | 3 articles | Viewed by 3376 | Submission Open

Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation

(This special issue belongs to the Section Physiology and Pathology)

Effects of Exercise Training on Muscle Function—2nd Edition

edited by

Marco Duca

and

Athos Trecroci

submission deadline 30 Mar 2026 | 2 articles | Viewed by 2878 | Submission Open

Keywords: exercise; training; muscle function; resistance training; HIIT

(This special issue belongs to the Section Physiology and Pathology)

Biological Insights into Drug Safety for Vulnerable Populations

edited by

Dulce Estêvão

and

Margarida Espírito-Santo

submission deadline 30 Mar 2026 | Viewed by 398 | Submission Open

Keywords: drug safety; vulnerable populations; pharmacotherapy; drug metabolism and efficacy; pediatric medication safety; drug pharmacokinetics and pharmacodynamics

(This special issue belongs to the Section Pharmaceutical Science)

Recent Advances in Non-Invasive Diagnosis Based on Volatile Metabolites

edited by Kiran Sankar Maiti

submission deadline 30 Mar 2026 | Viewed by 344 | Submission Open

Keywords: volatile metabolites; breath analysis; headspace analysis; biofluids; non-invasive; diagnosis

(This special issue belongs to the Section Medical Research)

Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure

edited by

Chun-Chao Chen

Wen-Rui Hao

and

Ju-Chi Liu

submission deadline 30 Mar 2026 | Viewed by 127 | Submission Open

Keywords: heart failure; biomarkers; molecular mechanisms

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Structure and Function of Microbial Communities

edited by

Qing Hu

and

Xuliang Zhuang

submission deadline 31 Mar 2026 | 4 articles | Viewed by 10323 | Submission Open

Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability

(This special issue belongs to the Section Microbiology)

New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease: 2nd Edition

edited by

Laura Patton

and

Guido Gabriele

submission deadline 31 Mar 2026 | 1 articles | Viewed by 7194 | Submission Open

Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain

(This special issue belongs to the Section Medical Research)

Vision Science and Optometry: 2nd Edition

edited by

Ana Sanchez-Cano

and

Elvira Orduna-Hospital

submission deadline 31 Mar 2026 | 5 articles | Viewed by 6256 | Submission Open

Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior pole; circadian light

(This special issue belongs to the Section Medical Research)

Advanced Machine Learning for Disease Prediction and Prevention

edited by

Jawad Khan

and

Dildar Hussain

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5314 | Submission Open

Keywords: advanced machine learning; disease prediction; disease prevention; biomedical data integration; multimodal data; explainable AI (XAI); AI Interpretability; algorithmic fairness; bias mitigation; predictive modeling; healthcare analytics; risk stratification; early disease detection; clinical decision support; computational health; public health informatics; AI ethics in healthcare; medical AI validation; health data science; personalized medicine

(This special issue belongs to the Section Medical Research)

Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges: 2nd Edition

edited by

Daniela Maria Tanase

Mariana Floria

and

Ionela Lacramioara Serban

submission deadline 31 Mar 2026 | 2 articles | Viewed by 5153 | Submission Open

Keywords: hyperlipidemia; neuropathy; nephropathy; retinopathy; psychological effects; epigenetic imprinting; molecular profiling; glucose control; vascular damage and regeneration; diabetes complications

(This special issue belongs to the Section Physiology and Pathology)

Enhancements in Screening Pathways for Early Detection of Lung Cancer

edited by

Paolo Albino Ferrari

and

Antonio Maccio

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4509 | Submission Open

Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence

(This special issue belongs to the Section Medical Research)

Allergies and Allergic Diseases—Perspectives in Diagnosis and Management: 2nd Edition

edited by

Kinga Lis

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3902 | Submission Open

Keywords: allergy; anaphylaxis; cross-allergies; IgE; exercise-induced anaphylaxis; component-resolved diagnosis

(This special issue belongs to the Section Medical Research)

New Insights into Athlete Physiology

edited by

Maamer Slimani

and

Nicola Luigi Bragazzi

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3885 | Submission Open

Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship

(This special issue belongs to the Section Physiology and Pathology)

Space Medicine Advancements: From Human Health to Biomedical System Design

edited by

Jiwoon Park

and

Atul Chander

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2620 | Submission Open

Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations

(This special issue belongs to the Section Medical Research)

Innovation and Translation in Cardiovascular Interventions

edited by Jacek Bil

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2496 | Submission Open

Keywords: cardiovascular interventions; innovation; translational research; interventional cardiology; structural heart disease; device development; percutaneous therapy; imaging guidance; physiology-guided intervention; drug– device combination; artificial intelligence; digital health; bioresorbable scaffolds; clinical translation; cardiovascular technology

(This special issue belongs to the Section Medical Research)

The Contribution of Neurogenetics in Disentangling the Pathophysiology of Neurodegenerative Diseases

edited by

Giuseppe Lanza

, Michele Salemi and

Francesca Schillaci

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2468 | Submission Open

Keywords: neurodegenerative diseases; translational neurogenetics; early diagnosis; prevention; therapies; clinical practice; advanced genetic techniques; outcome measures

(This special issue belongs to the Section Physiology and Pathology)

From Vessel to Muscle—an Integrative Approach to Ischemic Heart Disease

edited by

Irina Iuliana Costache Enache

Ciprian Rezus

and

Minerva Codruta Badescu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2266 | Submission Open

Keywords: ischemic heart disease; atherosclerotic plaque features; microvascular dysfunction; coronary vasospasm; percutaneous transluminal coronary angioplasty; coronary artery bypass grafting; cardiac magnetic resonance imaging; coronary computed tomography angiography

(This special issue belongs to the Section Physiology and Pathology)

Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment—4th Edition

edited by

Mariana Floria

Daniela Maria Tanase

and

Anca Trifan

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1752 | Submission Open

Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steatohepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Epidemiology, Physiology, Diagnosis and Treatment of Breast Cancer

edited by

Florin Teodor Bobirca

, Traian Pǎtraşcu, Petronel Mustatea and

Octavian Enciu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1368 | Submission Open

Keywords: epidemiology; physiology; conservative breast surgery; sentinel lymph node biopsy; artificial intelligence in breast cancer

(This special issue belongs to the Section Medical Research)

Thyroid and Parathyroid Diseases: Advances in Molecular Imaging

edited by

Petra Petranović Ovčariček

and

Luca Giovanella

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1309 | Submission Open

Keywords: thyroid cancer; parathyroid imaging; hyperparathyroidism; benign thyroid diseases; molecular imaging; radioactive iodine; radioiodine-refractory thyroid cancer; theranostics

(This special issue belongs to the Section Medical Research)

New Advances in Natural Product Research for Drug Discovery and Therapeutics

edited by

Luciana R. Tallini

and

Laura Torras-Claveria

submission deadline 31 Mar 2026 | 1 articles | Viewed by 545 | Submission Open

Keywords: plant extract; natural Product; biological activity; chemical profiling; drug discovery; clinical applications

(This special issue belongs to the Section Plant Science)

Role of the Kynurenine System in Neurological Disorders

edited by

Gábor Nagy-Grócz

and Tamás Körtési

submission deadline 31 Mar 2026 | Viewed by 446 | Submission Open

Keywords: kynurenine pathway; neurological disorders; kynurenic acid; quinolinic acid

(This special issue belongs to the Section Physiology and Pathology)

Environmental Stress and Adaptation: Molecular Mechanisms and Ecosystems Biodiversity

edited by

Mizanur Rahman

and

Takashi Asaeda

submission deadline 31 Mar 2026 | Viewed by 446 | Submission Open

Keywords: abiotic oxidative stress; aquatic biodiversity monitoring; reactive oxygen species; riparian and mangrove vegetation management; environmental DNA (eDNA) metabarcoding

(This special issue belongs to the Section Diversity and Ecology)

New Treatment Options for Metastatic Non-Small Cell Lung Cancer and Gastrointestinal Cancer

edited by Lydia Meder and Anna M. Dmitrieva

submission deadline 31 Mar 2026 | Viewed by 348 | Submission Open

Keywords: non-small cell lung cancer; gastrointestinal cancer; metastasis; molecular mechanisms; targeted therapy; immunotherapy; chemotherapy; vaccines; cancer treatment

(This special issue belongs to the Section Medical Research)

Livestock Genomics: Decoding Complex Traits Through Network Biology

edited by Ikhide Godwin Imumorin,

Moses Okpeku

and Olanrewaju B. Morenikeji

submission deadline 31 Mar 2026 | Viewed by 300 | Submission Open

Keywords: network biology; systems biology; computational genomics; complex phenotypes; economic traits; livestock improvement; molecular genetics

(This special issue belongs to the Section Animal Science)

Fatty Liver Disease: From Molecular Mechanisms to Novel Therapeutics

edited by Stephen Malnick and

Manuela G. Neuman

submission deadline 31 Mar 2026 | Viewed by 225 | Submission Open

Keywords: fatty liver disease; metabolic-associated liver disease-MAFLD; alcoholic liver disease; non-alcoholic steatohepatitis; alcohol and COVID-19; cytokine storm; microbiome

(This special issue belongs to the Section Medical Research)

Back to Basics in Palaeontology: 2nd Edition

edited by Hua Stephane

submission deadline 31 Mar 2026 | Viewed by 219 | Submission Open

Keywords: fundamentals; natural history; multidisciplinarity; firsthand bibliography; actualism

(This special issue belongs to the Section Paleobiology)

Water Pollution Solutions: From Ecological Risk Assessment to Biological Restoration

edited by Lei Wang

submission deadline 31 Mar 2026 | Viewed by 187 | Submission Open

Keywords: water pollution; emerging contaminants; biological restoration; ecological risk assessment; microbial bioremediation; phytoremediation; aquatic ecosystem restoration; bio-based technologies; biomimetic technologies

(This special issue belongs to the Section Diversity and Ecology)

Stem Cell Biology, Tissue Formation, Cell Plasticity and Regenerative Medicine

edited by

Eustace Johnson

submission deadline 31 Mar 2026 | Viewed by 146 | Submission Open

Keywords: stem cell biology; development and tissue formation; growth; tissue repair and regeneration; cell plasticity; model organisms and systems; clinical translation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Cellular Responses to Hypoxia

edited by

Arvydas Kanopka

submission deadline 31 Mar 2026 | Viewed by 133 | Submission Open

Keywords: hypoxia ; cellular responses ; molecular mechanisms ; hypoxia signaling; adaptive pathways

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Neurological Disorders: Pathophysiological Mechanisms, Translational Breakthroughs, and Therapeutic Horizons

edited by

Julius Höhne

and

Szabolcs Keri

submission deadline 31 Mar 2026 | Viewed by 122 | Submission Open

Keywords: neurological disorders; pathophysiological mechanisms; translational neuroscience; precision medicine; biomarkers; immunotherapy; digital health; brain– computer interfaces; regenerative medicine; nanomedicine

(This special issue belongs to the Section Medical Research)

Molecular Crossroads: Microbial Interactions and Metabolic Regulation in Livestock Health

edited by

György Csikó

and Orsolya Palócz

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: livestock microbiome; metabolic regulation; host– microbe interactions; animal health; nutrient metabolism; precision livestock farming

(This special issue belongs to the Section Animal Science)

Molecular Epidemiology of Animal Viral Diseases

edited by

Massimo Giangaspero

submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open

Keywords: animal health; epidemiology; molecular characterization; virology

(This special issue belongs to the Section Animal Science)

Therapeutic Potential of Natural Products in Chronic Diseases

edited by

Yu-Chiang Hung

and Wen-Long Hu

submission deadline 10 Apr 2026 | 1 articles | Viewed by 1749 | Submission Open

Keywords: natural products; herbs; chronic disease

(This special issue belongs to the Section Medical Research)

Innovative Soil Amendments for Food Security: Biochar, Nanoparticles and Waste Valorization

edited by

Sami Abou Fayssal

submission deadline 10 Apr 2026 | Viewed by 275 | Submission Open

Keywords: food security; soil– plant-microbiome interactions; soil amendment; waste valorization

(This special issue belongs to the Section Plant Science)

Innovation in Rheumatology: Advances in Diagnostics, Therapeutics and AI Applications

edited by

Arvind Nune

submission deadline 10 Apr 2026 | Viewed by 138 | Submission Open

Keywords: innovation; rheumatology; artificial intelligence (AI); new therapeutics; personalised therapy; wearable technologies; electronic health records; gene therapy; nanotechnology

(This special issue belongs to the Section Medical Research)

Stem Cells and Signaling Pathways in Pulmonary Biology

edited by

Bingqiang Wen

submission deadline 12 Apr 2026 | Viewed by 140 | Submission Open

Keywords: pulmonary biology; lung progenitor stem cells; signaling pathways; lung repair and regeneration; multi-omics

(This special issue belongs to the Section Physiology and Pathology)

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