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Therapeutic Advances and Emerging Treatments in Inflammatory Bowel Disease

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (20 August 2026) | Viewed by 305

Editor


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Guest Editor
IBD Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Interests: inflammatory bowel disease; ulcerative colitis; Crohn's disease; clinical gastroenterology

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming article series entitled “Therapeutic Advances and Emerging Treatments in Inflammatory Bowel Disease.” This collection aims to provide a comprehensive and up-to-date overview of the rapidly evolving therapeutic landscape in IBD, highlighting both established strategies and cutting-edge innovations. We seek high-quality manuscripts that explore topics such as novel biologics and small molecules, optimization of current therapies, precision medicine approaches, biomarkers for treatment selection, endoscopic and histologic targets, and emerging modalities, encompassing antifibrotic agents and microbiome-directed approaches. Original research, systematic or narrative reviews, clinical perspectives, and real-world evidence studies are all welcome. Our goal is to offer clinicians and researchers a reference that advances understanding and supports evidence-based decision-making in the management of ulcerative colitis and Crohn’s disease. We would be delighted to count on your expertise and scientific contribution to enrich this focused series. Please let us know if you are interested in participating.

Dr. Laura Ramos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • therapeutic advances emerging treatments
  • biologics and small molecules
  • precision medicine in IBD
  • pharmacokinetic model

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Published Papers (1 paper)

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Research

16 pages, 541 KB  
Article
Assessment of 25(OH)D Levels, Their Association with Disease Activity and Nutritional Status in Inflammatory Bowel Disease: A Cross-Sectional Comparative Study
by Małgorzata Godala, Ewelina Gaszyńska, Izabela Materek-Kuśmierkiewicz and Ewa Małecka-Wojciesko
J. Clin. Med. 2026, 15(18), 7044; https://doi.org/10.3390/jcm15187044 - 11 Sep 2026
Abstract
Background/Objectives: Vitamin D deficiency may increase the risk of IBD and be associated with disease activity. The aim of the study was to assess vitamin D levels, their association with disease activity in patients with IBD. Methods: A total of 231 subjects took [...] Read more.
Background/Objectives: Vitamin D deficiency may increase the risk of IBD and be associated with disease activity. The aim of the study was to assess vitamin D levels, their association with disease activity in patients with IBD. Methods: A total of 231 subjects took part in the cross-sectional comparative study, including 129 patients with IBD and 102 healthy individuals Disease Activity Index and the Montreal classification were used to assess disease activity in patients with CD. For patients with UC, the Partial Mayo Score and the Montreal classification were applied. To determine total 25(OH)D chemiluminescent immunoassay (CLIA) technology was used. Results: The concentration of 25(OH)D was significantly lower in the group of patients with IBD compared to the control group (25.5 ng/mL vs. 28.8 ng/mL, p = 0.0027). Differences in 25(OH)D concentrations depended on IBD activity, with significantly higher vitamin D concentrations found in patients in remission compared to those with active IBD (28.9 ± 7.2 ng/mL vs. 22.3 ± 6.1 ng/mL, p = 0.0022). This association was confirmed for both UC and CD patients. A multivariate adaptive regression model using spline curves revealed a relationship between serum 25(OH)D concentrations in patients with IBD and total dietary vitamin D intake, including vitamin D supplementation, consumption of one serving of fish per week, and disease remission. Conclusions: Serum 25(OH)D levels in IBD patients may serve as an additional, useful, and non-invasive marker of disease activity. Full article
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