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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances and Prospects in Gynecologic Oncology Surgery submission deadline 25 Nov 2026 | Viewed by 131 | Submission Open
Keywords: gynecologic oncology; ERAS pathways; ERAS protocols; sentinel lymph node; laparoscopy; robotic surgery; molecular profiling; multidisciplinary team
(This special issue belongs to the Section Obstetrics & Gynecology)
Cerebral Palsy: Considerations for Clinical Practice
edited by Joav Merrick and
submission deadline 25 Nov 2026 | Viewed by 125 | Submission Open
Keywords: cerebral palsy; seizures; spasticity; feeding management; bowel and bladder incontinence
(This special issue belongs to the Section Clinical Neurology)
Otitis Media and Other Ear Disorders: Diagnosis and Management
edited by
submission deadline 25 Nov 2026 | Viewed by 124 | Submission Open
Keywords: otitis media; chronic otitis media; otitis media with effusion; cholesteatoma; tympanoplasty and mastoidectomy; hearing loss; tympanic membrane perforation; ear infection diagnosis; pediatric otology; conductive hearing loss
(This special issue belongs to the Section Otolaryngology)
Advances in Immunotherapy for Tumors: From Biomarkers to Novel Therapeutics and Exosome-Mediated Modulation submission deadline 25 Nov 2026 | Viewed by 119 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; exosomes; extracellular vesicles; tumor microenvironment; predictive biomarkers; liquid biopsy; immuno-oncology; precision medicine
(This special issue belongs to the Section Oncology)
Kidney Transplantation and Rehabilitation: Current Updates and Future Perspectives
edited by Zoltán Sándor
submission deadline 25 Nov 2026 | Viewed by 107 | Submission Open
Keywords: chronic kidney disease; kidney transplantation; transplant rehabilitation; transplant care; physical therapy; intervention; recovery; quality of life
(This special issue belongs to the Section Nephrology & Urology)
Microsurgery: Current and Future Challenges, 2nd Edition submission deadline 25 Nov 2026 | Viewed by 99 | Submission Open
Keywords: microsurgery; reconstruction; reconstructive surgery; breast reconstruction; extremity reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Bleeding Disorders and Hemophilia: Clinical Advances and Treatment submission deadline 25 Nov 2026 | Viewed by 94 | Submission Open
Keywords: hematology; hemophilia A and B; von willebrand disease (VWD); thrombocytopenia; thrombocytopathy; platelet function disorders; rare bleeding disorders (RBDs); coagulation factors; gene therapy; inhibitors; prophylaxis; clinical management; patient-reported outcomes
(This special issue belongs to the Section Hematology)
Beyond the Bench: Insights into Infectious Disease Epidemiology and Public Health
edited by Antonella Arghittu
submission deadline 25 Nov 2026 | Viewed by 92 | Submission Open
Keywords: antimicrobial resistance; infection prevention and control; one health; environmental monitoring; antimicrobial stewardship; surveillance; risk management; health communication; vaccine hesitancy
(This special issue belongs to the Section Epidemiology & Public Health)
Advances in Sports-Related Orthopedic Injury and Surgery
edited by Paolo Schiavi and Francesco Pogliacomi
submission deadline 25 Nov 2026 | Viewed by 81 | Submission Open
Keywords: sports medicine; sport injury; sport surgery; sport trauma; performance; athletes; rapid recovery
(This special issue belongs to the Section Sports Medicine)
Clinical Management and Revascularization of Coronary Artery Disease
edited by Simone Calcagno
submission deadline 25 Nov 2026 | Viewed by 76 | Submission Open
Keywords: coronary calcified lesion; IVUS; OCT; intravascular lithotripsy; bifurcation coronary lesions; chronic total occlusions; multivessel disease; STEMI; NSTEMI; coronary artery disease
(This special issue belongs to the Section Cardiovascular Medicine)
Colon and Rectal Surgery: Recent Advances and Future Trends
edited by Paraskevi Chatzikomnitsa and Alexandros E. Giakoustidis
submission deadline 26 Nov 2026 | Viewed by 186 | Submission Open
Keywords: colorectal surgery; minimally invasive surgery; robotic surgery; artificial intelligence in surgery; surgical innovation
(This special issue belongs to the Section General Surgery)
Novel Biomarkers and Treatment Strategies for Gastrointestinal Malignancies: From the Bench to the Bedside submission deadline 26 Nov 2026 | Viewed by 143 | Submission Open
Keywords: gastrointestinal (GI) malignancies; medical oncology; immunotherapy; biomarkers; target therapies
(This special issue belongs to the Section Oncology)
Life-Threatening Conditions in Pediatric Patients: Clinical Challenges and Emergency Management Strategies
edited by , Piotr Konrad Leszczyński, Alina Minarowska and
submission deadline 27 Nov 2026 | Viewed by 672 | Submission Open
Keywords: child; pediatrics; pediatric emergencies; injuries; illnesses; clinical intervention; emergency treatment; acute care; life-threatening condition; therapeutic outcome
(This special issue belongs to the Section Emergency Medicine)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Nov 2026 | 4 articles | Viewed by 13335 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Current Challenges and Updates in Therapeutic Advancements of Prostatectomy submission deadline 30 Nov 2026 | 2 articles | Viewed by 1029 | Submission Open
Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes
(This special issue belongs to the Section Nephrology & Urology)
New Insights into Sports Injuries and Rehabilitation: From Injury to Performance
edited by , Matteo Guzzini and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 514 | Submission Open
Keywords: sports medicine; sports injuries; orthopedic rehabilitation; upper limb injuries; tendon and ligament injuries; return to sport; injury prevention; regenerative therapies
(This special issue belongs to the Section Sports Medicine)
Recent Advances in Clinical Therapeutic Methods of Kidney Stone submission deadline 30 Nov 2026 | Viewed by 453 | Submission Open
Keywords: retrograde intrarenal surgery; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques
(This special issue belongs to the Section Nephrology & Urology)
From Imaging to Impact: Improving Breast Cancer Diagnosis and Outcomes
edited by Dana Samir Al-Mousa and Kelly Bentley-Spuur
submission deadline 30 Nov 2026 | Viewed by 269 | Submission Open
Keywords: breast cancer diagnosis; breast imaging; breast cancer screening; screening mammography; diagnostic breast imag-ing; breast density assessment; early detection of breast cancer; breast imaging innovation; diagnostic accuracy in breast imaging; artificial intelligence in breast imaging; radiation dose optimisation in breast imaging; image quality in breast imaging; clinical implementation of breast imaging technologies; patient outcomes in breast cancer care; health system efficiency in breast imaging
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Cruciate Ligament Injuries in Sport Medicines: Diagnosis, Treatment and Rehabilitation
edited by
submission deadline 30 Nov 2026 | Viewed by 230 | Submission Open
Keywords: cruciate ligament; sport medicine; trauma; meniscus; knee instability; anterior cruciate ligament reconstruction; posterior cruciate ligament; rehabilitation; return to sport; injury prevention
(This special issue belongs to the Section Sports Medicine)
Interventional Treatment of Coronary Artery Disease: Clinical Insights and Current Practice
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 147 | Submission Open
Keywords: percutaneous coronary intervention (PCI); coronary artery disease (CAD); complex coronary intervention; physiology-guided revascularization (FFR/iFR); post-PCI Integrated non-pharmacological therapies; intravascular imaging (IVUS/OCT); severe coronary calcification; personalized antiplatelet therapy; spontaneous coronary artery dissection; high bleeding risk; drug-coated balloons; artificial intelligence in interventional cardiology
(This special issue belongs to the Section Cardiology)
The Use of Artificial Intelligence in Cancer Research, Diagnosis, and Care
edited by
submission deadline 30 Nov 2026 | Viewed by 130 | Submission Open
Keywords: artificial intelligence; oncology; cancer diagnosis; prognostic modeling; clinical validation; digital twins
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Targeted Management and Diagnosis of Rheumatoid Arthritis submission deadline 30 Nov 2026 | Viewed by 99 | Submission Open
Keywords: rheumatoid arthritis; difficult-to-treat rheumatoid arthritis; erosive arthritis; JAK inhibitors; biological drugs; window-of-opportunity
(This special issue belongs to the Section Immunology & Rheumatology)
Placental Dysfunction and Cardiovascular Maternal Risk-Timing Assessment and Postpartum Challenges
edited by , Anca Huniadi and
submission deadline 8 Dec 2026 | Viewed by 163 | Submission Open
Keywords: cardiovascular risk; pre-eclampsia; fetal growth restriction; placental dysfunction; cardiac function; biomarkers
(This special issue belongs to the Section Obstetrics & Gynecology)
The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases
edited by
submission deadline 10 Dec 2026 | 3 articles | Viewed by 11073 | Submission Open
Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function
(This special issue belongs to the Section Cardiology)
Prevention and Management of Sexual Dysfunction
edited by and Katarzyna Plagens-Rotman
submission deadline 10 Dec 2026 | 2 articles | Viewed by 1865 | Submission Open
Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Translational Immunology in Clinical Medicine: From Preclinical Insights to Therapeutic Impact
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1777 | Submission Open
Keywords: translational immunology; autoimmune disease; autoinflammatory disease; immune-mediated diseases; oncology; preclinical models; immune efficacy and safety; mechanism of action; immunotoxicity assessment
(This special issue belongs to the Section Immunology & Rheumatology)
Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1021 | Submission Open
Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions
(This special issue belongs to the Section Respiratory Medicine)
The Current Trend in the Management of Bruxism and Temporomandibular Disorders, 2nd Edition submission deadline 10 Dec 2026 | Viewed by 334 | Submission Open
Keywords: bruxism; temporomandibular disorders (TMDs); dental health; treatment modalities; diagnosis; clinical interventions
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Cosmetic Dermatology: From Health to Aesthetics and Restoring Confidence
edited by
submission deadline 10 Dec 2026 | Viewed by 123 | Submission Open
Keywords: aesthetic dermatology; cosmetic dermatology; energy-based devices; dermal fillers; botulinum toxin; biostimulators; skin rejuvenation; regenerative medicine; scar treatment; hair disorders; pigmentary disorders
(This special issue belongs to the Section Dermatology)
Obstructive Sleep Apnea: Advances and Challenges in Diagnosis, Phenotyping, and Clinical Impact
edited by , Muna Irfan and Andrew Namen
submission deadline 10 Dec 2026 | Viewed by 111 | Submission Open
Keywords: obstructive sleep apnea; sleep diagnostics; screening tools; pulse oximetry; polysomnography; home sleep apnea testing; diagnostic accuracy; phenotyping; cardiometabolic comorbidity; neuropsychiatric outcomes; sleep -disordered breathing; real-world implementation
(This special issue belongs to the Section Respiratory Medicine)
Optimizing Management of Advanced Ovarian Cancer: From Cytoreduction to Targeted Treatment
edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis
submission deadline 10 Dec 2026 | Viewed by 104 | Submission Open
Keywords: ovarian cancer; cytoreduction; HIPEC; targeted therapies; post-operative complications
(This special issue belongs to the Section Obstetrics & Gynecology)
Contemporary Advances in Esophageal and Upper Gastrointestinal Surgery
edited by and Carlo Castoro
submission deadline 10 Dec 2026 | Viewed by 102 | Submission Open
Keywords: esophageal surgery; gastric surgery; upper gastrointestinal cancer; minimally invasive surgery; robotic surgery; artificial intelligence; radiomics; neoadjuvant therapy; surgical quality assessment; fluorescence-guided surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Rehabilitation and Management of Chronic Musculoskeletal Pain Conditions
edited by
submission deadline 10 Dec 2026 | Viewed by 63 | Submission Open
Keywords: reproducibility of results; rehabilitation; physical therapy; artificial intelligence; machine learning; musculoskeletal system; treatment outcome
(This special issue belongs to the Section Clinical Rehabilitation)
Hospital-Acquired Infections: Epidemiology, Prevention, Treatment, and Organizational and Clinical Challenges
edited by and Jarosław Drobnik
submission deadline 10 Dec 2026 | Viewed by 58 | Submission Open
Keywords: hospital-acquired infections; healthcare-associated infections; nosocomial infections; epidemiology; infection prevention and control; antimicrobial resistance; antimicrobial stewardship; patient safety
(This special issue belongs to the Section Epidemiology & Public Health)
Updates in Gynecologic Surgery
edited by and Giulio Sozzi
submission deadline 13 Dec 2026 | Viewed by 105 | Submission Open
Keywords: gynecologic surgery; minimally invasive surgery (MIS); robotic-assisted surgery; vNOTES; endometriosis; pelvic organ prolapses
(This special issue belongs to the Section Obstetrics & Gynecology)
Diagnosis and Treatment Strategies for Endometriosis: Evidence and Practice
edited by and Carlo Alviggi
submission deadline 14 Dec 2026 | Viewed by 70 | Submission Open
Keywords: endometriosis; ultrasound; fertility preservation; ovarian stimulation; cryopreservation
(This special issue belongs to the Section Obstetrics & Gynecology)
Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management submission deadline 15 Dec 2026 | 2 articles | Viewed by 1943 | Submission Open
Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Outcomes and Emerging Strategies in Neovascualr Age-Related Macular Degeneration submission deadline 15 Dec 2026 | Viewed by 297 | Submission Open
Keywords: neovascular age-related macular degeneration; exudative retinal disease; anti-VEGF therapy; tyrosine kinase inhibitors; angiopoietin/Tie-2 modulation; gene therapy; sustained-release platforms; complement pathway inhibition; real-world clinical outcomes
(This special issue belongs to the Section Ophthalmology)
Integrating Mental Health Into Chronic Illness Care: Interdisciplinary Clinical Strategies
edited by Emanuele Maria Merlo
submission deadline 15 Dec 2026 | Viewed by 110 | Submission Open
Keywords: clinical psychology; psychosomatic medicine; assessment; chronic illness; mental health; patient-centred care
(This special issue belongs to the Section Mental Health)
Advances in Monitoring and Optimization of Non-Invasive Respiratory Support in Acute and Chronic Respiratory Failure
edited by and Teresa Renda
submission deadline 15 Dec 2026 | Viewed by 106 | Submission Open
Keywords: acute and chronic respiratory failure; acute hypoxemic respiratory failure (AHRF); acute respiratory distress syndrome (ARDS); respiratory monitoring; respiratory drive; inspiratory effort; non-invasive ventilation (NIV); high-flow nasal cannula (HFNC); home ventilation; telemonitoring
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Cardiac Arrhythmias and Electrophysiology
edited by Giovanni Volpato and
submission deadline 15 Dec 2026 | Viewed by 96 | Submission Open
Keywords: atrial fibrillation; conduction system pacing; ablation; ventricular tachycardia; electroanatomical mapping; endomyocardial biopsy
(This special issue belongs to the Section Cardiology)
Surgical Treatment for Lung Cancer—2nd Edition
edited by , Cezary Piwkowski and Marek Ochman
submission deadline 15 Dec 2026 | Viewed by 96 | Submission Open
Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; enhanced recovery after surgery; segmentectomy
(This special issue belongs to the Section Respiratory Medicine)
Self-Injurious Thoughts and Behaviors: Risk, Mechanisms, and Clinical Intervention
edited by
submission deadline 15 Dec 2026 | Viewed by 95 | Submission Open
Keywords: self-injurious thoughts and behaviors; suicide; suicidal ideation; suicide attempts; non-suicidal self-injury; NSSI; self-harm; emotion dysregulation; trauma; risk factors; resilience; prevention; clinical intervention; adolescents; young adults
(This special issue belongs to the Section Mental Health)
Beyond Survival: Precision, Innovation, and Lifelong Care in Congenital Heart Disease
edited by
submission deadline 15 Dec 2026 | Viewed by 90 | Submission Open
Keywords: congenital heart disease; adult congenital heart disease; lifespan care; precision medicine; advanced cardiac imaging; transcatheter interventions; neurodevelopmental outcomes; arrhythmia management; digital health and artificial intelligence
(This special issue belongs to the Section Cardiology)
Inherited Cardiac Disorders in Pediatrics: Present Challenges and Future Innovations
edited by Sara Moscatelli, and
submission deadline 15 Dec 2026 | Viewed by 83 | Submission Open
Keywords: paediatric cardiomyopathy; inherited cardiac diseases; cardiomyopathies; cardiovascular genetics; arthropathies; channelopathies
(This special issue belongs to the Section Cardiology)
Coronary CT Angiography, Cardiac MRI and PET/CT Scan: Advancing Cardiac Imaging and Clinical Decision Making in Cardiomyopathies submission deadline 15 Dec 2026 | Viewed by 83 | Submission Open
Keywords: coronary CT angiography; cardiac magnetic resonance imaging; cardiac positron emission tomography; cardiac imaging; cardiomyopathies; cardiac amyloidosis; cardiac sarcoidosis; hypertrophic cardiomyopathy; dilated cardiomyopathy; non-dilated left ventricular cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; restrictive cardiomyopathy; risk stratification; clinical decision making; artificial intelligence; radiomics
(This special issue belongs to the Section Cardiology)
Clinical Advances in Rhinitis and Sinusitis: Diagnosis, Therapy and Multimorbidity Management
edited by , and Veronica Seccia
submission deadline 18 Dec 2026 | Viewed by 108 | Submission Open
Keywords: allergy; asthma; biologics; chronic rhinosinusitis; chronic rhinosinusitis with nasal polyps; endoscopic sinus surgery; NSAID-ERD; olfaction; personalized treatment; precision medicine; quality of life; respiratory disease; rhinitis; sinusitis; type-2 inflammation
(This special issue belongs to the Section Otolaryngology)
Spine Surgery: Current Practice and Future Directions
edited by Claudio Bernucci and Francesco Costa
submission deadline 20 Dec 2026 | 3 articles | Viewed by 7608 | Submission Open
Keywords: degenerative; spinal trauma; spine tumors; neurosurgery; spine surgery; spinal deformity; scoliosis; robotics surgery; spinal cord injury; clinical practices; regenerative therapies
(This special issue belongs to the Section Clinical Neurology)
Physiotherapy in Clinical Practice: From Assessment to Rehabilitation submission deadline 20 Dec 2026 | 4 articles | Viewed by 3382 | Submission Open
Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 Dec 2026 | 4 articles | Viewed by 3381 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
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