Plastic Surgery: New Perspectives and Innovative Techniques

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Regenerative Medicine and Therapeutics".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 972

Special Issue Editors


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Guest Editor
Department of Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Interests: breast cancer reconstruction; lymphedema surgery; microsurgery; supermicrosurgery; head and neck reconstruction; body contouring surgery

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Guest Editor
Syracuse Plastic Surgery, Surgery Center, 3107 East Genesee Street, Syracuse, NY 13224, USA
Interests: breast cancer reconstruction; lymphedema surgery; microsurgery; gender-affirming procedures
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Special Issue Information

Dear Colleagues,

Background: Plastic surgery, a specialized branch of medicine, focuses on the restoration, reconstruction, or alteration of the human body. It encompasses both reconstructive and aesthetic procedures. The field has evolved significantly, driven by advancements in medical technology and an increasing demand for aesthetic improvements.

History: The roots of plastic surgery can be traced back to ancient civilizations. It spans from the initial reports of surgical techniques for repairing nasal injuries, from as early as 600 BC, to the advent of robotic supermicrosurgery. Certainly, plastic surgery has made remarkable advancements.

Aim and scope: The aim of modern plastic surgery is to improve the quality of life for patients through both reconstructive and aesthetic procedures. This involves restoring function and form to damaged body parts, correcting congenital anomalies, and enhancing physical appearance to boost self-esteem and psychological well-being.

Cutting-edge research: The implementation and advancement of regenerative medicine and stem cell therapy, 3D printing and custom implants, minimally invasive techniques, laser and energy-based therapies, tissue engineering and supermicrosurgery are now particularly relevant for reconstructive surgery, where restoring function and form is crucial.

Types of papers we are soliciting: This Special Issue, "Plastic Surgery: New Perspectives and Innovative Techniques," invites full research articles and comprehensive reviews on plastic surgery that evaluate and report pioneering, ground-breaking surgical techniques and state-of-the-art viewpoints on common plastic surgery challenges, supported by the highest level of evidence possible.

Dr. Joseph M. Escandón
Dr. Oscar Javier Manrique
Guest Editors

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Keywords

  • plastic surgery procedures
  • free tissue flaps
  • gender-affirmation surgery
  • reconstructive procedures
  • lymphedema
  • breast cancer
  • oncologic reconstruction
  • body contouring
  • regenerative medicine
  • stem cell therapy
  • aesthetic surgery

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Published Papers (1 paper)

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16 pages, 1668 KiB  
Systematic Review
Use of COX Inhibitors in Plastic Surgery Fibroproliferative Disorders: A Systematic Review
by Yu Ting Tay, Elisha Purcell, Ishith Seth, Gianluca Marcaccini and Warren M. Rozen
J. Pers. Med. 2025, 15(6), 257; https://doi.org/10.3390/jpm15060257 - 17 Jun 2025
Viewed by 359
Abstract
Background/Objectives: Fibroproliferative disorders (FPDs), such as Dupuytren’s contracture, scleroderma, capsular contracture, rhinophyma, and keloid scars, are characterised by excessive fibroblast activity and collagen deposition. These conditions are frequently encountered in plastic and reconstructive surgery and remain therapeutically challenging. Cyclooxygenase (COX) inhibitors have emerged [...] Read more.
Background/Objectives: Fibroproliferative disorders (FPDs), such as Dupuytren’s contracture, scleroderma, capsular contracture, rhinophyma, and keloid scars, are characterised by excessive fibroblast activity and collagen deposition. These conditions are frequently encountered in plastic and reconstructive surgery and remain therapeutically challenging. Cyclooxygenase (COX) inhibitors have emerged as a potential adjunct therapy to modulate fibrotic pathways and improve clinical outcomes. This systematic review aims to evaluate the efficacy and safety profile of COX inhibitors in the management of plastic-surgery-related FPDs. In doing so, it explores how phenotype-guided and route-specific COX-inhibitor use may contribute to precision, patient-centred care. Methods: To identify eligible studies, a comprehensive search was conducted in MEDLINE, Embase, and the Cochrane Library. Data were synthesised using both tabular summaries and narrative analysis. The certainty of evidence was appraised according to the GRADE guidelines. Results: Thirteen studies from 1984 to 2024 met inclusion criteria, addressing FPDs such as hypertrophic scarring, Dupuytren’s contracture, and desmoid tumours, representing 491 patients. Of those, five studies were related to Dupuytren contracture, three studies were related to hypertrophic scar, and one study each was on topics related to scleroderma, keloid scar, osteogenesis imperfecta, actinic keloidalis nuchae/dissecting cellulitis of the scalp, and desmoid tumours. Nine studies reported clinical improvements (four demonstrating statistically significant outcomes), three showed no difference, and one did not assess outcomes. The thirteen studies show minor side effects from oral and topical COX inhibitors. The overall certainty of evidence was graded as “low.” Conclusions: COX inhibitors demonstrate promising efficacy with minimal adverse effects in the management of plastic-surgery-related FPDs. Their accessibility, safety, and potential to reduce fibrosis underscore the need for future high-quality, large-scale studies to establish definitive clinical recommendations. Full article
(This article belongs to the Special Issue Plastic Surgery: New Perspectives and Innovative Techniques)
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