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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Acute Coronary Syndromes: From Diagnosis to Treatment
edited by and Christos Eftychiou
submission deadline 25 Feb 2026 | 1 articles | Viewed by 1180 | Submission Open
Keywords: acute coronary syndrome; diagnosis; biomarkers; interventional cardiology; imaging; pharmacotherapy; patient management; health systems; special populations; clinical trials
(This special issue belongs to the Section Cardiology)
Recent Advances in Reconstructive Oral and Maxillofacial Surgery submission deadline 25 Feb 2026 | 2 articles | Viewed by 1108 | Submission Open
Keywords: oral surgery; maxillofacial surgery; new technologies; free flap; reconstructive surgery; artificial intelligence
(This special issue belongs to the Section General Surgery)
Helicobacter pylori-Associated Intestinal Diseases and Beyond submission deadline 25 Feb 2026 | 1 articles | Viewed by 458 | Submission Open
Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights
edited by
submission deadline 25 Feb 2026 | 1 articles | Viewed by 403 | Submission Open
Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology
(This special issue belongs to the Section Infectious Diseases)
Evidence-Based Physiotherapy: Prospects and Challenges
edited by Roman Nowobilski and
submission deadline 25 Feb 2026 | Viewed by 179 | Submission Open
Keywords: evidence-based practice; physiotherapy; critique; certainty of evidence; clinical practice guidelines; implementa-tion; clinical settings; clinical practice; clinical processing
(This special issue belongs to the Section Clinical Rehabilitation)
Advancing Clinical Medicine Through Artificial Intelligence (AI) and Digital Technology: 2nd Edition submission deadline 25 Feb 2026 | Viewed by 82 | Submission Open
Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes
(This special issue belongs to the Section Intensive Care)
Clinical Research Progress in Diabetes and Cardiovascular Diseases
edited by
submission deadline 25 Feb 2026 | Viewed by 74 | Submission Open
Keywords: diabetes; cardiovascular diseases; risk factor; vascular function; diagnosis; treatment
(This special issue belongs to the Section Cardiovascular Medicine)
Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy submission deadline 25 Feb 2026 | Viewed by 72 | Submission Open
Keywords: cognition; prodromal; Alzheimer’ s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI
(This special issue belongs to the Section Clinical Neurology)
Spinal Surgery: Recent Advance and Future Perspective submission deadline 25 Feb 2026 | Viewed by 59 | Submission Open
Keywords: spine surgery; diagnostic technology; AI; images; biomarkers; genetics; robotic surgery; minimum invasive surgery; pain control; VR
(This special issue belongs to the Section Orthopedics)
Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)
edited by , Carmen Mora-Fernández and
submission deadline 25 Feb 2026 | Viewed by 59 | Submission Open
Keywords: CKD; CKD progression; biomarkers; disease-modifying treatments; diabetic kidney disease; cardiorenal disease; glomerunephritis; genetic kidney diseases
(This special issue belongs to the Section Nephrology & Urology)
Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities
edited by Rami S Kantar
submission deadline 25 Feb 2026 | Viewed by 48 | Submission Open
Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Current Advances and Future Perspectives of Sepsis and Septic Shock
edited by Filippo Mearelli and Gianni Biolo
submission deadline 25 Feb 2026 | Viewed by 38 | Submission Open
Keywords: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication
(This special issue belongs to the Section Emergency Medicine)
Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management
edited by Yujin Kudo
submission deadline 25 Feb 2026 | Viewed by 35 | Submission Open
Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect
edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo
submission deadline 25 Feb 2026 | Viewed by 31 | Submission Open
Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology
(This special issue belongs to the Section Ophthalmology)
Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)
edited by Aikaterini Detoraki
submission deadline 25 Feb 2026 | Viewed by 31 | Submission Open
Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management
(This special issue belongs to the Section Immunology)
Application of Echocardiography in Clinical Practice
edited by
submission deadline 25 Feb 2026 | Viewed by 25 | Submission Open
Keywords: echocardiography; three-dimensional imaging; mechanical imaging; strain; artificial intelligence; interventional echocardiography; POCUS; hand-held echocardiography; cancer therapy and cardiotoxicity
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Update on the Diagnosis and Treatment of Heart Failure
edited by Giulia Nardi and Alessio Mattesini
submission deadline 26 Feb 2026 | 4 articles | Viewed by 7482 | Submission Open
Keywords: ejection fraction; acute heart failure; multidisciplinary management; right heart failure; left ventricle remodeling systems; HF percutaneous treatment; pharmacotherapy; HF prevention; cardiomyopathies
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Arrhythmia Diagnosis and Management
edited by Zoltán Csanádi
submission deadline 26 Feb 2026 | 4 articles | Viewed by 2430 | Submission Open
Keywords: catheter ablation; atrial fibrillation; ventricular tachycardia; conduction system pacing; cardiac resynchronization; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Unraveling Myopia: Current Science, Clinical Impact, and Future Horizons
edited by Neeraj K Singh and Pablo De Gracia
submission deadline 27 Feb 2026 | 1 articles | Viewed by 543 | Submission Open
Keywords: accommodation; contact lenses; ophthalmic lenses; myopia progression; epidemiology; myopia control interventions; pharmaceutical treatments; environmental and behavioral risk factors; imaging innovations in myopia
(This special issue belongs to the Section Ophthalmology)
Harnessing Photobiomodulation Light for Therapeutic or Prevention of Human Diseases
edited by
submission deadline 28 Feb 2026 | 5 articles | Viewed by 14136 | Submission Open
Keywords: neurorehabilitation; supportive care for cancer; reproductive health; dental and oral diseases; viral and bacterial diseases; wound care; dermatology; sports rehabilitation; bone and musculoskeletal diseases; PBM mechanism; ophthalmology; stem cells and regenerative medicine; pain and addiction management; PBM-tissue interaction
Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition submission deadline 28 Feb 2026 | 1 articles | Viewed by 1016 | Submission Open
Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan
(This special issue belongs to the Section Clinical Neurology)
Epidemiology Associated Risks and Intervention Strategies of Childhood Obesity
edited by , and Eduardo Guzmán-Muñoz
submission deadline 28 Feb 2026 | Viewed by 151 | Submission Open
Keywords: childhood obesity; overweight; eating disorders; nutritional programs; psychological interventions; physical activity exercise; sport; physical well-being; mental well-being; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Hysterectomy Surgery—Recent Developments and Emerging Trends
edited by , and Dimitrios Zacharakis
submission deadline 28 Feb 2026 | Viewed by 109 | Submission Open
Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care
(This special issue belongs to the Section Obstetrics & Gynecology)
Current and Emerging Treatment Options in Chronic Liver Diseases
edited by Chandana B. Herath and Michael Praktiknjo
submission deadline 28 Feb 2026 | Viewed by 74 | Submission Open
Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advances and Clinical Outcomes of Pediatric Endocrinology
edited by
submission deadline 28 Feb 2026 | Viewed by 70 | Submission Open
Keywords: congenital hypothyroidism; rare bone diseases; growth hormone deficiency; endocrine sequelae of cancer treatments; disorders of sex development; central diabetes insipidus; gender dysphoria
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Updates in Cardiovascular Computed Tomography (CT)
edited by
submission deadline 28 Feb 2026 | Viewed by 63 | Submission Open
Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection
(This special issue belongs to the Section Cardiovascular Medicine)
Neuromuscular Diseases and Musculoskeletal Disorders
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 54 | Submission Open
Keywords: neuromuscular diseases; osteoporosis; fractures; muscle weakness; muscle intolerance; shoulder dysfunction; myopathy; physiotherapy; rehabilitation
(This special issue belongs to the Section Clinical Neurology)
New Insights into Head and Neck Surgery—2nd Edition submission deadline 28 Feb 2026 | Viewed by 54 | Submission Open
Keywords: otorhinolaryngology; head and neck surgery; ear surgery; sinonasal surgery; skull base surgery; salivary gland surgery; thyroid gland surgery; head and neck cancer surgery
(This special issue belongs to the Section General Surgery)
Towards a New Paradigm: Opioid-Free and Opioid-Sparing Strategies in Modern Anesthesia submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open
Keywords: opioid-free anesthesia; opioid-sparing strategies; multimodal analgesia; regional anesthesia; non-opioid analgesics; enhanced recovery after surgery (ERAS); perioperative pain management; postoperative analgesia; anesthesia innovation; chronic pain prevention; patient-centered anesthesia; clinical outcomes in anesthesia
(This special issue belongs to the Section Anesthesiology)
Emerging Therapies: Clinical Trials and Insights in Psoriasis
edited by and Elżbieta Krajewska-Kułak
submission deadline 28 Feb 2026 | Viewed by 46 | Submission Open
Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy
(This special issue belongs to the Section Dermatology)
Clinical Therapeutic Advances of Mitral Regurgitation
edited by Angelo Squeri
submission deadline 28 Feb 2026 | Viewed by 39 | Submission Open
Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography
(This special issue belongs to the Section Cardiovascular Medicine)
Tumor Microenvironment—Current Status and Therapeutic Targets
edited by
submission deadline 28 Feb 2026 | Viewed by 34 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies
(This special issue belongs to the Section Oncology)
Inflammatory Bowel Disease: Clinical Pathogenesis and Management Strategies
edited by
submission deadline 28 Feb 2026 | Viewed by 25 | Submission Open
Keywords: epithelial barrier dysfunction; intestinal microbiota dysbiosis; minimally invasive surgery in IBDs; disease monitoring; perianal disease treatment; surgical complications in IBD; prehabilitation; stoma formation and management; timing of surgery in IBDs; risk stratification for IBD surgery; patient-reported outcomes post-surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances in Prevention, Management, and Rehabilitation of Head and Neck Injuries
edited by , Pier Enrico Gallenga and
submission deadline 5 Mar 2026 | 1 articles | Viewed by 1156 | Submission Open
Keywords: neck injuries; whiplash injuries; head injuries; concussion; neck pain; cervicalgia; post-concussive syndrome; post-concussive symptoms; vision disorders; hearing disorders; emergency care; emergency therapies; physical medicine and rehabilitation; musculoskeletal rehabilitation; sports medicine
(This special issue belongs to the Section Sports Medicine)
New Insights in the Endovascular Treatment of Aortic Type A Dissection
edited by
submission deadline 10 Mar 2026 | 2 articles | Viewed by 3700 | Submission Open
Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection
(This special issue belongs to the Section Cardiology)
Clinical Diagnosis and Management of Corneal Diseases
edited by , and Panagiota Ntonti
submission deadline 10 Mar 2026 | Viewed by 42 | Submission Open
Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty
(This special issue belongs to the Section Ophthalmology)
Neurological Injury After Cardiac Arrest: Mechanisms, Prognostication, and Emerging Therapies
edited by and Nikos Gorgoraptis
submission deadline 10 Mar 2026 | Viewed by 31 | Submission Open
Keywords: cardiac arrest; hypoxic– ischaemic brain injury; neuroprognostication; neuroprotection; biomarkers; targeted tem-perature management; multimodal monitoring; neurorehabilitation
(This special issue belongs to the Section Emergency Medicine)
Clinical Advances in Minimally Invasive Gynecologic Surgery
edited by
submission deadline 10 Mar 2026 | Viewed by 20 | Submission Open
Keywords: minimally invasive gynecological surgery; MIGS; laparoscopy; robotics; natural orifice transluminal endoscopic surgery; endometriosis; endometrial cancer; vaginal hysterectomy; leiomyomas; fibroids; vNOTES
(This special issue belongs to the Section Obstetrics & Gynecology)
Bladder Cancer: Clinical Diagnosis and Treatment
edited by Răzvan Bardan and Bogdan Petrut
submission deadline 10 Mar 2026 | Viewed by 15 | Submission Open
Keywords: bladder cancer; non-muscle invasive bladder cancer (NMIBC); muscle-invasive bladder cancer (MIBC); urinary biomarkers; immunotherapy; risk stratification; surgical treatment; AI in urology; personalized medicine
(This special issue belongs to the Section Nephrology & Urology)
Current Trends and Future Challenges in Coronary Artery Disease
edited by Federica Agnello
submission deadline 10 Mar 2026 | Viewed by 14 | Submission Open
Keywords: coronary artery disease; cardiovascular prevention; coronary computed tomography angiography (CCTA); CT-derived fractional flow reserve (FFR-CT); intracoronary imaging; residual risk; functional assessment; artificial intelligence in cardiology; percutaneous coronary intervention
(This special issue belongs to the Section Cardiology)
Prevention, Diagnosis, and Clinical Treatment of Corneal Diseases
edited by Rossella Anna Maria Colabelli-Gisoldi and Fabio Scarinci
submission deadline 10 Mar 2026 | Viewed by 3 | Submission Open
Keywords: dry eye disease; cornea transplant; stem cell therapy; corneal imaging; cornea disease; deep anterior lamellar keratoplasty; descemet stripping automated endothelial keratoplasty; descemet membrane endothelial keratoplasty; keratoconus; eye bank
(This special issue belongs to the Section Ophthalmology)
Novel Developments in Dental and Oral Surgery submission deadline 15 Mar 2026 | Viewed by 69 | Submission Open
Keywords: guided bone regeneration; dental implant osseointegration; laser dentistry; maxillofacial reconstruction; sinus lift techniques
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Oral Hygiene: Updates and Clinical Progress: 2nd Edition
edited by
submission deadline 15 Mar 2026 | Viewed by 52 | Submission Open
Keywords: periodontal disease; dental caries; plaque control; oral hygiene practices; gingivitis; dental prophylaxis; oral health education
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Thyroid Disease: Updates from Diagnosis to Treatment: 2nd Edition submission deadline 15 Mar 2026 | Viewed by 51 | Submission Open
Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism
(This special issue belongs to the Section Endocrinology & Metabolism)
Research Progress in Kawasaki Disease: Epidemiology, Treatment and Cardiovascular Outcomes
edited by Andre Jakob
submission deadline 15 Mar 2026 | Viewed by 38 | Submission Open
Keywords: Kawasaki disease; immune pathogenesis; immunomodulatory treatment; coronary artery pathology; cardiovascular outcomes
(This special issue belongs to the Section Clinical Pediatrics)
Cardiovascular Disease in MASLD: New Advances in Therapeutic Targets
edited by
submission deadline 15 Mar 2026 | Viewed by 30 | Submission Open
Keywords: MASLD; cardiovascular disease (CVD); metabolic dysfunction; steatotic liver disease; insulin resistance; dyslipidemia; atherosclerosis; inflammation; GLP-1 receptor agonists; SGLT2 inhibitors; lipid-lowering therapies; cardiometabolic risk; clinical trials; therapeutic targets
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Antithrombotic Therapy in Cardiovascular Medicine
edited by Daniele Giacoppo and Antonio Greco
submission deadline 15 Mar 2026 | Viewed by 26 | Submission Open
Keywords: anticoagulant; antiplatelet; antithrombotic therapy; cardiovascular pharmacotherapy; coronary artery disease; in-flammation; lipid-lowering drugs; lipid metabolism; residual cardiovascular risk; thrombosis
(This special issue belongs to the Section Cardiovascular Medicine)
Early-Stage Non-Small Cell Lung Cancer: Diagnostic Challenges and Therapeutic Innovations
edited by Efimia Boutsikou, Georgia F. Hardavella and
submission deadline 15 Mar 2026 | Viewed by 20 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); early-stage lung cancer; diagnostic imaging; stereotactic ablative radiotherapy (SABR); molecular profiling; adjuvant targeted therapy; immunotherapy in early-stage NSCLC
(This special issue belongs to the Section Respiratory Medicine)
Clinical Diagnosis and Treatment of Uveitis
edited by
submission deadline 15 Mar 2026 | Viewed by 17 | Submission Open
Keywords: uveitis; intraocular tumors; medical retina; pediatric retina
(This special issue belongs to the Section Ophthalmology)
Progress in Clinical Diagnosis and Therapy in Ophthalmology
edited by
submission deadline 16 Mar 2026 | 1 articles | Viewed by 322 | Submission Open
Keywords: ophthalmic imaging; artificial intelligence in ophthalmology; retinal diseases; corneal transplantation; glaucoma diagnostics; ocular therapeutics; personalized medicine; ocular genetics
(This special issue belongs to the Section Ophthalmology)
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