Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management

Dear Colleagues, 

This Special Issue aims to provide an updated overview of root canal treatment (RCT) outcomes with a focus on the clinical application of endodontic biomaterials and postoperative management. Despite recent advances in bioceramic sealers and other innovative materials, important questions remain unresolved: which biomaterials ensure predictable long-term healing? What postoperative strategies minimize complications and pain? How do systemic conditions affect treatment outcomes?

The scope of this Special Issue includes original clinical studies, randomized controlled trials, cohort studies, as well as systematic reviews addressing the effectiveness of endodontic biomaterials and sealers. Contributions on radiographic and clinical healing outcomes, biological mechanisms of periapical repair, and postoperative protocols for pain control, infection prevention, and patient follow-up are particularly welcome.

We invite clinicians, endodontists, and researchers in clinical biomaterials to submit their work. Through an interdisciplinary approach, this Special Issue aims to generate high-quality clinical evidence and promote evidence-based approaches to improve healing outcomes of patients undergoing root canal therapy.

Dr. Fausto Zamparini
Prof. Dr. Carlo Prati
Dr. Andrea Spinelli
Guest Editors

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