Pharmacogenetics and Synaptic Plasticity in Neurological Disorders: From Mechanisms to Therapies
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: 15 September 2026 | Viewed by 165
Special Issue Editors
2. Institute of Medical Science and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada
3. Postgrado En Ciencias Cognitivas, Universidad Autonoma Del Estado de Morelos, Cuernavaca, Mexico
Interests: pharmacogenetics; neurodegenerative disorders; neurobiology; synaptic plasticity
Special Issue Information
Dear Colleagues,
This Special Issue aims to provide a comprehensive perspective on how genetic, epigenetic, and synaptic mechanisms converge to shape neurological disorders and therapeutic responses. By combining insights from pharmacogenetics with advances in synaptic plasticity research, we seek to highlight both the molecular determinants of drug response and the circuit-level processes that underlie resilience, vulnerability, and recovery.
Key topics of interest include the following:
- Pharmacokinetic and pharmacodynamic pharmacogenetics in neuropsychiatric and neurodegenerative disorders.
- Mitochondrial and nuclear genetics underlying neuronal bioenergetics and synaptic function.
- Epigenetic mechanisms and gene expression changes induced by pharmacological agents, with implications for synaptic remodeling and long-term therapeutic outcomes.
- Gene–drug interactions in clinical contexts and their impact on circuit adaptability.
- Cellular and molecular mechanisms of synaptic plasticity in health and disease.
- Translational approaches that integrate pharmacogenetic insights with the modulation of synaptic plasticity for innovative therapies.
By integrating these domains, this Special Issue seeks to foster a multidimensional understanding of how genetic and synaptic factors jointly shape therapeutic response. Original research articles, reviews, and translational studies are welcome—particularly those proposing innovative frameworks for precision neurotherapeutics grounded in synaptic plasticity.
Dr. Hector Vargas-Perez
Dr. América Vanoye-Carlo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacogenetics
- precision neurotherapeutics
- mitochondrial bioenergetics
- epigenetic regulation
- gene–drug interactions
- synaptic plasticity
- neuropsychiatric and neurodegenerative disorders
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
