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Genitourinary Tumors and Radiation Therapy: Current Advances and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 924

Special Issue Editor


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Guest Editor
Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA
Interests: prostate cancer; bladder cancer; kidney cancer

Special Issue Information

Dear Colleagues,

As we all know, radiation treatment has a vital role in the treatment of prostate, bladder, and kidney cancers. However, radiation treatment can also be associated with short- and long-term toxicity. Most recently, the development and usage of biomarkers have helped improve personalization for the treatment of genitourinary diseases. The aim of this Special Issue is to present original clinical research that has helped improve outcomes and quality of life for patients with bladder, kidney, and/or prostate cancer. Specifically, we are considering research topics focused on clinical outcomes, both prospective trials and retrospective reviews, as well as meta-analyses of large data and various relevant quality of life topics. Additionally, we welcome any papers focusing on novel treatment techniques, such as adaptive radiotherapy, in the setting of treatment for GU cancers.

I look forward to receiving your contributions.

Dr. Shalini Moningi
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer
  • prostate cancer
  • bladder cancer
  • kidney cancer
  • radiation therapy

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Published Papers (1 paper)

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Research

11 pages, 747 KB  
Article
Association Between Cribriform Architecture and Lymphovascular Invasion in Prostate Cancer
by Jacqueline Chan, Yetkin Tuac, Okan Argun, Christina M. Breneman, Nora Seeley, Haley N. Moriarty, Keerthana Senthil Kumar, Fallon E. Chipidza, Jonathan E. Leeman and Mutlay Sayan
J. Clin. Med. 2026, 15(3), 1032; https://doi.org/10.3390/jcm15031032 - 28 Jan 2026
Cited by 1 | Viewed by 671
Abstract
Background/Objectives: Cribriform architecture is an adverse histopathologic feature in prostate cancer and has been associated with poor oncologic outcomes. Emerging evidence suggests that cribriform-positive tumors may behave as a biologically non-localized disease, raising the possibility of early occult dissemination. Lymphovascular invasion (LVI) is [...] Read more.
Background/Objectives: Cribriform architecture is an adverse histopathologic feature in prostate cancer and has been associated with poor oncologic outcomes. Emerging evidence suggests that cribriform-positive tumors may behave as a biologically non-localized disease, raising the possibility of early occult dissemination. Lymphovascular invasion (LVI) is a key pathological marker of metastatic potential, but its relationship with cribriform architecture has not been evaluated. We examined the association between cribriform morphology and LVI to provide biological context for the aggressive clinical course of cribriform-positive prostate cancer. Methods: We performed a retrospective analysis of patients with prostate adenocarcinoma who underwent radical prostatectomy and had available clinicopathologic data. Cribriform architecture was determined by a centralized pathology review, and LVI status was obtained from original pathology reports. Unadjusted associations were evaluated using contingency tables. Multivariable logistic regression was used to assess whether cribriform architecture was independently associated with LVI after adjustments for Gleason score, tumor stage, and nodal status. Results: Among 338 patients, 28 (8.3%) had LVI and 123 (36.4%) had cribriform architecture. LVI was more common in cribriform-positive than cribriform-negative tumors (17.9% vs. 2.8%; p < 0.001), corresponding to a crude odds ratio (OR) of 7.6 (95% CI, 3.0–19.3). Cribriform architecture remained independently associated with LVI after adjustment (adjusted OR, 5.20; 95% CI, 2.12–1.40; p < 0.001). Conclusions: Cribriform architecture is strongly and independently associated with LVI, supporting a biological link between cribriform morphology and early metastatic dissemination. These findings support the design of prospective, biomarker-driven studies to evaluate treatment intensification strategies in this high-risk subgroup. Full article
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