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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management and Rehabilitation of Spinal Cord Injury
edited by Tsunehiko Konomi
submission deadline 20 Aug 2025 | 11 articles | Viewed by 29091 | Submission Open
Keywords: spinal cord injury; rehabilitation; diagnosis and prognosis; comprehensive management; social support
(This special issue belongs to the Section Orthopedics)
Clinical Aspects of Return to Sport After Injuries
edited by and
submission deadline 20 Aug 2025 | 6 articles | Viewed by 22400 | Submission Open
Keywords: musculoskeletal system; tissue overload; diagnostic methods; rehabilitation; treatment; injury prevention; return to sport; rehabilitation medicine; sports medicine
(This special issue belongs to the Section Sports Medicine)
Gastrointestinal Cancer: Outcomes and Therapeutic Management
edited by Maximos Frountzas
submission deadline 20 Aug 2025 | 9 articles | Viewed by 16057 | Submission Open
Keywords: surgical oncology; gastrointestinal cancer; esophageal; gastric; hepatic; biliary; pancreatic; colon; rectal; neoplasm
(This special issue belongs to the Section Oncology)
Cardiovascular and Cerebrovascular Emergencies: Advances in Clinical Research
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 11019 | Submission Open
Keywords: cardiovascular emergencies; neurovascular emergencies; stroke; cardiac arrest; acute myocardial infarction
(This special issue belongs to the Section Cardiovascular Medicine)
Traumatic Brain Injury: Emergency Management, Prevention of Secondary Injury, and Rehabilitation
edited by and Lori Shutter
submission deadline 20 Aug 2025 | 4 articles | Viewed by 9121 | Submission Open
Keywords: traumatic brain injury; neuromonitoring; neurocritical care; neurorehabilitation; secondary injury; outcome; prognostication
(This special issue belongs to the Section Brain Injury)
New Advances in Prenatal Diagnosis and Newborn Screening submission deadline 20 Aug 2025 | 5 articles | Viewed by 6688 | Submission Open
Keywords: sonographic parameters; molecular markers; extravillous and villous trophoblasts; perinatal ultrasound; serum markers for complications of pregnancy; histopathology of the placenta; neonatal pathological conditions
(This special issue belongs to the Section Obstetrics & Gynecology)
Frailty in the Elderly: Risk Factors, Prevention and Clinical Management
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 6261 | Submission Open
Keywords: sarcopenia; frailty; elderly; geriatrics; personalized medicine
(This special issue belongs to the Section Epidemiology & Public Health)
Endodontic and Periodontal Medicine: Systemic Implications of Oral Infections submission deadline 20 Aug 2025 | 6 articles | Viewed by 5222 | Submission Open
Keywords: dentistry; endodontics; apical periodontitis; endodontic medicine; periodontal disease; periodontal medicine; pulpitis; systemic diseases; root canal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Kidney Transplantation
edited by Pedro Ruiz-Esteban, Domingo Hernández and Veronica López
submission deadline 20 Aug 2025 | 4 articles | Viewed by 4423 | Submission Open
Keywords: kidney transplant; acute rejection; biomarkers; artificial intelligence; post-transplant complications; graft survival
(This special issue belongs to the Section Nephrology & Urology)
Interstitial Lung Disease: From Diagnosis to Treatment
edited by and Tomohisa Baba
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3941 | Submission Open
Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds
(This special issue belongs to the Section Respiratory Medicine)
Clinical Management of Salivary Gland Disorders
edited by Masao Yagi
submission deadline 20 Aug 2025 | 4 articles | Viewed by 3329 | Submission Open
Keywords: salivary gland tumour; parotidectomy; nerve monitoring; molecular-targeted therapy; immunotherapy
(This special issue belongs to the Section Otolaryngology)
Liver Transplantation: Current Hurdles and Future Perspectives
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 2840 | Submission Open
Keywords: machine perfusion; donation after circulatory death; liver preservation; living donation; acute-on-chronic liver failure; frailty; liver malignancies; surgical technique; liver transplant recipient care; immunosuppression
(This special issue belongs to the Section General Surgery)
Multiple Sclerosis: Prediction, Diagnosis and Treatment
edited by Rosaria Sacco
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2653 | Submission Open
Keywords: neurological diseases; multiple sclerosis; prodromal symptoms; diagnosis; treatment
(This special issue belongs to the Section Clinical Neurology)
State of the Art in Invasive Vascular Interventions (Second Edition)
edited by and Luca Mezzetto
submission deadline 20 Aug 2025 | 3 articles | Viewed by 2136 | Submission Open
Keywords: coronary artery interventions; non-coronary artery cardiac interventions; open surgical cardiac procedures; endo-vascular interventions; open surgical vascular procedures
(This special issue belongs to the Section Vascular Medicine)
Clinical Updates in Trauma and Emergency Medicine
edited by Yong-Soo Cho and Hyun Ho Ryu
submission deadline 20 Aug 2025 | 3 articles | Viewed by 1615 | Submission Open
Keywords: emergency medicine; epidemiology; cardiovascular disease
(This special issue belongs to the Section Emergency Medicine)
Juvenile Idiopathic Arthritis (JIA): Diagnosis, Treatment and Latest Updates
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1545 | Submission Open
Keywords: juvenile idiopathic arthritis; pathophysiology; genetic predisposition; immunologic abnormalities; diagnosis; treatment; outcome
(This special issue belongs to the Section Clinical Pediatrics)
Cardio-Oncology: Novel Concepts in Diagnosis, Prevention and Treatment of Cardiotoxicity, from Gender Differences and Beyond (Second Edition) submission deadline 20 Aug 2025 | 1 articles | Viewed by 1484 | Submission Open
Keywords: cardio-oncology; cardiotoxicity; gender medicine; chemotherapy; radiotherapy; immune and targeted therapeutics; physical activity; quality of life
(This special issue belongs to the Section Cardiovascular Medicine)
Advancements and Challenges in Managing Hepato-Pancreato-Biliary Cancers
edited by and Niccolò Petrucciani
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1475 | Submission Open
Keywords: liver; pancreas; HPB technology; artificial intelligence for HPB; surgical oncology; MIS
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Diabetic Nephropathy: Advances in Pathogenesis and Novel Therapies
edited by Meritxell Ibernon
submission deadline 20 Aug 2025 | Viewed by 313 | Submission Open
Keywords: pathogenesis of diabetic nephropathy; novel therapies; risk factors for disease progression; proteomic approach; serologic biomarkers; histological classification
(This special issue belongs to the Section Nephrology & Urology)
Management of Pregnancy Complications: 2nd Edition
edited by Ariel Many
submission deadline 20 Aug 2025 | Viewed by 191 | Submission Open
Keywords: high-risk pregnancy; preterm labor; fetal growth restriction; gestational diabetes; twins; hypertensive disorders during pregnancy; preeclampsia; IUGR; prenatal genetics; congenital anomaly detection; cesarean section; complications of labor and delivery
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advancements in Preoperative Optimization for Patients Undergoing Colorectal Surgery
edited by Tim Lubbers
submission deadline 20 Aug 2025 | Viewed by 151 | Submission Open
Keywords: preoperative optimization; colorectal surgery; postoperative recovery; complication; clinical innovations; patient outcome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Catheter Ablation for Cardiac Arrhythmias: Clinical Updates and Perspectives in Cardiac Electrophysiology
edited by Karolina Weinmann-Emhardt, Ingo Staudacher and Jonas Wormann
submission deadline 21 Aug 2025 | 1 articles | Viewed by 2826 | Submission Open
Keywords: electrophysiology; arrhythmia; atrial fibrillation; atrial flutter; ablation; 3D mapping; pulsed field ablation; radiofrequency ablation; pulmonary vein isolation
(This special issue belongs to the Section Cardiovascular Medicine)
Acute Pancreatitis: Clinical Management and Treatment submission deadline 21 Aug 2025 | 2 articles | Viewed by 1168 | Submission Open
Keywords: acute pancreatitis; classification; complications; intervention; management; prevention; severity; treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Acute and Chronic Heart Failure: Clinical Updates and Perspectives
edited by Luigi Cappannoli and Cristina Aurigemma
submission deadline 25 Aug 2025 | 6 articles | Viewed by 14852 | Submission Open
Keywords: acute heart failure; chronic heart failure; devices; drugs therapy; percutaneous ventricular assist devices; cardiogenic shock; arrhythmias; ischemic heart disease
(This special issue belongs to the Section Cardiovascular Medicine)
More than Skin Deep—Latest Advances in Congenital and Autoimmune Pigmentation Disorders submission deadline 25 Aug 2025 | 1 articles | Viewed by 11500 | Submission Open
Keywords: dermatology; congenital pigmentation disorders; autoimmune pigmentation disorders; melanoma; vitiligo; skin problems; systemic diseases; alopecia areata; wound care
(This special issue belongs to the Section Dermatology)
Musculoskeletal Imaging and Intervention submission deadline 25 Aug 2025 | 6 articles | Viewed by 11388 | Submission Open
Keywords: ultrasound; invasive physiotherapy; minimally invasive surgical procedures; magnetic resonance; image analysis
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Myocardial Infarction: Current Status and Future Challenges
edited by Isaac Pascual and
submission deadline 25 Aug 2025 | 7 articles | Viewed by 11324 | Submission Open
Keywords: myocardial infarction; acute coronary syndrome (ACS); ischemic heart disease; coronary artery disease (CAD); percutaneous coronary intervention; pharmacological therapy; cardiovascular risk factors
(This special issue belongs to the Section Cardiology)
New Directions for Treatment and Assessment of Ulcerative Colitis submission deadline 25 Aug 2025 | 4 articles | Viewed by 10265 | Submission Open
Keywords: treatment; ulcerative colitis; treatment target; ultrasound assessment; approach
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Challenges in Heart Failure Management
edited by Paolo Severino and Gaetano M. Ruocco
submission deadline 25 Aug 2025 | 7 articles | Viewed by 7347 | Submission Open
Keywords: acute heart failure; chronic heart failure; inotropic support; left ventricular assist device; cardiac contractility modulation; guanylate cyclase stimulators; quality of life; telemedicine; palliative care
(This special issue belongs to the Section Cardiology)
Emerging Therapies and Strategies in Thalassemia: Toward a New Era in Management—2nd Edition
edited by and Raffaella Origa
submission deadline 25 Aug 2025 | 4 articles | Viewed by 6731 | Submission Open
Keywords: HSCT; gene therapy; new drugs; iron chelation; aging; long-term observation; biomarkers; new strategies
(This special issue belongs to the Section Hematology)
Cystic Fibrosis: Clinical Manifestations and Treatment submission deadline 25 Aug 2025 | 6 articles | Viewed by 5759 | Submission Open
Keywords: cystic fibrosis; modifier genes; CFTR modulator; CF newborn screening; CF nutrition; CF complications
(This special issue belongs to the Section Respiratory Medicine)
New Insights into Lung Imaging
edited by
submission deadline 25 Aug 2025 | 4 articles | Viewed by 4767 | Submission Open
Keywords: lung disease; lung cancer; chest-CT; chest X-ray; imaging
(This special issue belongs to the Section Respiratory Medicine)
Multidisciplinary Endocarditis Perspectives: 2nd Edition
edited by
submission deadline 25 Aug 2025 | 2 articles | Viewed by 4713 | Submission Open
Keywords: endocarditis; clinical diagnostic; multimodality imaging; cardiology; clinical phenotypes
(This special issue belongs to the Section Cardiovascular Medicine)
Navigating Pregnancy and Its Complications: Challenges and Innovations in Maternal–Fetal Medicine submission deadline 25 Aug 2025 | 3 articles | Viewed by 4045 | Submission Open
Keywords: pregnancy; obstetrics; diabetes; high risk; preeclampsia; labor; delivery; hypertension; hemorrhage; embryo; screening
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Orthopaedic Treatment of Lumbar and Spine Diseases: 2nd Edition
edited by Nissim Ohana
submission deadline 25 Aug 2025 | 3 articles | Viewed by 3331 | Submission Open
Keywords: lumbar spine surgery; spine surgery; robotic-assisted spine surgery; spinal fusion; minimally invasive surgical; spinal deformities
(This special issue belongs to the Section Orthopedics)
Advancing Pediatric Sports Medicine: Insights and Innovations
edited by Brian C. Lau
submission deadline 25 Aug 2025 | 3 articles | Viewed by 3246 | Submission Open
Keywords: sport surgery; patellar instability; early sport specialization; triplane fractures; pediatric sports medicine; orthopedic surgery; access to care; arthroscopic
(This special issue belongs to the Section Orthopedics)
Psoriasis and Psoriatic Arthritis: How to Treat in the Era of Biologics and Small Molecule Inhibitors: 3rd Edition submission deadline 25 Aug 2025 | 2 articles | Viewed by 3097 | Submission Open
Keywords: psoriasis; psoriatic arthritis; biologics; small molecule inhibitors; conventional therapies
(This special issue belongs to the Section Dermatology)
Recent Advances in Immunotherapy of Cancer submission deadline 25 Aug 2025 | 2 articles | Viewed by 2708 | Submission Open
Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events
(This special issue belongs to the Section Oncology)
New Insights into Cardiorenal Metabolic Syndrome
edited by
submission deadline 25 Aug 2025 | 2 articles | Viewed by 1649 | Submission Open
Keywords: cardiorenal medicine; diabetes; chronic renal failure; heart failure; cardiorenal syndrome; nephrocardiology
(This special issue belongs to the Section Cardiovascular Medicine)
Updates on Rheumatoid Arthritis: From Diagnosis to Treatment
edited by
submission deadline 25 Aug 2025 | 1 articles | Viewed by 896 | Submission Open
Keywords: rheumatoid arthritis; pharmacological intervention; treatment; clinical development; effectiveness; safety; immune therapy; biological disease-modifying antirheumatic drugs (bDMARDs); synthetic disease-modifying antirheumatic drugs (sDMARDs)
(This special issue belongs to the Section Immunology)
Non-Small-Cell Lung Cancer: Recent Advances in Therapeutic Approaches submission deadline 25 Aug 2025 | 1 articles | Viewed by 827 | Submission Open
Keywords: lung diseases; lung cancer; non-small-cell lung cancer(NSCLC); diagnosis; surgery; treatment; artificial intelligence; robotic surgery; minimally invasive surgery; eletromagnetic navigation; ION robotic bronchoscopy
(This special issue belongs to the Section Respiratory Medicine)
Recent Advances in Clinical Pharmacology Based on Pharmacokinetics
edited by , and
submission deadline 25 Aug 2025 | Viewed by 805 | Submission Open
Keywords: PK/PD modeling; dose optimization; clinical decision-making tools; therapeutic drug monitoring; personalized medicine
(This special issue belongs to the Section Pharmacology)
Recent Advances in Gynecological Cancer
edited by Ilaria Sabatucci
submission deadline 25 Aug 2025 | 1 articles | Viewed by 629 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; clinical trials; ADCs; PARPi
(This special issue belongs to the Section Oncology)
Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases
edited by Mario J. Garcia and
submission deadline 25 Aug 2025 | Viewed by 330 | Submission Open
Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S
(This special issue belongs to the Section Cardiology)
Clinical and Interventional Therapeutic Advances of Acute Myocardial Infarction
edited by Konstantinos C. Theodoropoulos and Antonios Ziakas
submission deadline 25 Aug 2025 | Viewed by 316 | Submission Open
Keywords: coronary artery disease; acute myocardial infarction; PPCI; antiplatelet agents; stents; radial access; snuffbox; intracoronary imaging; calcium modification; interventional thrombus modification
(This special issue belongs to the Section Cardiovascular Medicine)
Innovations in Advanced Echocardiography
edited by Rebecca T. Hahn and Alexandros Papachristidis
submission deadline 25 Aug 2025 | Viewed by 259 | Submission Open
Keywords: advanced echocardiography; ultrafast ultrasound; contrast echocardiography; subharmonic aided pressure estima-tion; artificial intelligence; 3D echocardiography
(This special issue belongs to the Section Cardiology)
Current Opinion in Dental Implant Surgery and Peri-Implant Disease
edited by and Giovanni Corrocher
submission deadline 25 Aug 2025 | Viewed by 235 | Submission Open
Keywords: dental implant surgery; dental implantology; peri-implant disease; oral surgery; dental implantology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Management and Treatment of Hypertension According to the Newest Guidelines
edited by Francesca Saladini, and
submission deadline 25 Aug 2025 | Viewed by 221 | Submission Open
Keywords: hypertension; diagnosis; management; treatment; high blood pressure
(This special issue belongs to the Section Cardiovascular Medicine)
Current Opinion of Reconstructive and Aesthetic Breast Surgery
edited by , Konstantin Frank and Vanessa Brébant
submission deadline 25 Aug 2025 | Viewed by 214 | Submission Open
Keywords: reconstructive breast surgery; lipofilling; microsurgery; aesthetic breast surgery; PROM; digital anthropometry; autologous fat transfer; ADM; synthetic mesh; BIA-ALCL; BII
(This special issue belongs to the Section General Surgery)
Current Concept and Emerging Treatments of Bullous Skin Diseases
edited by
submission deadline 25 Aug 2025 | Viewed by 182 | Submission Open
Keywords: epidermolysis bullosa hereditary; Hailey-Hailey disease; autoimmune subepidermal bullous diseases; pemphigus; dermatology
(This special issue belongs to the Section Dermatology)
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