Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Photodynamic Therapy for Medical Applications: From Infections to Tissue Regeneration
edited by Rafał Wiench and
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1060 | Submission Open
Keywords: photodynamic therapy (PDT); photosensitizers; reactive oxygen species (ROS); infections and antimicrobial PDT (aPDT); tissue regeneration and wound healing; oral potentially malignant disorders (OPMDs); oncology and cancer treatment; dermatology and skin disorders
(This special issue belongs to the Section Medical Research)
From Prediction to Experimental Assays of More Selective and Cleaner Bioactive Synthetics: A Systemic View
edited by and Petrônio Filgueiras de Athayde-Filho
submission deadline 25 Nov 2025 | Viewed by 380 | Submission Open
Keywords: antimicrobial activity; artemia salina; bioinformatics; drug research; green chemistry; lipophilicity; medicinal chemistry
(This special issue belongs to the Section Pharmaceutical Science)
Advances in Geriatric Medicine: Risk Assessment, Biomarkers, and Management Strategies
edited by and Yochai Levy
submission deadline 26 Nov 2025 | 2 articles | Viewed by 3443 | Submission Open
Keywords: geriatric risk assessment; biomarkers in aging; personalized geriatric care
(This special issue belongs to the Section Medical Research)
Sialic Acid and Sialic Acid Derivatives in Biomedicine
edited by and
submission deadline 26 Nov 2025 | 2 articles | Viewed by 2416 | Submission Open
Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker
(This special issue belongs to the Section Physiology and Pathology)
Advances in Medical Imaging of Animal Models for Human Diseases
edited by and Tsai-Hsien Hung
submission deadline 26 Nov 2025 | Viewed by 327 | Submission Open
Keywords: medical imaging; animal models; preclinical research; human disease; oncology
(This special issue belongs to the Section Medical Research)
Advances in Regenerative Medicine in Disease Treatment: Harnessing Potential and Bridging Challenges
edited by Edward H. Ntege and
submission deadline 26 Nov 2025 | Viewed by 134 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; molecular therapy; personalized medicine; targeted delivery; immunomodulation
(This special issue belongs to the Section Physiology and Pathology)
Musculoskeletal Medicine in Rheumatic Diseases
edited by and Emilio Filippucci
submission deadline 28 Nov 2025 | 3 articles | Viewed by 7483 | Submission Open
Keywords: rheumatic disease; rheumatoid arthritis; spondylarthritis; microcrystal arthritis; musculoskeletal ultrasonography; biologic treatment; disease-modifying antirheumatic drugs; imagining techniques
(This special issue belongs to the Section Medical Research)
Space Medicine Ophthalmology: Insights from Molecular Observations to the Clinical Management of Ocular Risks in Microgravity
edited by Joshua Ong
submission deadline 28 Nov 2025 | 3 articles | Viewed by 4127 | Submission Open
Keywords: spaceflight; space medicine; ophthalmology; space medicine; microgravity; cornea; retina; ocular surface
(This special issue belongs to the Section Astrobiology)
Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 2044 | Submission Open
Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components
(This special issue belongs to the Section Physiology and Pathology)
Muscle Wasting, Aging, and Cancer: The Effects of Physical Exercise
edited by
submission deadline 28 Nov 2025 | 1 articles | Viewed by 1361 | Submission Open
Keywords: sarcopenia; aging; cancer; muscle wasting; physical exercise; resistance training; satellite cells; inflammation; metabolic health; quality of life
(This special issue belongs to the Section Physiology and Pathology)
Helicobacter pylori: 2nd Edition
edited by and
submission deadline 28 Nov 2025 | 1 articles | Viewed by 619 | Submission Open
Keywords: H. pylori; cancers; antioxidative process; diagnostic methods
(This special issue belongs to the Section Microbiology)
Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition submission deadline 28 Nov 2025 | Viewed by 218 | Submission Open
Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover
(This special issue belongs to the Section Plant Science)
Artificial Intelligence and Computational Models in Understanding Human Diseases
edited by Sergey K. Aityan
submission deadline 28 Nov 2025 | Viewed by 205 | Submission Open
Keywords: artificial intelligence; AI; diagnostics; computational medicine; medical modeling; medical simulation; medical data analysis
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
Trends in Microbiology 2025 submission deadline 30 Nov 2025 | 12 articles | Viewed by 21216 | Submission Open
Keywords: agricultural microbiology; clinical microbiology; environmental microbiology; food microbiology; industrial microbiology; marine microbiology; microbial biochemistry; microbial biofuel and bioenergy; microbial ecology; microbial evolution; microbial genetics; microbial metabolism; microbial pathogenesis; microbial physiology
(This special issue belongs to the Section Microbiology)
Traumatic Brain Injury (TBI)
edited by and Andrew J. Kobets
submission deadline 30 Nov 2025 | 4 articles | Viewed by 14060 | Submission Open
Keywords: neurosurgery; neuroscience; Traumatic Brain Injury; TBI; head injury; imaging; prognosis; labaratory findings; quality of life
(This special issue belongs to the Section Medical Research)
Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases
edited by Amosy Ephreim M’Koma
submission deadline 30 Nov 2025 | 5 articles | Viewed by 10224 | Submission Open
Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment
(This special issue belongs to the Section Physiology and Pathology)
Plant Functional Genomics and Breeding
edited by
submission deadline 30 Nov 2025 | 7 articles | Viewed by 9518 | Submission Open
Keywords: functional genomics; biological breeding; gene cloning; molecular network; genetic improvement
(This special issue belongs to the Section Plant Science)
Noninvasive Skin Imaging: The Present and the Future in General Dermatology
edited by and
submission deadline 30 Nov 2025 | 4 articles | Viewed by 9264 | Submission Open
Keywords: skin imaging; dermatoscopy; dermatology imaging; dermatosurgery; clinical dermatology
(This special issue belongs to the Section Medical Research)
Clinical Research in Male Reproduction
edited by Andrea Crafa, and Richard Quinton
submission deadline 30 Nov 2025 | 4 articles | Viewed by 6670 | Submission Open
Keywords: male infertility; male fertility; male sub-fertility; idiopathic male infertility; male reproduction
(This special issue belongs to the Section Medical Research)
New Insights into Parkinson’s Disease: From Molecular Basis to Therapy submission deadline 30 Nov 2025 | 4 articles | Viewed by 5172 | Submission Open
Keywords: Parkinson’ s disease; neurodegeneration; genes; GWAs; polygenic risk score; therapy; precision medicine; pathways; pharmacogenetics; surgicogenomics
(This special issue belongs to the Section Medical Research)
Synthesis and Evaluation of Novel Anticancer and Anti-Inflammatory Agents
edited by Po-Jen Chen, and Shun-Hua Chen
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4521 | Submission Open
Keywords: anticancer agents; anti-inflammatory agents; pharmacology; molecular and cell biology; drug design; medicinal chemistry; pharmacodynamics; pharmacokinetics; structure– activity relationship (SAR)
(This special issue belongs to the Section Pharmaceutical Science)
Advanced Research in Exercise Medicine
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4172 | Submission Open
Keywords: exercise and chronic disease; cardiovascular dysfunction/disease; metabolic syndrome; aging; athletic training; sports medicine; rehabilitation
(This special issue belongs to the Section Physiology and Pathology)
Pediatric Ophthalmic Pathology—Integrating Clinical and Basic Research
edited by and Brenda L. Bohnsack
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2684 | Submission Open
Keywords: congenital eye anomalies; anterior segment disorders; genetic eye disorders; pediatric eye conditions; pediatric ophthalmology
(This special issue belongs to the Section Physiology and Pathology)
Pharmacokinetic and Pharmacogenetic Approaches in Personalized Medicine
edited by and Giuliana Abbadessa
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2486 | Submission Open
Keywords: pharmacogenetics; pharmacokinetics; sex; gender; drugs; personalization
(This special issue belongs to the Section Pharmaceutical Science)
Sleep and Sleep Apnea: Impacts, Mechanisms, and Interventions
edited by Yung-An Tsou and Wen-Dien Chang
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2224 | Submission Open
Keywords: obstructive sleep apnea; sleep medicine; sleep surgery; sleep quality; insomnia
(This special issue belongs to the Section Physiology and Pathology)
Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases submission deadline 30 Nov 2025 | 2 articles | Viewed by 1498 | Submission Open
Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; thoracic surgery
(This special issue belongs to the Section Medical Research)
Prostate Cancer: 4th Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 1038 | Submission Open
Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling
(This special issue belongs to the Section Medical Research)
Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-Related Disease submission deadline 30 Nov 2025 | 1 articles | Viewed by 920 | Submission Open
Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer
(This special issue belongs to the Section Physiology and Pathology)
Total Joint Arthroplasty and Joint Replacement submission deadline 30 Nov 2025 | 1 articles | Viewed by 878 | Submission Open
Keywords: robotic and technology-assisted joint replacement; periprosthetic joint infection— prevention; diagnosis; and therapeutics; biomaterials and implant design; tissue engineering; muscle strengthening and conditioning; implant designs; edema and pain
(This special issue belongs to the Section Medical Research)
Novel Therapeutic Strategies for Targeting Glioblastoma Stem Cells
edited by and
submission deadline 30 Nov 2025 | Viewed by 829 | Submission Open
Keywords: glioblastoma; chemotherapeutic resistance; glioblastoma stem cells; immunosuppression; brain– blood barrier
(This special issue belongs to the Section Physiology and Pathology)
Gender Medicine: Current Knowledge and Future Perspectives
edited by
submission deadline 30 Nov 2025 | Viewed by 351 | Submission Open
Keywords: gender; gender medicine; LGBTQ + health; health equity in gender medicine; intersectionality; pharmacology; reproductive health; chronic diseases; transgender healthcare; sex-specific healthcare
(This special issue belongs to the Section Medical Research)
Prosthetic Joint Infections: A Multidisciplinary Approach
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 349 | Submission Open
Keywords: orthoplastic approach; prosthetic joint infection; diagnosis and management of PJI; antibiotic therapy in periprosthetic infections
(This special issue belongs to the Section Medical Research)
New Horizons: Autoimmune-Related Thrombosis
edited by and
submission deadline 30 Nov 2025 | Viewed by 200 | Submission Open
Keywords: chronic or transient autoantibodies; autoimmune thrombosis; lupus anticoagulant (LA); thrombotic thrombocytopenic Purpura (TTP); anti-phospholipid syndrome (APS); heparin induced thrombocytopenia/and thrombosis (HIT/HITT); vaccine induced thrombotic thrombocytopenia (VITT)
(This special issue belongs to the Section Medical Research)
Sports Biomechanics, Injury, and Physiotherapy
edited by Manos Stefanakis
submission deadline 30 Nov 2025 | Viewed by 173 | Submission Open
Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play
(This special issue belongs to the Section Physiology and Pathology)
Environment, Genetics, and Cardiovascular Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics
(This special issue belongs to the Section Medical Research)
Advanced Research in Chronic Obstructive Pulmonary Disease: Physiology and Pathology
edited by
submission deadline 30 Nov 2025 | Viewed by 142 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); biomarkers; inflammation; genomics; microbiome; air pollution
(This special issue belongs to the Section Medical Research)
Coagulation and Its Disorders: Physiology and Pathological Mechanisms submission deadline 30 Nov 2025 | Viewed by 138 | Submission Open
Keywords: coagulation; bleeding disorders; thrombotic mechanisms; animal models; molecular mechanisms; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammatory response; thrombin generation; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations
(This special issue belongs to the Section Physiology and Pathology)
Pleural and Pulmonary Fibrosis: Pathogenesis and Possible Treatment Strategies
edited by Oluwaseun Adeyanju
submission deadline 30 Nov 2025 | Viewed by 138 | Submission Open
Keywords: pulmonary fibrosis; pleural fibrosis; pathogenesis; therapeutic strategies; inflammation
(This special issue belongs to the Section Physiology and Pathology)
Update on Obstructive Sleep Apnea (OSA) submission deadline 30 Nov 2025 | Viewed by 136 | Submission Open
Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea
(This special issue belongs to the Section Physiology and Pathology)
Endocrinology and Metabolic Syndrome: Epidemiology
edited by Roman Junik and
submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open
Keywords: metabolic syndrome; obesity; hypertension; diabetes; dyslipidemia; endocrinology
(This special issue belongs to the Section Epidemiology)
Advances in Biomedical Frontier Technologies and Disease Diagnosis
edited by
submission deadline 30 Nov 2025 | Viewed by 129 | Submission Open
Keywords: nanomedicine  ; biomaterials  ; gene therapy  ; drug delivery  ; bacteriotherapy  ; nanobiotechnology  ; hereditary diseases  ; bioinformatics  ; personalized medicine  ; smart biomaterials
(This special issue belongs to the Section Medical Research)
Advances in Millimeter-Wave-Based Pain Therapy
edited by and David Crouzier
submission deadline 30 Nov 2025 | Viewed by 98 | Submission Open
Keywords: millimetric waves; pain therapy; pain management; electromagnetic radiations; biophysics
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Etiology, Diagnosis, and Treatment of Coeliac Diseases
edited by Paul J Ciclitira
submission deadline 30 Nov 2025 | Viewed by 88 | Submission Open
Keywords: coeliac disease; blood tests; dietary treatment; etiology
(This special issue belongs to the Section Medical Research)
Investigations of Circular RNAs in Plants submission deadline 1 Dec 2025 | 1 articles | Viewed by 678 | Submission Open
Keywords: plant circRNAs; miRNAs; stress responses; abiotic; biotic; translation; gene regulation; growth; development
(This special issue belongs to the Section Plant Science)
MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives
edited by
submission deadline 1 Dec 2025 | Viewed by 332 | Submission Open
Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies
(This special issue belongs to the Section Medical Research)
MASLD and Its Comorbidities: From Pathophysiology Perspectives
edited by
submission deadline 1 Dec 2025 | Viewed by 260 | Submission Open
Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research
(This special issue belongs to the Section Physiology and Pathology)
Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation
edited by and Gelu Onose
submission deadline 2 Dec 2025 | 5 articles | Viewed by 10141 | Submission Open
Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions
(This special issue belongs to the Section Medical Research)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 310 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology
edited by and Panagiotis Tsiakanikas
submission deadline 12 Dec 2025 | Viewed by 256 | Submission Open
Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes
(This special issue belongs to the Section Genetics and Genomics)
Microvascular Dynamics: Insights and Applications
edited by and Friedrich Jung
submission deadline 15 Dec 2025 | 6 articles | Viewed by 12910 | Submission Open
Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical
(This special issue belongs to the Section Physiology and Pathology)
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