Bleeding and Thrombotic Complications in Patients with Premalignant Hematologic Conditions: Diagnostic and Therapeutic Challenges
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 17
Special Issue Editors
Interests: platelet biology; platelet immunology; hypercogulability; thrombosis; bleeding; disorders of hemostasis; antithrombotics
Special Issues, Collections and Topics in MDPI journals
Interests: multiple myeloma; AL amyloidosis; plasma cell dyscrasias; monoclonal gammopathies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is dedicated to highlighting recent advances and challenges in the field of thrombotic and bleeding complications in otherwise asymptomatic individuals with premalignant hematologic conditions characterized by clonal hematopoiesis of myeloid or lymphoid origin. Special focus will be given to emerging data indicating a cross-talk of hemostasis with monoclonal gammopathy of undetermined significance, monoclonal B-cell lymphocytosis, and clonal hematopoiesis.
These conditions are increasingly recognized for their association not only with progression to overt malignancy, but also with vascular complications. Recent evidence has drawn attention to newly recognized thrombogenic entities, grouped under the term monoclonal gammopathy of thrombotic significance, including VITT-like syndrome. Moreover, the link between somatic mutations in genes commonly associated with myeloid neoplasms identified in individuals without overt disease or cardiovascular risk raises important clinical questions that are currently under active debate. Bleeding risk appears to be a less recognized complication that may be overlooked in clinical practice.
This issue aims to foster dialogue between researchers and clinicians, encouraging multidisciplinary collaboration in this rapidly evolving field.
You may choose our Joint Special Issue in Hematology Reports.
Dr. Vasiliki Gkalea
Dr. Despina Fotiou
Guest Editors
Manuscript Submission Information
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Keywords
- bleeding
- thrombosis
- hematologic malignancies
- premalignant hematologic conditions
- clonal hematopoiesis of indeterminate potential (CHIP)
- clonal cytopenias of undetermined significance (CCUS)
- monoclonal gammopathy of undetermined significance (MGUS)
- monoclonal B-cell lymphocytosis (MBL)
- monoclonal gammopathy of thrombotic significance (MGTS)
- VITT-like MGTS
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