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Clinical Research on Pulmonary Hypertension and Its Complications
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Clinical Research on Pulmonary Hypertension and Its Complications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 793

Special Issue Editors

Dr. Gabor G. Kovacs

grade E-Mail Website
Guest Editor
Division of Pneumology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
Interests: pulmonary hypertension; pulmonary circulation; exercise hemodynamics; pulmonary hemodynamics; COPD; interstitial lung disease
Dr. Anna Birnhuber

E-Mail Website
Guest Editor
Otto Loewi Research Center, Lung Research Cluster, Medical University of Graz, Graz, Austria
Interests: systemic sclerosis associated lung involvement; interstitial lung disease; pulmonary hypertension; molecular pathomechanisms of pulmonary remodelling; cross-talk of immune and structural cells; animal models of SSc-ILD/PH

Special Issue Information

Dear Colleagues,

Pulmonary hypertension (PH) is characterized by the elevation of pulmonary arterial pressure and affects around 1% of the world’s population. Based on their etiology, five clinical groups have been identified, each representing different diagnostic and therapeutic challenges. In the last two decades, there have been significant advances in the management of PH; however, several questions remain unanswered, requiring further research.

To this end, we would like to invite innovative, original clinical research papers in the field of PH for this Special Issue. Our aim is to present the most recent clinical advances relating to PH and to address topics of high interest, in order to contribute to a better understanding of the disease and, ultimately, to improved patient management.

We look forward to your submissions!

Dr. Gabor G. Kovacs
Dr. Anna Birnhuber
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pulmonary hypertension
  • PH
  • pulmonary arterial pressure
  • different diagnostic
  • therapeutic challenges

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Published Papers (1 paper)

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Research

13 pages, 565 KB  
Article
Echocardiographic Pulmonary Hypertension in Patients Positive for Myositis-Specific and Myositis-Associated Antibodies
by Kristina Akopyan, Jessica Peterson, Oluyemisi Amoda, Majd Khasawneh, Susheela Hadigal, Christopher Harden, Diana Gomez Manjarres, Raju Reddy and Faye Pais
J. Clin. Med. 2026, 15(1), 77; https://doi.org/10.3390/jcm15010077 - 22 Dec 2025
Viewed by 591
Abstract
Background: The prevalence of pulmonary hypertension (PH) in patients who are positive for myositis-specific antibody (MSA) and myositis-associated antibody (MAA) remains unclear. Methods: We conducted a retrospective study of patients with an age of 18 years or older diagnosed with myositis interstitial lung [...] Read more.
Background: The prevalence of pulmonary hypertension (PH) in patients who are positive for myositis-specific antibody (MSA) and myositis-associated antibody (MAA) remains unclear. Methods: We conducted a retrospective study of patients with an age of 18 years or older diagnosed with myositis interstitial lung disease (ILD) at our university’s ILD clinic between 2019 and 2022. Echocardiographic PH was defined by tricuspid regurgitation velocity (TRV) ≥ 2.9 m/s on transthoracic echocardiography (TTE) consistent with intermediate probability of PH using 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines. We grouped patients based on low probability of PH vs. intermediate to high probability of PH. We examined 6 min walk test (6MWT) data, pulmonary function tests (PFTs), all-cause mortality, and rate of lung transplantation. We also evaluated patients who were on immunosuppression vs. those not on immunosuppression. Results: The intermediate to high probability of PH group had a higher prevalence of dermato-specific antibodies (14.2% vs. 34.5%, p = 0.048). Specifically, MDA-5 was found to be more prevalent in patients with intermediate to high probability of PH (7.1% vs. 24.1%, p = 0.040). There was no difference in 6MWT parameters between groups (363.2 ± 115.6 m vs. 294.9 ± 147.5 m, p = 0.108). FVC and DLCO were lower in patients with intermediate to high probability of PH (71.3 ± 22.4 L vs. 58.8 ± 16.7 L, p = 0.037; 56.3 ± 21.8 mL/min/mmHg vs. 36.9 ± 15.5 mL/min/mmHg, p = 0.003). The all-cause mortality and rate of lung transplantation was higher in the intermediate to high probability of PH group (5.4% vs. 20.7%, p = 0.041, 0% vs. 6.9%, p = 0.049). There was no difference in all-cause mortality between patients who were on immunosuppression vs. those who were not on immunosuppression in patients with intermediate to high probability of PH (33.3% vs. 7.1%; p = 0.169). Conclusions: Patients with MSA/MAA may have an increased risk of PH with reduced lung function, higher mortality, and greater rate of lung transplantation. Our study further elucidates the growing body of evidence that dermato-specific antibodies, such as MDA-5 are associated with an increased risk of PH. Further research is needed to investigate the role of PH and immunosuppression in these patients. Full article
(This article belongs to the Special Issue Clinical Research on Pulmonary Hypertension and Its Complications)
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