Synaptic Plasticity in Neurological Disorders: From Mechanisms to Therapies

Dear Colleagues,

This Special Issue explores the evolving landscape of pharmacogenetics in neuropsychiatric and neurodegenerative disorders, aiming to bridge molecular insights with personalized therapeutic strategies.
Key topics of interest include

• Pharmacokinetic pharmacogenetics, focusing on genetic variants that influence drug metabolism, transport, and elimination;
• Pharmacodynamic pharmacogenetics, addressing polymorphisms in receptors, ion channels, and intracellular signaling pathways that modulate therapeutic efficacy;
• Mitochondrial and nuclear genetics underlying neuronal bioenergetics, including SNPs and regulatory genes involved in biogenesis, redox balance, and calcium homeostasis;
• Epigenetic mechanisms and gene expression changes induced by pharmacological agents, with implications for synaptic plasticity and long-term therapeutic outcomes; and
• Gene–drug interactions in clinical contexts, emphasizing the use of genetic profiles to optimize treatment strategies for conditions such as depression, schizophrenia, PTSD, and Alzheimer’s disease.

By integrating these domains, this issue seeks to foster a multidimensional understanding of how genetic and epigenetic factors shape therapeutic response while encouraging contributions that bridge molecular biology, clinical pharmacology, and systems neuroscience. Original research articles, reviews, and translational studies are welcome—particularly those proposing innovative frameworks for precision neurotherapeutics.

Dr. Hector Vargas-Perez
Dr. América Vanoye-Carlo
Guest Editors

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