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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health
edited by and Anne-Marie Iselin
submission deadline 31 Dec 2025 | Viewed by 27 | Submission Open
Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms
(This special issue belongs to the Section Mental Health)
Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment
edited by
submission deadline 31 Dec 2025 | Viewed by 24 | Submission Open
Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy
(This special issue belongs to the Section Oncology)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Paradigms, Advances and Future Directions in Oral Medicine
edited by
submission deadline 31 Dec 2025 | Viewed by 21 | Submission Open
Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Progress in the Multimodal Treatment of Pancreatic Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 18 | Submission Open
Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment
edited by
submission deadline 5 Jan 2026 | Viewed by 70 | Submission Open
Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition
edited by
submission deadline 9 Jan 2026 | Viewed by 26 | Submission Open
Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention
edited by Anbukarasi Maran and Kevin Croce
submission deadline 9 Jan 2026 | Viewed by 20 | Submission Open
Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology  
(This special issue belongs to the Section Cardiovascular Medicine)
From Acute Injury to Personalized Prevention—Developing Modern Strategies submission deadline 10 Jan 2026 | Viewed by 72 | Submission Open
Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention
(This special issue belongs to the Section Orthopedics)
Advances in Vascular and Endovascular Surgery: Second Edition
edited by and Afshin Assadian
submission deadline 11 Jan 2026 | Viewed by 3 | Submission Open
Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms
(This special issue belongs to the Section Vascular Medicine)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by
submission deadline 15 Jan 2026 | Viewed by 22 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 15 Jan 2026 | Viewed by 5 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Up-to-Date Research in Liver Transplantation
edited by
submission deadline 15 Jan 2026 | Viewed by 3 | Submission Open
Keywords: liver transplantation; acute or chronic liver diseases; hepatitis C virus infection; hepatocellular carcinoma (HCC); cirrhosis; intrahepatic (ICCA); perihilar (PCCA) cholangiocarcinoma; unresectable liver metastases; acute or chronic liver failure (ACLF); acute alcoholic hepatitis (AAH)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Innovations in Plastic and Reconstructive Research
edited by Damiano Tambasco and Roberta Albanese
submission deadline 18 Jan 2026 | 2 articles | Viewed by 1056 | Submission Open
Keywords: microvascular surgery; 3D printing; regenerative medicine; aesthetic surgery; minimally invasive techniques
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
POTS, ME/CFS and Long COVID: Recent Advances and Future Direction
edited by Svetlana Blitshteyn
submission deadline 20 Jan 2026 | Viewed by 220 | Submission Open
Keywords: POTS; ME/CFS; long COVID; dysautonomia; orthostatic intolerance; autoimmunity
(This special issue belongs to the Section Immunology)
Current Practice and Future Perspectives on Laryngeal Surgery submission deadline 20 Jan 2026 | Viewed by 18 | Submission Open
Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery
(This special issue belongs to the Section Otolaryngology)
Clinical Advances in Prenatal Diagnosis and Fetal Therapy
edited by
submission deadline 20 Jan 2026 | Viewed by 5 | Submission Open
Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiopulmonary Resuscitation in the Emergency Care Unit
edited by , Felipe Fernández-Méndez, and
submission deadline 20 Jan 2026 | Viewed by 5 | Submission Open
Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit
(This special issue belongs to the Section Emergency Medicine)
Insights and Innovations in Sports Cardiology submission deadline 20 Jan 2026 | Viewed by 4 | Submission Open
Keywords: sports cardiology; athlete heart; cardiovascular screening; arrhythmias; sudden cardiac death; cardiac rehabilitation; exercise prescription; mobile health; preventive cardiology; personalized medicine; pediatric fitness
(This special issue belongs to the Section Sports Medicine)
New Insights in Trauma and Emergency Surgery
edited by Kai Oliver Jensen and Valentin Neuhaus
submission deadline 20 Jan 2026 | Viewed by 3 | Submission Open
Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma
(This special issue belongs to the Section Emergency Medicine)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 25 Jan 2026 | Viewed by 11 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Inflammatory Bowel Disease: Pathogenesis and Management Strategies
edited by
submission deadline 28 Jan 2026 | Viewed by 26 | Submission Open
Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment submission deadline 28 Jan 2026 | Viewed by 17 | Submission Open
Keywords: Clostridioides difficile infection; infection control; contact isolation; community-acquired CDI; CDI recurrence; recurrence prevention; rCDI; host and microbiota interaction; antimicrobial treat-ment; microbiota transplant; underdiagnosis
(This special issue belongs to the Section Infectious Diseases)
The Optimal Hybrid Revascularization Approach for Multilevel Peripheral Arterial Disease
edited by
submission deadline 30 Jan 2026 | Viewed by 19 | Submission Open
Keywords: peripheral arterial disease; revascularization; endovascular procedure; endarterectomy; limb salvage; patency; hybrid procedures; lower extremity; stents; angioplasty
(This special issue belongs to the Section Vascular Medicine)
Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations
edited by
submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open
Keywords: neuroendovascular surgery; neuroimaging; neurosurgery; neuroendoscopic surgery
(This special issue belongs to the Section Clinical Neurology)
Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management
edited by István Szokodi and
submission deadline 31 Jan 2026 | Viewed by 28 | Submission Open
Keywords: cardiac resynchronization therapy; heart failure; pacing strategies; patient selection; multi-point pacing; clinical innovations; nonresponders
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 31 Jan 2026 | Viewed by 5 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Hysterectomy Surgery—Recent Developments and Emerging Trends
edited by , and Dimitrios Zacharakis
submission deadline 28 Feb 2026 | Viewed by 11 | Submission Open
Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care
(This special issue belongs to the Section Obstetrics & Gynecology)
Progress in Clinical Diagnosis and Therapy in Ophthalmology
edited by
submission deadline 16 Mar 2026 | Viewed by 21 | Submission Open
Keywords: ophthalmic imaging; artificial intelligence in ophthalmology; retinal diseases; corneal transplantation; glaucoma diagnostics; ocular therapeutics; personalized medicine; ocular genetics
(This special issue belongs to the Section Ophthalmology)
Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition
edited by and
submission deadline 31 Mar 2026 | Viewed by 11 | Submission Open
Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms
(This special issue belongs to the Section Cardiology)
Selected Papers from the 3rd International Online Conference on Clinical Medicine submission deadline 28 Apr 2026 | Viewed by 19 | Submission Open
Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology
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