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Heart Failure: Treatment and Clinical Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 2

Special Issue Editors


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Guest Editor
Cardiology Department, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy
Interests: heart failure; echocardiography; clinical cardiology; cardiac rehabilitation; cardiomyopathies

E-Mail Website
Guest Editor
Cardiology Department, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy
Interests: heart failure; clinical cardiology; cardiac rehabilitation; cardiomyopathies

E-Mail Website
Guest Editor
Department of Cardiovascular Sciences, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy
Interests: heart failure; echocardiography; clinical cardiology; cardiomyopathies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, representing a complex clinical syndrome with heterogeneous phenotypes, trajectories, and responses to therapy. Despite significant advances in pharmacological and non-pharmacological management, HF continues to pose major challenges for healthcare systems—both in terms of clinical outcomes and healthcare resource utilization. In recent years, novel diagnostic tools, including advanced cardiac imaging, biomarkers, and cardiopulmonary exercise testing (CPET), have improved our ability to phenotype HF patients more precisely and to tailor therapies accordingly. Of particular interest is the integration of CPET with stress echocardiography (CPET-TTE), which offers a comprehensive, dynamic assessment of central and peripheral determinants of exercise intolerance. This combined approach is emerging as a powerful tool to refine risk stratification, distinguish between cardiac and extracardiac limitations, and guide the selection of optimal therapeutic strategies in both HF with reduced and preserved ejection fraction. Moreover, the incorporation of artificial intelligence, remote monitoring, and multidisciplinary care models is reshaping the landscape of HF management, with promising implications for precision medicine. With this Special Issue, we aim to capture cutting-edge research and clinical perspectives on the treatment of HF.

We welcome original research, reviews, and expert opinions on topics such as disease-modifying therapies in HFrEF and HFpEF, the evolving role of SGLT2 inhibitors, device-based therapies, management of comorbidities, and cardiac rehabilitation. Special attention will also be given to innovations in imaging, omics-based personalization of therapy, digital health solutions, and the physiological insights offered by tools such as CPET-TTE.

We invite you to contribute your most innovative work to this Special Issue, with the hope of advancing our collective understanding and improving the lives of patients living with heart failure.

Dr. Geza Halasz
Prof. Dr. Domenico Gabrielli
Prof. Dr. Francesco Grigioni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • chronic heart failure
  • acute heart failure
  • treatment
  • cardiac imaging
  • diagnostics
  • patient outcomes
  • prognosis

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Published Papers

This special issue is now open for submission.
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