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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Extracorporeal Membrane Oxygenation (ECMO): Clinical Challenges and Opportunities

edited by

Yutaka Fujii

submission deadline 15 May 2025 | 8 articles | Viewed by 16074 | Submission Open

Keywords: extracorporeal membrane oxygenation (ECMO); clinical emergencies; intensive care; respiratory failure; COVID-19; cardiovascular– pulmonary disease; organ support; challenges; strategies; complications; acute respiratory distress syndrome (ARDS); cardiopulmonary bypass; cardiac function; basic research

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Therapy of Trauma and Surgical Critical Care

edited by Rita Galeiras

submission deadline 15 May 2025 | 4 articles | Viewed by 7412 | Submission Open

Keywords: trauma management; trauma care; burn; critical care; damage control surgery; traumatic spinal cord injury

(This special issue belongs to the Section Emergency Medicine)

Clinical Management of Patients with Multiple Sclerosis (MS)

edited by Maddalena Sparaco

submission deadline 15 May 2025 | 6 articles | Viewed by 4916 | Submission Open

Keywords: multiple sclerosis; clinical management; patient reported outcomes; patient-reported outcome measures; biomarkers; therapeutic approaches; monitoring strategies

(This special issue belongs to the Section Clinical Neurology)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 15 May 2025 | 3 articles | Viewed by 4037 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

New Insights into Diagnostic and Interventional Radiology

edited by

Domenico Laganà

and

Roberto Minici

submission deadline 15 May 2025 | 2 articles | Viewed by 3555 | Submission Open

Keywords: radiomics; interventional radiology; endovascular interventions; interventional oncology; ablation therapy; locore-gional treatments; artificial intelligence; peripheral arterial disease (PAD); aortic disease; vascular access

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Joint Arthroplasties: From Surgery to Recovery

edited by Paolo Schiavi and Guido Grappiolo

submission deadline 15 May 2025 | 2 articles | Viewed by 2980 | Submission Open

Keywords: total joint arthroplasty; hip; knee; ankle; shoulder; elbow; rehabilitation

(This special issue belongs to the Section Orthopedics)

Pediatric Palliative Care and Surgery

edited by Danielle B. Cameron and Amy Porter

submission deadline 15 May 2025 | Viewed by 262 | Submission Open

Keywords: palliative care; pediatric surgery; pediatric surgical oncology; pediatric palliative care; palliative medicine

(This special issue belongs to the Section Clinical Pediatrics)

Biomarkers and Diagnostics in Respiratory Diseases: 2nd Edition

edited by

Silvano Dragonieri

and

Andras Bikov

submission deadline 15 May 2025 | Viewed by 178 | Submission Open

Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests

(This special issue belongs to the Section Respiratory Medicine)

Technological Advancements and Clinical Innovations in Diagnostic and Interventional Radiology

edited by

Massimo Venturini

and

Federico Fontana

submission deadline 20 May 2025 | 17 articles | Viewed by 34779 | Submission Open

Keywords: artificial intelligence; radiomics; image fusion; spectral computed tomography; functional magnetic resonance imaging; CO2 angiography; balloon-occluded transcatheter arterial chemoembolization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Refractive Surgery—Where Are We Now?

edited by

Anna Maria Roszkowska

Domenico Schiano-Lomoriello

and

Davide Borroni

submission deadline 20 May 2025 | 15 articles | Viewed by 34512 | Submission Open

Keywords: refractive surgery; laser refractive surgery; intra-ocular lens for refractive surgery; PRK; LASEK; transPRK; LASIK; FemtoLASIK; SMILE; Phakic IOLs; presbyopia treatments; monovision

(This special issue belongs to the Section Ophthalmology)

What We See through Cardiac Imaging

edited by

Valeria Pergola

and Martina Perazzolo Marra

submission deadline 20 May 2025 | 9 articles | Viewed by 23820 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; echocardiography; cardiac-computed tomography; cardiac magnetic resonance; prognosis; arrhythmias; heart failure

(This special issue belongs to the Section Cardiology)

Clinical Advances in Critical Care Medicine

edited by Pietro Caironi

submission deadline 20 May 2025 | 7 articles | Viewed by 22074 | Submission Open

Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma

(This special issue belongs to the Section Intensive Care)

Head and Neck Surgery: Clinical Updates on Diagnosis, Management and Prognosis

edited by Gabriele Molteni and

Albino Eccher

submission deadline 20 May 2025 | 9 articles | Viewed by 14946 | Submission Open

Keywords: head and neck surgery; laryngeal cancer; immunotherapy; AI; head and neck radiology

(This special issue belongs to the Section General Surgery)

Subarachnoid Hemorrhage: Clinical Advances and Challenges

edited by

Tihamér Molnár

and

Péter Csécsei

submission deadline 20 May 2025 | 7 articles | Viewed by 11126 | Submission Open

Keywords: subarachnoid hemorrhage; epidural and subdural hematomas; intracerebral and intraventricular hemorrhage; hemorrhagic stroke; cerebral infarction; hypertension; early brain damage; delayed cerebral vasospasm; neurobehavioral aspects; ruptured intracranial aneurysm; neuroinflammation; epidemiological studies; neuroimaging; clinical guidelines; neurocritical care management; surgery; new drug therapies; diagnosis; treatment; management; risk factors; prognosis; clinical outcome

(This special issue belongs to the Section Clinical Neurology)

Advances in Trauma and Orthopedic Surgery: 2nd Edition

edited by

Christian von Rüden

submission deadline 20 May 2025 | 9 articles | Viewed by 8467 | Submission Open

Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome

(This special issue belongs to the Section Orthopedics)

Association Between Sleep Disorders and Diabetes

edited by

Patrizio Tatti

and Desiderio Passàli

submission deadline 20 May 2025 | 1 articles | Viewed by 7389 | Submission Open

Keywords: diabetes; OSAS; complications; insulin; resistance

(This special issue belongs to the Section Endocrinology & Metabolism)

Thromboembolic Disease and Antithrombotic Therapy

edited by Prahlad Ho

submission deadline 20 May 2025 | 5 articles | Viewed by 6914 | Submission Open

Keywords: thrombosis; pulmonary embolism; manticoagulation; DOAC (direct oral anticoagulants); DVT (deep vein thrombosis); novel anticoagulants (factor XIa inhibitors); thrombin; fibrin generation; risk stratification; biomarkers; Virchow’ s triad; post thrombotic syndrome

(This special issue belongs to the Section Hematology)

Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders

edited by

Paweł T. Matusik

submission deadline 20 May 2025 | 5 articles | Viewed by 6785 | Submission Open

Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter-defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Updates on Renal Transplantation and Its Complications

edited by Nada Kanaan and Arnaud Devresse

submission deadline 20 May 2025 | 3 articles | Viewed by 3842 | Submission Open

Keywords: cardiovascular complications; infections; CMV; EBV; viral hepatitis; mineral bone disease; cancer; rejection; post-transplant diabetes; immunosuppression

(This special issue belongs to the Section Nephrology & Urology)

Challenges in Liver and Nephrology Diseases in Pediatrics

edited by

Anna Di Sessa

submission deadline 20 May 2025 | 2 articles | Viewed by 3813 | Submission Open

Keywords: pediatric; liver disease; nephrology disease; renal and urinary tract diseases; nonalcoholic fatty liver disease (NAFLD); metabolic syndrome; liver transplantation; diagnosis; treatment; challenges; metabolic (dysfunction) associated fatty liver disease (MAFLD); omics; biomarkers; early diagnosis

(This special issue belongs to the Section Clinical Pediatrics)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine

edited by

Carlos Escobar

submission deadline 20 May 2025 | 6 articles | Viewed by 3373 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Clinical Guidelines)

Early-Stage and Operable Non-Small Cell Lung Cancer Treatment: Current Practice and Future Perspectives

edited by

Francisco Aécio Almeida

and Debora S. Bruno

submission deadline 20 May 2025 | 2 articles | Viewed by 3257 | Submission Open

Keywords: non-small cell lung cancer; biomarker testing; checkpoint inhibitors; perioperative therapy; targeted therapy; next-generation sequencing; radiation therapy; pulmonary rehabilitation in NSCLC

(This special issue belongs to the Section Oncology)

Advances in Pediatric Anesthesiology

edited by

Keira Mason

submission deadline 20 May 2025 | 2 articles | Viewed by 3029 | Submission Open

Keywords: pediatric anesthesiology; anesthesia; pediatric deep sedation; perioperative anesthesia; general anesthesia

(This special issue belongs to the Section Clinical Pediatrics)

New Clinical Advances in Macular Degeneration

edited by

Alaa Din Abdin

and

Berthold Seitz

submission deadline 20 May 2025 | 2 articles | Viewed by 2953 | Submission Open

Keywords: age-related macular degeneration; anti-vascular endothelial growth factor; complement factor; geographic atrophy; macular neovascularization; OCT and OCT angiography; biomarkers

(This special issue belongs to the Section Ophthalmology)

Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition)

edited by

Jacek Matys

Kinga Grzech-Lesniak

and

Tomasz Gedrange

submission deadline 20 May 2025 | 3 articles | Viewed by 2396 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; dentistry; biological safety

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Psoriatic Arthritis—New Insights, Challenges, Unmet Needs and Controversies

edited by

Daniela Opris-Belinski

submission deadline 20 May 2025 | 2 articles | Viewed by 2343 | Submission Open

Keywords: psoriatic arthritis; psoriasis; enthesitis; dactylitis; spondyloarthritis; radiological progression; biologics; JAK-inhibitors; immune-mediated inflammatory diseases; comorbidities

(This special issue belongs to the Section Immunology)

Clinical Advances in Orthopedic Infections

edited by

Hyonmin Choe

submission deadline 20 May 2025 | 2 articles | Viewed by 1950 | Submission Open

Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Therapy of Trauma and Surgical Critical Care

edited by Rabail Chaudhry, George W. Williams and Tanya Anand

submission deadline 20 May 2025 | 1 articles | Viewed by 1252 | Submission Open

Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations

(This special issue belongs to the Section Intensive Care)

Cardiovascular Disease in the Elderly: Prevention and Diagnosis

edited by Ioana Dana Alexa, Gabriel Ioan Prada and

Ciprian Rezus

submission deadline 20 May 2025 | 2 articles | Viewed by 1055 | Submission Open

Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction

(This special issue belongs to the Section Cardiovascular Medicine)

Enteric Nervous System: Neuropathic Gastrointestinal Motility—2nd Edition

edited by

Carolina Pellegrini

and

Vanessa D’Antongiovanni

submission deadline 20 May 2025 | 1 articles | Viewed by 1043 | Submission Open

Keywords: gastrointestinal dysmotility; intestinal inflammation; enteric bacteria– neuro– immune network; brain– gut axis; metabolic disorders; neurological disorders; enteric neuroplasticity

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Management of Postoperative Care in Neurosurgery

edited by

Slavica Kvolik

submission deadline 20 May 2025 | 1 articles | Viewed by 884 | Submission Open

Keywords: postoperative care; neurosurgery; neurotrauma; enhanced recovery after surgery (ERAS); postoperative pain; postoperative treatment

(This special issue belongs to the Section Intensive Care)

Cardiovascular Issues in Critical Care

edited by

Epaminondas G. Zakynthinos

and

Vasiliki Tsolaki

submission deadline 20 May 2025 | 1 articles | Viewed by 447 | Submission Open

Keywords: circulatory failure; hemodynamic monitoring; heart– lung interactions; shock; ultrasonography; cardiomyopathy; septic shock; cardiogenic shock; tachyarrhythmias; atrial fibrillation; right ventricular function; left ventricular function; fluid responsiveness

(This special issue belongs to the Section Cardiovascular Medicine)

Challenges and Opportunities in Geriatric Nephrology and Urology

edited by Giulio Romano

submission deadline 20 May 2025 | Viewed by 330 | Submission Open

Keywords: kidney disease; elderly patient; epidemiology; pharmacological therapy; lifestyle diet

(This special issue belongs to the Section Nephrology & Urology)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 May 2025 | Viewed by 266 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

Kidney Health Under Microscope

edited by

Magdi Yaqoob

submission deadline 20 May 2025 | Viewed by 186 | Submission Open

Keywords: complications; IgA nephropathy; glomerulonephritis; atypical haemolytic uraemic syndrome; systemic vasculitis; lupus nephritis; mineral bone disease; anaemia; xenotransplantation; nephrolithiasis

(This special issue belongs to the Section Nephrology & Urology)

State of the Art in Pediatric Surgery

edited by Vincenzo Bagnara and

Carmelo Romeo

submission deadline 20 May 2025 | Viewed by 179 | Submission Open

Keywords: pediatric surgery; abdominal diseases; pediatric urology; laparoscopy; minimally invasive surgery

(This special issue belongs to the Section Clinical Pediatrics)

Robotic Technology Applied to Kidney Transplantation

edited by Pierpaolo Di Cocco and Ivo G. Tzvetanov

submission deadline 20 May 2025 | Viewed by 154 | Submission Open

Keywords: end-stage renal disease; robotic-assisted kidney transplant; kidney transplantation; transplantation surgery; robotic and minimally invasive surgery; solid organ transplantation

(This special issue belongs to the Section Nephrology & Urology)

Patent Foramen Ovale 2023: More Lights than Shadows

edited by

Eustaquio Maria Onorato

and Christian Pristipino

submission deadline 25 May 2025 | 2 articles | Viewed by 5031 | Submission Open

Keywords: patent foramen ovale; patent foramen ovale closure; paradoxical embolism; right-to-left shunt; stroke; cryptogenic stroke; decompression illness; migraine aura; platypnea– orthodeoxia syndrome; posterior fossa neurosurgery; major orthopaedic surgery and paradoxical fat embolism

(This special issue belongs to the Section Cardiology)

Cardiothoracic Surgery and Enhanced Recovery: Recent Advances and Perspectives

edited by Edris A.F. Mahtab

submission deadline 25 May 2025 | 3 articles | Viewed by 3788 | Submission Open

Keywords: coronary artery bypass surgery; valve repair/replacement; minimally invasive cardiac procedures; aortic dissection repair; thoracic aortic aneurysm surgery; lung transplantation; ventricular assist devices; esophagectomy; lung surgery; heart transplantation; use of XR and AI in Enhanced recovery

(This special issue belongs to the Section General Surgery)

Anterior Cruciate Ligament (ACL): Innovations in Clinical Management

edited by Xaver Feichtinger,

Thomas Hoffelner

and Georg Brandl

submission deadline 25 May 2025 | 3 articles | Viewed by 3361 | Submission Open

Keywords: ACL; graft choice; ACL repair; ALL; tibial slope

(This special issue belongs to the Section Orthopedics)

New Insights into Augmentative Therapy for Parkinson’s Disease

edited by Adam Thrasher

submission deadline 25 May 2025 | 2 articles | Viewed by 2556 | Submission Open

Keywords: Parkinson’ s Disease; postural instability; locomotion; physical therapy; neuromodulation; augmentative therapies

(This special issue belongs to the Section Clinical Neurology)

A Multi-Faceted Approach to Urinary Incontinence and Other Pelvic Floor Dysfunction—from Prevention to Therapy

edited by

Agnieszka Mazur-Bialy

submission deadline 25 May 2025 | 2 articles | Viewed by 2459 | Submission Open

Keywords: urinary incontinence; pelvic floor dysfunction; urinary and fecal incontinence; pelvic organs prolapse; pelvic pain; pelvic floor disorders

(This special issue belongs to the Section Nephrology & Urology)

Thoracic Surgery: Recent Developments and Future Challenges

edited by

Marco Andolfi

and Lucio Cagini

submission deadline 25 May 2025 | 1 articles | Viewed by 2211 | Submission Open

Keywords: VATS; RATS; ERAS; sublobar resection; minimally invasive thoracic surgery; target therapy; nodule localization

(This special issue belongs to the Section Respiratory Medicine)

New Clinical Advances in Chronic Asthma

edited by Vitaliano Nicola Quaranta

submission deadline 25 May 2025 | 2 articles | Viewed by 2140 | Submission Open

Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids

(This special issue belongs to the Section Respiratory Medicine)

New Challenges of Cardiovascular Diseases: From Clinical to Preclinical Research

edited by

Mario Gutierrez-Bedmar

and Jorge Rodriguez Capitan

submission deadline 25 May 2025 | 2 articles | Viewed by 2140 | Submission Open

Keywords: cardiovascular diseases; cardiovascular prevention; risk factors; population aging; public health; medical innovation; personalized treatments; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Chronic Lung Conditions: Integrative Approaches to Long-Term Care

edited by

Antigona Carmen Trofor

submission deadline 25 May 2025 | 2 articles | Viewed by 2033 | Submission Open

Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes

(This special issue belongs to the Section Respiratory Medicine)

Endometriosis: Clinical Challenges and Prognosis

edited by

Francisco Artacho-Cordon

submission deadline 25 May 2025 | 1 articles | Viewed by 1732 | Submission Open

Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Assessing Strategies and Challenges in Heart Failure: An Update

edited by

Shiro Hoshida

submission deadline 25 May 2025 | 1 articles | Viewed by 1499 | Submission Open

Keywords: cardiac MR; coronary microvascular dysfunction; diagnosis; endothelial function; heart failure; myocardial metabolism; prognosis

(This special issue belongs to the Section Cardiology)

Recent Advances in Intracranial Aneurysm Treatment

edited by Victor Volovici

submission deadline 25 May 2025 | 1 articles | Viewed by 1198 | Submission Open

Keywords: intracranial aneurysm; cerebrovascular disease; microneurosurgery; endovascular treatment; subarachnoid hemorrhage

(This special issue belongs to the Section Clinical Neurology)

Vascular Surgery: Current Advances and Future Directions

edited by Giovanni Coppi

submission deadline 25 May 2025 | 2 articles | Viewed by 1036 | Submission Open

Keywords: stroke; carotid artery stenosis; carotid artery stenting; carotid endarterectomy; occlusion

(This special issue belongs to the Section General Surgery)

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