Recent Advances in Hypercholesterolemia

Dear Colleagues,

Hypercholesterolemia remains a major global contributor to atherosclerotic cardiovascular disease, yet significant gaps persist in early detection, molecular diagnosis, and personalised therapeutic management. Although substantial progress has been made in understanding the genetic architecture of conditions such as familial hypercholesterolemia (FH), challenges remain in the interpretation of variants of uncertain significance (VUS), in predicting treatment response, and in integrating genomic data into routine clinical care. New advances in genetic testing, functional characterisation, biomarker discovery, and targeted lipid-lowering strategies are rapidly transforming the field and offer opportunities for more precise risk stratification and management.

This Special Issue, “Recent Advances in Hypercholesterolemia”, aims to highlight cutting-edge research addressing these unmet needs. It welcomes contributions spanning clinical genetics, functional studies, epidemiology, implementation science, and precision-medicine approaches to lipid disorders. By bringing together multidisciplinary evidence and novel methodologies, this Special Issue seeks to advance the understanding of disease mechanisms, improve diagnostic accuracy, and support more effective and individualised therapy.

We invite researchers and clinicians to contribute original studies and reviews that will help shape the future of hypercholesterolemia research and patient care.

Dr. Ana Catarina Alves
Guest Editor

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