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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Space Medicine Ophthalmology: Insights from Molecular Observations to the Clinical Management of Ocular Risks in Microgravity

edited by Joshua Ong

submission deadline 28 Nov 2025 | 3 articles | Viewed by 4281 | Submission Open

Keywords: spaceflight; space medicine; ophthalmology; space medicine; microgravity; cornea; retina; ocular surface

(This special issue belongs to the Section Astrobiology)

Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity

edited by

Berit Hippe

submission deadline 28 Nov 2025 | 2 articles | Viewed by 2539 | Submission Open

Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components

(This special issue belongs to the Section Physiology and Pathology)

Muscle Wasting, Aging, and Cancer: The Effects of Physical Exercise

edited by

Paula Tavares

submission deadline 28 Nov 2025 | 1 articles | Viewed by 1529 | Submission Open

Keywords: sarcopenia; aging; cancer; muscle wasting; physical exercise; resistance training; satellite cells; inflammation; metabolic health; quality of life

(This special issue belongs to the Section Physiology and Pathology)

Helicobacter pylori: 2nd Edition

edited by

Ovidiu Pop

and

Simona Gurzu

submission deadline 28 Nov 2025 | 1 articles | Viewed by 754 | Submission Open

Keywords: H. pylori; cancers; antioxidative process; diagnostic methods

(This special issue belongs to the Section Microbiology)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 28 Nov 2025 | Viewed by 226 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Artificial Intelligence and Computational Models in Understanding Human Diseases

edited by Sergey K. Aityan

submission deadline 28 Nov 2025 | Viewed by 224 | Submission Open

Keywords: artificial intelligence; AI; diagnostics; computational medicine; medical modeling; medical simulation; medical data analysis

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Trends in Microbiology 2025

edited by

Pabulo Rampelotto

and

Milan Kolar

submission deadline 30 Nov 2025 | 12 articles | Viewed by 22274 | Submission Open

Keywords: agricultural microbiology; clinical microbiology; environmental microbiology; food microbiology; industrial microbiology; marine microbiology; microbial biochemistry; microbial biofuel and bioenergy; microbial ecology; microbial evolution; microbial genetics; microbial metabolism; microbial pathogenesis; microbial physiology

(This special issue belongs to the Section Microbiology)

Traumatic Brain Injury (TBI)

edited by

Seyed Ahmad Naseri Alavi

and Andrew J. Kobets

submission deadline 30 Nov 2025 | 4 articles | Viewed by 15316 | Submission Open

Keywords: neurosurgery; neuroscience; Traumatic Brain Injury; TBI; head injury; imaging; prognosis; labaratory findings; quality of life

(This special issue belongs to the Section Medical Research)

Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases

edited by Amosy Ephreim M’Koma

submission deadline 30 Nov 2025 | 5 articles | Viewed by 11287 | Submission Open

Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment

(This special issue belongs to the Section Physiology and Pathology)

Plant Functional Genomics and Breeding

edited by

Yifeng Wang

submission deadline 30 Nov 2025 | 7 articles | Viewed by 9974 | Submission Open

Keywords: functional genomics; biological breeding; gene cloning; molecular network; genetic improvement

(This special issue belongs to the Section Plant Science)

Noninvasive Skin Imaging: The Present and the Future in General Dermatology

edited by

Bijan Safai

and

Banu Farabi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 9720 | Submission Open

Keywords: skin imaging; dermatoscopy; dermatology imaging; dermatosurgery; clinical dermatology

(This special issue belongs to the Section Medical Research)

Clinical Research in Male Reproduction

edited by Andrea Crafa,

Aldo E. Calogero

and Richard Quinton

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7011 | Submission Open

Keywords: male infertility; male fertility; male sub-fertility; idiopathic male infertility; male reproduction

(This special issue belongs to the Section Medical Research)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy

edited by

Kallirhoe Kalinderi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5730 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; genes; GWAs; polygenic risk score; therapy; precision medicine; pathways; pharmacogenetics; surgicogenomics

(This special issue belongs to the Section Medical Research)

Advanced Research in Exercise Medicine

edited by

Ai-Lun Yang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5227 | Submission Open

Keywords: exercise and chronic disease; cardiovascular dysfunction/disease; metabolic syndrome; aging; athletic training; sports medicine; rehabilitation

(This special issue belongs to the Section Physiology and Pathology)

Synthesis and Evaluation of Novel Anticancer and Anti-Inflammatory Agents

edited by Po-Jen Chen,

Yu-Chia Chang

and Shun-Hua Chen

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4728 | Submission Open

Keywords: anticancer agents; anti-inflammatory agents; pharmacology; molecular and cell biology; drug design; medicinal chemistry; pharmacodynamics; pharmacokinetics; structure– activity relationship (SAR)

(This special issue belongs to the Section Pharmaceutical Science)

Pediatric Ophthalmic Pathology—Integrating Clinical and Basic Research

edited by

Antionette L. Williams

and Brenda L. Bohnsack

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2806 | Submission Open

Keywords: congenital eye anomalies; anterior segment disorders; genetic eye disorders; pediatric eye conditions; pediatric ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Sleep and Sleep Apnea: Impacts, Mechanisms, and Interventions

edited by Yung-An Tsou and Wen-Dien Chang

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2678 | Submission Open

Keywords: obstructive sleep apnea; sleep medicine; sleep surgery; sleep quality; insomnia

(This special issue belongs to the Section Physiology and Pathology)

Pharmacokinetic and Pharmacogenetic Approaches in Personalized Medicine

edited by

Silvia De Francia

and Giuliana Abbadessa

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2659 | Submission Open

Keywords: pharmacogenetics; pharmacokinetics; sex; gender; drugs; personalization

(This special issue belongs to the Section Pharmaceutical Science)

Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases

edited by

Doina-Adina Todea

Anca-Diana Maierean

and

Damiana-Maria Vulturar

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1618 | Submission Open

Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; thoracic surgery

(This special issue belongs to the Section Medical Research)

Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1122 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-Related Disease

edited by

Laura Cianfruglia

and

Salvatore Vaiasicca

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1010 | Submission Open

Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer

(This special issue belongs to the Section Physiology and Pathology)

Total Joint Arthroplasty and Joint Replacement

edited by

Corrado Ciatti

Luca Andriollo

Francesco Benazzo

and

Stefano Marco Paolo Rossi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: robotic and technology-assisted joint replacement; periprosthetic joint infection— prevention; diagnosis; and therapeutics; biomaterials and implant design; tissue engineering; muscle strengthening and conditioning; implant designs; edema and pain

(This special issue belongs to the Section Medical Research)

Novel Therapeutic Strategies for Targeting Glioblastoma Stem Cells

edited by

Tsung-I Hsu

and

Chih Jie Shen

submission deadline 30 Nov 2025 | Viewed by 838 | Submission Open

Keywords: glioblastoma; chemotherapeutic resistance; glioblastoma stem cells; immunosuppression; brain– blood barrier

(This special issue belongs to the Section Physiology and Pathology)

Prosthetic Joint Infections: A Multidisciplinary Approach

edited by

Andrea Sambri

submission deadline 30 Nov 2025 | 1 articles | Viewed by 673 | Submission Open

Keywords: orthoplastic approach; prosthetic joint infection; diagnosis and management of PJI; antibiotic therapy in periprosthetic infections

(This special issue belongs to the Section Medical Research)

Gender Medicine: Current Knowledge and Future Perspectives

edited by

Laura Franza

submission deadline 30 Nov 2025 | Viewed by 368 | Submission Open

Keywords: gender; gender medicine; LGBTQ + health; health equity in gender medicine; intersectionality; pharmacology; reproductive health; chronic diseases; transgender healthcare; sex-specific healthcare

(This special issue belongs to the Section Medical Research)

New Horizons: Autoimmune-Related Thrombosis

edited by

Jean Amiral

and

Osamu Kumano

submission deadline 30 Nov 2025 | Viewed by 202 | Submission Open

Keywords: chronic or transient autoantibodies; autoimmune thrombosis; lupus anticoagulant (LA); thrombotic thrombocytopenic Purpura (TTP); anti-phospholipid syndrome (APS); heparin induced thrombocytopenia/and thrombosis (HIT/HITT); vaccine induced thrombotic thrombocytopenia (VITT)

(This special issue belongs to the Section Medical Research)

Sports Biomechanics, Injury, and Physiotherapy

edited by Manos Stefanakis

submission deadline 30 Nov 2025 | Viewed by 186 | Submission Open

Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play

(This special issue belongs to the Section Physiology and Pathology)

Environment, Genetics, and Cardiovascular Disease

edited by

Andrea Borghini

submission deadline 30 Nov 2025 | Viewed by 176 | Submission Open

Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics

(This special issue belongs to the Section Medical Research)

Advanced Research in Chronic Obstructive Pulmonary Disease: Physiology and Pathology

edited by

I-Shiang Tzeng

submission deadline 30 Nov 2025 | Viewed by 152 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); biomarkers; inflammation; genomics; microbiome; air pollution

(This special issue belongs to the Section Medical Research)

Coagulation and Its Disorders: Physiology and Pathological Mechanisms

edited by

Anna Lisa Montemari

submission deadline 30 Nov 2025 | Viewed by 151 | Submission Open

Keywords: coagulation; bleeding disorders; thrombotic mechanisms; animal models; molecular mechanisms; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammatory response; thrombin generation; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

(This special issue belongs to the Section Physiology and Pathology)

Pleural and Pulmonary Fibrosis: Pathogenesis and Possible Treatment Strategies

edited by Oluwaseun Adeyanju

submission deadline 30 Nov 2025 | Viewed by 147 | Submission Open

Keywords: pulmonary fibrosis; pleural fibrosis; pathogenesis; therapeutic strategies; inflammation

(This special issue belongs to the Section Physiology and Pathology)

Advances in Biomedical Frontier Technologies and Disease Diagnosis

edited by

Alexey Yaremenko

submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open

Keywords: nanomedicine ; biomaterials ; gene therapy ; drug delivery ; bacteriotherapy ; nanobiotechnology ; hereditary diseases ; bioinformatics ; personalized medicine ; smart biomaterials

(This special issue belongs to the Section Medical Research)

Update on Obstructive Sleep Apnea (OSA)

edited by

Konstantinos Chaidas

submission deadline 30 Nov 2025 | Viewed by 145 | Submission Open

Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea

(This special issue belongs to the Section Physiology and Pathology)

Endocrinology and Metabolic Syndrome: Epidemiology

edited by Roman Junik and

Szymon Suwała

submission deadline 30 Nov 2025 | Viewed by 141 | Submission Open

Keywords: metabolic syndrome; obesity; hypertension; diabetes; dyslipidemia; endocrinology

(This special issue belongs to the Section Epidemiology)

Advances in Millimeter-Wave-Based Pain Therapy

edited by

Jean-Claude Debouzy

and David Crouzier

submission deadline 30 Nov 2025 | Viewed by 107 | Submission Open

Keywords: millimetric waves; pain therapy; pain management; electromagnetic radiations; biophysics

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Etiology, Diagnosis, and Treatment of Coeliac Diseases

edited by Paul J Ciclitira

submission deadline 30 Nov 2025 | Viewed by 98 | Submission Open

Keywords: coeliac disease; blood tests; dietary treatment; etiology

(This special issue belongs to the Section Medical Research)

Investigations of Circular RNAs in Plants

edited by

Srividhya Venkataraman

submission deadline 1 Dec 2025 | 1 articles | Viewed by 726 | Submission Open

Keywords: plant circRNAs; miRNAs; stress responses; abiotic; biotic; translation; gene regulation; growth; development

(This special issue belongs to the Section Plant Science)

MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives

edited by

Simona Cernea

submission deadline 1 Dec 2025 | Viewed by 342 | Submission Open

Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies

(This special issue belongs to the Section Medical Research)

MASLD and Its Comorbidities: From Pathophysiology Perspectives

edited by

Simona Cernea

submission deadline 1 Dec 2025 | Viewed by 271 | Submission Open

Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research

(This special issue belongs to the Section Physiology and Pathology)

Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation

edited by

Constantin Munteanu

and Gelu Onose

submission deadline 2 Dec 2025 | 5 articles | Viewed by 11024 | Submission Open

Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions

(This special issue belongs to the Section Medical Research)

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Dec 2025 | Viewed by 313 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology

edited by

Panagiotis Adamopoulos

and Panagiotis Tsiakanikas

submission deadline 12 Dec 2025 | Viewed by 271 | Submission Open

Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes

(This special issue belongs to the Section Genetics and Genomics)

Microvascular Dynamics: Insights and Applications

edited by

Aristotle G. Koutsiaris

and Friedrich Jung

submission deadline 15 Dec 2025 | 6 articles | Viewed by 13253 | Submission Open

Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical

(This special issue belongs to the Section Physiology and Pathology)

Unusual Genomic Traits in Their Evolutionary Context

edited by Miguel Naranjo-Ortiz

submission deadline 15 Dec 2025 | Viewed by 144 | Submission Open

Keywords: unusual genomes; genomic traits; comparative genomics; descriptive genomics; evolutionary genomics; non-model organisms; methodological limitations in genomics

(This special issue belongs to the Section Genetics and Genomics)

2nd Edition—Featured Papers on the Origins of Life

edited by James R. Lyons

submission deadline 17 Dec 2025 | 4 articles | Viewed by 4482 | Submission Open

Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems

(This special issue belongs to the Section Origin of Life)

Unravelling the Molecular Mechanisms of Different Stress Responses in Plants

edited by

Hakim Manghwar

submission deadline 18 Dec 2025 | 1 articles | Viewed by 1563 | Submission Open

Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms

(This special issue belongs to the Section Plant Science)

Innovative Approaches in Dermatological Therapies and Diagnostics

edited by

Federica Li Pomi

and

Francesco Borgia

submission deadline 26 Dec 2025 | 5 articles | Viewed by 8934 | Submission Open

Keywords: dermatology; inflammatory diseases; skin cancer; non-invasive diagnosis; dermoscopy; confocal dermoscopy; targeted therapy; JAK inhibitors; biologics; artificial intelligence

(This special issue belongs to the Section Medical Research)

Recent Advances in Shockwave Therapy for Musculoskeletal and Soft-Tissue Disorders

edited by

Marco Gesi

Mario Vetrano

, Maria Chiara Vulpiani, Maria Cristina D'Agostino, Larisa Ryskalin and Federica Fulceri

submission deadline 26 Dec 2025 | 3 articles | Viewed by 7510 | Submission Open

Keywords: shockwave; tissue regeneration; pain; functional recovery and healing; physical medicine and rehabilitation; clinical applications; imaging

(This special issue belongs to the Section Medical Research)

Advances in Diagnostic Imaging for Systemic Disorders

edited by Christoph Strolz

submission deadline 29 Dec 2025 | Viewed by 125 | Submission Open

Keywords: high-resolution computed tomography (HRCT); diffusion-weighted imaging (DWI); dual-energy CT in musculoskeletal imaging; high-resolution ultrasonography; SPECT/CT; PET/CT modalities

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Current Views on Knee Osteoarthritis: 3rd Edition

edited by

Sevdalina Nikolova Lambova

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1799 | Submission Open

Keywords: knee osteoarthritis; metabolic syndrome; obesity; pathogenesis; adipokines; disease-modifying; treatment; personalized medicine

(This special issue belongs to the Section Medical Research)

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