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Personalized Medicine in Otolaryngology: New Challenges and Future Perspectives
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Personalized Medicine in Otolaryngology: New Challenges and Future Perspectives

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 102

Special Issue Editor

Dr. Jerome Rene Lechien

E-Mail Website
Guest Editor
1. Department of Otolaryngology-Head & Neck Surgery, CHU Saint Pierre, 1000 Brussels, Belgium
2. Department of Otolaryngology, Elsan, Polyclinic of Atlantique, Poitiers, France
3. Department of Surgery, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000 Mons, Belgium
4. Department of Otolaryngology, Foch Hospital, Paris Saclay University, Paris, France
Interests: otolaryngology; oral cancer; oncology; head and neck surgery; rhinology; ENT; artificial intelligence; laryngology; laryngopharyngeal reflux

Special Issue Information

Dear Colleagues,

In the field of otolaryngology, the application of personalized medicine is changing the ways in which diseases are diagnosed, treated, and prevented, enabling doctors to provide more precise and effective medical services.

The basis of personalized medicine lies in a comprehensive understanding of patients, including genetic factors, molecular markers, clinical symptoms, and lifestyle factors. With the development of high-throughput biotechnologies such as genomics, proteomics, and metabolomics, it is now possible to gain a deeper understanding of the molecular mechanisms underlying diseases and identify gene variants or biomarkers associated with specific diseases. This information opens up new possibilities for early diagnosis, risk prediction, and targeted treatment in otolaryngological diseases.

With advances in technology, artificial intelligence, and policy support, personalized medicine is expected to play an increasingly important role in otolaryngology and other medical fields, enabling the development of more accurate and efficient treatment options for patients.

Dr. Jerome Rene Lechien
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • otolaryngology
  • oral cancer
  • oncology
  • head and neck surgery
  • minimally invasive
  • laryngology
  • artificial intelligence
  • rhinology
  • ENT
  • personalized

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

Article
Objective Evaluation of Nasal Obstruction in Cleft Lip and Palate Patients: A Preliminary Study
by Nicolas Pachebat, Jiad N. Mcheik, Maxime Fieux, Valentin Favier, Aurélien Binet, Xavier Dufour and Florent Carsuzaa
J. Pers. Med. 2025, 15(9), 403; https://doi.org/10.3390/jpm15090403 (registering DOI) - 1 Sep 2025
Abstract
Introduction: Cleft lip and/or palate (CLP) is frequently associated with persistent nasal obstruction, often due to structural deformities unaddressed by primary surgical repair. While subjective assessment tools are commonly used to evaluate nasal patency, they underestimate functional impairment, particularly nasal valve collapse. [...] Read more.
Introduction: Cleft lip and/or palate (CLP) is frequently associated with persistent nasal obstruction, often due to structural deformities unaddressed by primary surgical repair. While subjective assessment tools are commonly used to evaluate nasal patency, they underestimate functional impairment, particularly nasal valve collapse. This study aims to objectively evaluate nasal obstruction and identify its anatomical causes in CLP patients after primary rhinoplasty. Methods: We conducted an observational study involving 21 children aged 8–16 with CLP who had undergone primary cheilorhinoplasty but not secondary nasal surgery. Each participant underwent clinical evaluation, nasal endoscopy, acoustic rhinometry, and active anterior rhinomanometry (AAR), both before and after nasal decongestion. The Nasal Obstruction Symptom Evaluation (NOSE) scale was used to assess subjective symptoms. Obstructive sites were diagnosed based on established criteria combining endoscopic and functional findings. Results: Objective nasal obstruction was identified in 80.9% of patients, with nasal valve collapse observed in 66.7%, most commonly among unilateral and bilateral CLP subtypes. External nasal valve collapse was the predominant form (57.1%), followed by internal valve involvement (38.1%). Notably, the NOSE score did not reliably correlate with the AAR results, underlining the limitations of subjective assessment tools. Structural anomalies such as septal deviation (52.5%) and turbinate hypertrophy (23.8%) were also prevalent. Conclusions: This study highlights nasal valve collapse as a major, underrecognized contributor to persistent nasal obstruction in CLP patients after primary repair. Objective assessment methods like AAR and targeted endoscopy should be routinely integrated into secondary rhinoplasty planning. These findings advocate for a personalized approach to secondary nasal reconstruction in CLP patients, integrating objective functional data into surgical planning. Such strategies align with personalized medicine principles by tailoring interventions to individual anatomical and physiological characteristics. Full article
(This article belongs to the Special Issue Personalized Medicine in Otolaryngology: New Challenges and Future Perspectives)
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