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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research
edited by , Arnaud Wattiez and
submission deadline 20 Feb 2026 | Viewed by 147 | Submission Open
Keywords: endometriosis; guidelines; surgery; medical treatment; training; heuristics
(This special issue belongs to the Section Clinical Guidelines)
Current Advances and Future Perspectives of Ischemic Stroke
edited by
submission deadline 20 Feb 2026 | Viewed by 95 | Submission Open
Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood– brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke
(This special issue belongs to the Section Clinical Neurology)
Maxillofacial Surgery in the Modern Era: Surgical Advances and Clinical Innovation submission deadline 20 Feb 2026 | Viewed by 88 | Submission Open
Keywords: maxillofacial surgery; oral surgery; craniofacial surgery; plastic surgery; bone
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Minimally Invasive Surgery for Gastrointestinal Disorder submission deadline 20 Feb 2026 | Viewed by 78 | Submission Open
Keywords: minimally invasive surgery; gastrointestinal disorder; laparoscopy; robotic surgery; colorectal surgery; gastric surgery; endoscopic technique; oncological outcomes; surgical innovation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation
edited by
submission deadline 20 Feb 2026 | Viewed by 73 | Submission Open
Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation
(This special issue belongs to the Section Orthopedics)
Current Challenges and Innovations in Emergency Medicine: From Prehospital Care to Critical Decision-Making in the Emergency Department
edited by Efstratios Karagiannidis, Barbara P. Fyntanidou and Aikaterini Apostolopoulou
submission deadline 20 Feb 2026 | Viewed by 69 | Submission Open
Keywords: emergency medicine; prehospital care; triage strategies; acute care; point-of-care diagnostics; artificial intelligence; telemedicine; emergency department; patient flow; healthcare systems; burnout in emergency care
(This special issue belongs to the Section Emergency Medicine)
Current Trends and Future Challenges in Percutaneous Coronary Intervention
edited by Deniz Mutlu
submission deadline 20 Feb 2026 | Viewed by 68 | Submission Open
Keywords: PCI; IVUS; OCT; FFR; physiology; CT-guided PCI; complex PCI; CTO; bifurcation; coronary complications; mechanical circulatory support
(This special issue belongs to the Section Cardiovascular Medicine)
Advances and Innovations in Radiology: From Contrast-Enhanced Mammography to Artificial Intelligence and Beyond
edited by
submission deadline 20 Feb 2026 | Viewed by 68 | Submission Open
Keywords: contrast-enhanced mammography (CEM); artificial intelligence; radiomics; diagnostic imaging innovations; inter-ventional radiology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Cancer Immunotherapy: Recent Advances and Clinical Challenges
edited by
submission deadline 20 Feb 2026 | Viewed by 67 | Submission Open
Keywords: immune checkpoint inhibitors; solid tumors; early-stage disease; metastatic disease; prognostic factors; biomarkers; resistance mechanisms
(This special issue belongs to the Section Oncology)
Endocrine Disorders in Children: 2nd Edition submission deadline 20 Feb 2026 | Viewed by 65 | Submission Open
Keywords: endocrinology; pediatrics; hormones; genetics; growth; nutrition; development  ; adolescence  ; prevention
(This special issue belongs to the Section Clinical Pediatrics)
Myocarditis and Pericarditis: Clinical Advances and Current Challenges submission deadline 20 Feb 2026 | Viewed by 63 | Submission Open
Keywords: pericarditis; myocarditis; pericardial effusion; cardiac tamponade; interleukin-1 inhibitors; pericardium
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Updates on Acromegaly
edited by , Jowita Halupczok-Żyła, Aleksandra Gilis-Januszewska and Przemysław Witek
submission deadline 20 Feb 2026 | Viewed by 63 | Submission Open
Keywords: acromegaly; GH; IGH-1; growth hormone-secreting pituitary adenoma; pituitary adenoma
(This special issue belongs to the Section Endocrinology & Metabolism)
Rheumatoid Arthritis: Insights into Appropriate Diagnosis, Treatment and Management
edited by
submission deadline 20 Feb 2026 | Viewed by 61 | Submission Open
Keywords: rheumatoid arthritis; precision medicine; difficult-to-treat rheumatoid arthritis; late-onset rheumatoid arthritis; ageing society; comorbidities
(This special issue belongs to the Section Immunology)
Clinical Translation of Technological Innovations in Diabetes Therapeutics
edited by
submission deadline 20 Feb 2026 | Viewed by 60 | Submission Open
Keywords: diabetes management; remote patient monitoring (RPM); artificial intelligence (AI); machine learning (ML); wearable sensors; point-of-care diagnostics; centrifugal microfluidics; glucose monitoring
(This special issue belongs to the Section Endocrinology & Metabolism)
Recent Advances and Future Perspectives on Spinal Surgeries
edited by
submission deadline 20 Feb 2026 | Viewed by 58 | Submission Open
Keywords: minimally invasive spine procedures; robotic-assisted spine surgery; image-guided navigation; spinal implants and biomaterials; artificial intelligence in spinal care; regenerative spine therapies; clinical outcomes in spine surgery; future trends in spinal interventions
(This special issue belongs to the Section Orthopedics)
Advances in the Diagnosis and Management of Atherosclerosis submission deadline 20 Feb 2026 | Viewed by 57 | Submission Open
Keywords: atherosclerosis; cardiovascular disease; coronary artery disease; endothelial function; acute coronary syndromes
(This special issue belongs to the Section Cardiology)
Advances and Updates in Migraine
edited by and Carl H. Göbel
submission deadline 20 Feb 2026 | Viewed by 56 | Submission Open
Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research
(This special issue belongs to the Section Clinical Neurology)
New Insights into Orthodontic Treatment
edited by Federico Brugnami and Simonetta Meuli
submission deadline 20 Feb 2026 | Viewed by 56 | Submission Open
Keywords: digital orthodontics; clear aligners; artificial intelligence; digital superimpositions; cone beam computed tomography; growing patients; periodontal patients; maxillofacial surgery; long-term stability; prediction of orthodontic movements
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Intrarenal Surgery for Kidney Stones and Other Kidney Diseases
edited by Razvan Multescu
submission deadline 20 Feb 2026 | Viewed by 55 | Submission Open
Keywords: intrarenal surgery; flexible ureteroscopy; percutaneous nephrolithotomy (PCNL); Mini-PCNL; thulium laser; ureteral access sheaths; flexible and navigable suction (FANS); upper urinary tract urothelial tumors
(This special issue belongs to the Section Nephrology & Urology)
Age-Related Macular Degeneration: Challenges and Opportunities
edited by Deepayan Kar
submission deadline 20 Feb 2026 | Viewed by 55 | Submission Open
Keywords: age-related macular degeneration; imaging biomarkers; visual function testing; optical coherence tomography; anti-VEGF; complement; artificial intelligence
(This special issue belongs to the Section Ophthalmology)
Advances in Posttraumatic Stress Disorder (PTSD): Clinical Update
edited by An-Fu Hsiao and
submission deadline 20 Feb 2026 | Viewed by 54 | Submission Open
Keywords: PTSD; stellate ganglion block; transcranial magnetic stimulations; neurobiology; trauma disorders; mind– body medicine; psychophysiology
(This special issue belongs to the Section Mental Health)
Treatment and Long-Term Outcome of Fracture
edited by Corrado Ciatti, and Fabrizio Quattrini
submission deadline 20 Feb 2026 | Viewed by 53 | Submission Open
Keywords: traumatology; osteosynthesis; plating; nailing; osteosynthesis devices; surgical technique; approach
(This special issue belongs to the Section Orthopedics)
Novel Research in Pediatric Dentistry: 2nd Edition
edited by Christian Hirsch and
submission deadline 20 Feb 2026 | Viewed by 52 | Submission Open
Keywords: early childhood caries; primary teeth; caries prevention; caries treatment; behavioral management; molar incisor hypomineralization; dental trauma; sedation; oral health-related quality of life
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain submission deadline 20 Feb 2026 | Viewed by 52 | Submission Open
Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain
(This special issue belongs to the Section Orthopedics)
Metastatic Colorectal Cancer Beyond Second-Line Treatment
edited by Jacopo Giuliani
submission deadline 20 Feb 2026 | Viewed by 50 | Submission Open
Keywords: metastatic colorectal cancer; subsequent lines; chemotherapy; targeted agents; radiotherapy; local therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Diagnosis and Treatment of Gastrointestinal Malignancies
edited by and Gianmauro Numico
submission deadline 20 Feb 2026 | Viewed by 50 | Submission Open
Keywords: gastrointestinal cancers; immunotherapy; targeted therapy; chemotherapy; microsatellite instability; driver mutations
(This special issue belongs to the Section Oncology)
Endoscopic Imaging for the Diagnosis and Treatment of Gastrointestinal Diseases
edited by Mariana Jinga and
submission deadline 20 Feb 2026 | Viewed by 49 | Submission Open
Keywords: endoscopy; endoscopic ultrasound; endoscopic retrograde cholangiopancreatography; artificial intelligence; diagnosis; therapy; decision making; endobiopsy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Insights and Emerging Strategies in Chronic Pain Management
edited by
submission deadline 20 Feb 2026 | Viewed by 48 | Submission Open
Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care
(This special issue belongs to the Section Anesthesiology)
Optimizing Rehabilitation in Kidney Disease
edited by Henry H. L. Wu and Rajkumar Chinnadurai
submission deadline 20 Feb 2026 | Viewed by 47 | Submission Open
Keywords: chronic kidney disease; renal rehabilitation; exercise intervention; nutrition; multidisciplinary; frailty; physical conditioning
(This special issue belongs to the Section Clinical Rehabilitation)
Novel Developments in Digestive Endoscopy
edited by
submission deadline 20 Feb 2026 | Viewed by 47 | Submission Open
Keywords: endoscopy for IBD; AI in endoscopy; therapeutic endoscopy; EUS; interventional EUS; AI in digestive endoscopy; quality in endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Hypercholesterolemia: Update on Treatment Approaches and Outcomes
edited by and Lucia Barbieri
submission deadline 20 Feb 2026 | Viewed by 45 | Submission Open
Keywords: hypercholesterolemia; dyslipidemia; atherosclerosis; cardiovascular risk; LDL; HDL; lipoprotein(a)
(This special issue belongs to the Section Cardiovascular Medicine)
Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition submission deadline 20 Feb 2026 | Viewed by 45 | Submission Open
Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis
(This special issue belongs to the Section Hematology)
Progress and Innovation in the Clinical Management of Psychosis
edited by
submission deadline 20 Feb 2026 | Viewed by 45 | Submission Open
Keywords: psychosis; schizophrenia; clinical interventions; neurobiological mechanisms; early intervention
(This special issue belongs to the Section Mental Health)
Recent Advances in Gynecologic Surgery
edited by Adam Ostrzenski
submission deadline 20 Feb 2026 | Viewed by 44 | Submission Open
Keywords: gynecologic surgery; pelvic reconstruction surgery; female stress urinary incontinence surgery; cosmetic gynecology surgery; surgical meshes slings; native tissue
(This special issue belongs to the Section Obstetrics & Gynecology)
Innovations and Challenges in the Burden and Rehabilitation of Musculoskeletal Disorders submission deadline 20 Feb 2026 | Viewed by 44 | Submission Open
Keywords: musculoskeletal diseases; rehabilitation; physical therapy modalities; telemedicine; mobile applications; health information technology; patient-centered care; quality of life; health care innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Innovative Approaches to the Challenges of Neurodegenerative Disease
edited by Brian T. Bicknell and
submission deadline 20 Feb 2026 | Viewed by 44 | Submission Open
Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation
edited by Adriano Pellicelli
submission deadline 20 Feb 2026 | Viewed by 42 | Submission Open
Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Breast Cancer: Symptoms, Types, Causes & Treatment
edited by Min-Jeong Cho and Sara Myers
submission deadline 20 Feb 2026 | Viewed by 41 | Submission Open
Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies
(This special issue belongs to the Section Obstetrics & Gynecology)
New Insights in Cognitive Aging and Mild Cognitive Impairment submission deadline 20 Feb 2026 | Viewed by 39 | Submission Open
Keywords: cognitive aging; mild cognitive impairment; normative aging; neuropsychological assessment; diagnosis; gerontology; prevention; intervention; multidisciplinary approach; measurement
(This special issue belongs to the Section Geriatric Medicine)
Clinical Advances in Meningioma Surgery
edited by
submission deadline 20 Feb 2026 | Viewed by 39 | Submission Open
Keywords: meningioma; cranial neurosurgery; brain tumors; skull base surgery; endoscopic neurosurgery; intraoperative techniques; surgical outcomes; minimally invasive neurosurgery; perioperative management; clinical meningioma research
(This special issue belongs to the Section Clinical Neurology)
Diagnosis and Treatment of Cardiovascular Diseases in the Elderly submission deadline 20 Feb 2026 | Viewed by 39 | Submission Open
Keywords: cardiovascular diseases; elderly population; diagnosis and management; age-related pathophysiology; frailty and cognitive impairment
(This special issue belongs to the Section Geriatric Medicine)
Rising Star: Advanced Physical Therapy and Expansion
edited by
submission deadline 20 Feb 2026 | Viewed by 37 | Submission Open
Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach
(This special issue belongs to the Section Clinical Rehabilitation)
Bleeding and Thrombotic Complications in Patients with Premalignant Hematologic Conditions: Diagnostic and Therapeutic Challenges
edited by Vasiliki Gkalea and Despina Fotiou
submission deadline 20 Feb 2026 | Viewed by 37 | Submission Open
Keywords: bleeding; thrombosis; hematologic malignancies; premalignant hematologic conditions; clonal hematopoiesis of indeterminate potential (CHIP); clonal cytopenias of undetermined significance (CCUS); monoclonal gammopathy of undetermined significance (MGUS); monoclonal B-cell lymphocytosis (MBL); monoclonal gammopathy of thrombotic significance (MGTS); VITT-like MGTS
(This special issue belongs to the Section Hematology)
Advances in the Personalized Management of Chronic Obstructive Pulmonary Disease (COPD)
edited by and Georgios Hillas
submission deadline 20 Feb 2026 | Viewed by 37 | Submission Open
Keywords: artificial intelligence; biologics; biomarkers; diagnostics; oscillometry; COPD pharmacotherapy; imaging
(This special issue belongs to the Section Respiratory Medicine)
Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies submission deadline 20 Feb 2026 | Viewed by 35 | Submission Open
Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT
(This special issue belongs to the Section Cardiology)
New Insights into Management of Chronic Rhinosinusitis submission deadline 20 Feb 2026 | Viewed by 32 | Submission Open
Keywords: chronic rhinosinusitis; management; surgery; minimally invasive surgery; surgical oncology; cancer surgery; skull base surgery; hoarseness; laryngeal neoplasms; laryngoscopy; general surgery; X-ray computed tomography
(This special issue belongs to the Section Otolaryngology)
Clinical Advances in Sepsis and Septic Shock
edited by and Lorenzo Ghiadoni
submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open
Keywords: sepsis-induced coagulopathy; endothelial dysfunction in sepsis; fluid balance in sepsis
(This special issue belongs to the Section Emergency Medicine)
Clinical Advances in Head and Neck Cancer Diagnostics and Treatment
edited by and Alice L. Tang
submission deadline 20 Feb 2026 | Viewed by 12 | Submission Open
Keywords: head and neck; reconstruction; free flap; surgical margin; biomarker; human papillomavirus (HPV); extranodal extension; immunotherapy; virtual surgical planning
(This special issue belongs to the Section Otolaryngology)
Current and Emerging Treatment Options for Aortic Aneurysms
edited by Spyros Ioannis Papadoulas and
submission deadline 24 Feb 2026 | Viewed by 66 | Submission Open
Keywords: thoracic aortic aneurysms; abdominal aortic aneurysm; vascular surgery; cardiac surgery; treatment
(This special issue belongs to the Section Vascular Medicine)
Knee Arthroplasty Surgery: Management and Future Opportunities: 2nd Edition submission deadline 25 Feb 2026 | 3 articles | Viewed by 2831 | Submission Open
Keywords: knee; knee replacement; knee arthroplasty; knee alignment technique; robotic knee arthroplasty
(This special issue belongs to the Section Orthopedics)
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