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Hip and Knee Arthroplasty: Update on Clinical Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 473

Special Issue Editor


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Guest Editor
Department of Orthopedic Surgery and Traumatology, Evangelisches Krankenhaus, 1180 Vienna, Austria
Interests: hip arthroplasty; knee arthroplasty; orthopedic surgery

Special Issue Information

Dear Colleagues,

Total hip and knee arthroplasties are among the most successful surgical interventions in modern medicine, providing substantial improvements in pain relief, function, and quality of life. Nevertheless, increasing procedure volumes, evolving patient demographics, and the adoption of new care models underscore the need for continuous refinement of clinical management strategies.

This Special Issue, "Hip and Knee Arthroplasty: Update on Clinical Management", offers a comprehensive, evidence-based overview of contemporary practices and emerging innovations in both primary and revision arthroplasty. The scope spans the entire perioperative pathway, covering advances in surgical techniques, perioperative optimization, infection prevention, multimodal analgesia, thromboprophylaxis, and enhanced recovery protocols.

Modern alignment philosophies in total knee arthroplasty (TKA)—ranging from traditional mechanical alignment to patient-specific functional approaches—are highlighted, alongside the evolving role of robotic-assisted surgery. Furthermore, this Special Issue explores recent developments for complex reconstructions and personalized implant solutions.

Collectively, these contributions provide an up-to-date, clinically relevant, and concise resource to support evidence-based decision-making in contemporary hip and knee arthroplasty practice.

Dr. Maximilian F. Kasparek
Guest Editor

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Keywords

  • total hip arthroplasty (THA)
  • total knee arthroplasty (TKA)
  • revision arthroplasty
  • implant fixation
  • cemented
  • cementless
  • hybrid
  • alignment in TKA
  • mechanical alignment
  • kinematic alignment
  • restricted kinematic alignment
  • functional alignment
  • navigation
  • robotic-assisted surgery
  • patient-specific instrumentation
  • additive manufacturing
  • 3D printing
  • personalized implant

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Published Papers (1 paper)

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Research

11 pages, 1914 KB  
Article
Synovial Periprosthetic Infection Markers Show High Variability in Different Clinical and Microbiological Settings
by Joachim Ortmayr, Jennifer Straub, Klemens Vertesich, Irene Katharina Sigmund, Christoph Böhler, Reinhard Windhager and Kevin Staats
J. Clin. Med. 2026, 15(1), 52; https://doi.org/10.3390/jcm15010052 - 21 Dec 2025
Viewed by 298
Abstract
Background/Objectives: Accurately diagnosing a periprosthetic joint infection (PJI) represents a challenging and complex task. Especially in the case of low-grade infections, important diagnostic modalities may be inconclusive and synovial markers such as white blood cell count (WBC) and polymorphonuclear percentage (PMN) gain relevance. [...] Read more.
Background/Objectives: Accurately diagnosing a periprosthetic joint infection (PJI) represents a challenging and complex task. Especially in the case of low-grade infections, important diagnostic modalities may be inconclusive and synovial markers such as white blood cell count (WBC) and polymorphonuclear percentage (PMN) gain relevance. We therefore aim to assess WBC and PMN in different clinical and microbiological settings. Methods: We performed a retrospective analysis of 115 patients with a diagnosed PJI. WBC and PMN were compared between patients with low- and high-virulent infections, negative and positive histology, symptom duration ≤ 4 weeks and >4 weeks, and positive and negative pathogen detection. Results: Synovial WBC was significantly higher in patients with successful pathogen detection (42.44 [87.0] G/L vs. 16.35 [32.0] G/L; p < 0.01), as was PMN (86.0 [60.0]% vs. 91.0 [89.0]%; p < 0.01). PJIs with high-virulent pathogens showed higher WBC compared to low-virulent pathogens (58.27 [102.0] G/L vs. 27.27 [46.0] G/L; p < 0.01). Patients with onset of symptoms ≤ 4 weeks demonstrated higher WBC (58.27 [112.0] G/L vs. 16.42 [46.0] G/L]; p < 0.01) as well as higher PMN (91.5 [9.0]% vs. 88.0 [20.0]%); p = 0.042). Cases with negative histology showed significantly lower WBC (16.73 [44.0] G/L vs. 42.86 [87.0] G/L; p < 0.01) and lower PMN (86.0 [67.0]% vs. 91.0 [9.0]%; p = 0.036). Conclusions: WBC and PMN show high variability and appear to be influenced by virulence, histology, onset of symptoms, and pathogen detection. Full article
(This article belongs to the Special Issue Hip and Knee Arthroplasty: Update on Clinical Management)
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