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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Age-Related Macular Degeneration: Challenges and Opportunities

edited by Deepayan Kar

submission deadline 20 Feb 2026 | Viewed by 27 | Submission Open

Keywords: age-related macular degeneration; imaging biomarkers; visual function testing; optical coherence tomography; anti-VEGF; complement; artificial intelligence

(This special issue belongs to the Section Ophthalmology)

Advances in the Diagnosis and Management of Atherosclerosis

edited by

Adrian Covic

and

Cristian Stătescu

submission deadline 20 Feb 2026 | Viewed by 27 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; coronary artery disease; endothelial function; acute coronary syndromes

(This special issue belongs to the Section Cardiology)

Minimally Invasive Surgery for Gastrointestinal Disorder

edited by

Amosy Ephreim M'Koma

submission deadline 20 Feb 2026 | Viewed by 27 | Submission Open

Keywords: minimally invasive surgery; gastrointestinal disorder; laparoscopy; robotic surgery; colorectal surgery; gastric surgery; endoscopic technique; oncological outcomes; surgical innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Gynecologic Surgery

edited by Adam Ostrzenski

submission deadline 20 Feb 2026 | Viewed by 25 | Submission Open

Keywords: gynecologic surgery; pelvic reconstruction surgery; female stress urinary incontinence surgery; cosmetic gynecology surgery; surgical meshes slings; native tissue

(This special issue belongs to the Section Obstetrics & Gynecology)

Current Challenges and Innovations in Emergency Medicine: From Prehospital Care to Critical Decision-Making in the Emergency Department

edited by Efstratios Karagiannidis, Barbara P. Fyntanidou and Aikaterini Apostolopoulou

submission deadline 20 Feb 2026 | Viewed by 25 | Submission Open

Keywords: emergency medicine; prehospital care; triage strategies; acute care; point-of-care diagnostics; artificial intelligence; telemedicine; emergency department; patient flow; healthcare systems; burnout in emergency care

(This special issue belongs to the Section Emergency Medicine)

Advances in Posttraumatic Stress Disorder (PTSD): Clinical Update

edited by An-Fu Hsiao and

Michael Hollifield

submission deadline 20 Feb 2026 | Viewed by 24 | Submission Open

Keywords: PTSD; stellate ganglion block; transcranial magnetic stimulations; neurobiology; trauma disorders; mind– body medicine; psychophysiology

(This special issue belongs to the Section Mental Health)

Maxillofacial Surgery in the Modern Era: Surgical Advances and Clinical Innovation

edited by

Jeremie Oliver Piña

submission deadline 20 Feb 2026 | Viewed by 23 | Submission Open

Keywords: maxillofacial surgery; oral surgery; craniofacial surgery; plastic surgery; bone

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Insights in Cognitive Aging and Mild Cognitive Impairment

edited by

Irene Fernández

and

Laura Galiana

submission deadline 20 Feb 2026 | Viewed by 23 | Submission Open

Keywords: cognitive aging; mild cognitive impairment; normative aging; neuropsychological assessment; diagnosis; gerontology; prevention; intervention; multidisciplinary approach; measurement

(This special issue belongs to the Section Geriatric Medicine)

Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care

edited by

Peter Radermacher

and Thomas Kapapa

submission deadline 20 Feb 2026 | Viewed by 23 | Submission Open

Keywords: intracranial hypertension; cerebral perfusion pressure; decompressive craniectomy; brain tissue oxygenation; brain tissue microdialysis; blood brain barrier; neuro-critical care

(This special issue belongs to the Section Brain Injury)

Recent Advances and Future Perspectives on Spinal Surgeries

edited by

Sung-kyu Kim

submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open

Keywords: minimally invasive spine procedures; robotic-assisted spine surgery; image-guided navigation; spinal implants and biomaterials; artificial intelligence in spinal care; regenerative spine therapies; clinical outcomes in spine surgery; future trends in spinal interventions

(This special issue belongs to the Section Orthopedics)

Hypercholesterolemia: Update on Treatment Approaches and Outcomes

edited by

Massimiliano Ruscica

and Lucia Barbieri

submission deadline 20 Feb 2026 | Viewed by 20 | Submission Open

Keywords: hypercholesterolemia; dyslipidemia; atherosclerosis; cardiovascular risk; LDL; HDL; lipoprotein(a)

(This special issue belongs to the Section Cardiovascular Medicine)

Treatment and Long-Term Outcome of Fracture

edited by Corrado Ciatti,

Edoardo Bori

and Fabrizio Quattrini

submission deadline 20 Feb 2026 | Viewed by 20 | Submission Open

Keywords: traumatology; osteosynthesis; plating; nailing; osteosynthesis devices; surgical technique; approach

(This special issue belongs to the Section Orthopedics)

Novel Developments in Digestive Endoscopy

edited by

Arnaldo Amato

submission deadline 20 Feb 2026 | Viewed by 20 | Submission Open

Keywords: endoscopy for IBD; AI in endoscopy; therapeutic endoscopy; EUS; interventional EUS; AI in digestive endoscopy; quality in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Bleeding and Thrombotic Complications in Patients with Premalignant Hematologic Conditions: Diagnostic and Therapeutic Challenges

edited by Vasiliki Gkalea and Despina Fotiou

submission deadline 20 Feb 2026 | Viewed by 20 | Submission Open

Keywords: bleeding; thrombosis; hematologic malignancies; premalignant hematologic conditions; clonal hematopoiesis of indeterminate potential (CHIP); clonal cytopenias of undetermined significance (CCUS); monoclonal gammopathy of undetermined significance (MGUS); monoclonal B-cell lymphocytosis (MBL); monoclonal gammopathy of thrombotic significance (MGTS); VITT-like MGTS

(This special issue belongs to the Section Hematology)

Endoscopic Imaging for the Diagnosis and Treatment of Gastrointestinal Diseases

edited by Mariana Jinga and

Daniel Vasile Balaban

submission deadline 20 Feb 2026 | Viewed by 19 | Submission Open

Keywords: endoscopy; endoscopic ultrasound; endoscopic retrograde cholangiopancreatography; artificial intelligence; diagnosis; therapy; decision making; endobiopsy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Research in Pediatric Dentistry: 2nd Edition

edited by Christian Hirsch and

Katrin Bekes

submission deadline 20 Feb 2026 | Viewed by 18 | Submission Open

Keywords: early childhood caries; primary teeth; caries prevention; caries treatment; behavioral management; molar incisor hypomineralization; dental trauma; sedation; oral health-related quality of life

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights into Orthodontic Treatment

edited by Federico Brugnami and Simonetta Meuli

submission deadline 20 Feb 2026 | Viewed by 17 | Submission Open

Keywords: digital orthodontics; clear aligners; artificial intelligence; digital superimpositions; cone beam computed tomography; growing patients; periodontal patients; maxillofacial surgery; long-term stability; prediction of orthodontic movements

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition

edited by

Pablo Demelo-Rodríguez

submission deadline 20 Feb 2026 | Viewed by 16 | Submission Open

Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis

(This special issue belongs to the Section Hematology)

Endocrine Disorders in Children: 2nd Edition

edited by

Juan Pedro López-Siguero

submission deadline 20 Feb 2026 | Viewed by 16 | Submission Open

Keywords: endocrinology; pediatrics; hormones; genetics; growth; nutrition; development ; adolescence ; prevention

(This special issue belongs to the Section Clinical Pediatrics)

Metastatic Colorectal Cancer Beyond Second-Line Treatment

edited by Jacopo Giuliani

submission deadline 20 Feb 2026 | Viewed by 15 | Submission Open

Keywords: metastatic colorectal cancer; subsequent lines; chemotherapy; targeted agents; radiotherapy; local therapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders

edited by

Clara Martinez-Perez

submission deadline 20 Feb 2026 | Viewed by 14 | Submission Open

Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science

(This special issue belongs to the Section Ophthalmology)

Rising Star: Advanced Physical Therapy and Expansion

edited by

Hyolyun Roh

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach

(This special issue belongs to the Section Clinical Rehabilitation)

Rheumatoid Arthritis: Insights into Appropriate Diagnosis, Treatment and Management

edited by

Satoshi Takanashi

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: rheumatoid arthritis; precision medicine; difficult-to-treat rheumatoid arthritis; late-onset rheumatoid arthritis; ageing society; comorbidities

(This special issue belongs to the Section Immunology)

Clinical Insights and Emerging Strategies in Chronic Pain Management

edited by

Cheol Lee

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care

(This special issue belongs to the Section Anesthesiology)

Clinical Advances in Meningioma Surgery

edited by

Makoto Nakamura

submission deadline 20 Feb 2026 | Viewed by 12 | Submission Open

Keywords: meningioma; cranial neurosurgery; brain tumors; skull base surgery; endoscopic neurosurgery; intraoperative techniques; surgical outcomes; minimally invasive neurosurgery; perioperative management; clinical meningioma research

(This special issue belongs to the Section Clinical Neurology)

Advances and Updates in Migraine

edited by

Hartmut Göbel

and Carl H. Göbel

submission deadline 20 Feb 2026 | Viewed by 11 | Submission Open

Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research

(This special issue belongs to the Section Clinical Neurology)

Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies

edited by

Nicola Maurea

and

Alfredo Mauriello

submission deadline 20 Feb 2026 | Viewed by 11 | Submission Open

Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT

(This special issue belongs to the Section Cardiology)

Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain

edited by

Maciej Rachwał

and

Joanna Baran

submission deadline 20 Feb 2026 | Viewed by 11 | Submission Open

Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain

(This special issue belongs to the Section Orthopedics)

Innovations and Challenges in the Burden and Rehabilitation of Musculoskeletal Disorders

edited by

Carla Sílvia Fernandes

Marta Campos Ferreira

and

Oscar F. Goncalves

submission deadline 20 Feb 2026 | Viewed by 10 | Submission Open

Keywords: musculoskeletal diseases; rehabilitation; physical therapy modalities; telemedicine; mobile applications; health information technology; patient-centered care; quality of life; health care innovation

(This special issue belongs to the Section Clinical Rehabilitation)

Diagnosis and Treatment of Cardiovascular Diseases in the Elderly

edited by

Carmelo Massimiliano Rao

submission deadline 20 Feb 2026 | Viewed by 9 | Submission Open

Keywords: cardiovascular diseases; elderly population; diagnosis and management; age-related pathophysiology; frailty and cognitive impairment

(This special issue belongs to the Section Geriatric Medicine)

Breast Cancer: Symptoms, Types, Causes & Treatment

edited by Min-Jeong Cho and Sara Myers

submission deadline 20 Feb 2026 | Viewed by 8 | Submission Open

Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies

(This special issue belongs to the Section Obstetrics & Gynecology)

Innovative Approaches to the Challenges of Neurodegenerative Disease

edited by Brian T. Bicknell

submission deadline 20 Feb 2026 | Viewed by 8 | Submission Open

Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation

edited by Adriano Pellicelli

submission deadline 20 Feb 2026 | Viewed by 7 | Submission Open

Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Diagnosis and Treatment of Gastrointestinal Malignancies

edited by

Carmelo Laface

and Gianmauro Numico

submission deadline 20 Feb 2026 | Viewed by 7 | Submission Open

Keywords: gastrointestinal cancers; immunotherapy; targeted therapy; chemotherapy; microsatellite instability; driver mutations

(This special issue belongs to the Section Oncology)

Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research

edited by

Philippe R. Koninckx

, Arnaud Wattiez and

Sun-Wei Guo

submission deadline 20 Feb 2026 | Viewed by 7 | Submission Open

Keywords: endometriosis; guidelines; surgery; medical treatment; training; heuristics

(This special issue belongs to the Section Clinical Guidelines)

Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation

edited by

Emmanouil Liodakis

submission deadline 20 Feb 2026 | Viewed by 7 | Submission Open

Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation

(This special issue belongs to the Section Orthopedics)

Advances in the Personalized Management of Chronic Obstructive Pulmonary Disease (COPD)

edited by

Athena Gogali

and Georgios Hillas

submission deadline 20 Feb 2026 | Viewed by 5 | Submission Open

Keywords: artificial intelligence; biologics; biomarkers; diagnostics; oscillometry; COPD pharmacotherapy; imaging

(This special issue belongs to the Section Respiratory Medicine)

New Insights into Management of Chronic Rhinosinusitis

edited by

Giandomenico Maggiore

submission deadline 20 Feb 2026 | Viewed by 5 | Submission Open

Keywords: chronic rhinosinusitis; management; surgery; minimally invasive surgery; surgical oncology; cancer surgery; skull base surgery; hoarseness; laryngeal neoplasms; laryngoscopy; general surgery; X-ray computed tomography

(This special issue belongs to the Section Otolaryngology)

Clinical Research Progress in Diabetes and Cardiovascular Diseases

edited by

Ken-ichi Aihara

submission deadline 25 Feb 2026 | Viewed by 40 | Submission Open

Keywords: diabetes; cardiovascular diseases; risk factor; vascular function; diagnosis; treatment

(This special issue belongs to the Section Cardiovascular Medicine)

Advancing Clinical Medicine through Artificial Intelligence (AI) and Digital Technology: 2nd Edition

edited by

Antonio Jorge Forte

submission deadline 25 Feb 2026 | Viewed by 38 | Submission Open

Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes

(This special issue belongs to the Section Intensive Care)

Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy

edited by

Daniel H. S. Silverman

submission deadline 25 Feb 2026 | Viewed by 32 | Submission Open

Keywords: cognition; prodromal; Alzheimer’ s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI

(This special issue belongs to the Section Clinical Neurology)

Spinal Surgery: Recent Advance and Future Perspective

edited by

Yoshiharu Kawaguchi

submission deadline 25 Feb 2026 | Viewed by 31 | Submission Open

Keywords: spine surgery; diagnostic technology; AI; images; biomarkers; genetics; robotic surgery; minimum invasive surgery; pain control; VR

(This special issue belongs to the Section Orthopedics)

Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)

edited by

Juan F. Navarro-González

, Carmen Mora-Fernández and

Javier Donate-Correa

submission deadline 25 Feb 2026 | Viewed by 29 | Submission Open

Keywords: CKD; CKD progression; biomarkers; disease-modifying treatments; diabetic kidney disease; cardiorenal disease; glomerunephritis; genetic kidney diseases

(This special issue belongs to the Section Nephrology & Urology)

Helicobacter pylori-Associated Intestinal Diseases and Beyond

edited by

Antonio Facciorusso

submission deadline 25 Feb 2026 | Viewed by 24 | Submission Open

Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights

edited by

Amir Nutman

submission deadline 25 Feb 2026 | Viewed by 21 | Submission Open

Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology

(This special issue belongs to the Section Infectious Diseases)

Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities

edited by Rami S Kantar

submission deadline 25 Feb 2026 | Viewed by 17 | Submission Open

Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Advances and Future Perspectives of Sepsis and Septic Shock

edited by Filippo Mearelli and Gianni Biolo

submission deadline 25 Feb 2026 | Viewed by 13 | Submission Open

Keywords: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect

edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo

submission deadline 25 Feb 2026 | Viewed by 9 | Submission Open

Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology

(This special issue belongs to the Section Ophthalmology)

Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management

edited by Yujin Kudo

submission deadline 25 Feb 2026 | Viewed by 8 | Submission Open

Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning

(This special issue belongs to the Section Respiratory Medicine)

Application of Echocardiography in Clinical Practice

edited by

Shemy Carasso

submission deadline 25 Feb 2026 | Viewed by 6 | Submission Open

Keywords: echocardiography; three-dimensional imaging; mechanical imaging; strain; artificial intelligence; interventional echocardiography; POCUS; hand-held echocardiography; cancer therapy and cardiotoxicity

(This special issue belongs to the Section Cardiovascular Medicine)

Displaying special issue 1351-1400 on page 28 of 29.

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