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Plastic Surgery: New Perspectives and Innovative Techniques
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Plastic Surgery: New Perspectives and Innovative Techniques

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Regenerative Medicine and Therapeutics".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 2088

Special Issue Editors

Dr. Joseph M. Escandón

E-Mail Website
Guest Editor
Department of Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Interests: breast cancer reconstruction; lymphedema surgery; microsurgery; supermicrosurgery; head and neck reconstruction; body contouring surgery
Dr. Oscar Javier Manrique

E-Mail Website
Guest Editor
Syracuse Plastic Surgery, Surgery Center, 3107 East Genesee Street, Syracuse, NY 13224, USA
Interests: breast cancer reconstruction; lymphedema surgery; microsurgery; gender-affirming procedures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background:
Plastic surgery, a specialized branch of medicine, focuses on the restoration, reconstruction, or alteration of the human body. It encompasses both reconstructive and esthetic procedures. The field has evolved significantly, driven by advancements in medical technology and an increasing demand for esthetic improvements. With the application and development of personalized medicine, accuracy, efficacy, and patient satisfaction in plastic surgery have significantly improved.

Aim and Scope:
This Special Issue aims to highlight advances in plastic surgery that enable the delivery of personalized, effective, and safe surgical treatment plans, ultimately improving patients' quality of life. This includes restoring function and form to damaged body parts, correcting congenital anomalies, and enhancing physical appearance to boost self-esteem and psychological well-being.

Cutting-Edge Research:
The implementation and advancement of regenerative medicine and stem cell therapy, craniofacial surgery, 3D printing and custom implants, minimally invasive techniques, laser and energy-based therapies, pediatric plastic surgery, body contouring, esthetic facial plastic surgery, tissue engineering, microsurgery, and supermicrosurgery are now particularly relevant to reconstructive surgery, where restoring both function and form is essential.

Types of Papers We Are Soliciting:
This Special Issue invites full research articles and comprehensive reviews on plastic surgery that evaluate and report pioneering, ground-breaking surgical techniques and State-of-the-Art perspectives on common challenges in the field, supported by the highest level of evidence possible. Manuscripts on breast surgery (esthetic, alloplastic reconstruction, or autologous reconstruction), cosmetic surgery, experimental medicine/surgery, hand surgery, pediatric plastic surgery, craniofacial surgery, and reconstructive surgery are welcome for submission to contribute to the evolving field of precision medicine in plastic surgery and reconstruction.

Dr. Joseph M. Escandón
Dr. Oscar Javier Manrique
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plastic surgery procedures
  • free tissue flaps
  • gender-affirmation surgery
  • reconstructive procedures
  • lymphedema
  • breast cancer
  • oncologic reconstruction
  • body contouring
  • regenerative medicine
  • stem cell therapy
  • aesthetic surgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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10 pages, 217 KB  
Article
Systemic Effects of Enzymatic Necrosectomy in Minor Burn Wounds Using NexoBrid®
by David Breidung, Moritz Billner, Felix Ortner, Philipp von Imhoff, Simonas Lapinskas, Konrad Karcz, Sarina Delavari and Denis Ehrl
J. Pers. Med. 2025, 15(8), 330; https://doi.org/10.3390/jpm15080330 - 25 Jul 2025
Viewed by 383
Abstract
Background/Objectives: Enzymatic debridement with NexoBrid® is an effective alternative to surgical debridement in burn care, but its potential systemic effects remain unclear. In the context of personalized burn care, understanding individual patient responses to topical agents is essential to optimize outcomes and [...] Read more.
Background/Objectives: Enzymatic debridement with NexoBrid® is an effective alternative to surgical debridement in burn care, but its potential systemic effects remain unclear. In the context of personalized burn care, understanding individual patient responses to topical agents is essential to optimize outcomes and minimize risks. This study aimed to characterize laboratory and clinical parameter changes following NexoBrid® application in patients with small burn injuries (≤10% TBSA). Methods: We retrospectively analyzed 75 burn patients treated with NexoBrid® to evaluate changes in systemic inflammatory markers, coagulation parameters, and clinical parameters before and after enzymatic debridement. Results: Statistically significant increases in body temperature (p = 0.018), decreases in hemoglobin (p < 0.001), and increases in C-reactive protein (CRP) levels (p < 0.001) were observed, suggesting mild systemic inflammatory changes. However, leukocyte counts did not change significantly (p = 0.927), and body temperature remained within the normothermic range, indicating that these changes were not clinically significant. A significant decrease in the prothrombin time ratio (% of normal; p = 0.002) was also observed, suggesting potential impacts on coagulation. Importantly, while body temperature was slightly higher in patients with a higher degree of BSA exposure within the ≤10% TBSA cohort (p = 0.036), the extent of NexoBrid® application did not correlate with other inflammatory markers. Conclusions: These findings suggest that measurable systemic changes can occur following NexoBrid® application in small burns, particularly affecting inflammatory and coagulation parameters. These observations contribute to the understanding of treatment-related responses and may help inform clinical decision-making. Full article
(This article belongs to the Special Issue Plastic Surgery: New Perspectives and Innovative Techniques)

Other

Jump to: Research

21 pages, 3076 KB  
Systematic Review
Poly-4-Hydroxybutyrate as a Novel Biomaterial in Personalized Breast Surgery: A Systematic Review and Meta-Analysis
by Joseph M. Escandón, Ajani Nugent, Nolan S. Karp, Krishna Vyas, Carter J. Boyd, Lucas Kreutz-Rodrigues and Oscar J. Manrique
J. Pers. Med. 2025, 15(8), 368; https://doi.org/10.3390/jpm15080368 - 12 Aug 2025
Viewed by 445
Abstract
Background/Objectives: In the search for optimal meshes and matrices in breast surgery, poly-4-hydroxybutyrate (P4HB) has emerged as a promising alternative. This review evaluates the clinical application of P4HB scaffolds, focusing on complication rates and surgical outcomes. Methods: A systematic search was [...] Read more.
Background/Objectives: In the search for optimal meshes and matrices in breast surgery, poly-4-hydroxybutyrate (P4HB) has emerged as a promising alternative. This review evaluates the clinical application of P4HB scaffolds, focusing on complication rates and surgical outcomes. Methods: A systematic search was conducted using PubMed and ScienceDirect. Clinical studies assessing perioperative outcomes and complications associated with P4HB scaffolds in breast surgery were included. Results were stratified into aesthetic and reconstructive surgery categories. Meta-analysis was implemented to assess the rate of complications and satisfaction. Results: This systematic review included 13 studies evaluating the use of P4HB scaffold in breast reconstruction (636 cases) and aesthetic breast surgery (462 patients). Breast reconstruction studies were all retrospective, mainly reporting two-stage, prepectoral, immediate reconstructions. Aesthetic studies included both prospective and retrospective designs, with varied implant planes and incision patterns. P4HB use was associated with high satisfaction (95.5%) and favorable outcomes, including lower odds of wound complications (log-OR = −1.135, p = 0.003). Complication rates were low across both surgical categories. P4HB scaffold showed promise in supporting implant-based procedures and maintaining breast shape over time, with minimal increase in surgical time and stable anthropometric measurements. Conclusions: The use of P4HB scaffold in breast reconstruction and aesthetic surgery shows promising results, notably in reducing wound-related complications. Breast reconstruction studies report low complication rates and favorable patient-reported outcomes. In aesthetic procedures, P4HB contributes to improved long-term breast shape and high satisfaction. Despite encouraging findings, further research is necessary to validate long-term efficacy and refine surgical approaches. Full article
(This article belongs to the Special Issue Plastic Surgery: New Perspectives and Innovative Techniques)
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16 pages, 1668 KB  
Systematic Review
Use of COX Inhibitors in Plastic Surgery Fibroproliferative Disorders: A Systematic Review
by Yu Ting Tay, Elisha Purcell, Ishith Seth, Gianluca Marcaccini and Warren M. Rozen
J. Pers. Med. 2025, 15(6), 257; https://doi.org/10.3390/jpm15060257 - 17 Jun 2025
Viewed by 523
Abstract
Background/Objectives: Fibroproliferative disorders (FPDs), such as Dupuytren’s contracture, scleroderma, capsular contracture, rhinophyma, and keloid scars, are characterised by excessive fibroblast activity and collagen deposition. These conditions are frequently encountered in plastic and reconstructive surgery and remain therapeutically challenging. Cyclooxygenase (COX) inhibitors have emerged [...] Read more.
Background/Objectives: Fibroproliferative disorders (FPDs), such as Dupuytren’s contracture, scleroderma, capsular contracture, rhinophyma, and keloid scars, are characterised by excessive fibroblast activity and collagen deposition. These conditions are frequently encountered in plastic and reconstructive surgery and remain therapeutically challenging. Cyclooxygenase (COX) inhibitors have emerged as a potential adjunct therapy to modulate fibrotic pathways and improve clinical outcomes. This systematic review aims to evaluate the efficacy and safety profile of COX inhibitors in the management of plastic-surgery-related FPDs. In doing so, it explores how phenotype-guided and route-specific COX-inhibitor use may contribute to precision, patient-centred care. Methods: To identify eligible studies, a comprehensive search was conducted in MEDLINE, Embase, and the Cochrane Library. Data were synthesised using both tabular summaries and narrative analysis. The certainty of evidence was appraised according to the GRADE guidelines. Results: Thirteen studies from 1984 to 2024 met inclusion criteria, addressing FPDs such as hypertrophic scarring, Dupuytren’s contracture, and desmoid tumours, representing 491 patients. Of those, five studies were related to Dupuytren contracture, three studies were related to hypertrophic scar, and one study each was on topics related to scleroderma, keloid scar, osteogenesis imperfecta, actinic keloidalis nuchae/dissecting cellulitis of the scalp, and desmoid tumours. Nine studies reported clinical improvements (four demonstrating statistically significant outcomes), three showed no difference, and one did not assess outcomes. The thirteen studies show minor side effects from oral and topical COX inhibitors. The overall certainty of evidence was graded as “low.” Conclusions: COX inhibitors demonstrate promising efficacy with minimal adverse effects in the management of plastic-surgery-related FPDs. Their accessibility, safety, and potential to reduce fibrosis underscore the need for future high-quality, large-scale studies to establish definitive clinical recommendations. Full article
(This article belongs to the Special Issue Plastic Surgery: New Perspectives and Innovative Techniques)
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