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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Updates on Geriatric Oncology
edited by Cherif N. Boutros
submission deadline 12 Dec 2025 | Viewed by 21 | Submission Open
Keywords: geriatric oncology; cancer in elderly; geriatric cancer care; frailty; access to cancer care
(This special issue belongs to the Section Geriatric Medicine)
Cataract and Refractive Surgery and Intraocular Lens Implantation: Clinical Advances and Perspectives
edited by Janusz Skrzypecki
submission deadline 15 Dec 2025 | Viewed by 427 | Submission Open
Keywords: cataract surgery; intraocular lens power calculation; intraocular lenses; EDoF IOL; multifocal IOL; monofocal IOL; laser refractive surgery
(This special issue belongs to the Section Ophthalmology)
Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life: 2nd Edition submission deadline 15 Dec 2025 | Viewed by 247 | Submission Open
Keywords: gynecological cancers; e.g.; endometrial; cervical; ovarian; and vulvar cancer; urogenital tract cancers in men; e.g.; bladder; prostate; penis; and testicular cancer; gastrointestinal cancers; complications of oncological treatment; e.g.; pelvic floor disfunction: incontinence and POP; patients’ quality of life and possibilities of its improvement; oncofertility; physiotherapy; oncology treatment (modern surgical approach; including robotics; chemotherapy; radiotherapy; immunotherapy; targeted therapy); biological basis of pathogenesis and cancer progression; biological markers; anticancer agents; cancer prophylaxis and prevention— current trends and opportunities
(This special issue belongs to the Section Oncology)
Advances in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 15 Dec 2025 | Viewed by 83 | Submission Open
Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine
(This special issue belongs to the Section Ophthalmology)
Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors
edited by Eleni T. Timotheadou and Emmanouil Saloustros
submission deadline 15 Dec 2025 | Viewed by 69 | Submission Open
Keywords: ovarian; endometrial; cervical; chemotherapy; immunotherapy; primary debulking surgery; interval debulking; fertility-sparing surgery; PARP inhibitors; radiotherapy; HIPEC; sex cord tumors; dysgerminoma; leiomyosarcoma; liquid biopsies; circulating tumor cells; ctDNA
(This special issue belongs to the Section Obstetrics & Gynecology)
Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle: 2nd Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 41 | Submission Open
Keywords: male sexual dysfunction; reproductive health; erectile dysfunction; premature ejaculation; infertility; epidemiology; causes; diagnosis; treatments; environmental factors; lifestyle
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition
edited by Senthil Sambandam
submission deadline 15 Dec 2025 | Viewed by 40 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement
(This special issue belongs to the Section Orthopedics)
New Clinical Advances in Pediatric Asthma
edited by
submission deadline 15 Dec 2025 | Viewed by 38 | Submission Open
Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Advancements in Intraocular Lens Power Calculation Methods
edited by and Thomas Kohnen
submission deadline 15 Dec 2025 | Viewed by 34 | Submission Open
Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment
edited by Massimiliano Mariani
submission deadline 15 Dec 2025 | Viewed by 33 | Submission Open
Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies
(This special issue belongs to the Section Cardiology)
Key Advances in the Treatment of the Critically Ill: 3rd Edition submission deadline 15 Dec 2025 | Viewed by 32 | Submission Open
Keywords: respiration; artificial; prone position; respiratory distress syndrome; respiratory insufficiency; heart arrest; hypothermia; induced; amiodarone; vasopressins; steroids; epinephrine; multiple trauma; wounds and injuries; tranexamic acid; sepsis; anti-bacterial agents; COVID-19; COVID-19 vaccines; COVID-19 breakthrough infections; COVID-19 drug treatment; extracorporeal membrane oxygenation
(This special issue belongs to the Section Intensive Care)
Clinical Advances in Cardio-Rheumatology submission deadline 15 Dec 2025 | Viewed by 29 | Submission Open
Keywords: cardio-rheumatology; autoimmune diseases; cardiac imaging; cardiovascular disease; autoimmune rheumatic diseases
(This special issue belongs to the Section Cardiology)
Latest Advances in Pediatric Surgery
edited by Francesco Macchini and Andrea Zanini
submission deadline 15 Dec 2025 | Viewed by 25 | Submission Open
Keywords: pediatric surgery; innovations; fluorescence-guided surgery; pediatric robotic surgery; minimally invasive surgery
(This special issue belongs to the Section General Surgery)
Novel Prognostic Risk Factors in Acute Coronary Syndrome submission deadline 15 Dec 2025 | Viewed by 24 | Submission Open
Keywords: acute coronary syndrome; risk stratification; biomarkers; cardiovascular imaging; inflammation; genetics; heart– kidney interaction; cardio-pulmonary complications; neurological dysfunction; precision medicine
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: Current Practice and Future Directions: 2nd Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 23 | Submission Open
Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS
(This special issue belongs to the Section Respiratory Medicine)
Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies
edited by Claus Schildberg and Frank Meyer
submission deadline 15 Dec 2025 | Viewed by 22 | Submission Open
Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Emergency Surgery: Clinical Updates and New Perspectives
edited by
submission deadline 15 Dec 2025 | Viewed by 19 | Submission Open
Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach
(This special issue belongs to the Section Emergency Medicine)
New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases: 2nd Edition submission deadline 15 Dec 2025 | Viewed by 18 | Submission Open
Keywords: therapeutic drug monitoring; inflammatory bowel diseases; immune mediated inflammatory diseases; pharmacokinetics; anti-TNF; vedolizumab; ustekinumab; risankizumab; point-of-care assays; model informed precision dosing
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders
edited by Natalia Motas and Veronica Manolache
submission deadline 17 Dec 2025 | Viewed by 24 | Submission Open
Keywords: lung cancer; minimally invasive thoracic surgery (MITS); video-assisted thoracoscopic surgery (VATS); robot-assisted thoracic surgery (RATS); interventional pneumology; bronchoscopy; endobronchial ultrasound (EBUS); artificial intelligence (AI); lung nodule
(This special issue belongs to the Section Respiratory Medicine)
Recent Advances in Transcatheter Aortic Valve Replacement: Second Edition
edited by and Maciej Dąbrowski
submission deadline 18 Dec 2025 | Viewed by 39 | Submission Open
Keywords: aortic stenosis; transcatheter; bioprosthesis; TAVI; transcatheter aortic valve replacement
(This special issue belongs to the Section Cardiovascular Medicine)
Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation submission deadline 19 Dec 2025 | 1 articles | Viewed by 206 | Submission Open
Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa
(This special issue belongs to the Section Ophthalmology)
Updates on the Clinical Applications of Dental Restorative Materials
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 269 | Submission Open
Keywords: restorative dentistry; restorations; adhesive dentistry; resin composites; ceramics; aesthetics; dental materials; direct restorations; indirect restorations; conservative dentistry; prosthetic dentistry; partial restorations; total restorations
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights submission deadline 20 Dec 2025 | Viewed by 111 | Submission Open
Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors
(This special issue belongs to the Section Clinical Rehabilitation)
Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition) submission deadline 20 Dec 2025 | Viewed by 105 | Submission Open
Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Anesthesia and Intensive Care in Orthopedic and Trauma Surgery
edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi
submission deadline 20 Dec 2025 | Viewed by 102 | Submission Open
Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium
(This special issue belongs to the Section Intensive Care)
New Clinical Advances in Breast Reconstruction
edited by
submission deadline 20 Dec 2025 | Viewed by 64 | Submission Open
Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Key Challenges in Heart Transplantation and Their Solutions
edited by Elizabeth J. Maynes
submission deadline 20 Dec 2025 | Viewed by 53 | Submission Open
Keywords: heart transplantation; heart failure; cardiac surgery; minimally invasive techniques; general surgery; heart diseases
(This special issue belongs to the Section Cardiology)
Current and Emerging Treatment Options in Intestinal and Stomach Neoplasms submission deadline 20 Dec 2025 | Viewed by 43 | Submission Open
Keywords: colorectal cancer; colon cancer; gastric carcinoma; malignancy; gastroenterology; endoscopic techniques; therapeutic advancements; intestinal neoplasms
(This special issue belongs to the Section Oncology)
Clinical Innovations in Dental Implant: Expanding Possibilities for Oral Rehabilitation
edited by Marco Severino
submission deadline 20 Dec 2025 | Viewed by 42 | Submission Open
Keywords: dental implants; oral rehabilitation; computer-guided surgery; biocompatibility; regenerative treatments; mini-implants; minimally invasive surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Status, Application and Future Directions of Artificial Urinary Sphincters
edited by JiSung Shim
submission deadline 20 Dec 2025 | Viewed by 40 | Submission Open
Keywords: ISD; robot surgery; neurogenic SUI; female AUS; complication; erosion; urethroplasty; malfunction; PPI; BOO
(This special issue belongs to the Section Nephrology & Urology)
Surgical Oncology: Clinical Application of Translational Medicine
edited by Domenico Parmeggiani
submission deadline 20 Dec 2025 | Viewed by 32 | Submission Open
Keywords: surgical oncology; drug safety; adverse events; nanovesicles; targeted drug delivery; cancer biomarkers; precision oncology; tumor microenvironment; nanomedicine; personalized medicine; diagnostics; prognosis; innovative therapies; translational research
(This special issue belongs to the Section Oncology)
Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice
edited by
submission deadline 20 Dec 2025 | Viewed by 31 | Submission Open
Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse
(This special issue belongs to the Section Cardiology)
New Perspectives in Maternal–Fetal Medicine
edited by Catalina de Paco-Matallana
submission deadline 20 Dec 2025 | Viewed by 30 | Submission Open
Keywords: maternal– fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Research and Insights in Endometriosis submission deadline 20 Dec 2025 | Viewed by 30 | Submission Open
Keywords: endometriosis; pelvic pain; infertility; inflammation; minimal access surgery; laparoscopy; hysteroscopy; robotics
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Lung Transplantation and Interventional Pulmonology
edited by Anupam Kumar and Frye Laura
submission deadline 20 Dec 2025 | Viewed by 29 | Submission Open
Keywords: lung transplantation; interventional pulmonology; immunosuppressive therapies; organ rejection; pulmonary rehabilitation; surgical innovations; post-transplant complications; diagnostic advancements; donor lung shortage; thoracic surgery
(This special issue belongs to the Section Respiratory Medicine)
Elevating Standards in Anesthesia Monitoring
edited by
submission deadline 20 Dec 2025 | Viewed by 27 | Submission Open
Keywords: monitoring; analgesia; pain; nociception; awareness anesthesia; postoperative delirium; closed-loop anes-thesia; artificial intelligence
(This special issue belongs to the Section Anesthesiology)
Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes
edited by Thomas Mokrusch and Frank Kirchhoff
submission deadline 20 Dec 2025 | Viewed by 25 | Submission Open
Keywords: neurorehabilitation; therapeutic approaches; repair mechanism; plasticity; neurology
(This special issue belongs to the Section Clinical Neurology)
Risk Factors in Neonatal Intensive Care submission deadline 20 Dec 2025 | Viewed by 25 | Submission Open
Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity
(This special issue belongs to the Section Clinical Pediatrics)
Advances in Periodontitis and Other Periodontal Diseases
edited by
submission deadline 20 Dec 2025 | Viewed by 24 | Submission Open
Keywords: periodontal diseases; gingivitis; periodontitis; systemic disease; classification
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management of Bladder Cancer
edited by , Antonio Cicione and
submission deadline 20 Dec 2025 | Viewed by 22 | Submission Open
Keywords: bladder cancer; minimally invasive surgery; immunotherapy; targeted therapy; biomarkers; imaging techniques; muscle invasive bladder cancer; non-muscle-invasive bladder cancer
(This special issue belongs to the Section Nephrology & Urology)
Clinical Perspectives of Vascular and Endovascular Surgeries submission deadline 20 Dec 2025 | Viewed by 21 | Submission Open
Keywords: vascular surgery; varicose veins; abdominal aortic aneurysms; carotid disease; peripheral arterial disease
(This special issue belongs to the Section Vascular Medicine)
The Treatment of BPO with Minimal Invasive Approach
edited by
submission deadline 20 Dec 2025 | Viewed by 21 | Submission Open
Keywords: benign prostatic obstruction (BPO); prostatectomy; non-muscle invasive bladder cancer; muscle invasive bladder cancer; robotic surgery
(This special issue belongs to the Section Nephrology & Urology)
Recent Developments in Urinary Incontinence
edited by
submission deadline 20 Dec 2025 | Viewed by 20 | Submission Open
Keywords: urinary incontinence; overactive bladder; stress urinary incontinence; pelvic floor dysfunction; urodynamics; minimally invasive treatment; neuromodulation; regenerative medicine; conservative management; digital health in urology
(This special issue belongs to the Section Nephrology & Urology)
Laparoscopy and Surgery in Gynecologic Oncology: 2nd Edition
edited by Zoltan Novak
submission deadline 20 Dec 2025 | Viewed by 17 | Submission Open
Keywords: gynecologic cancers; ovarian; uterine; cervical; laparoscopy; diagnosis; staging; treatment; palliative care; fertility preservation
(This special issue belongs to the Section Obstetrics & Gynecology)
Hospital-Acquired Infections: Insights, Prevention, and Control Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 16 | Submission Open
Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department
(This special issue belongs to the Section Epidemiology & Public Health)
New Insights in Maxillofacial Surgery
edited by
submission deadline 20 Dec 2025 | Viewed by 15 | Submission Open
Keywords: maxillofacial surgery; surgical techniques; imaging technologies; biomaterials; regenerative medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Clinical Management of Temporomandibular Joint Diseases submission deadline 20 Dec 2025 | Viewed by 8 | Submission Open
Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Gastric Cancer: Epidemiology, Clinical Management and Emerging Biomarkers submission deadline 20 Dec 2025 | Submission Open
Keywords: gastric cancer; metabolism; biomarkers; surgical stress; adjuvant therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Scoliosis: Advances in Diagnosis and Management
edited by Michal Latalski
submission deadline 22 Dec 2025 | Viewed by 101 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life
(This special issue belongs to the Section Orthopedics)
Oral Surgery: Recent Advances and Future Perspectives submission deadline 22 Dec 2025 | Viewed by 34 | Submission Open
Keywords: oral surgery; implant dentistry; atrophic jaws; bone regeneration; digital dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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