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Kidney Transplantation and Rehabilitation: Current Updates and Future Perspectives
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Kidney Transplantation and Rehabilitation: Current Updates and Future Perspectives

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 November 2026 | Viewed by 644

Editor

Dr. Zoltán Sándor

E-Mail Website
Guest Editor
Department of Surgery, Clinical Center, University of Pécs, 7622 Pecs, Hungary
Interests: chronic kidney disease; kidney transplantation; transplant rehabilitation; transplant care; physical therapy; intervention; recovery; quality of life
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Kidney transplantation remains the gold-standard treatment for end-stage renal disease (ESRD). Compared to chronic dialysis, transplantation results in lower mortality rates and a better quality of life (QOL) for our patients. However, to achieve the desired increase in QOL, our patients need long-term follow-up and individualized rehabilitation. The rising prevalence of ESRD worldwide necessitates the likewise expansion of kidney transplantation, and the expansion of transplantation has been followed by an explosion in the number of patients in need of postoperative care. A multidisciplinary approach incorporating physical, mental, and social assistance is needed to alleviate the disability caused by ESRD. An effective system would ideally allow our patients to lead fulfilling, independent lives and even return to the workforce.

Unfortunately, only a relatively small number of resources and studies are aimed at improving rehabilitation outcomes. A myriad of problems, such as understaffing and low patient compliance, undermine the implementation of modern rehabilitation techniques. Too often, this lack of adequate rehabilitation negates the labor behind a successful transplantation.

In this Special Issue, we invite authors to submit high-quality, original articles concerning recent advances in the postoperative rehabilitation of kidney transplant recipients. Recognizing the multifaceted nature of rehabilitation, we welcome articles examining any aspect of QOL (quality of life).

We look forward to receiving your contributions!

Dr. Zoltán Sándor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • kidney transplantation
  • transplant rehabilitation
  • transplant care
  • physical therapy
  • intervention
  • recovery
  • quality of life

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Published Papers (1 paper)

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Research

13 pages, 7093 KB  
Article
Azvudine for COVID-19 in Kidney Transplant Recipients: A Real-World Observational Study of Long-Term Renal Outcomes
by Xiaoyu Li, Xin Xu, Wenyuan Leng, Shufang Deng, Zhenpeng Zhu, Meng Zhang, Wenke Han, Yaqun Zhang, Gengyan Xiong, Cheng Shen and Jian Lin
J. Clin. Med. 2026, 15(14), 5417; https://doi.org/10.3390/jcm15145417 - 10 Jul 2026
Viewed by 422
Abstract
Objectives: Coronavirus disease 2019 (COVID-19) poses a significant threat to kidney transplant recipients (KTRs) due to chronic immunosuppression. While Azvudine has demonstrated antiviral efficacy, its long-term impact on allograft function in KTRs remains unknown. This single-arm retrospective study provides a comprehensive evaluation [...] Read more.
Objectives: Coronavirus disease 2019 (COVID-19) poses a significant threat to kidney transplant recipients (KTRs) due to chronic immunosuppression. While Azvudine has demonstrated antiviral efficacy, its long-term impact on allograft function in KTRs remains unknown. This single-arm retrospective study provides a comprehensive evaluation of the outcomes. Methods: This single-center, retrospective study consecutively enrolled 20 KTRs diagnosed with COVID-19 during the Omicron surge (December 2022–January 2023), all treated with an Azvudine-centered regimen. Clinical data, treatment responses, and serial renal function parameters were analyzed. Long-term follow-up extended to a median of 39 months. Results: The median time to COVID-19 nucleic acid negativity was 13.22 days. Renal function improved significantly during treatment: estimated glomerular filtration rate increased by a mean of 27.29 mL/min/1.73 m2, and serum creatinine decreased by 57.72 µmol/L (both p < 0.01). Common complications included electrolyte imbalances and co-infections (50% of patients). Crucially, at a median follow-up of 39 months, 75% (15/20) of patients maintained normal allograft function. No Azvudine-related adverse events or drug interactions with immunosuppressants were observed. Conclusions: While acknowledging the inherent limitations of a non-comparative design, this study provides preliminary evidence suggesting that an Azvudine-centered regimen may be associated with promising efficacy, a favorable safety profile without interference with immunosuppressive therapy, and—most importantly—durable renal allograft survival in KTRs with COVID-19. Our data suggest that this regimen could contribute to mitigating the long-term risk of allograft dysfunction, potentially bringing outcomes closer to the expected baseline for stable recipients. Coupled with its low risk of drug–drug interactions, potential immunomodulatory benefits, and superior cost-effectiveness, Azvudine could be considered a valuable therapeutic option for this high-risk population in the post-pandemic era, although these findings warrant cautious interpretation. Controlled trials are ultimately needed to confirm these observations. Full article
(This article belongs to the Special Issue Kidney Transplantation and Rehabilitation: Current Updates and Future Perspectives)
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