Clinical Updates on Reproductive Endocrinology in Children and Adolescents

Dear Colleagues,

Reproductive endocrinology in pediatric and adolescent patients encompasses a diverse range of disorders and developmental processes spanning from birth to early adulthood. As a multidisciplinary field, it integrates aspects of assisted reproductive technologies, reproductive behavior, gonadal physiology, pubertal development, and endocrine pharmacology. Its scope is of relevance to endocrinologists, gynecologists, pediatric endocrinologists, specialists in adolescent medicine, and experts in pediatric and adolescent gynecology. This Special Issue seeks to present a comprehensive synthesis of current advances and emerging themes in reproductive endocrinology, with particular attention to evolving areas such as adolescent transgender health, the influence of the microbiome, and disorders of the adolescent male gonads.

Topics include the following:

• Primary amenorrhea;
• Secondary amenorrhea;
• Prepubertal vaginal bleeding;
• Abnormal menstrual bleeding;
• Premature ovarian failure;
• Polycystic ovary syndrome (PCOS);
• Functional hypothalamic amenorrhea;
• Congenital adrenal hyperplasia (CAH);
• Preservation of fertility in pediatric and adolescent oncology patients;
• Genetic syndromes: Turner’s, Kallman’s, Perrault’s, Mayer–Rokitansky–Küster–Hauser, and Antley–Bixler’s syndromes;
• Male hypogonadism in pediatrics and adolescents;
• Disorders of sex development;
• Adolescent gynecomastia;
• Receptor abnormalities and enzyme defects (complete androgen insensitivity syndrome, 5-a reductase deficiency, P450 oxidoreductase deficiency (PORD), and estrogen resistance);
• Adolescent contraception;
• Teen pregnancy issues;
• Transgender health.

Dr. Charikleia Stefanaki
Guest Editor

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