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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Perspectives on Diagnosis, Prognosis and Treatment of Tricuspid Regurgitation According to Etiology

edited by Sergio Moral

submission deadline 15 Apr 2026 | Viewed by 37 | Submission Open

Keywords: tricuspid regurgitation; transcatheter tricuspid intervention; 3D echocardiography; cardiac magnetic resonance; valve repair techniques

(This special issue belongs to the Section Cardiology)

Management of Coronary Syndrome for Better Outcome

edited by

Cristina Madaudo

Vincenzo Sucato

and Antonio Luca Maria Parlati

submission deadline 15 Apr 2026 | Viewed by 35 | Submission Open

Keywords: acute coronary syndrome; chronic coronary syndrome; percutaneous coronary intervention; dual antiplatelet therapy; intravascular imaging; risk stratification; secondary prevention; cardiovascular outcomes; artificial intelligence; digital health

(This special issue belongs to the Section Cardiology)

Clinical Advances in the Management of Melanoma

edited by

Kelly M. Mahuron

and

Yan Xing

submission deadline 15 Apr 2026 | Viewed by 29 | Submission Open

Keywords: melanoma immunotherapy; targeted therapy; immune checkpoint inhibitors; melanoma subtypes; adjuvant treatment; neoadjuvant treatment; tumor-infiltrating lymphocytes (TILs) therapy; combination therapy; molecular profiling; bi-omarker-driven therapy; clinical decision-making; liquid biopsy

(This special issue belongs to the Section Dermatology)

The State of the Art in Adjuvant Breast Irradiation: Technical, Clinical, and Genomic Advances in the Adjuvant and Neo-Adjuvant Fields

edited by Grazia Lazzari

submission deadline 15 Apr 2026 | Viewed by 27 | Submission Open

Keywords: radiation oncology; breast cancer therapy; deep inspiration breath hold; DIBH; stereotactic body radiation therapy; SBRT; intraoperative radiation therapy; IORT; prone positioning; protons; hypofractionation

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Cruciate Ligament Injuries in Sport Medicines: Diagnosis, Treatment and Rehabilitation

edited by

Rafal Kamiński

submission deadline 15 Apr 2026 | Viewed by 15 | Submission Open

Keywords: cruciate ligament; sport medicine; trauma; meniscus; knee instability; anterior cruciate ligament reconstruction; posterior cruciate ligament; rehabilitation; return to sport; injury prevention

(This special issue belongs to the Section Sports Medicine)

Haemodialysis and Peritoneal Dialysis: Current Clinical Practices and Innovations

edited by Susanne Angermann

submission deadline 17 Apr 2026 | Viewed by 65 | Submission Open

Keywords: haemodialysis; peritoneal dialysis; end-stage kidney disease; chronic kidney disease; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Periodontology and Dental Implants: State of the Art and Future Perspectives

edited by Magda Mensi and

Davide Farronato

submission deadline 17 Apr 2026 | Viewed by 57 | Submission Open

Keywords: periodontology; dental implants; regenerative dentistry; peri-implant diseases; digital dentistry; implant surface modifications; tissue engineering; oral microbiome; risk assessment; personalized treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management of Corneal Diseases

edited by Hyeck Soo Son

submission deadline 18 Apr 2026 | Viewed by 46 | Submission Open

Keywords: corneal diseases; keratoconus; corneal dystrophy; corneal ectasia; corneal transplantation; DMEK; DSAEK; kerato-prosthesis; crosslinking; ICRS; CAIRS; Bowman layer transplantation; treatment outcomes; clinical management

(This special issue belongs to the Section Ophthalmology)

Artificial Intelligence and Eye Disease

edited by

Andrzej Grzybowski

Louis Arnould

and

Haoyu Chen

submission deadline 20 Apr 2026 | 5 articles | Viewed by 6208 | Submission Open

Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder

(This special issue belongs to the Section Ophthalmology)

Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update

edited by Yacob G. Tedla

submission deadline 20 Apr 2026 | 1 articles | Viewed by 473 | Submission Open

Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification

(This special issue belongs to the Section Vascular Medicine)

Clinical Management for Anesthesia Critical Care

edited by Gianluca Zani

submission deadline 20 Apr 2026 | Viewed by 94 | Submission Open

Keywords: anesthesia; critical care medicine; clinical management; critically ill patients; organ failure; organ dysfunction; per-sonalized therapy; outcome; technical skills; non-technical skills

(This special issue belongs to the Section Anesthesiology)

Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques

edited by Argyrios Tzamalis

submission deadline 20 Apr 2026 | Viewed by 93 | Submission Open

Keywords: oculoplastic surgery; eyelid reconstruction; orbital surgery; novel minimally invasive; image guided

Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes

edited by Athanassios A. Kyrgidis and

Aimilios Lallas

submission deadline 20 Apr 2026 | Viewed by 92 | Submission Open

Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life

(This special issue belongs to the Section Dermatology)

The Latest Research on Male Infertility

edited by Gianmaria Salvio and Nicola delli Muti

submission deadline 20 Apr 2026 | Viewed by 84 | Submission Open

Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Chronic Disease Management and Rehabilitation in Older Adults

edited by

Justyna Mazurek

submission deadline 20 Apr 2026 | Viewed by 83 | Submission Open

Keywords: chronic disease; older adults; geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; health promotion

(This special issue belongs to the Section Geriatric Medicine)

Clinical Advances in Musculoskeletal Pain

edited by

Dariusz Kosson

Barbara Lisowska

and

Paweł Łęgosz

submission deadline 20 Apr 2026 | Viewed by 82 | Submission Open

Keywords: musculoskeletal pain; chronic pain; primary musculoskeletal pain; secondary chronic musculoskeletal pain; multi-disciplinary pain treatment; imaging in interventional pain management

(This special issue belongs to the Section Orthopedics)

Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition

edited by Michael D. Diamantidis

submission deadline 20 Apr 2026 | Viewed by 81 | Submission Open

Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)

(This special issue belongs to the Section Hematology)

Advances in Maternal Fetal Medicine

edited by

Georgios Eleftheriou

and Anna Franca Cavaliere

submission deadline 20 Apr 2026 | Viewed by 79 | Submission Open

Keywords: drugs use during pregnancy; fetal treatment; pregnancy complications; infectious diseases; neonatal poor adaptation syndrome

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Updates in Imaging of Musculoskeletal Diseases

edited by

Federico Zaottini

and

Riccardo Picasso

submission deadline 20 Apr 2026 | Viewed by 74 | Submission Open

Keywords: musculoskeletal imaging; ultrasound; magnetic resonance; sport imaging; rheumatology; nerve imaging

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Myocardial Infarction: The Latest Advances and Prospects

edited by

Stylianos Daios

and Antonios Ziakas

submission deadline 20 Apr 2026 | Viewed by 74 | Submission Open

Keywords: coronary artery disease; myocardial infarction; PPCI; echocardiography; antiplatelet agents; radial access; global longitudinal strain

(This special issue belongs to the Section Cardiology)

Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques and Rehabilitation

edited by Marco Minelli,

Mattia Loppini

and Federico Della Rocca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 74 | Submission Open

Keywords: total joint arthroplasty; hip replacement; knee arthroplasty; robotic-assisted surgery; minimally invasive techniques; implant design; postoperative rehabilitation; periprosthetic joint infection; surgical innovation

(This special issue belongs to the Section Orthopedics)

Innate Immunity in Overdrive: Novel Insights into Autoinflammatory Syndromes

edited by Alessandro Conforti

submission deadline 20 Apr 2026 | Viewed by 72 | Submission Open

Keywords: autoinflammatory diseases; innate immunity; inflammasome; cytokines; Interleukin-1; monogenic syndromes; polygenic autoinflammatory disorders; adult-onset Still’ s disease; Behç et’ s disease; targeted therapy; disease registries; real-world evidence; VEXAS syndrome; UBA1 mutations; precision medicine; biomarkers; outcome assessment

(This special issue belongs to the Section Immunology & Rheumatology)

Pediatric Dentistry: Real-World Clinical Insights

edited by

Ruth M. Santamaría

submission deadline 20 Apr 2026 | Viewed by 71 | Submission Open

Keywords: pediatric dentistry; minimally invasive dentistry; new technologies; biomaterials; innovative management approaches; caries management; pulp management; dental trauma; molar incisor hypomineralization; public health services research; epidemiological research; translational research

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Heart Failure: Treatment and Clinical Perspectives

edited by Geza Halasz, Domenico Gabrielli and Francesco Grigioni

submission deadline 20 Apr 2026 | Viewed by 69 | Submission Open

Keywords: heart failure; chronic heart failure; acute heart failure; treatment; cardiac imaging; diagnostics; patient outcomes; prognosis

(This special issue belongs to the Section Cardiology)

Pharmacotherapy of Mental Diseases: Latest Developments

edited by

Lavinia Maria Hogea

and

Laura Alexandra Nussbaum

submission deadline 20 Apr 2026 | Viewed by 67 | Submission Open

Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases

(This special issue belongs to the Section Mental Health)

Advances and Challenges in Head and Neck Reconstructive Surgery

edited by

Valeria Navach

Olindo Massarelli

and Luca Calabrese

submission deadline 20 Apr 2026 | Viewed by 62 | Submission Open

Keywords: reconstructive surgery; head and neck; innovation; microsurgery; virtual surgical planning; 3D-printed implants; tissue engineering

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Advances in Minimally Invasive Spinal Treatment: 2nd Edition

edited by

Akihiko Hiyama

Haruki Funao

and

Masayuki Ishihara

submission deadline 20 Apr 2026 | Viewed by 61 | Submission Open

Keywords: robotic-assisted spine surgery; artificial intelligence (AI); machine learning (ML); cement-augmented pedicle screws; cement leakage risk stratification; osteoporosis pharmacotherapy; surgical navigation systems; image-guided spine surgery; predictive analytics in spine care; spine technology innovation

(This special issue belongs to the Section Orthopedics)

Geriatric Fracture Care: Bridging Orthopedics and Gerontology

edited by Tom Knauf and Daphne Asimenia Eschbach

submission deadline 20 Apr 2026 | Viewed by 57 | Submission Open

Keywords: geriatric fracture; proximal femur fractures; hip fracture; geriatric trauma patient; ortho-geriatric treatment; periprosthetic fracture; end of life decision; orthopedic surgery in the elderly

(This special issue belongs to the Section Geriatric Medicine)

Advances in the Management of Pediatric Neuromuscular Diseases

edited by Nicolas Deconinck

submission deadline 20 Apr 2026 | Viewed by 56 | Submission Open

Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines

(This special issue belongs to the Section Clinical Neurology)

Recent Management and Future Perspectives on Knee Arthroplasty

edited by

Georgios Komnos

submission deadline 20 Apr 2026 | Viewed by 56 | Submission Open

Keywords: knee arthroplasty; individualized approach; implant designs; robotic-assisted; knee alignment

(This special issue belongs to the Section Orthopedics)

Advancements in Minimally Invasive Neurosurgery

edited by Sanjeeva Jeyaretna and Kumar Abhinav

submission deadline 20 Apr 2026 | Viewed by 56 | Submission Open

Keywords: minimally invasive surgery; skull base surgery; neurosurgery; transorbital; endoscopic transnasal

(This special issue belongs to the Section Clinical Neurology)

Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis

edited by Francescamaria Donati

submission deadline 20 Apr 2026 | Viewed by 53 | Submission Open

Keywords: magnetic resonance imaging (MRI); clinical diagnosis; high-field MRI; diffusion-weighted imaging (DWI); perfusion MRI (pMRI); artificial intelligence in imaging; diagnostic imaging; early disease detection; disease monitoring; treatment planning

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Advances in Risk Minimization Through Robot-Assisted Surgery

edited by Radko Komadina

submission deadline 20 Apr 2026 | Viewed by 51 | Submission Open

Keywords: robot-assisted technology; robotic surgery; laparoscopic surgery; spinal surgery; robot-assisted gynecological operations; robot-assisted operations in urology; robot-assisted prostatectomy

(This special issue belongs to the Section General Surgery)

Hip and Knee Arthroplasty: Update on Clinical Management

edited by Maximilian F. Kasparek

submission deadline 20 Apr 2026 | Viewed by 51 | Submission Open

Keywords: total hip arthroplasty (THA); total knee arthroplasty (TKA); revision arthroplasty; implant fixation; cemented; cementless; hybrid; alignment in TKA; mechanical alignment; kinematic alignment; restricted kinematic alignment; functional alignment; navigation; robotic-assisted surgery; patient-specific instrumentation; additive manufacturing; 3D printing; personalized implant

(This special issue belongs to the Section Orthopedics)

Coronary Artery Disease: Recent Developments and Emerging Trends

edited by

Attila Kardos

submission deadline 20 Apr 2026 | Viewed by 50 | Submission Open

Keywords: coronary atherosclerosis; diagnostic strategies; therapeutic options; timing of intervention; artificial intelligence; novel therapeutic pathways

(This special issue belongs to the Section Cardiology)

Insights from Cardiopulmonary Exercise Testing to Cardiac Rehabilitation

edited by

Gaia Cattadori

submission deadline 20 Apr 2026 | Viewed by 48 | Submission Open

Keywords: cardiac rehabilitation; exercise physiology; exercise performance; exercise testing; physical activity assessment; exercise; physical activity; oxygen consumption; cardiopulmonary exercise testing

(This special issue belongs to the Section Cardiology)

Clinical Advances in Endodontic Dentistry

edited by

Luciano Giardino

and

Luigi Generali

submission deadline 20 Apr 2026 | Viewed by 48 | Submission Open

Keywords: antimicrobial agents; biofilm; confocal laser scanning microscopy; endodontic materials; irrigants; microbiome; micro-CT; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights in Joint Arthroplasty—2nd Edition

edited by

Richard Lass

submission deadline 20 Apr 2026 | Viewed by 48 | Submission Open

Keywords: total hip arthroplasty; total knee arthroplasty; robotic-assisted technology and navigation; modern implant materials; modern implant fixation techniques; alignment in TKA; spinopelvic alignment in THA

(This special issue belongs to the Section Orthopedics)

Vertebral Fractures and Spinal Cord Injury: Advances in Management

edited by Marc Dreimann

submission deadline 20 Apr 2026 | Viewed by 47 | Submission Open

Keywords: fracture management; spinal cord injuries; artificial intelligence; machine learning; spinal trauma

(This special issue belongs to the Section Orthopedics)

New Sights in Retinal Diseases Therapeutics: Innovation and Clinical Practice

edited by

Giacomo Boscia

Pasquale Viggiano

, Stefano Dore and Alfonso Savastano

submission deadline 20 Apr 2026 | Viewed by 46 | Submission Open

Keywords: retinal diseases; central serous chorioretinopathy; age-related macular degeneration; eye diseases; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

New Insights in Retina Diseases

edited by Fabio Scarinci and Giulio Pocobelli

submission deadline 20 Apr 2026 | Viewed by 45 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; vitreoretinal diseases; retinal imaging analysis; biomarkers; segmentation; retinal ischemia; retinal blood flow; choroidal blood flow

(This special issue belongs to the Section Ophthalmology)

Recent Advances in Endocrine Surgery—2nd Edition

edited by

Gregorio Scerrino

submission deadline 20 Apr 2026 | Viewed by 44 | Submission Open

Keywords: endocrine surgery; thyroid; thyroid cancer; parathyroid; parathyroidectomy; adrenal glands; disorders of hepatobiliary and gastrointestinal tract

(This special issue belongs to the Section General Surgery)

Peritoneal Dialysis and Hemodialysis: Early and Late Outcomes

edited by Keren Cohen-Hagai and

David Pereg

submission deadline 20 Apr 2026 | Viewed by 43 | Submission Open

Keywords: peritoneal dialysis; dialysis; hemodialysis; chronic kidney disease; end-stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Female Infertility: Clinical Diagnosis and Treatment—Second Edition

edited by

Laurie Henry

submission deadline 20 Apr 2026 | Viewed by 43 | Submission Open

Keywords: infertility; assisted reproductive techniques; diagnosis; implantation; gametes

(This special issue belongs to the Section Obstetrics & Gynecology)

New Advances in Orthopedic Knee Joint Preserving and Reconstructive Surgery

edited by

Dong Jin Ryu

and

Sung-Sahn Lee

submission deadline 20 Apr 2026 | Viewed by 43 | Submission Open

Keywords: cartilage regeneration; patient-specific instrumentation; knee robotic surgery; patient-specific surgical device; future orthopedics

(This special issue belongs to the Section Orthopedics)

Optimizing Outcomes in Emergency Medicine and Cardiopulmonary Resuscitation

edited by

Andreas S. Papazoglou

and

Dimitrios V. Moysidis

submission deadline 20 Apr 2026 | Viewed by 41 | Submission Open

Keywords: emergency medicine; cardiopulmonary resuscitation; prehospital care; outcome prediction; post-pesuscitation care; advanced life support; emergency response systems; medical ethics; simulation in medicine

(This special issue belongs to the Section Emergency Medicine)

Orofacial Pain: Innovations in Treatment Modalities and Patient Care

edited by Takahiko Nagamine

submission deadline 20 Apr 2026 | Viewed by 40 | Submission Open

Keywords: orofacial pain; treatment; patient care; oral dysfunction; chronic pain; burning mouth syndrome; temporomandibular joint pain: oral cenesthopathy; atypical odontalgia; phantom bite syndrome

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Schizophrenia and Psychotic Disorders: Clinical Updates

edited by Octavian Vasiliu and

Adela Magdalena Ciobanu

submission deadline 20 Apr 2026 | Viewed by 38 | Submission Open

Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities

(This special issue belongs to the Section Mental Health)

Recent Advancements in Nuclear Medicine and Radiology: 2nd Edition

edited by Adriaan A. Lammertsma

submission deadline 20 Apr 2026 | Viewed by 36 | Submission Open

Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

New Insights into Breast Neoplasms: Prevention, Multidisciplinary Management and Beyond the Core Team

edited by

Marco Materazzo

and

Antonia Girardi

submission deadline 20 Apr 2026 | Viewed by 36 | Submission Open

Keywords: breast cancer; tumor heterogeneity; estrogen receptor; progesterone receptor; triple-negative breast cancer; metastasis; immunotherapy; targeted therapy; early detection; prognosis; adjuvant treatment

(This special issue belongs to the Section Oncology)

Displaying special issue 1251-1300 on page 26 of 29.

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