Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Prostate Cancer: 3rd Edition submission deadline 30 Apr 2025 | 9 articles | Viewed by 13876 | Submission Open
Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modelling
(This special issue belongs to the Section Medical Research)
Advances in Artificial Intelligence for Medical Image Analysis
edited by
submission deadline 30 Apr 2025 | 6 articles | Viewed by 11899 | Submission Open
Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by
submission deadline 30 Apr 2025 | 4 articles | Viewed by 4458 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Alkaloids: Extraction, Analysis and Function Research submission deadline 30 Apr 2025 | 2 articles | Viewed by 4196 | Submission Open
Keywords: alkaloids; biological activity; chemical profiling; structural elucidation; computational experiments
(This special issue belongs to the Section Plant Science)
Physical Rehabilitation for Musculoskeletal Disorders
edited by You Gyoung Yi
submission deadline 30 Apr 2025 | 4 articles | Viewed by 4024 | Submission Open
Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation
(This special issue belongs to the Section Medical Research)
AI and Precision Medicine: Using Machine Learning for Disease Diagnosis and Prediction
edited by and Sarantis Chlamydas
submission deadline 30 Apr 2025 | 3 articles | Viewed by 3854 | Submission Open
Keywords: AI; machine learning; cancer; cardiovascular diseases; neurological disorders; genomics; diagnosis; prognosis; treatment response; disease-risk prediction
(This special issue belongs to the Section Medical Research)
Pancreatic Cancer: Long Survivals
edited by Francesco Leonardi and
submission deadline 30 Apr 2025 | 1 articles | Viewed by 3262 | Submission Open
Keywords: pancreatic cancer; long survival; outcome; pancreatic adenocarcinoma; long-term survival; surgical resection; chemotherapy; NGS
(This special issue belongs to the Section Physiology and Pathology)
The Treatments for Cardiovascular Diseases submission deadline 30 Apr 2025 | 2 articles | Viewed by 2796 | Submission Open
Keywords: nitric oxide; hydrogen sulfide; reactive oxygen species; angiotensin; endothelin
(This special issue belongs to the Section Medical Research)
New Insights into Breast Cancer: Current Controversies and Future Perspectives
edited by , Angela Bucaro and Flavia de Lauretis
submission deadline 30 Apr 2025 | 2 articles | Viewed by 1954 | Submission Open
Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies
(This special issue belongs to the Section Medical Research)
Novel Breakthroughs in Sepsis and Septic Shock Management
edited by and Vittorio Pavoni
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1867 | Submission Open
Keywords: decatecholaminisation; non-amine-based therapy; beta blockers; hormone replacement; levosimendan; Angiotensin II; sepsis; septic shock; septic cardiomyopathy
(This special issue belongs to the Section Pharmaceutical Science)
G Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity: Second Edition submission deadline 30 Apr 2025 | 1 articles | Viewed by 1508 | Submission Open
Keywords: G protein-coupled receptors; chemokines; dimerization; beta arrestin; biased agonist; pain; inflammation; neuroinflammation
(This special issue belongs to the Section Genetics and Genomics)
Molecular Mechanisms of Preeclampsia
edited by Feng Li
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1320 | Submission Open
Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
From Muscle to Fascia: Current Trends and Future Perspectives submission deadline 30 Apr 2025 | 1 articles | Viewed by 1065 | Submission Open
Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research in Biocatalysis: 2nd Edition
edited by and
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1055 | Submission Open
Keywords: biochemical; biomedical; biomaterials; biocatalysis; biodegradation; biofuels; bioplastics; directed evolution of enzymes; environmental remediation
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
New Perspectives and Innovations in Prosthetic Joint Infections
edited by Novella Cesta and
submission deadline 30 Apr 2025 | Viewed by 482 | Submission Open
Keywords: prosthetic joint infection; phage therapy; diagnostic tools in PJIs; antimicrobial resistance; biofilm-associated infections; antimicrobial therapy in PJIs; surgical outcomes; surgical management
(This special issue belongs to the Section Physiology and Pathology)
Gynecologic Oncology: Recent Advances and Future Perspectives
edited by Theodoros A. Panoskaltsis and
submission deadline 30 Apr 2025 | Viewed by 411 | Submission Open
Keywords: gynecologic cancer; gynecologic oncology; biomarkers in gynecology
(This special issue belongs to the Section Medical Research)
Innovations in Dairy Cattle Health and Nutrition Management
edited by Rasa Želvytė and Ingrida Monkevičienė
submission deadline 30 Apr 2025 | Viewed by 348 | Submission Open
Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers
(This special issue belongs to the Section Animal Science)
Sleep and Sleep Disorders in Sports and Advanced Physical Exercise: 2nd Edition submission deadline 30 Apr 2025 | Viewed by 294 | Submission Open
Keywords: sleep; sport; performance; physical exercise; sleep disorders; sleep regimens; fractured sleep; sleep at altitude; sleep medications
(This special issue belongs to the Section Physiology and Pathology)
The Interactions Between Cells and Their Microenvironment
edited by and
submission deadline 30 Apr 2025 | Viewed by 257 | Submission Open
Keywords: cell microenvironment; extracellular matrix; interstitial cells
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions
edited by Josipa Bukić
submission deadline 30 Apr 2025 | Viewed by 253 | Submission Open
Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs
(This special issue belongs to the Section Pharmaceutical Science)
Traumatic Brain Injury (TBI)
edited by and Andrew J. Kobets
submission deadline 30 Apr 2025 | Viewed by 251 | Submission Open
Keywords: neurosurgery; neuroscience; Traumatic Brain Injury; TBI; head injury; imaging; prognosis; labaratory findings; quality of life
(This special issue belongs to the Section Medical Research)
Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides
edited by and
submission deadline 30 Apr 2025 | Viewed by 229 | Submission Open
Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging
(This special issue belongs to the Section Pharmaceutical Science)
The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache
edited by , , Muneto Tatsumoto and Shingo Shimoda
submission deadline 30 Apr 2025 | Viewed by 203 | Submission Open
Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences
(This special issue belongs to the Section Medical Research)
Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity
edited by Elisa Na
submission deadline 30 Apr 2025 | Viewed by 183 | Submission Open
Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics
(This special issue belongs to the Section Physiology and Pathology)
Multidisciplinary Approach for Diagnosis and Management of Cardiac Sarcoidosis—the Role of Multi-Centre Registry Development
edited by Vasileios Kouranos, Rakesh Sharma, Thomas Luescher and Khattar Rajdeep
submission deadline 30 Apr 2025 | Viewed by 176 | Submission Open
Keywords: cardiac sarcoidosis; registry; multidisciplinary
(This special issue belongs to the Section Physiology and Pathology)
Agri-Food Waste Extracts: Structural and Functional Characterization
edited by
submission deadline 30 Apr 2025 | Viewed by 158 | Submission Open
Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules
(This special issue belongs to the Section Plant Science)
Organogenesis and Regeneration: From Basic Research to Medical Study—2nd Edition
edited by , Junzheng Zhang and Ju Li
submission deadline 30 Apr 2025 | Viewed by 121 | Submission Open
Keywords: organogenesis; regeneration; development; proliferation; differentiation; blastema; signaling pathway
(This special issue belongs to the Section Reproductive and Developmental Biology)
Advances in Brain-Machine Interfaces
edited by
submission deadline 30 Apr 2025 | Viewed by 114 | Submission Open
Keywords: brain– machine interfaces; brain– computer interfaces; neurorehabilitation; neuroengineering; neurophysiology
(This special issue belongs to the Section Physiology and Pathology)
Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations
edited by Manuel Gil Lozano and Marina Romaní-Pérez
submission deadline 30 Apr 2025 | Viewed by 111 | Submission Open
Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin
(This special issue belongs to the Section Physiology and Pathology)
Advances in Non-Invasive Brain Stimulation
edited by Mariagiovanna Cantone and
submission deadline 1 May 2025 | 2 articles | Viewed by 1691 | Submission Open
Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound
(This special issue belongs to the Section Medical Research)
Advances in the Biomedical Applications of Plants and Plant Extracts
edited by and Annamária Pallag
submission deadline 5 May 2025 | 15 articles | Viewed by 26093 | Submission Open
Keywords: herbals; plant extracts; polyphenols; anthocyanins; isolation; characterization; preparation; oxidative stress; apoptosis; inflammation; dermatitis; CNS; new target molecules
(This special issue belongs to the Section Pharmaceutical Science)
Obstructive Sleep Apnea and Related Disorders: Pathophysiological Traits and Strategies for Treatment
edited by
submission deadline 5 May 2025 | 6 articles | Viewed by 10882 | Submission Open
Keywords: obstructive sleep apnea; sleep fragmentation; cardiometabolic dysfunction; inflammation; co-morbidities
(This special issue belongs to the Section Physiology and Pathology)
Unravelling the Molecular Mechanisms of Different Stress Responses in Plants
edited by
submission deadline 9 May 2025 | Viewed by 483 | Submission Open
Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms
(This special issue belongs to the Section Plant Science)
MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 173 | Submission Open
Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies
(This special issue belongs to the Section Medical Research)
MASLD and Its Comorbidities: From Pathophysiology Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 154 | Submission Open
Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research
(This special issue belongs to the Section Physiology and Pathology)
Ruminant Nutrition Strategies to Improve Feed Efficiency and Reduce Methane Emissions: 2nd Edition
edited by , Tongjun Guo and
submission deadline 15 May 2025 | Viewed by 242 | Submission Open
Keywords: ruminant nutrition; roughage utilization; unconventional feed materials; feed efficiency; production performance; methane emissions; feed additive
(This special issue belongs to the Section Animal Science)
Personalized Prevention and Treatment in Endocrinology, Diabetes and Metabolic Diseases
edited by Grigorios Panagiotou
submission deadline 16 May 2025 | 10 articles | Viewed by 17557 | Submission Open
Keywords: personalized medicine; precision prevention; multi-omics; obesity; diabetes and endocrinology
(This special issue belongs to the Section Medical Research)
Advances in Substance Abuse and Addiction
edited by , and Chieh-Liang Huang
submission deadline 16 May 2025 | 4 articles | Viewed by 5682 | Submission Open
Keywords: addiction medicine; opioid pharmacology; substance abuse; addictive disorders intervention
(This special issue belongs to the Section Pharmaceutical Science)
Innovations in Thoracic Surgery and Medicine: Advancements and Challenges
edited by Paolo Scanagatta
submission deadline 18 May 2025 | 2 articles | Viewed by 2261 | Submission Open
Keywords: thoracic medicine; thoracic surgery; lung cancer; artificial intelligence (AI); VATS; thoracic anesthesia; innovations
(This special issue belongs to the Section Medical Research)
Innovative Perspectives in Physical Therapy and Health submission deadline 22 May 2025 | 2 articles | Viewed by 1791 | Submission Open
Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies
(This special issue belongs to the Section Medical Research)
Pain and Therapy: Historical Perspectives and Future Directions submission deadline 22 May 2025 | 1 articles | Viewed by 634 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Medical Research)
Conservative Management of Chronic Disease
edited by
submission deadline 26 May 2025 | 5 articles | Viewed by 11044 | Submission Open
Keywords: chronic disease  ; conservative management; trial protocol; clinical research; interventions
(This special issue belongs to the Section Medical Research)
Effects of Exercise Training on Muscle Function
edited by Marco Duca and
submission deadline 26 May 2025 | 5 articles | Viewed by 9874 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Feature Papers in Synthetic Biology and Systems Biology 2024
edited by
submission deadline 26 May 2025 | Viewed by 337 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods submission deadline 28 May 2025 | 12 articles | Viewed by 14672 | Submission Open
Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging
(This special issue belongs to the Section Pharmaceutical Science)
Plant Biotic and Abiotic Stresses 2024
edited by and
submission deadline 30 May 2025 | 15 articles | Viewed by 17419 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
New Updates in Adipocytes and Adipose Tissue: 2nd Edition submission deadline 30 May 2025 | 4 articles | Viewed by 11949 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges submission deadline 30 May 2025 | 7 articles | Viewed by 11941 | Submission Open
Keywords: cardiovascular disease; hyperlipidemia; neuropathy; nephropathy; retinopathy; skin conditions; impaired wound healing; hearing impairment; psychological effects; epigenetic imprinting; molecular profiling; biomarkers; targeted therapy; glucose control; conventional and complementary approaches; stem cell damage; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
Fish Nutrition, Production, and Welfare
edited by Liviu-Dan Miron, , and
submission deadline 30 May 2025 | 4 articles | Viewed by 8008 | Submission Open
Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management
(This special issue belongs to the Section Animal Science)
Bioactive Natural Compounds: Therapeutic Insights and Applications
edited by Vaidotas Žvikas
submission deadline 30 May 2025 | 7 articles | Viewed by 7964 | Submission Open
Keywords: medicinal plants; bioactive compounds; plant extracts; phytochemicals; analytical method validation
(This special issue belongs to the Section Pharmaceutical Science)
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