Clinical Advances and Prospects in Gynecologic Oncology Surgery

Dear Colleagues,

Gynecologic malignancies, including mainly but not exclusively endometrial, cervical, and ovarian cancer, represent a significant global health burden that is responsible for significant morbidity and mortality worldwide. Surgical management remains a cornerstone of treatment, playing a critical role in staging, cytoreduction, and overall disease control. In recent years, rapid technological innovation, evolving perioperative care pathways, and the integration of molecular diagnostics have transformed the landscape of gynecologic oncology surgery. These developments present both opportunities and challenges for clinicians trying to optimize oncologic outcomes while minimizing treatment-related morbidity.

Globally, there is increasing emphasis on individualized treatment strategies through multidisciplinary teams in oncology, value-based care, and the reduction in surgical complications. The implementation of structured perioperative pathways, the application of minimally invasive techniques, and the incorporation of molecular tumor profiling into clinical decision-making are reshaping surgical standards. As evidence continues to evolve, it is essential to critically evaluate emerging data and define best practices that bridge research findings with everyday clinical application.

This Special Issue aims to present and disseminate the most recent advances related to surgical innovation, perioperative optimization, and precision-based approaches in gynecologic oncology. We consider contributions addressing clinical and oncological outcomes, innovative research, and evidence-based surgical strategies that improve patient care and support informed decision-making in modern gynecologic oncology practice.

Topics of interest for publication include, but are not limited to, the following:

• Implementation and clinical outcomes of Enhanced Recovery After Surgery (ERAS) protocols in gynecologic oncology;
• Sentinel lymph node mapping: indications, techniques, accuracy, and oncologic safety;
• Minimally invasive surgery (laparoscopy and robotic-assisted surgery) in gynecologic malignancies: perioperative and long-term outcomes;
• Molecular profiling and tumor classification and their impact on surgical planning and treatment individualization;
• Patient selection criteria in surgical management of advanced-stage disease.

Through a multidisciplinary and evidence-based perspective, this Special Issue seeks to contribute to the advancement of surgical standards and the development of personalized therapeutic strategies in gynecologic oncology.

Prof. Dr. Alexandros Daponte
Dr. George Delinasios
Guest Editors

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• gynecologic oncology
• ERAS pathways
• ERAS protocols
• sentinel lymph node
• laparoscopy
• robotic surgery
• molecular profiling
• multidisciplinary team