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Life
Special Issues
Pathological and Clinical Updates on Eye Diseases
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Pathological and Clinical Updates on Eye Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 588

Special Issue Editors

Dr. Pier Luigi Surico

E-Mail Website
Guest Editor
Department of Ophthalmology, Campus Bio-Medico University Hospital, Rome, Italy
Interests: eye; ocular surface; ocular immunology; cornea; anterior segment; ocular pathology; refractive surgery
Dr. Rohan Bir Singh

E-Mail Website
Guest Editor
1. Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
2. Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
3. Discipline of Ophthalmology and Visual Sciences, Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Adelaide, Australia
Interests: cornea; dry eye disease; corneal transplantation; corneal regeneration; epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the field of ophthalmology has witnessed remarkable advancements in the diagnosis and management of eye diseases, driven by innovations in gene therapy, cutting-edge imaging technologies, nanomedicine, molecular treatments, and other transformative approaches. These developments have enhanced our ability to address complex ocular conditions, including immune-mediated diseases, by integrating multidisciplinary strategies that bridge clinical and experimental insights.

This Special Issue aims at deepening the understanding of the challenges posed by eye diseases and their diverse impacts on individual patients. It provides a platform for sharing and discussing the latest advancements in ophthalmological research and practice in a comprehensive and collaborative manner.

We invite submissions of articles focusing on clinical and experimental research that significantly contribute to the diagnosis and treatment of ocular diseases, emphasizing the integration of multidisciplinary approaches and novel therapeutic strategies.

Dr. Pier Luigi Surico
Dr. Rohan Bir Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ophthalmology
  • eye diseases
  • gene therapy
  • ocular surface
  • ocular immunology
  • cornea

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Published Papers (1 paper)

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Research

15 pages, 259 KiB  
Article
Etiology and Anatomical Location of Uveitis—Prognostic Factors for Disease Course and Laterality
by Vesela Todorova Mitkova-Hristova and Marin Anguelov Atanassov
Life 2025, 15(6), 882; https://doi.org/10.3390/life15060882 - 30 May 2025
Viewed by 341
Abstract
Background: Uveitis encompasses a broad group of diseases with infectious and non-infectious etiologies, potentially leading to permanent and irreversible visual impairment. This study aimed to determine whether the etiology and anatomical location of uveitis influence the course and laterality of the disease. Methods: [...] Read more.
Background: Uveitis encompasses a broad group of diseases with infectious and non-infectious etiologies, potentially leading to permanent and irreversible visual impairment. This study aimed to determine whether the etiology and anatomical location of uveitis influence the course and laterality of the disease. Methods: This retrospective observational study included patients with uveitis treated at the University Eye Clinic of “St. George” University Hospital in Plovdiv, Bulgaria, between January 2011 and December 2023. All participants underwent a comprehensive eye examination and minimal laboratory screening, with additional tests and specialist consultations performed when necessary. Uveitis cases were categorized into anterior, intermediate, posterior, and panuveitis according to anatomical location; unilateral or bilateral according to laterality; and acute, chronic, or recurrent based on disease course. Results: The study included 606 patients aged between 3 and 87 years. The etiology and anatomical location of uveitis were significantly associated with the course and laterality of the disease (p < 0.001). Anterior and posterior uveitis were mostly unilateral, with a defined cause and characterized by acute or recurring progression. Intermediate uveitis was mostly idiopathic and chronic, while panuveitis had a more uniform distribution regarding disease progression. Among cases with a determined etiology, HLA-B27-associated uveitis was the most common (32.5%), characterized by sequential involvement of both eyes and a recurrent course. Viral and toxoplasmic uveitis were more frequently unilateral. Conclusions: Our findings indicate that the etiology and anatomical location of uveitis can serve as prognostic factors for contralateral eye involvement and the progression of the inflammatory process. We found that anterior and posterior uveitis were predominantly unilateral and typically presented with an acute or recurrent course, whereas intermediate uveitis and panuveitis were more commonly chronic. In men, uveitis more often had an acute onset, while in women, it tended to follow a chronic course. Full article
(This article belongs to the Special Issue Pathological and Clinical Updates on Eye Diseases)
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