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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management of Cholecystitis and Complications

edited by Dimitrios Balalis,

Dimitrios K. Manatakis

and Nikolaos Vassos

submission deadline 28 Mar 2026 | 1 articles | Viewed by 471 | Submission Open

Keywords: gallbladder; cholecystitis; right upper quadrant pain; ultrasound; laparoscopic approach

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition

edited by

Eyal Klang

and

Adi Lahat

submission deadline 28 Mar 2026 | Viewed by 204 | Submission Open

Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis

(This special issue belongs to the Section Oncology)

Mitral Valve Stenosis or Aortic Valve Stenosis: Progress from Diagnosis to Treatment

edited by Francesco Melillo

submission deadline 28 Mar 2026 | Viewed by 82 | Submission Open

Keywords: aortic stenosis; mitral stenosis; TAVI

(This special issue belongs to the Section Cardiology)

Management of Female Pelvic Floor Disorders and Incontinence

edited by Luis López Fando

submission deadline 28 Mar 2026 | Viewed by 70 | Submission Open

Keywords: pelvic floor disorders; urinary incontinence; pelvic organ prolapse; reconstructive urology; voiding dysfunction; multidisciplinary care; surgical techniques; urodynamics; patient-centered outcomes; digital learning in urology

(This special issue belongs to the Section Nephrology & Urology)

Acute Trauma and Trauma Care in Orthopedics: 2nd Edition

edited by

Pietro Maniscalco

and

Gianfilippo Caggiari

submission deadline 31 Mar 2026 | 1 articles | Viewed by 700 | Submission Open

Keywords: orthopedics; trauma; injury; musculoskeletal; surgery; knee; osteoarthritis; spinal deformity; fracture; joint replacement; hip fractur; fragility fracture; minimally invasive surgery; post-traumatic care and rehabilitation; pain management; emergency assessment

(This special issue belongs to the Section Orthopedics)

Paradigm Changes in Cardiac Surgery and Interventional Cardiology

edited by

Miklos Bitay

submission deadline 31 Mar 2026 | 1 articles | Viewed by 670 | Submission Open

Keywords: cardiac surgery; trans-catheter interventions; ischaemic heart disease; structural heart disease; electrophysiological interventions; state-of-the-art techniques; golden standards; therapeutic guidelines

(This special issue belongs to the Section Cardiology)

Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation: 2nd Edition

edited by

Carlos Cerdán Santacruz

submission deadline 31 Mar 2026 | 1 articles | Viewed by 411 | Submission Open

Keywords: perioperative care; enhanced recovery after surgery; prehabilitation; minimally invasive surgery; patient-related outcome measures; colorectal surgery; general surgery; thoracic surgery; vascular surgery; optimal functional recovery

(This special issue belongs to the Section General Surgery)

JSOPB 2025–2026 Congress Special Issue–Update on Organ Preservation and Transplantation

edited by

Issei Saitoh

and

Takashi Kenmochi

submission deadline 31 Mar 2026 | Viewed by 221 | Submission Open

Keywords: organ preservation; transplantation; pharmacology; engineering; stem cell therapy

(This special issue belongs to the Section General Surgery)

Artificial Intelligence in Women’s Health and Medicine: Improving Clinical Practice, Diagnosis, Treatment Management and Patient Experiences

edited by

Shivaram Poigai Arunachalam

and Nasibeh Zanjirani Farahani

submission deadline 31 Mar 2026 | Viewed by 143 | Submission Open

Keywords: women’ s health; artificial intelligence; machine learning; personalized medicine; reproductive health; health equity; social determinants of health; mental health; cancer; cardiovascular disease

(This special issue belongs to the Section Epidemiology & Public Health)

Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition

edited by

Vera Geraldes

and

Isabel Rocha

submission deadline 31 Mar 2026 | Viewed by 136 | Submission Open

Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms

(This special issue belongs to the Section Cardiology)

New Insights into Clinical Application of Embolization Techniques

edited by

Bedros Taslakian

and Yan Epelboym

submission deadline 31 Mar 2026 | Viewed by 123 | Submission Open

Keywords: embolization; interventional radiology; musculoskeletal embolization; uterine artery embolization; prostate artery embolization; vascular malformations; catheter-directed therapy

(This special issue belongs to the Section Vascular Medicine)

Pregnancy and Delivery Complications: Bridging Research and Clinical Practice

edited by

Maria Patricia Roman

, Andrei Mihai Malutan and Răzvan Ciortea

submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open

Keywords: maternal– fetal medicine; obstetric complications; perinatal health; pelvic floor disorders; childbirth perineal trauma; risk stratification; patient-reported outcomes; patient-reported outcome measures

(This special issue belongs to the Section Obstetrics & Gynecology)

Thoracic Radiochemoimmunotherapy for Non-Small Cell Lung Cancer (NSCLC): Evolving Techniques and Clinical Applications

edited by

Franz Zehentmayr

submission deadline 31 Mar 2026 | Viewed by 74 | Submission Open

Keywords: radiotherapy; radiology; oncology; non-small cell lung cancer; real-world data; immunotherapy; radiation dose escalation

(This special issue belongs to the Section Oncology)

Latest Advances in Glaucoma, Cataracts, and Refractive Surgery

edited by

Adrian Gericke

, Felix Wagner and

Julia Verena Stingl

submission deadline 31 Mar 2026 | Viewed by 73 | Submission Open

Keywords: glaucoma; cataract surgery; refractive surgery; minimally invasive glaucoma surgery (MIGS); laser vision correc-tion (LVC); keratorefractive lenticule extraction (KLEx); lenticule implantation; multifocal IOLs; extended depth-of-focus (EDOF) lenses; ocular imaging; optical coherence tomography (OCT); artificial intelligence in ophthalmology; corneal biomechanics; surgical innovation

(This special issue belongs to the Section Ophthalmology)

Endodontic Diseases: Prevalence, Risk Factors, and Treatment Outcomes

edited by Iris Slutzky-Goldberg, Shlomo Matalon and

Hagay Slutzky

submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open

Keywords: cone beam computed tomography (cbct); diagnostic tools; endodontic therapy; peri-radicular pathologies; regenerative endodontics; risk factors; systemic disease; treatment outcome; vital pulp therapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Clinical Perspective in Kidney Transplantation

edited by Nikolina Bašić-Jukić

submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open

Keywords: kidney transplantation; outcomes; desensitization; xenotransplantation; transplant nephropathology; multiorgan transplantations; post-transplant complications; inequities in transplantation

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in Laser Dentistry: Emerging Therapeutic Concepts

edited by

Satoshi Watanabe

and Risako Mikami

submission deadline 31 Mar 2026 | Viewed by 62 | Submission Open

Keywords: laser dentistry; dental treatment guidelines; refractory endodontic infection; root canal therapy; minimally invasive endodontics; anatomy; cone-beam computed tomography

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Emerging Treatment Options in Atrial Fibrillation

edited by Hoang Nhat Pham and Amitoj Singh

submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open

Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants

(This special issue belongs to the Section Cardiology)

Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities

edited by

Danilo Menichelli

and Flavio Giuseppe Biccirè

submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open

Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy

(This special issue belongs to the Section Cardiology)

Advancements in Lumbar Spine Surgery: Modern Strategies and Techniques

edited by Christian von der Brelie and Frank Beyer

submission deadline 31 Mar 2026 | Viewed by 52 | Submission Open

Keywords: lumbar spine; spine surgery; new techniques; robotics; minimally-invasive; artificial intelligence (AI); navigation

(This special issue belongs to the Section Orthopedics)

New Insights into Cardiovascular Radiology

edited by Amalia Lupi and Riccardo Cau

submission deadline 31 Mar 2026 | Viewed by 50 | Submission Open

Keywords: CMR; tissue characterization; 4Dflow; CCTA; photon counting CT; plaque characterization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Oral Biology: Advances of Translating Experimental Findings into Clinical Dentistry and Oral Medicine

edited by

Andrea Palermo

submission deadline 31 Mar 2026 | Viewed by 49 | Submission Open

Keywords: oral surgery; biomaterials; tissue engineering; regenerative medicine; dentistry dentin graft; growth factors; ad-vances orthodontics; skeletal anchorage with miniscrews; TADS; MADS; MARPE; aligner

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Glaucoma: Diagnosis and Management Insights

edited by

Stamatios Lampsas

and Eythimios Karmiris

submission deadline 31 Mar 2026 | Viewed by 45 | Submission Open

Keywords: glaucoma; risk factors; progression; novel biomarkers; diagnosis; management

(This special issue belongs to the Section Ophthalmology)

Current Challenges and Updates in Therapeutic Advancements of Prostatectomy

edited by

Luca Lambertini

and

Francesco Lasorsa

submission deadline 31 Mar 2026 | Viewed by 36 | Submission Open

Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes

(This special issue belongs to the Section Nephrology & Urology)

Acute Care Surgery: The Evolution of a Modern Specialty

edited by Mayur Narayan

submission deadline 31 Mar 2026 | Viewed by 30 | Submission Open

Keywords: acute care surgery; emergency surgery; health equity; global surgery; trauma care; surgical workforce; surgical in-novation; decision-making

(This special issue belongs to the Section Emergency Medicine)

Geriatric Diseases: Management and Epidemiology

edited by

Luís Midão

submission deadline 5 Apr 2026 | 8 articles | Viewed by 12774 | Submission Open

Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults

(This special issue belongs to the Section Geriatric Medicine)

Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity

edited by

Antenor Rodrigues

submission deadline 5 Apr 2026 | Viewed by 79 | Submission Open

Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Inflammatory Bowel Disease: 2nd Edition

edited by

Lorenzo Bertani

submission deadline 5 Apr 2026 | Viewed by 53 | Submission Open

Keywords: inflammatory bowel diseases; IBD; Crohn’ s disease; ulcerative colitis; biomarkers; biologics; anti-JAKs; personalized medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

COVID-19 and Endocrine Complications

edited by

Kamyar Asadipooya

submission deadline 10 Apr 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Management of Patients with Heart Failure: 3rd Edition

edited by

Cristina Tudoran

submission deadline 10 Apr 2026 | 1 articles | Viewed by 304 | Submission Open

Keywords: acute heart failure; chronic heart failure; treatment options; management of heart failure; lifestyle changes; diagnosis of heart failure

(This special issue belongs to the Section Cardiovascular Medicine)

Current Updates on Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis

edited by

Nikolaos Tsetsos

, Georgios Fyrmpas and

Konstantinos Garefis

submission deadline 10 Apr 2026 | Viewed by 68 | Submission Open

Keywords: endoscopic sinus surgery; rhinology; chronic rhinosinusitis management; functional endoscopic sinus surgery (FESS); sinonasal inflammation; transnasal approach; postoperative outcomes

(This special issue belongs to the Section Otolaryngology)

Cesarean Section Versus Vaginal Delivery

edited by

Demetra Gabriela Socolov

Angela Vinturache

and

Liana Ples

submission deadline 10 Apr 2026 | Viewed by 49 | Submission Open

Keywords: cesarean section; vaginal delivery; birth outcomes; birth complications; delivery mode; labor process; obstetric care; trial of labor after cesarean (TOLAC); intrapartum care; obstetric decision-making

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Diagnosis and Treatment for Thymic Pathology

edited by Charalambos Zisis

submission deadline 10 Apr 2026 | Viewed by 34 | Submission Open

Keywords: immunobiology; myasthenia gravis; thymoma; thymic carcinoma; thymic hyperplasia; paraneoplastic disorders; histology; classification; staging; Masaoka; autoimmune disorders

(This special issue belongs to the Section Oncology)

Clinical Therapeutic Innovations in Maternal Fetal Medicine

edited by

Martina Derme

and

Giuseppe Rizzo

submission deadline 10 Apr 2026 | Viewed by 21 | Submission Open

Keywords: maternal-fetal medicine; prenatal screening; artificial intelligence; prenatal imaging; gene therapy

(This special issue belongs to the Section Obstetrics & Gynecology)

Oral and Maxillofacial Surgery: Current Trends, Innovations and Techniques

edited by Gabriel Armencea and

Florin Onisor

submission deadline 15 Apr 2026 | Viewed by 968 | Submission Open

Keywords: maxillofacial; trauma; deformities; cleft lip and palate; OMF surgery; head and neck; head and neck oncology; orthognathic surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Nasopharyngeal Carcinoma: Recent Advances in Clinical Diagnosis and Treatment

edited by

Federico Sireci

submission deadline 15 Apr 2026 | 1 articles | Viewed by 396 | Submission Open

Keywords: nasopharyngeal carcinoma; early diagnosis; radiotherapy advances; immunotherapy; targeted therapy; biomarkers; precision medicine; recurrence and metastasis management

(This special issue belongs to the Section Otolaryngology)

AI-Enhanced Medical Imaging for Cancer Diagnosis

edited by

Aruni Ghose

Sola Adeleke

and

Stergios Boussios

submission deadline 15 Apr 2026 | Viewed by 115 | Submission Open

Keywords: artificial intelligence; imaging; MRI; precise diagnosis; oncology

(This special issue belongs to the Section Oncology)

Orthopedic Surgery: Latest Advances and Future Prospects—2nd Edition

edited by Andrea Marinozzi and

Biagio Zampogna

submission deadline 15 Apr 2026 | Viewed by 101 | Submission Open

Keywords: custom-made; regenerative; prosthetic; noninvasive surgery; robotic surgery; percutaneous surgery; minimally invasive surgery

(This special issue belongs to the Section Orthopedics)

Innovations in Parkinson’s Disease

edited by

Sneha Mantri

submission deadline 15 Apr 2026 | Viewed by 100 | Submission Open

Keywords: Parkinson’ s disease; parkinsonism; patient-reported outcomes; wearable technology; disease-modifying therapies; non-pharmacological therapies; care delivery; models of care

(This special issue belongs to the Section Clinical Neurology)

Advances in Gynecological Diseases (Second Edition)

edited by

Guglielmo Stabile

submission deadline 15 Apr 2026 | Viewed by 72 | Submission Open

Keywords: gynecology; women's health; mini-invasive surgery; laparoscopy; hysteroscopy; diagnostic imaging; gynecological oncology; endometriosis; new therapy; urogynecology; female healthcare

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiac Amyloidosis and Heart Failure: Clinical Pathophysiology, Diagnosis, and Therapeutic Strategies

edited by Ilaria Dentamaro and

Laura Fusini

submission deadline 15 Apr 2026 | Viewed by 61 | Submission Open

Keywords: cardiology; cardiac heart failure; cardiac amyloidosis; cardiac imaging; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Advances in Antiplatelet Therapy After Cardiovascular Surgery

edited by

Marek T. Tomala

submission deadline 15 Apr 2026 | Viewed by 54 | Submission Open

Keywords: antiplatelet therapy; cardiac surgery; P2Y12 inhibitors; platelet function testing; dual antiplatelet therapy (DAPT); perioperative management; bleeding risk stratification

(This special issue belongs to the Section Cardiovascular Medicine)

Updates and Advances in Aplastic Anemia and Other Bone Marrow Failures

edited by

Alicia Rovo

, Beatrice Drexler and Olaia Naveiras

submission deadline 15 Apr 2026 | Viewed by 53 | Submission Open

Keywords: aplastic anemia; severe aplastic anemia (SAA); bone marrow failures; paroxysmal nocturnal hemoglobinuria (PNH); inherited bone marrow failures

(This special issue belongs to the Section Hematology)

Heart Transplantation: Surgery Updates and Complications

edited by Nicola Pradegan

submission deadline 15 Apr 2026 | Viewed by 52 | Submission Open

Keywords: donor heart optimization; antibody-mediated rejection; graft function monitoring; ventricular assist device bridging; post-transplant surveillance

(This special issue belongs to the Section Cardiology)

Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery: 2nd Edition

edited by

Konstantinos Chaidas

submission deadline 15 Apr 2026 | Viewed by 51 | Submission Open

Keywords: otorhinolaryngology; head and neck; innovation; diagnosis; treatment; surgery

(This special issue belongs to the Section Otolaryngology)

Retinal Diseases: Emerging Therapies and Vision Rehabilitation

edited by

Hisanori Imai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 48 | Submission Open

Keywords: vitreoretinal disorder; vitrectomy; digital assisted vitrectomy; intraoperative optical coherence tomography; diabetic retinopathy; epiretinal membrane

(This special issue belongs to the Section Ophthalmology)

Hepato-Pancreato-Biliary Surgery in the Era of Immunotherapy

edited by Niv Pencovich

submission deadline 15 Apr 2026 | Viewed by 47 | Submission Open

Keywords: hepatobiliary surgery; immunotherapy; pancreatic and liver cancer; conversion surgery; immune checkpoint inhibitors

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Most Advanced Therapeutic Agents Redefining Neurological Health

edited by Clarissa Fantin Cavarsan

submission deadline 15 Apr 2026 | Viewed by 40 | Submission Open

Keywords: disease-modifying therapy; biomarker-guided treatment; gene therapy; neuroprotection; clinical trials; neurological disorders; precision neurology

(This special issue belongs to the Section Clinical Neurology)

Prenatal Diagnosis and Intervention: Shaping the Future of Maternal–Fetal Medicine

edited by

Misgav Rottenstreich

submission deadline 15 Apr 2026 | Viewed by 39 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Pharmacotherapy and Patient Care in Rheumatoid Arthritis

edited by