Clinical Advances in Rhinitis and Sinusitis: Diagnosis, Therapy and Multimorbidity Management

Dear Colleagues,

Rhinitis and rhinosinusitis are among the most prevalent chronic conditions worldwide, representing a substantial burden on patients, healthcare systems, and society. These disorders are increasingly recognized as complex and multifactorial diseases, frequently occurring within a broader framework of multimorbidity that includes asthma, allergies, and other systemic inflammatory conditions. Their impact extends beyond nasal symptoms, significantly affecting sleep quality, cognitive performance, and overall quality of life. Despite their high prevalence, they often remain underdiagnosed and undertreated, reflecting persistent gaps in awareness, diagnostic precision, and therapeutic strategies.

In recent years, advances in the understanding of inflammatory pathways—particularly type-2 inflammation—have led to a paradigm shift in the management of upper airway diseases. The integration of novel diagnostic tools, endotyping approaches, and targeted therapies, including biologics, has opened new opportunities for personalized medicine. At the same time, the close interaction between upper and lower airways highlights the importance of a holistic, multidisciplinary approach to patient care. Addressing multimorbidity, optimizing treatment selection, and defining meaningful clinical outcomes remain key challenges and priorities for both research and clinical practice.

This Special Issue, entitled ‘Clinical Advances in Rhinitis and Sinusitis: Diagnosis, Therapy and Multimorbidity Management’, aims to present and disseminate the most recent developments in the field. We welcome contributions that provide new insights into disease mechanisms, improve diagnostic accuracy, and evaluate innovative therapeutic strategies, with particular attention to integrated and patient-centered care models.

Topics of interest for publication include, but are not limited to, the following: 

• Advances in the diagnosis and classification of rhinitis and sinusitis;
• Endotypes, phenotypes, and biomarkers in upper airway diseases;
• Role of type-2 and non-type-2 inflammation;
• Biologic therapies and targeted treatments;
• Surgical management and its integration with medical therapy;
• Multimorbidity and united airway disease (e.g., asthma, allergy, and NSAID-ERD);
• Olfactory dysfunction and its clinical implications;
• Real-world evidence and long-term outcomes;
• Patient-reported outcomes and quality of life;
• Precision medicine and individualized treatment strategies;
• Emerging therapies and future perspectives.

Dr. Claudio Montuori
Dr. Eugenio De Corso
Dr. Veronica Seccia
Guest Editors

Manuscript Submission Information

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