New Insights into Personalized Medicine for Anesthesia and Pain

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Medical Care".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 3191

Special Issue Editors


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Guest Editor
Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, 84 Heukseok-ro, Dongjak-gu, Seoul 06911, Republic of Korea
Interests: general anesthesia; cardiac surgery; echocardiography; postoperative pain; biostatistics; epidemiology; systematic review and meta-analysis; lipid; atherosclerosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, 84 Heukseok-ro, Dongjak-gu, Seoul 06911, Republic of Korea
Interests: ambulatory anesthesia; airway management; procedural sedation; monitored anesthesia care

Special Issue Information

Dear Colleagues,

Modern medicine is undergoing a profound transformation, with personalized medicine emerging as a key beneficiary of these advancements, representing an approach that tailors medical treatment to the unique genetic, environmental, and lifestyle characteristics of each patient. Our Special Issue, "New Insights into Personalized Medicine for Anesthesia and Pain", explores the latest research and developments that are redefining anesthesia and pain management paradigms.

Personalized medicine marks a shift from the traditional "one-size-fits-all" model to a more nuanced strategy. In anesthesia, this tailored approach promises to optimize drug efficacy, minimize adverse effects, and enhance patient safety and surgical outcomes. In pain management, personalized strategies are essential for addressing the complexities of chronic pain, often requiring multifaceted and individualized treatment plans.

Our Special Issue aims to illuminate the path forward for personalized medicine in anesthesia and pain management. By fostering a deeper understanding of individual patient variability and its implications for clinical practice, we hope to inspire ongoing innovation and collaboration in this dynamic field. Ultimately, our goal is to enhance patient outcomes and quality of life through more targeted and personalized therapeutic strategies.

Prof. Dr. Hyun Kang
Dr. Guen Joo Choi
Guest Editors

Manuscript Submission Information

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Keywords

  • new insights
  • personalized medicine
  • anesthesia
  • pain management
  • perioperative analgesia
  • airway management
  • perioperative nausea
  • interventional pain care
  • critical care
  • minimally invasive surgery/robotic surgery
  • mechanical ventilation
  • chronic pain
  • acute pain
  • lumbar/cervical/thoracic/spinal pain
  • musculoskeletal pain

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Published Papers (2 papers)

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11 pages, 1000 KB  
Article
Ultrasound-Guided Regional Block in Renal Transplantation: Toward Personalized Pain Management
by Ahmad Mirza, Munazza Khan, Zachary Massey, Usman Baig, Imran Gani and Shameem Beigh
J. Pers. Med. 2025, 15(9), 411; https://doi.org/10.3390/jpm15090411 - 2 Sep 2025
Viewed by 394
Abstract
Introduction: The management of peri-operative pain significantly impacts the post-operative recovery following kidney transplant. For decades, regional blocks have been utilized for post-operative pain management following abdominal surgery. The data on the routine use of regional blocks peri-operatively during kidney transplants are limited. [...] Read more.
Introduction: The management of peri-operative pain significantly impacts the post-operative recovery following kidney transplant. For decades, regional blocks have been utilized for post-operative pain management following abdominal surgery. The data on the routine use of regional blocks peri-operatively during kidney transplants are limited. We aim to review our current clinical practice of peri-operative use of regional blocks during kidney transplants and management of peri-operative pain up to 24 h. Methods: A consecutive series of 100 patients who underwent kidney transplant was reviewed. All demographic data including patient’s age, gender, race, and body mass index were collected. Pre-transplant co-morbidities were summarized for all patients and included the American Society of Anesthesiologists (ASA) score. Patients were divided into two groups based on whether they received a transversus abdominis plane (TAP) block. Group A consisted of patients who received an ultrasound-guided TAP block, while Group B included patients who did not receive any form of TAP block. The intra-operative and post-operative use of analgesia was recorded for up to 24 h post kidney transplant. All peri-operative complications were reviewed. The chi-square test and Fisher’s exact test was used to compare symptoms (nausea, vomiting, and pruritus) between the two groups. Similarly, the use of analgesia was also compared. Results: A total of 100 patients were identified and equally distributed between the two groups [Group A = 50 (TAP block), Group B = 50 (non-TAP block)]. There was a statistically significant reduction in the use of intraoperative fentanyl (p = 0.04) in Group A. There was no difference in the post-operative use of hydromorphone (p = 0.665), oxycodone (p = 0.75), and acetaminophen (p = 0.64) up to 24 h after the kidney transplant procedure. There was no difference between post-operative nausea (p = 0.766), vomiting (p = 0.436), and pruritus. There were no complications recorded secondary to the use of regional blocks in Group A. Conclusions: The use of regional anesthesia in kidney transplant recipients is a safe approach without complications. The study concluded that regional blocks decrease the use of intra-operative opioids. However, there was no difference in the use of post-operative requirements for analgesia or side effects up to 24 h after kidney transplant. Full article
(This article belongs to the Special Issue New Insights into Personalized Medicine for Anesthesia and Pain)
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38 pages, 3012 KB  
Systematic Review
Effect of Prophylactic Tropisetron on Post-Operative Nausea and Vomiting in Patients Undergoing General Anesthesia: Systematic Review and Meta-Analysis with Trial Sequential Analysis
by In Jung Kim, Geun Joo Choi, Hyeon Joung Hwang and Hyun Kang
J. Pers. Med. 2024, 14(8), 797; https://doi.org/10.3390/jpm14080797 - 27 Jul 2024
Cited by 1 | Viewed by 2188
Abstract
This systematic review and meta-analysis of randomized controlled trials (RCTs) with trial sequential analysis (TSA) aimed to comprehensively evaluate and compare the efficacy of the prophylactic administration of tropisetron in the prevention of the incidence of post-operative nausea and vomiting (PONV) in patients [...] Read more.
This systematic review and meta-analysis of randomized controlled trials (RCTs) with trial sequential analysis (TSA) aimed to comprehensively evaluate and compare the efficacy of the prophylactic administration of tropisetron in the prevention of the incidence of post-operative nausea and vomiting (PONV) in patients undergoing surgery under general anesthesia. This study was registered with PROSPERO (CRD42024372692). RCTs comparing the efficacy of the perioperative administration of tropisetron with that of a placebo, other anti-emetic agents, or a combination of anti-emetic injections were retrieved from the databases of Ovid-MEDLINE, Ovid-EMBASE, the Cochrane Central Register of Controlled Trials, and Google Scholar. The frequency of rescue anti-emetic use (RA) and the incidence of PON, POV, and PONV (relative risk [RR]: 0.718; 95% confidence interval [CI] 0.652–0.790; I2 = 0.0, RR: 0.587; 95% CI 0.455–0.757; I2 = 63.32, RR: 0.655; 95% CI 0.532–0.806; I2 = 49.09, and RR: 0.622; 95% CI 0.552–0.700; I2 = 0.00, respectively) in the tropisetron group were lower than those in the control group; however, the incidence of complete response (CR) was higher in the tropisetron group (RR: 1.517;95% CI 1.222–1.885; I2 = 44.14). TSA showed the cumulative Z-curve exceeded both the conventional test and trial sequential monitoring boundaries for RA, PON, POV, and PONV between the tropisetron group and the control group. Thus, the prophylactic administration of tropisetron exhibited superior efficacy in the prevention of PON, POV, and PONV. Furthermore, a lower incidence of RA and a higher incidence of CR were observed with its use. Full article
(This article belongs to the Special Issue New Insights into Personalized Medicine for Anesthesia and Pain)
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