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Interventional Treatment of Coronary Artery Disease: Clinical Insights and Current Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 147

Special Issue Editor


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Guest Editor
Division of Cardiology, Parma University Hospital, Parma, Italy
Interests: interventional cardiology; coronary artery disease; acute myocardial infarction; cardiogenic shock; cardiac arrest

Special Issue Information

Dear Colleagues,

Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide. In recent years, interventional cardiology has undergone profound evolution, driven by advances in stent technology, intracoronary imaging, physiology-guided strategies and optimization of pharmacological therapy. These developments aim to improve clinical outcomes in an increasingly complex patient population, characterized by older age and more advanced coronary artery disease.

This Special Issue aims to provide a clinically oriented update on contemporary coronary intervention, focusing on patient selection, procedural optimization, and long-term outcomes. Particular emphasis will be placed on translating randomized trial data and real-world evidence into daily clinical practice.

We welcome contributions that address practical challenges and emerging paradigms in the management of patients undergoing percutaneous coronary intervention (PCI).

To translate technological innovation and clinical trials into concrete therapeutic, procedural and pharmacological decisions in clinical practice.

Submissions may include, but are not limited to:

Clinical Decision-Making

  • Management of elderly, frail patients, women
  • Chronic coronary syndromes: indications for intervention

Complex PCI in Clinical Practice

  • Severe coronary calcification (especially requiring debulking strategies) in women
  • Multivessel disease
  • PCI in cardiogenic shock
  • Challenging PCI in SCAD

Imaging contributions- and Physiology-Guided PCI

  • FFR/iFR in routine practice
  • IVUS- and OCT-guided PCI and impact on outcomes
  • Stent optimization strategies
  • MSCT and coronary disease

Pharmacotherapy After PCI

  • Personalized antiplatelet therapy
  • Antiplatelet therapy in SCAD
  • Short DAPT strategies
  • High bleeding risk management
  • Antithrombotic therapy in complex patients

Emerging Clinical Strategies

  • Drug-coated balloons
  • Bioresorbable stentsNon pharmacological options in secondary prevention after PCI
  • Artificial intelligence in PCI planning

We warmly invite researchers, interventional cardiologists, clinical practitioners, and allied professionals to contribute to this Special Issue. Your expertise, clinical experience, and scientific insight are essential to advancing the discussion on contemporary coronary intervention. By submitting original research and comprehensive reviews, you will help shape a clinically relevant resource that bridges innovation, evidence, and everyday practice. We particularly encourage contributions that translate emerging data into practical therapeutic strategies and address real-world challenges faced in the catheterization laboratory and outpatient care. Through collaborative engagement, this Special Issue aims to foster meaningful dialogue and provide guidance for clinicians managing increasingly complex patient populations.

As coronary artery disease continues to pose a major global health burden, the refinement of interventional strategies remains a cornerstone of modern cardiovascular medicine. This Special Issue seeks to consolidate current knowledge, critically appraise evolving evidence, and highlight forward-looking approaches that will define the next era of PCI. By bringing together leading experts and innovative research, we aim to create a comprehensive and practice-oriented reference that advances both scientific understanding and clinical care. We look forward to your valuable contributions and to collectively shaping the future of coronary intervention.

Dr. Emilia Solinas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • percutaneous coronary intervention (PCI)
  • coronary artery disease (CAD)
  • complex coronary intervention
  • physiology-guided revascularization (FFR/iFR)
  • post-PCI Integrated non-pharmacological therapies
  • intravascular imaging (IVUS/OCT)
  • severe coronary calcification
  • personalized antiplatelet therapy
  • spontaneous coronary artery dissection
  • high bleeding risk
  • drug-coated balloons
  • artificial intelligence in interventional cardiology

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Published Papers (1 paper)

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Research

18 pages, 11649 KB  
Article
Complex CTO Revascularization in Patients with Ischemic Heart Failure and Reduced Ejection Fraction: An Illustrative Case Series
by Ioana Paula Blaj-Tunduc, Mihnea-Traian Nichita-Brendea, Vlad-Victor Babes, Ioana Adela Ratiu and Emilia Elena Babeș
J. Clin. Med. 2026, 15(11), 4235; https://doi.org/10.3390/jcm15114235 (registering DOI) - 30 May 2026
Abstract
Background/Objectives: Revascularization of chronic total occlusions (CTO) in patients with heart failure and reduced ejection fraction (HFrEF) remains controversial, as randomized trials have not demonstrated a clear prognostic benefit. Methods: We present an imaging-guided case series of patients with ischemic HFrEF [...] Read more.
Background/Objectives: Revascularization of chronic total occlusions (CTO) in patients with heart failure and reduced ejection fraction (HFrEF) remains controversial, as randomized trials have not demonstrated a clear prognostic benefit. Methods: We present an imaging-guided case series of patients with ischemic HFrEF who underwent CTO percutaneous coronary intervention (PCI) following myocardial viability assessment using single-photon emission computed tomography (SPECT). Contemporary antegrade and retrograde techniques were employed. Results: At 6- and 12-month follow-ups, all patients demonstrated marked improvement in NYHA (New York Heart Association) functional class, significant reductions in NT-proBNP (N-terminal pro-brain natriuretic peptide) levels, and substantial improvement in quality of life assessed by the Minnesota Living with Heart Failure Questionnaire (MLHFQ). These benefits occurred despite only modest improvement in left ventricular (LV) ejection fraction (EF) and limited reverse remodeling. SPECT enabled identification of viable but ischemic myocardium, supporting individualized revascularization decisions. Conclusions: In selected high-risk patients with ischemic HFrEF, CTO-PCI was associated with meaningful clinical and biomarker improvement independent of substantial EF recovery. Careful patient selection, incorporating myocardial viability assessment, may refine individualized clinical decision-making in selected patients. These findings support an imaging-guided approach and warrant further prospective evaluation. Full article
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