Gene Editing of Large Mammals: 2nd Edition

Dear Colleagues,

Genome editing technologies can be used to precisely alter genomic sequences and modify genetic information at specific target sites of an organism. Compared with the long breeding cycle and high cost of traditional genetic breeding, gene editing can be used to implement the cost-effective targeted editing of animal genomes, thereby providing a powerful application tool for rapid improvements in the production traits of large mammals. In addition, some large mammals are closely related to human beings. These large gene-edited mammals can serve as disease models, animal bioreactors, or be used in xenotransplantation. However, the application of gene editing to generate large gene-edited mammals is still in a stage of significant development. To stimulate progress on this topic, this Special Issue aims to cover the following non-exhaustive areas of relevance:

• The application of gene editing to large mammals and the successful generation of mutants;
• How to improve gene editing efficiency in large animals;
• Developing disease models using gene editing technology;
• Application of novel gene editing techniques in xenotransplantation, animal bioreactor, and humanized organ research.

Prof. Dr. Zhengxing Lian
Prof. Dr. Xuguang Du
Dr. Shou-Long Deng
Guest Editors

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