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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Research on Pulmonary Hypertension and Its Complications

edited by Gabor G. Kovacs and

Anna Birnhuber

submission deadline 20 Apr 2026 | Viewed by 33 | Submission Open

Keywords: pulmonary hypertension; PH; pulmonary arterial pressure; different diagnostic; therapeutic challenges

(This special issue belongs to the Section Respiratory Medicine)

Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly

edited by

Oded Hershkovich

and

Raphael Lotan

submission deadline 20 Apr 2026 | Viewed by 31 | Submission Open

Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty

(This special issue belongs to the Section Orthopedics)

Innovations in Surgical and Medical Approaches of Urologic Oncology

edited by

Sung Han Kim

submission deadline 20 Apr 2026 | Viewed by 29 | Submission Open

Keywords: urologic oncology; robotic surgery; immunotherapy; targeted therapy; image-guided techniques; personalized medicine; minimally invasive surgery; focal therapy

(This special issue belongs to the Section Nephrology & Urology)

Spinal Cord Injury in Elderly People: Prevention of Complications

edited by Vaidyanathan Subramanian

submission deadline 20 Apr 2026 | Viewed by 27 | Submission Open

Keywords: spinal cord injury; demography; morbidities; complications; spinal injuries; patients; family members; caregivers; general practitioners; discharge; elderly

(This special issue belongs to the Section Geriatric Medicine)

New Challenges and Perspectives in Surgical Treatment of Spinal Deformity

edited by Jung-Hee Lee

submission deadline 20 Apr 2026 | Viewed by 27 | Submission Open

Keywords: adult spinal deformity; decompensation; kyphosis; lateral lumbar interbody fusion; orthopedic surgery; osteotomy; proximal junctional kyphosis; rod fracture

(This special issue belongs to the Section Orthopedics)

Aiming for Early Detection and Prevention of Pulmonary Diseases

edited by

Nektarios Anagnostopoulos

and

Kostas A. Papavassiliou

submission deadline 20 Apr 2026 | Viewed by 22 | Submission Open

Keywords: early diagnosis; prevention strategies; respiratory diseases; artificial intelligence; asthma; chronic obstructive pulmonary disease (COPD); interstitial lung disease; sleep-disordered breathing

(This special issue belongs to the Section Respiratory Medicine)

Novel Advances in Lower Limb Trauma and Orthopaedic Surgery

edited by Konstantinos Tsikopoulos and

Panagiotis Givissis

submission deadline 20 Apr 2026 | Viewed by 20 | Submission Open

Keywords: lower limb orthopedic surgery; trauma; infection; research

(This special issue belongs to the Section Orthopedics)

Controversies in Hidradenitis Suppurativa: Bridging Gaps in Science and Practice

edited by Hadar Lev-Tov and Tammy González

submission deadline 21 Apr 2026 | Viewed by 58 | Submission Open

Keywords: hidradenitis suppurativa (HS); inflammatory skin disorder; controversies; treatment strategies; science and practice

(This special issue belongs to the Section Dermatology)

Clinical Management of Knee Arthroplasty

edited by

Sang-Hoon Park

submission deadline 21 Apr 2026 | Viewed by 44 | Submission Open

Keywords: knee surgery; knee arthroplasty; knee joint replacement; osteoarthritis; knee arthritis

(This special issue belongs to the Section Orthopedics)

Advances in Spine Surgery: Current Innovations and Future Directions

edited by

Gonzalo Mariscal

and Jesús Burgos

submission deadline 24 Apr 2026 | Viewed by 59 | Submission Open

Keywords: spine; clinical studies; robotics; minimally invasive; complications; patient-reported outcomes; reviews

(This special issue belongs to the Section Orthopedics)

Novel Diagnostic and Therapeutic Approaches to Urologic Oncology

edited by

Cosmin-Victor Ene

, Bogdan Florin Geavlete and

Cristian I. Surcel

submission deadline 25 Apr 2026 | Viewed by 194 | Submission Open

Keywords: diagnosis; therapy; up-to-date; uro-oncologic pathology

(This special issue belongs to the Section Oncology)

New Advances in Cleft Lip and Palate and Facial Plastic Surgery

edited by

Michael Schwaiger

, Wolfgang Zemann and Rainer Lutz

submission deadline 25 Apr 2026 | Viewed by 89 | Submission Open

Keywords: cleft lip repair; rhinoplasty; secondary rhinoplasty; cleft rhinoplasty; facial plastic surgery; nasolabial area; upper lid surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Liver Failure: Current Status and Future Opportunities

edited by

Stephen Riordan

submission deadline 25 Apr 2026 | Viewed by 79 | Submission Open

Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Pulmonary Embolism and Thrombosis: 2nd Edition

edited by

Andrea Boccatonda

and Elena Campello

submission deadline 25 Apr 2026 | Viewed by 76 | Submission Open

Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein thrombosis; venous thromboembolism

(This special issue belongs to the Section Respiratory Medicine)

Diagnosis, Treatment and Prognosis of Coronary Heart Disease: 2nd Edition

edited by

Simona Giubilato

submission deadline 25 Apr 2026 | Viewed by 59 | Submission Open

Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)

(This special issue belongs to the Section Cardiology)

General Surgical Oncology: Evolving Paradigms and Contemporary Challenges

edited by

Federica Ferracci

and

Antonio Sommariva

submission deadline 25 Apr 2026 | Viewed by 57 | Submission Open

Keywords: surgical oncology; minimally invasive surgery; robotic surgery; multidisciplinary cancer care; artificial intelligence in surgery; perioperative management; precision oncology; complex tumor resection; integrated surgical therapies; oncologic surgery innovation

(This special issue belongs to the Section Oncology)

Sarcoma—Clinical Updates: 2nd Edition

edited by

Julia Visgauss

submission deadline 25 Apr 2026 | Viewed by 55 | Submission Open

Keywords: sarcoma; osteosarcoma; ewing’ s sarcoma; chondrosarcoma; soft-tissue sarcoma; undifferentiated pleo-morphic sarcoma; liposarcoma; leiomyosarcoma; rhabdomyosarcoma; metastatic sarcoma; targeted molecular therapy; immunotherapy; orthopedic oncology

(This special issue belongs to the Section Oncology)

New Clinical Advances in Orthopedic Oncology

edited by

Julia Visgauss

submission deadline 25 Apr 2026 | Viewed by 55 | Submission Open

Keywords: orthopedic oncology; sarcoma; soft-tissue sarcoma; osteosarcoma; chondrosarcoma; Ewings sarcoma; giant cell tumor; limb salvage; mega-prosthetic reconstruction; targeted molecular therapy; immunotherapy

(This special issue belongs to the Section Orthopedics)

Personalized Therapy and Clinical Outcome for Retinal Diseases

edited by

Takeshi Iwase

submission deadline 25 Apr 2026 | Viewed by 45 | Submission Open

Keywords: retinal diseases; retinal imaging; clinical outcomes; artificial intelligence; biomarkers; optical coherence tomography (OCT); vitrectomy

(This special issue belongs to the Section Ophthalmology)

Emerging Surgical Techniques in the Management of Urological Diseases

edited by

Riccardo Lombardo

submission deadline 25 Apr 2026 | Viewed by 40 | Submission Open

Keywords: minimally invasive; robotics; partial nephrectomy; radical prostatectomy; focal therapy; benign prostatic hyperplasia; prostate cancer; bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Advances in Reconstructive and Aesthetic Plastic Surgery

edited by

Rafael Loucas

submission deadline 25 Apr 2026 | Viewed by 37 | Submission Open

Keywords: reconstructive plastic surgery; aesthetic innovation; fat grafting; microsurgery; regenerative medicine; cell-enriched lipotransfer; 3D imaging; minimally invasive techniques; hybrid injectables

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Complex Scenarios in Reverse Shoulder Arthroplasty: Bone Loss, Revisions, and Surgical Solutions

edited by Francesco Franceschi, Angelo Baldari and Antonio Caldaria

submission deadline 25 Apr 2026 | Viewed by 33 | Submission Open

Keywords: shoulder arthroplasty; revision shoulder arthroplasty; humeral fracture; failed shoulder prosthesis; bone loss management; implant failure

(This special issue belongs to the Section Orthopedics)

Sex- and Age-Related Differences in Exercise Response: Clinical Implications for Health and Disease

edited by

Rafael A. Casuso

submission deadline 26 Apr 2026 | Viewed by 71 | Submission Open

Keywords: exercise intervention; clinical exercise physiology; sex differences; age-related response; metabolic disorders; personalized medicine; physical activity; chronic disease management

(This special issue belongs to the Section Sports Medicine)

Selected Papers from the 3rd International Online Conference on Clinical Medicine

edited by

Kent Doi

and

Francisco Guillen-Grima

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology

Sequelae of COVID-19: Clinical to Prognostic Follow-Up

edited by

Mariana Tudoran

and

Cristina Tudoran

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2798 | Submission Open

Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19

(This special issue belongs to the Section Vascular Medicine)

New Advances in the Management of Voice Disorders: 2nd Edition

edited by

Ben Barsties v. Latoszek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures

(This special issue belongs to the Section Otolaryngology)

New Clinical Advances in Depressive Disorders and Treatment-Resistant Depression

edited by Giacomo d'Andrea and Miriam Olivola

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: treatment-resistant depression; MDD; ketamine; esketamine; rTMS; psylocibin; bipolar depression; clinical pheno-typing; precision psychiatry; biomarkers

(This special issue belongs to the Section Mental Health)

New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition

edited by

Diego Orsini

and Alessandra Narcisi

submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open

Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics

(This special issue belongs to the Section Dermatology)

Orthopedic Approaches to Acute Trauma: Insights and Strategies in Trauma Care

edited by

Gianfilippo Caggiari

submission deadline 30 Apr 2026 | Viewed by 69 | Submission Open

Keywords: acute trauma; orthopedic surgery; fractures and dislocations; ligament injuries; cartilage lesions; post-traumatic degeneration; emergency trauma care; surgical and non-surgical management; rehabilitation strategies; musculo-skeletal injury outcomes

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Craniofacial Reconstructive Surgery

edited by Rami S. Kantar

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: craniofacial; craniofacial conditions; craniofacial surgery; cleft; cleft lip; cleft palate; reconstructive surgery; craniofacial anomalies

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Advances in Cardiovascular Computed Tomography (CT)

edited by

David C. Rotzinger

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: computed tomography angiography; cardiovascular imaging; contrast media; spectral computed tomography; quantitative imaging; coronary artery disease; aortic disease; pulmonary embolism; structural heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates and New Perspectives of Chronic Pain

edited by

Yohannes Woldeamanuel

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: circadian rhythms; chronic pain; clock genes; neuroinflammation; chronotherapy; migraine; cancer survivors; sex differences; racial disparities; personalized medicine

(This special issue belongs to the Section Clinical Neurology)

Head and Neck Cancer: Clinical Diagnostics and Treatments

edited by Matti Anniko

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: head and neck cancer; treatment; surgery; chemotherapy; immunotherapy; diagnostics

(This special issue belongs to the Section Otolaryngology)

Antithrombotic Therapy in Special and Overlooked Populations with Cardiovascular Diseases

edited by

Leonardo De Luca

submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open

Keywords: antithrombotic therapy; high-risk patients; PCI; bleeding risk; atrial fibrillation; individualized treatment; real-world evidence; complex cardiovascular disease

(This special issue belongs to the Section Cardiovascular Medicine)

Surgical Insights into Foot and Ankle Diseases

edited by Konstantinos Tsikopoulos

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: lower limb surgery; infection research; foot and ankle

(This special issue belongs to the Section Orthopedics)

Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation

edited by

Meredith Holcomb

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life

(This special issue belongs to the Section Otolaryngology)

The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases

edited by

Aneta Aleksova

submission deadline 1 May 2026 | 1 articles | Viewed by 1026 | Submission Open

Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function

(This special issue belongs to the Section Cardiology)

Advances in Chronic Pain and Related Management

edited by

Sabine Sator

submission deadline 10 May 2026 | Viewed by 53 | Submission Open

Keywords: chronic pain; musculoskeletal pain; neuropathic pain; fibromyalgia syndrome; somatoform disorder; post-COVID syndrome; small fiber disease; invasive pain therapy; vagus stimulation

(This special issue belongs to the Section Anesthesiology)

Quality of Life in Patients with Gynecological Cancers

edited by

Katarzyna Plagens-Rotman

Piotr Merks

and Monika Englert-Golon

submission deadline 10 May 2026 | Viewed by 51 | Submission Open

Keywords: quality of life; gynecology oncology; ovarian cancer; breast cancer; cervical cancer; endometrial cancer; women; gynecological diseases; oncological diseases

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenging ICU Dogma: Where Routine Practice and Evidence Collide

edited by

Yujiro Matsuishi

and Nobutake Shimojo

submission deadline 10 May 2026 | Viewed by 22 | Submission Open

Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making

(This special issue belongs to the Section Intensive Care)

Prevention and Management of Sexual Dysfunction

edited by Grażyna Jarząbek-Bielecka and Katarzyna Plagens-Rotman

submission deadline 10 May 2026 | Viewed by 22 | Submission Open

Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Innovations, Biomarkers, and Challenges in Cancer Immunotherapy

edited by

Mohammad Mousaei Ghasroldasht

and Mahzad Akbarpour

submission deadline 10 May 2026 | Viewed by 12 | Submission Open

Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms

(This special issue belongs to the Section Oncology)

Advances in the Management of Chronic Lymphocytic Leukemia

edited by

Alberto Fresa

and

Luca Laurenti

submission deadline 12 May 2026 | Viewed by 19 | Submission Open

Keywords: chronic lymphocytic leukemia; lymphoproliferative disorders; prognostic factors; targeted therapy; CAR T cell; elderly patients; comorbidities

(This special issue belongs to the Section Hematology)

Thyroid Disorders: New Clinical Diagnosis and Management

edited by

Ioannis P. Iakovou

Rodis D. Paparodis

and

Nicholaos G. Angelopoulos

submission deadline 15 May 2026 | Viewed by 771 | Submission Open

Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging

(This special issue belongs to the Section Endocrinology & Metabolism)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 May 2026 | Viewed by 65 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 May 2026 | Viewed by 52 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Damage Control Surgery: New Insights into Resuscitation, Operative Strategies and Complications

edited by

Bruno de La Villéon

submission deadline 15 May 2026 | Viewed by 45 | Submission Open

Keywords: damage control surgery; damage control resuscitation; polytrauma management; massive transfusion protocol; hemorrhagic shock; trauma laparotomy; staged laparotomy; temporary abdominal closure; multidisciplinary trauma care

(This special issue belongs to the Section General Surgery)

Clinical Updates on Maternal Fetal Medicine: 2nd Edition

edited by

Roberta Granese

and

Gabriele Tonni

submission deadline 15 May 2026 | Viewed by 41 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD)

edited by

Alessandro Pallucchini

submission deadline 15 May 2026 | Viewed by 36 | Submission Open

Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone

(This special issue belongs to the Section Mental Health)

Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management

edited by

Fausto Zamparini

Carlo Prati

and

Andrea Spinelli

submission deadline 15 May 2026 | Viewed by 28 | Submission Open

Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Displaying special issue 1301-1350 on page 27 of 29.

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