Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Feature Paper in Genetics and Genomics submission deadline 30 Jun 2025 | 2 articles | Viewed by 1859 | Submission Open
Keywords: DNA; RNA; gene discovery and function; gene expression; population genetics; genome projects; comparative and functional genomics; medical genetics; complex traits; chromosome biology; epigenomics and epigenetics; statistical genetics and methodology; genomic assay technology; sequencing technologies; bioinformatics
(This special issue belongs to the Section Genetics and Genomics)
Neuroinflammation in Huntington’s Disease: Detrimental Crosstalk submission deadline 30 Jun 2025 | 2 articles | Viewed by 1846 | Submission Open
Keywords: Huntington’ s disease; mutant huntingtin (mHtt) protein; central nervous system; mutated protein; glial cells
(This special issue belongs to the Section Physiology and Pathology)
Genetics, Breeding and Reproduction of Honeybees: Second Edition
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1801 | Submission Open
Keywords: phenomics; genetics; genomics; functional genomics; metabolomics; functional genes identification; genetics editing; genome selection; genetic evaluation; hybrid breeding; egg-laying; honey production; queen breeding; varroa resistance
(This special issue belongs to the Section Animal Science)
Veterinary Pathology and Veterinary Anatomy: 3rd Edition submission deadline 30 Jun 2025 | 2 articles | Viewed by 1538 | Submission Open
Keywords: veterinary pathology; veterinary anatomy; SARS-CoV-2 pandemic; climate change; environmental pollution; diagnosis and treatment of animal diseases; computer modelling of pathological processes
(This special issue belongs to the Section Animal Science)
Acute Kidney Events in Intensive Care
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1493 | Submission Open
Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; biomarkers
(This special issue belongs to the Section Medical Research)
Advanced Heart Failure and Transplant Cardiology
edited by David Dobarro
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1464 | Submission Open
Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices
(This special issue belongs to the Section Medical Research)
Mechanism, Diagnostic and Therapeutic Novelties in Dermatology: 3rd Edition
edited by Jose Carlos Armario Hita, and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1023 | Submission Open
Keywords: physiopathology; skin sonography; dermoscopy; innovation; confocal microscopy; biological treatment; psoriasis; atopic dermatitis; inmmunomediated diseases; urticaria; laser CO2
(This special issue belongs to the Section Medical Research)
Mechanism, Diagnosis, and Treatment of Aortic Diseases: 2nd Edition
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1012 | Submission Open
Keywords: aorta; aortic disease; aortic aneurysm; aortic dissection; penetrating aortic ulcer; aortic stenosis; arteritis; pathomechanism; diagnosis; pharmacological therapy; invasive therapy; endovascular therapy; open surgery
(This special issue belongs to the Section Medical Research)
Advancements in Hematologic Malignancies: Innovations in Diagnosis and Therapy
edited by Chohao Lee
submission deadline 30 Jun 2025 | 1 articles | Viewed by 802 | Submission Open
Keywords: hematologic malignancies; stem cell transplantation; CAR-T cell therapy; immunotherapy; multiple myeloma; leukemia; precision medicine; hematopoietic stem cells; drug resistance; novel therapeutics
(This special issue belongs to the Section Medical Research)
Innovative Technologies in Pain Management submission deadline 30 Jun 2025 | 1 articles | Viewed by 790 | Submission Open
Keywords: pain management; extended reality (XR) technologies; gamification for pain relief; psychosocial variables; interdisciplinary approaches
(This special issue belongs to the Section Physiology and Pathology)
Advances and Applications of Neuroimaging in Brain Disorder
edited by Julio Plata-Bello
submission deadline 30 Jun 2025 | 1 articles | Viewed by 697 | Submission Open
Keywords: neuroimaging; magnetic resonance imaging; positron emission tomography; near infrared spectroscopy; brain; dementia; schizophrenia; depression; brain tumors; multiple sclerosis; autism
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Diabetes and Microbiome submission deadline 30 Jun 2025 | Viewed by 392 | Submission Open
Keywords: diabetes mellitus; microbiome; microbiota metabolites; metabolic disease; dysbiosis
(This special issue belongs to the Section Microbiology)
Advanced Neuroimaging Techniques in Stroke Management
edited by Foteini Christidi, and Efstratios Karavasilis
submission deadline 30 Jun 2025 | Viewed by 278 | Submission Open
Keywords: stroke; neuroimaging; MRI; CT; stroke management; biomarkers; acute stroke; chronic stroke; neuroplasticity; neuromodulation
(This special issue belongs to the Section Medical Research)
Chronic Obstructive Pulmonary Disease: Clinical, Epidemiological, and Molecular Bases
edited by
submission deadline 30 Jun 2025 | Viewed by 249 | Submission Open
Keywords: chronic obstructive pulmonary disease; COPD; emphysema; chronic bronchitis
(This special issue belongs to the Section Medical Research)
Biological Insights into Drug Safety for Vulnerable Populations submission deadline 30 Jun 2025 | Viewed by 234 | Submission Open
Keywords: drug safety; vulnerable populations; pharmacotherapy; drug metabolism and efficacy; pediatric medication safety; drug pharmacokinetics and pharmacodynamics
(This special issue belongs to the Section Pharmaceutical Science)
Recent Advances in Valve Therapy: Clinical and Molecular Perspectives
edited by , Konstantinos Toutouzas and Constantina Aggeli
submission deadline 30 Jun 2025 | Viewed by 206 | Submission Open
Keywords: transcatheter aortic valve implantation (TAVI); valve-in-valve; long-term outcomes; aortic stenosis; molecular mechanisms in valve disease; structural heart disease
(This special issue belongs to the Section Medical Research)
Recent Advances in Non-Invasive Diagnosis Based on Volatile Metabolites
edited by Kiran Sankar Maiti
submission deadline 30 Jun 2025 | Viewed by 203 | Submission Open
Keywords: volatile metabolites; breath analysis; headspace analysis; biofluids; non-invasive; diagnosis
(This special issue belongs to the Section Medical Research)
The Other Pediatric Primary Headaches: 2nd Edition
edited by , and Giuseppe Santangelo
submission deadline 30 Jun 2025 | Viewed by 177 | Submission Open
Keywords: pediatric TACs; primary pediatric headaches; pediatric tension headaches; preventive treatment; acute treatment; clinical features; children; pediatric headaches in IV 3ICHD
(This special issue belongs to the Section Medical Research)
Advances in CT Angiography and Perfusion
edited by Marcin Sawicki
submission deadline 30 Jun 2025 | Viewed by 168 | Submission Open
Keywords: CT angiography; CT perfusion; artificial intelligence; dynamic CT angiography; 4D CT angiography; acute ischemic stroke
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Integrating Bioinformatics and Artificial Intelligence: Transforming Data into Insights for Precision Medicine
edited by Usef Faghihi
submission deadline 30 Jun 2025 | Viewed by 165 | Submission Open
Keywords: bioinformatics; artificial intelligence; precision medicine; machine learning; computational biology; multi-omics data integration; biomarker discovery; predictive modeling; personalized medicine; computational drug discovery
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
Advances in Veterinary Ophthalmology: Innovative Approaches to Ocular Diseases in Animals
edited by
submission deadline 30 Jun 2025 | Viewed by 155 | Submission Open
Keywords: ocular diseases; dogs; cats; tear film; molecular mechanism
(This special issue belongs to the Section Animal Science)
Prevention, Evaluation, and Control of HIV Infection
edited by
submission deadline 30 Jun 2025 | Viewed by 138 | Submission Open
Keywords: HIV/AIDS; HIV testing; immune activation; HIV pathogenesis; inflammation; HIV transmission and prevention; antiretroviral therapy
(This special issue belongs to the Section Microbiology)
Role of the Kynurenine System in Neurological Disorders
edited by and Tamás Körtési
submission deadline 30 Jun 2025 | Viewed by 138 | Submission Open
Keywords: kynurenine pathway; neurological disorders; kynurenic acid; quinolinic acid
(This special issue belongs to the Section Physiology and Pathology)
Innovations in Pediatric Immunology and Environmental Health
edited by
submission deadline 30 Jun 2025 | Viewed by 107 | Submission Open
Keywords: indoor microbiome; children's health; environmental microorganisms; maternal factors; allergies and asthma; immune development
(This special issue belongs to the Section Physiology and Pathology)
Infection, Inflammation and Rheumatology
edited by
submission deadline 4 Jul 2025 | 1 articles | Viewed by 1518 | Submission Open
Keywords: infection; COVID-19; inflammation; vaccination; rheumatic diseases
(This special issue belongs to the Section Physiology and Pathology)
Update on Microalgae Metabolites submission deadline 10 Jul 2025 | 1 articles | Viewed by 1224 | Submission Open
Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests
(This special issue belongs to the Section Microbiology)
Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans
edited by
submission deadline 11 Jul 2025 | Viewed by 150 | Submission Open
Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; transcranial Doppler measurement; EEG; lifestyle
(This special issue belongs to the Section Physiology and Pathology)
Molecular Mechanisms and Function Impact of Protein Modifications
edited by
submission deadline 15 Jul 2025 | Viewed by 170 | Submission Open
Keywords: protein modifications; enzyme regulation; proteomics and functional; diversity disease mechanisms; diagnostic and therapeutic strategies
(This special issue belongs to the Section Proteins and Proteomics)
Cancer Treatment and Drug Resistance: 2nd Edition
edited by and
submission deadline 20 Jul 2025 | Viewed by 148 | Submission Open
Keywords: cancer treatment; drug resistance; cancer cell signaling; metastasis; apoptosis; cell cycle; novel therapies
(This special issue belongs to the Section Pharmaceutical Science)
Cardioncology: From Molecular Mechanisms to Advanced Imaging and New Treatments
edited by , Giuseppe Pacileo and
submission deadline 21 Jul 2025 | 2 articles | Viewed by 2517 | Submission Open
Keywords: cardiotoxicity; echocardiography; cardiac magnetic resonance; cardiac computed tomography; serum cardiac biomarkers; cancer therapy; arrhythmias; cardiotoxicity treatment
(This special issue belongs to the Section Physiology and Pathology)
Emerging Knowledge on Human Immunodeficiency Virus submission deadline 22 Jul 2025 | 2 articles | Viewed by 4216 | Submission Open
Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis
(This special issue belongs to the Section Medical Research)
Critical Issues in Intensive Care Medicine
edited by
submission deadline 22 Jul 2025 | 2 articles | Viewed by 2230 | Submission Open
Keywords: critical issues; intensive care; co-morbidities in ICUs; new technology issues in ICUs; hospital-acquired infections; end of life
(This special issue belongs to the Section Medical Research)
Emergency and Trauma Management
edited by Pietro Fransvea and Gabriele Sganga
submission deadline 22 Jul 2025 | 1 articles | Viewed by 1234 | Submission Open
Keywords: acute care surgery; trauma; general surgery; minimally invasive surgery; emergency management
(This special issue belongs to the Section Medical Research)
Spinal Neuromodulation: From Basic and Translational Research to Clinical Practice submission deadline 25 Jul 2025 | 1 articles | Viewed by 1470 | Submission Open
Keywords: spinal neuromodulation; translational neuroscience; spinal cord injury; neural plasticity; multi-disciplinary rehabilitation
(This special issue belongs to the Section Medical Research)
Diagnosis, Treatment and Prognosis of Prostate Cancer
edited by and Jesús Moreno-Sierra
submission deadline 26 Jul 2025 | Viewed by 223 | Submission Open
Keywords: active surveillance; hormonal treatment; personalized medicine; prostate cancer; robotic surgery; targeted therapy
(This special issue belongs to the Section Medical Research)
Blood Rheology: Insights & Innovations
edited by Nadia Antonova
submission deadline 28 Jul 2025 | Viewed by 181 | Submission Open
Keywords: hemorheology  ; microfluidics  ; blood viscosity  ; mechanobiology  ; cellular mechanics
(This special issue belongs to the Section Medical Research)
Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare
edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura
submission deadline 29 Jul 2025 | Viewed by 248 | Submission Open
Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19
(This special issue belongs to the Section Pharmaceutical Science)
Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies submission deadline 30 Jul 2025 | 5 articles | Viewed by 11322 | Submission Open
Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies
(This special issue belongs to the Section Physiology and Pathology)
Clinical Update for Resuscitation Science
edited by Mitsuaki Nishikimi
submission deadline 30 Jul 2025 | 5 articles | Viewed by 7034 | Submission Open
Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma
(This special issue belongs to the Section Medical Research)
Diagnosis, Treatment, and Prognosis of Neuroendocrine Neoplasms
edited by Pernille Holmager and
submission deadline 30 Jul 2025 | Viewed by 195 | Submission Open
Keywords: diagnosis; medical treatment; radionuclide treatment; prognosis
(This special issue belongs to the Section Medical Research)
Transformative Frontiers in Mental Health Treatment: Advances in Neuropsychopharmacology submission deadline 30 Jul 2025 | Viewed by 191 | Submission Open
Keywords: neuropsychopharmacology; mental health; novel drug therapies; biomarkers; personalized medicine; psychiatric conditions; treatment innovation; pharmacogenomics; synaptic plasticity; neuroinflammation; neuroendocrine systems
(This special issue belongs to the Section Pharmaceutical Science)
Advances in Upper Respiratory Tract Disorders and Head and Neck Cancers: From Pathophysiology to Innovative Approaches submission deadline 30 Jul 2025 | Viewed by 118 | Submission Open
Keywords: inflammation; infection; cancer; respiratory tract; head and neck
(This special issue belongs to the Section Physiology and Pathology)
Cardiovascular Diseases: From Basic Research to Clinical Application—2nd Edition submission deadline 31 Jul 2025 | 9 articles | Viewed by 15697 | Submission Open
Keywords: CVDs; risk factors; prevention; treatment; novelties in research; artificial intelligence
(This special issue belongs to the Section Medical Research)
The Effects of Neurosteroids on Neurological and Psychiatric Disorders
edited by Irina S. Balan
submission deadline 31 Jul 2025 | 5 articles | Viewed by 10487 | Submission Open
Keywords: pregnane neurosteroids; androstane neurosteroids; sulfated neurosteroids; neuroactive steroids; neurological disorders; psychiatric disorders; therapeutic potential; neuroprotective properties; anti-inflammatory properties
(This special issue belongs to the Section Physiology and Pathology)
Focus on Exercise Physiology and Sports Performance: 2nd Edition
edited by
submission deadline 31 Jul 2025 | 9 articles | Viewed by 8045 | Submission Open
Keywords: exercise; physical activity; nutrition; exercise physiology; sports performance
(This special issue belongs to the Section Physiology and Pathology)
Cornea and Anterior Eye Diseases: 2nd Edition
edited by , and Giancarlo Montani
submission deadline 31 Jul 2025 | 5 articles | Viewed by 7294 | Submission Open
Keywords: cornea; anterior eye; corneal dystrophy; dry eye; ocular surface; ocular imaging; contact lenses; myopia control with contact lenses; contact lens complications; primary eye care
(This special issue belongs to the Section Medical Research)
Ion Channels and Neurological Disease: 2nd Edition
edited by and Marzia Martina
submission deadline 31 Jul 2025 | 3 articles | Viewed by 6460 | Submission Open
Keywords: ion channels; neurological diseases; neurodegeneration; pain; cellular and animal models; neuronal excitability; neuronal activity; synaptic transmission; structural and functional correlates; computational modeling; pathophysiology and pathogenesis; channelopathies; altered currents; neuropharmacology and ethnopharmacology; drug screening; delivery; and targeting; pharmacological treatments; molecular therapeutic options; neuroprotection
(This special issue belongs to the Section Pharmaceutical Science)
Advances in the Structure and Function of Microbial Communities
edited by and
submission deadline 31 Jul 2025 | 3 articles | Viewed by 6056 | Submission Open
Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability
(This special issue belongs to the Section Microbiology)
Biological and Clinical Research of Germ Cells
edited by
submission deadline 31 Jul 2025 | 3 articles | Viewed by 5265 | Submission Open
Keywords: germ cells; spermatozoa; oocytes; cumulus oocyte complex; sexually transmitted infections; ICSI; IVF; infertility; reproduction
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
What Is New in Psychiatry and Psychopharmacology—2nd Edition submission deadline 31 Jul 2025 | 3 articles | Viewed by 4484 | Submission Open
Keywords: clinical psychiatry; biomarkers; psychopharmacology; addictions; agitations; pharmacological resistance; transcranial magnetic resonance
(This special issue belongs to the Section Pharmaceutical Science)
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