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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management for Anesthesia Critical Care

edited by Gianluca Zani

submission deadline 20 Apr 2026 | Viewed by 114 | Submission Open

Keywords: anesthesia; critical care medicine; clinical management; critically ill patients; organ failure; organ dysfunction; per-sonalized therapy; outcome; technical skills; non-technical skills

(This special issue belongs to the Section Anesthesiology)

The Latest Research on Male Infertility

edited by Gianmaria Salvio and Nicola delli Muti

submission deadline 20 Apr 2026 | Viewed by 110 | Submission Open

Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Advances in Minimally Invasive Spinal Treatment: 2nd Edition

edited by

Akihiko Hiyama

Haruki Funao

and

Masayuki Ishihara

submission deadline 20 Apr 2026 | Viewed by 105 | Submission Open

Keywords: robotic-assisted spine surgery; artificial intelligence (AI); machine learning (ML); cement-augmented pedicle screws; cement leakage risk stratification; osteoporosis pharmacotherapy; surgical navigation systems; image-guided spine surgery; predictive analytics in spine care; spine technology innovation

(This special issue belongs to the Section Orthopedics)

Heart Failure: Treatment and Clinical Perspectives

edited by Geza Halasz, Domenico Gabrielli and Francesco Grigioni

submission deadline 20 Apr 2026 | Viewed by 101 | Submission Open

Keywords: heart failure; chronic heart failure; acute heart failure; treatment; cardiac imaging; diagnostics; patient outcomes; prognosis

(This special issue belongs to the Section Cardiology)

Advances and Challenges in Head and Neck Reconstructive Surgery

edited by

Valeria Navach

Olindo Massarelli

and Luca Calabrese

submission deadline 20 Apr 2026 | Viewed by 100 | Submission Open

Keywords: reconstructive surgery; head and neck; innovation; microsurgery; virtual surgical planning; 3D-printed implants; tissue engineering

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Hip and Knee Arthroplasty: Update on Clinical Management

edited by Maximilian F. Kasparek

submission deadline 20 Apr 2026 | Viewed by 100 | Submission Open

Keywords: total hip arthroplasty (THA); total knee arthroplasty (TKA); revision arthroplasty; implant fixation; cemented; cementless; hybrid; alignment in TKA; mechanical alignment; kinematic alignment; restricted kinematic alignment; functional alignment; navigation; robotic-assisted surgery; patient-specific instrumentation; additive manufacturing; 3D printing; personalized implant

(This special issue belongs to the Section Orthopedics)

New Insights into Retinal Diseases

edited by Fabio Scarinci and Giulio Pocobelli

submission deadline 20 Apr 2026 | Viewed by 96 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; vitreoretinal diseases; retinal imaging analysis; biomarkers; segmentation; retinal ischemia; retinal blood flow; choroidal blood flow

(This special issue belongs to the Section Ophthalmology)

Innate Immunity in Overdrive: Novel Insights into Autoinflammatory Syndromes

edited by Alessandro Conforti

submission deadline 20 Apr 2026 | Viewed by 95 | Submission Open

Keywords: autoinflammatory diseases; innate immunity; inflammasome; cytokines; Interleukin-1; monogenic syndromes; polygenic autoinflammatory disorders; adult-onset Still’ s disease; Behç et’ s disease; targeted therapy; disease registries; real-world evidence; VEXAS syndrome; UBA1 mutations; precision medicine; biomarkers; outcome assessment

(This special issue belongs to the Section Immunology & Rheumatology)

Myocardial Infarction: The Latest Advances and Prospects

edited by

Stylianos Daios

and Antonios Ziakas

submission deadline 20 Apr 2026 | Viewed by 95 | Submission Open

Keywords: coronary artery disease; myocardial infarction; PPCI; echocardiography; antiplatelet agents; radial access; global longitudinal strain

(This special issue belongs to the Section Cardiology)

Vertebral Fractures and Spinal Cord Injury: Advances in Management

edited by

Marc Dreimann

and Martin Stangenberg

submission deadline 20 Apr 2026 | Viewed by 93 | Submission Open

Keywords: fracture management; spinal cord injuries; artificial intelligence; machine learning; spinal trauma

(This special issue belongs to the Section Orthopedics)

Pharmacotherapy of Mental Diseases: Latest Developments

edited by

Lavinia Maria Hogea

and

Laura Alexandra Nussbaum

submission deadline 20 Apr 2026 | Viewed by 92 | Submission Open

Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases

(This special issue belongs to the Section Mental Health)

New Insights in Joint Arthroplasty—2nd Edition

edited by

Richard Lass

submission deadline 20 Apr 2026 | Viewed by 92 | Submission Open

Keywords: total hip arthroplasty; total knee arthroplasty; robotic-assisted technology and navigation; modern implant materials; modern implant fixation techniques; alignment in TKA; spinopelvic alignment in THA

(This special issue belongs to the Section Orthopedics)

Advances in the Management of Pediatric Neuromuscular Diseases

edited by Nicolas Deconinck

submission deadline 20 Apr 2026 | Viewed by 91 | Submission Open

Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines

(This special issue belongs to the Section Clinical Neurology)

Schizophrenia and Psychotic Disorders: Clinical Updates

edited by Octavian Vasiliu and

Adela Magdalena Ciobanu

submission deadline 20 Apr 2026 | Viewed by 89 | Submission Open

Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities

(This special issue belongs to the Section Mental Health)

Recent Management and Future Perspectives on Knee Arthroplasty

edited by

Georgios Komnos

submission deadline 20 Apr 2026 | Viewed by 88 | Submission Open

Keywords: knee arthroplasty; individualized approach; implant designs; robotic-assisted; knee alignment

(This special issue belongs to the Section Orthopedics)

Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis

edited by Francescamaria Donati

submission deadline 20 Apr 2026 | Viewed by 87 | Submission Open

Keywords: magnetic resonance imaging (MRI); clinical diagnosis; high-field MRI; diffusion-weighted imaging (DWI); perfusion MRI (pMRI); artificial intelligence in imaging; diagnostic imaging; early disease detection; disease monitoring; treatment planning

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly

edited by

Oded Hershkovich

and

Raphael Lotan

submission deadline 20 Apr 2026 | Viewed by 83 | Submission Open

Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty

(This special issue belongs to the Section Orthopedics)

Peritoneal Dialysis and Hemodialysis: Early and Late Outcomes

edited by Keren Cohen-Hagai and

David Pereg

submission deadline 20 Apr 2026 | Viewed by 82 | Submission Open

Keywords: peritoneal dialysis; dialysis; hemodialysis; chronic kidney disease; end-stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Novel Advances in Lower Limb Trauma and Orthopaedic Surgery

edited by Konstantinos Tsikopoulos and

Panagiotis Givissis

submission deadline 20 Apr 2026 | Viewed by 81 | Submission Open

Keywords: lower limb orthopedic surgery; trauma; infection; research

(This special issue belongs to the Section Orthopedics)

Geriatric Fracture Care: Bridging Orthopedics and Gerontology

edited by Tom Knauf and Daphne Asimenia Eschbach

submission deadline 20 Apr 2026 | Viewed by 80 | Submission Open

Keywords: geriatric fracture; proximal femur fractures; hip fracture; geriatric trauma patient; ortho-geriatric treatment; periprosthetic fracture; end of life decision; orthopedic surgery in the elderly

(This special issue belongs to the Section Geriatric Medicine)

Coronary Artery Disease: Recent Developments and Emerging Trends

edited by

Attila Kardos

and Tarun Mittal

submission deadline 20 Apr 2026 | Viewed by 79 | Submission Open

Keywords: coronary atherosclerosis; diagnostic strategies; therapeutic options; timing of intervention; artificial intelligence; novel therapeutic pathways

(This special issue belongs to the Section Cardiology)

Advancements in Minimally Invasive Neurosurgery

edited by Sanjeeva Jeyaretna and Kumar Abhinav

submission deadline 20 Apr 2026 | Viewed by 79 | Submission Open

Keywords: minimally invasive surgery; skull base surgery; neurosurgery; transorbital; endoscopic transnasal

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Endodontic Dentistry

edited by

Luciano Giardino

and

Luigi Generali

submission deadline 20 Apr 2026 | Viewed by 74 | Submission Open

Keywords: antimicrobial agents; biofilm; confocal laser scanning microscopy; endodontic materials; irrigants; microbiome; micro-CT; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Female Infertility: Clinical Diagnosis and Treatment—Second Edition

edited by

Laurie Henry

submission deadline 20 Apr 2026 | Viewed by 73 | Submission Open

Keywords: infertility; assisted reproductive techniques; diagnosis; implantation; gametes

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Risk Minimization Through Robot-Assisted Surgery

edited by Radko Komadina

submission deadline 20 Apr 2026 | Viewed by 71 | Submission Open

Keywords: robot-assisted technology; robotic surgery; laparoscopic surgery; spinal surgery; robot-assisted gynecological operations; robot-assisted operations in urology; robot-assisted prostatectomy

(This special issue belongs to the Section General Surgery)

New Advances in Orthopedic Knee Joint Preserving and Reconstructive Surgery

edited by

Dong Jin Ryu

and

Sung-Sahn Lee

submission deadline 20 Apr 2026 | Viewed by 69 | Submission Open

Keywords: cartilage regeneration; patient-specific instrumentation; knee robotic surgery; patient-specific surgical device; future orthopedics

(This special issue belongs to the Section Orthopedics)

Recent Advancements in Nuclear Medicine and Radiology: 2nd Edition

edited by Adriaan A. Lammertsma

submission deadline 20 Apr 2026 | Viewed by 65 | Submission Open

Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Insights from Cardiopulmonary Exercise Testing to Cardiac Rehabilitation

edited by

Gaia Cattadori

submission deadline 20 Apr 2026 | Viewed by 64 | Submission Open

Keywords: cardiac rehabilitation; exercise physiology; exercise performance; exercise testing; physical activity assessment; exercise; physical activity; oxygen consumption; cardiopulmonary exercise testing

(This special issue belongs to the Section Cardiology)

New Insights into Breast Neoplasms: Prevention, Multidisciplinary Management and Beyond the Core Team

edited by

Marco Materazzo

and

Antonia Girardi

submission deadline 20 Apr 2026 | Viewed by 63 | Submission Open

Keywords: breast cancer; tumor heterogeneity; estrogen receptor; progesterone receptor; triple-negative breast cancer; metastasis; immunotherapy; targeted therapy; early detection; prognosis; adjuvant treatment

(This special issue belongs to the Section Oncology)

New Sights in Retinal Diseases Therapeutics: Innovation and Clinical Practice

edited by

Giacomo Boscia

Pasquale Viggiano

, Stefano Dore and Alfonso Savastano

submission deadline 20 Apr 2026 | Viewed by 62 | Submission Open

Keywords: retinal diseases; central serous chorioretinopathy; age-related macular degeneration; eye diseases; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

Clinical Research on Pulmonary Hypertension and Its Complications

edited by Gabor G. Kovacs and

Anna Birnhuber

submission deadline 20 Apr 2026 | Viewed by 59 | Submission Open

Keywords: pulmonary hypertension; PH; pulmonary arterial pressure; different diagnostic; therapeutic challenges

(This special issue belongs to the Section Respiratory Medicine)

Clinical Cardiac Rehabilitation: Integrating Multidimensional Approaches for Enhanced Cardiovascular Health

edited by

Gaia Cattadori

submission deadline 20 Apr 2026 | Viewed by 58 | Submission Open

Keywords: cardiac rehabilitation; multidimensional approach; integrating approach; cardiovascular health; primary and secondary prevention

(This special issue belongs to the Section Clinical Rehabilitation)

Innovations in Surgical and Medical Approaches of Urologic Oncology

edited by

Sung Han Kim

submission deadline 20 Apr 2026 | Viewed by 57 | Submission Open

Keywords: urologic oncology; robotic surgery; immunotherapy; targeted therapy; image-guided techniques; personalized medicine; minimally invasive surgery; focal therapy

(This special issue belongs to the Section Nephrology & Urology)

Spinal Cord Injury in Elderly People: Prevention of Complications

edited by Vaidyanathan Subramanian

submission deadline 20 Apr 2026 | Viewed by 53 | Submission Open

Keywords: spinal cord injury; demography; morbidities; complications; spinal injuries; patients; family members; caregivers; general practitioners; discharge; elderly

(This special issue belongs to the Section Geriatric Medicine)

New Challenges and Perspectives in Surgical Treatment of Spinal Deformity

edited by Jung-Hee Lee

submission deadline 20 Apr 2026 | Viewed by 51 | Submission Open

Keywords: adult spinal deformity; decompensation; kyphosis; lateral lumbar interbody fusion; orthopedic surgery; osteotomy; proximal junctional kyphosis; rod fracture

(This special issue belongs to the Section Orthopedics)

Aiming for Early Detection and Prevention of Pulmonary Diseases

edited by

Nektarios Anagnostopoulos

and

Kostas A. Papavassiliou

submission deadline 20 Apr 2026 | Viewed by 40 | Submission Open

Keywords: early diagnosis; prevention strategies; respiratory diseases; artificial intelligence; asthma; chronic obstructive pulmonary disease (COPD); interstitial lung disease; sleep-disordered breathing

(This special issue belongs to the Section Respiratory Medicine)

What Part Do Circulating Tumor Cells Play in Cancers？

edited by

Monika Pizon

and

Katharina Pachmann

submission deadline 20 Apr 2026 | Viewed by 26 | Submission Open

Keywords: circulating tumor cells (CTCs); circulating cancer stem cells (cCSCs); liquid biopsy; therapy monitoring; metastasis; cancer progression

(This special issue belongs to the Section Oncology)

Genitourinary Tumors and Radiation Therapy: Current Advances and Future Directions

edited by Shalini Moningi

submission deadline 20 Apr 2026 | Viewed by 17 | Submission Open

Keywords: cancer; prostate cancer; bladder cancer; kidney cancer; radiation therapy

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Management of Knee Arthroplasty

edited by

Sang-Hoon Park

submission deadline 21 Apr 2026 | 1 articles | Viewed by 705 | Submission Open

Keywords: knee surgery; knee arthroplasty; knee joint replacement; osteoarthritis; knee arthritis

(This special issue belongs to the Section Orthopedics)

Controversies in Hidradenitis Suppurativa: Bridging Gaps in Science and Practice

edited by Hadar Lev-Tov and Tammy González

submission deadline 21 Apr 2026 | Viewed by 98 | Submission Open

Keywords: hidradenitis suppurativa (HS); inflammatory skin disorder; controversies; treatment strategies; science and practice

(This special issue belongs to the Section Dermatology)

Paediatric Anaesthesia: Clinical Updates and Perspectives

edited by Peter Marhofer, Philipp Opfermann and Markus Zadrazil

submission deadline 24 Apr 2026 | 7 articles | Viewed by 8630 | Submission Open

Keywords: pediatric anesthesia; anesthesia; conduction; ultrasonography; conscious sedation; deep sedation; drug-related side effects and adverse reactions; neurotoxicity syndromes

(This special issue belongs to the Section Anesthesiology)

Challenges and Advances in Geriatrics and Gerontology

edited by Elisa Fabbri

submission deadline 24 Apr 2026 | 3 articles | Viewed by 1859 | Submission Open

Keywords: aging; geriatric medicine; frailty; multimorbidity; sarcopenia; cognition; personalized-care; healthy longevity; decision making-management; prevention; artificial intelligence

(This special issue belongs to the Section Geriatric Medicine)

Advances in Spine Surgery: Current Innovations and Future Directions

edited by

Gonzalo Mariscal

and Jesús Burgos

submission deadline 24 Apr 2026 | Viewed by 121 | Submission Open

Keywords: spine; clinical studies; robotics; minimally invasive; complications; patient-reported outcomes; reviews

(This special issue belongs to the Section Orthopedics)

Innovations and Challenges in Clinical Toxicology and Therapeutic Drug Monitoring

edited by Zhicheng Jin

submission deadline 25 Apr 2026 | 2 articles | Viewed by 19609 | Submission Open

Keywords: toxicology screen; therapeutic drug monitoring; mass spectrometry; immunoassays; pain management; opioids

(This special issue belongs to the Section Pharmacology)

General Anesthesia: Recent Developments and Emerging Trends

edited by Basavana Goudra

submission deadline 25 Apr 2026 | 3 articles | Viewed by 15581 | Submission Open

Keywords: general anesthesia; recent advances; drug development; memory and awareness; brain monitoring; sugammadex; tegileridine

(This special issue belongs to the Section Anesthesiology)

Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition

edited by

Antonella Polimeni

and

Iole Vozza

submission deadline 25 Apr 2026 | 7 articles | Viewed by 13684 | Submission Open

Keywords: special needs patients; oral healthcare; pediatric dentistry; dental hygiene; oral pathology; orthodontics; periodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Perspectives on Surgical Management of Knee Injuries

edited by Min Jung

submission deadline 25 Apr 2026 | 6 articles | Viewed by 10398 | Submission Open

Keywords: osteoarthritis; meniscal repair; ligament reconstruction; cartilage restoration; knee surgery

(This special issue belongs to the Section Orthopedics)

Clinical Insights into Pulmonary Hypertension

edited by Simon Schneider

submission deadline 25 Apr 2026 | 5 articles | Viewed by 9922 | Submission Open

Keywords: pulmonary hypertension; pulmonary vascular disease (PVD); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); interstitial lung disease; chronic obstructive pulmonary disease (COPD); chronic pulmonary fibrosis; emphysema; respiratory disease; physiology; diagnosis; treatment; rehabilitation; altitude research

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Abdominal Surgery

edited by

Juan José Segura-Sampedro

and César P. Ramírez-Plaza

submission deadline 25 Apr 2026 | 5 articles | Viewed by 6396 | Submission Open

Keywords: abdominal surgery; oncologic surgery; minimal invasive techniques; HIPEC; PIPAC; peritoneal carcinomatosis; liver metastasis

(This special issue belongs to the Section General Surgery)

Assessment and Treatment of Trauma Patients

edited by

Arne Driessen

submission deadline 25 Apr 2026 | 2 articles | Viewed by 6305 | Submission Open

Keywords: trauma surgery; prehospital detection of trauma; assessment of trauma; trauma scale; trauma evaluation; trauma surgery

(This special issue belongs to the Section Emergency Medicine)

Displaying special issue 1151-1200 on page 24 of 31.

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