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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hypertrophic Cardiomyopathy: Lights and Shadows of Structural Pharmacological Treatment
edited by Daniel Dalos
submission deadline 15 May 2026 | Viewed by 26 | Submission Open
Keywords: hypertrophic cardiomyopathy; treatment; myosin inhibition; ventricular arrhythmia; atrial fibrillation
(This special issue belongs to the Section Cardiology)
Head and Neck Cancer: Clinical Diagnosis and Treatment
edited by Enrique Sanz-Garcia, Nicole Chau and Neus Baste
submission deadline 15 May 2026 | Viewed by 6 | Submission Open
Keywords: head and neck; multidisciplinary approaches; biomarkers; early detection; therapies
(This special issue belongs to the Section Otolaryngology)
Novel Insights into the Prevention and Treatment of Contact Dermatitis
edited by , Christoph Skudlik, Swen Malte John and
submission deadline 20 May 2026 | 1 articles | Viewed by 3276 | Submission Open
Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment
(This special issue belongs to the Section Dermatology)
Clinical Updates of Physical Therapy in Rehabilitation
edited by
submission deadline 20 May 2026 | Viewed by 87 | Submission Open
Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Management and Long-Term Prognosis in Intensive Care submission deadline 20 May 2026 | Viewed by 79 | Submission Open
Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation
(This special issue belongs to the Section Intensive Care)
Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 67 | Submission Open
Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates in Transfusion Medicine and Patient Blood Management submission deadline 20 May 2026 | Viewed by 62 | Submission Open
Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine
(This special issue belongs to the Section Hematology)
Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective
edited by and
submission deadline 20 May 2026 | Viewed by 57 | Submission Open
Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics
(This special issue belongs to the Section Sports Medicine)
Spine Surgery: Current Challenges and Opportunities
edited by Kambiz Sarahrudi
submission deadline 20 May 2026 | Viewed by 47 | Submission Open
Keywords: vertebral fracture; spine trauma; spinal cord injury; adjacent segment degeneration; infection; spondylodiscitis; verte-bral metastasis; osteoporotic fracture; fracture of sacrum; disk degeneration; degenerative spine surgery; minimally invasive spine surgery
(This special issue belongs to the Section Orthopedics)
Cardiomyopathies: A Contemporary Review of Advances and Clinical Strategies
edited by Carla Contaldi
submission deadline 20 May 2026 | Viewed by 46 | Submission Open
Keywords: cardiomyopathies; heart failure; genetic mutations; molecular mechanisms; advanced cardiac imaging; cardiac MRI; precision medicine; risk stratification
(This special issue belongs to the Section Cardiology)
Current Challenges in Oral and Maxillofacial Surgery
edited by and Lucia Memé
submission deadline 20 May 2026 | Viewed by 43 | Submission Open
Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Demyelinating and Neuroinflammatory Disorders submission deadline 20 May 2026 | Viewed by 42 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica spectrum disorder; MOG antibody– associated disease; neuroinflammation; biomarkers; advanced imaging; disease-modifying therapies; clinical outcomes
(This special issue belongs to the Section Clinical Neurology)
Myocardial Infarction: Current Status and Future Challenges—2nd Edition
edited by Isaac Pascual and
submission deadline 20 May 2026 | Viewed by 38 | Submission Open
Keywords: myocardial infarction; acute coronary syndrome (ACS); ischemic heart disease; coronary artery disease (CAD); percutaneous coronary intervention; pharmacological therapy; cardiovascular risk factors
(This special issue belongs to the Section Cardiology)
Clinical Advances in Hemodialysis: 2nd Edition
edited by Maurizio Bossola
submission deadline 20 May 2026 | Viewed by 37 | Submission Open
Keywords: hemodialysis; interdialytic weight gain; symptom burden and quality of life; impaired cognitive function; fatigue; dietary restrictions; depression; anxiety; frailty; polypharmacy
(This special issue belongs to the Section Nephrology & Urology)
The Application of Mechanical Circulatory Support Within Cardiology Practice
edited by
submission deadline 20 May 2026 | Viewed by 36 | Submission Open
Keywords: mechanical circulatory support (MCS); cardiogenic shock; intra-aortic balloon pumping (IABP); extracorporeal membranous oxygenation (ECMO); Impella; ventricular assist device (VAD)
(This special issue belongs to the Section Cardiology)
Clinical Advances in Ocular Surgeries: Innovations in Cataract, Retinal, and Beyond
edited by and Yu Cheol Kim
submission deadline 20 May 2026 | Viewed by 35 | Submission Open
Keywords: cataract surgery; retinal surgery; intraocular lenses; femtosecond laser; minimally invasive vitrectomy; ocular imaging; surgical innovation; ocular trauma; corneal transplantation; glaucoma surgery
(This special issue belongs to the Section Ophthalmology)
Acute Coronary Syndromes | Circulation Research submission deadline 20 May 2026 | Viewed by 32 | Submission Open
Keywords: acute coronary syndromes; cardiovascular risk; individualized therapy; STEMI; risk factors
(This special issue belongs to the Section Cardiology)
Clinical Challenges in Pancreatitis Management
edited by
submission deadline 20 May 2026 | Viewed by 31 | Submission Open
Keywords: acute pancreatitis; chronic pancreatitis; medical management; surgical management; nutritional support; pancreatic diabetes; clinical research; reviews
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes
edited by Giovanni Colombo and
submission deadline 20 May 2026 | Viewed by 30 | Submission Open
Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life
(This special issue belongs to the Section Otolaryngology)
Presbyopia, Laser, Cataract and Refractive Surgery: State-of-the-Art Research: Second Edition
edited by
submission deadline 20 May 2026 | Viewed by 29 | Submission Open
Keywords: presbyopia; cataract surgery; refractive surgery; femtosecond laser; intraocular lenses; corneal refractive procedures; phakic intraocular lenses; visual outcomes; patient-reported outcomes; surgical innovations
(This special issue belongs to the Section Ophthalmology)
Cutting Edge Research on Total Knee Arthroplasty
edited by
submission deadline 20 May 2026 | Viewed by 28 | Submission Open
Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery
(This special issue belongs to the Section Orthopedics)
Strategies in Complex Hand Trauma: Bridging Orthopedics, Plastic Surgery and Rehabilitation
edited by Clarisa Simón-Pérez and
submission deadline 20 May 2026 | Viewed by 27 | Submission Open
Keywords: complex hand trauma; orthopedics; plastic surgery; microsurgery; rehabilitation; functional reconstruction; multidis-ciplinary management
(This special issue belongs to the Section General Surgery)
Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine submission deadline 20 May 2026 | Viewed by 26 | Submission Open
Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness
(This special issue belongs to the Section Emergency Medicine)
Clinical Progress in Oral and Maxillofacial Surgery
edited by Luis M. Junquera and Giuseppe Consorti
submission deadline 20 May 2026 | Viewed by 25 | Submission Open
Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Neurovascular Interventions: Evolving Techniques and Insights
edited by Delia Cannizzaro
submission deadline 20 May 2026 | Viewed by 25 | Submission Open
Keywords: endovascular treatment; intracranial aneurysms; AI in neurointerventional surgery; intracranial vascular malformation; new endovascular device
(This special issue belongs to the Section Clinical Neurology)
Diagnosis and Treatment of Connective Tissue Diseases: A Clinician's Perspective: 2nd Edition
edited by , and Aleksandra Dańczak-Pazdrowska
submission deadline 20 May 2026 | Viewed by 25 | Submission Open
Keywords: connective tissue diseases; lupus erythematosus; scleroderma; dermatomyositis; MCTD; clinical picture; spectrum of clinical symptoms; treatment; complications; clinical follow-up
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 May 2026 | Viewed by 25 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Aspects of Return to Sport After Injuries: 2nd Edition
edited by and
submission deadline 20 May 2026 | Viewed by 23 | Submission Open
Keywords: musculoskeletal system; tissue overload; diagnostic methods; rehabilitation; treatment; injury prevention; return to sport; rehabilitation medicine; sports medicine
(This special issue belongs to the Section Sports Medicine)
Current Understanding and Management of Asthma and Chronic Obstructive Pulmonary Disease
edited by Josuel Ora
submission deadline 20 May 2026 | Viewed by 22 | Submission Open
Keywords: asthma; chronic obstructive pulmonary disease (COPD); personalized medicine; exacerbations; biomarkers; inhalation therapy; digital health; artificial intelligence; pulmonary rehabilitation; comorbidities
(This special issue belongs to the Section Respiratory Medicine)
Anesthesia in Head and Neck Surgery
edited by and Antonino Maniaci
submission deadline 20 May 2026 | Viewed by 22 | Submission Open
Keywords: airway management; hemodynamic stability; perioperative monitoring; head and neck surgery; anesthesia
(This special issue belongs to the Section Anesthesiology)
Total Joint Arthroplasty: Innovations, Outcomes, and Challenges—Second Edition
edited by Hendrik Kohlhof
submission deadline 20 May 2026 | Viewed by 22 | Submission Open
Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management
(This special issue belongs to the Section Orthopedics)
Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications
edited by Dilhana S. Badurdeen
submission deadline 20 May 2026 | Viewed by 21 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; Roux-en-Y Gastric Bypass (RYGB); sleeve gastrectomy; revisional bariatric surgery; complications; outcomes; weight loss maintenance; metabolic syndrome; type 2 diabetes remission; nutritional deficiencies; gastrointestinal adaptation; quality of life; long-term follow-up
(This special issue belongs to the Section General Surgery)
Clinical Updates on Perioperative Pain Management: 3rd Edition submission deadline 20 May 2026 | Viewed by 21 | Submission Open
Keywords: anesthesia and intensive care; pain management; spinal anesthesia; postoperative pain; breast surgery; fascial plane blocks; abdominal surgery; cardiac surgery; thoracotomy; knee surgery; orthopedic surgery; hip surgery; ultrasound
(This special issue belongs to the Section Anesthesiology)
Surgical Management of Complex Spinal Pathologies: Challenges and Innovations
edited by
submission deadline 20 May 2026 | Viewed by 21 | Submission Open
Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Clinical Trends and Prospects in Urology Surgery: 2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 20 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Clinical Challenges in Uterus Transplant Management
edited by Giuliano Testa
submission deadline 20 May 2026 | Viewed by 18 | Submission Open
Keywords: uterus transplant; absolute uterine infertility; fertility treatment; immunosuppression in uterus transplant; pregnancy complications; uterine donor evaluation
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 16 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Valvular Heart Disease: Current Knowledge and Therapeutic Prospects
edited by Simona Mega
submission deadline 20 May 2026 | Viewed by 16 | Submission Open
Keywords: valvular heart disease; echocardiographic assessment; cardiovascular imaging; valvular regurgitation; valvular stenosis; structural heart intervention; minimally invasive cardiac surgery; catheter-based interventions
(This special issue belongs to the Section Cardiology)
Advances in Diagnosis and Management of Scoliosis
edited by
submission deadline 20 May 2026 | Viewed by 15 | Submission Open
Keywords: scoliosis; spinal deformities; therapeutic strategies; personalized care; quality of life
(This special issue belongs to the Section Orthopedics)
Diagnosis, Monitoring, and Treatment of Myocardial Infarction: 2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 14 | Submission Open
Keywords: myocardial infarction; diagnosis; monitoring; treatment; acute MI
(This special issue belongs to the Section Cardiovascular Medicine)
Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges—2nd Edition
edited by Konstantinos Toutouzas and
submission deadline 20 May 2026 | Viewed by 14 | Submission Open
Keywords: TAVI; aortic stenosis; valve-in-valve; structural heart disease; TAVI-in-TAVI
(This special issue belongs to the Section Cardiology)
Alcohol-Associated Liver Disease: Diagnosis and Treatment of Acute and Chronic Conditions
edited by Halina Cichoz-Lach and Beata Kasztelan-Szczerbińska
submission deadline 20 May 2026 | Viewed by 13 | Submission Open
Keywords: alcohol-associated liver disease; alcohol-associated hepatitis; alcohol-associated liver cirrhosis; excessive alcohol intake; oxidative liver damage; gut– liver axis; organ-to-organ crosstalk
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Spine Surgery and Rehabilitation: Technical Nuances and Outcomes
edited by Sehan Park and Dong-Ho Lee
submission deadline 20 May 2026 | Viewed by 13 | Submission Open
Keywords: spine surgery; rehabilitation; postoperative outcomes; surgical techniques; patient centered perspective
(This special issue belongs to the Section Orthopedics)
Prevention, Treatment, and Prognosis of Cerebral Aneurysms
edited by Murai Yasuo
submission deadline 20 May 2026 | Viewed by 10 | Submission Open
Keywords: cerebral aneurysm; subarachnoid hemorrhage; clipping; interventional surgery; mortarity; long-term; surgical com-plication; bypass
(This special issue belongs to the Section Clinical Neurology)
Contemporary Advances in Joint Arthroplasty: Optimizing Outcomes and Expanding Indications submission deadline 20 May 2026 | Viewed by 8 | Submission Open
Keywords: joint arthroplasty; total joint replacement; revision arthroplasty; robotic-assisted surgery; periprosthetic joint infection (PJI); enhanced recovery after surgery (ERAS); machine learning; artifical intelligence
(This special issue belongs to the Section Orthopedics)
Neurological Surgery: Clinical Advances and AI-Driven Innovations
edited by Ali A. Alattar
submission deadline 20 May 2026 | Viewed by 7 | Submission Open
Keywords: neurosurgery; artificial intelligence; machine learning; deep learning; radiomics; image segmentation; surgical video analytics; navigation and robotics; predictive modeling; clinical decision support
(This special issue belongs to the Section Clinical Neurology)
Bladder Cancer: Diagnosis, Treatment and Future Opportunities submission deadline 20 May 2026 | Viewed by 6 | Submission Open
Keywords: urology; bladder cancer; urothelial cancer; non-muscle invasive bladder cancer; muscle invasive bladder cancer
(This special issue belongs to the Section Nephrology & Urology)
Advances in Maxillofacial Surgery—Historical and Future Perspectives and Controversies submission deadline 25 May 2026 | Viewed by 102 | Submission Open
Keywords: oral oncology; facial skeleton; oral cavity; surgical approaches; head and neck; parotid tumors; jaw cysts and tumors; bone healing; patient-specific solutions; surgery planning; artificial intelligence; soft tissues; cancers and tumors of the oral cavity; microsurgery perspectives; open surgery; endoscopic surgery; trauma surgery; facial traumatology; bone and soft tissues healing after trauma; jaw deformities; orthognathic surgery today and tomorrow
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in the Clinical Management of Diabetic Retinopathy
edited by
submission deadline 25 May 2026 | Viewed by 44 | Submission Open
Keywords: retinal imaging; clinical outcomes; optical coherence tomography (OCT); vitrectomy; blood flow
(This special issue belongs to the Section Ophthalmology)
Clinical Advances and Challenges in Vascular and Endovascular Medicine: 2nd Edition
edited by
submission deadline 25 May 2026 | Viewed by 34 | Submission Open
Keywords: vascular and endovascular medicine; minimally invasive cardiovascular surgery; vascular diseases; endovascular technologies
(This special issue belongs to the Section Vascular Medicine)
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