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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions

edited by Mauro Zaccarelli and

Alessandra Latini

submission deadline 20 Feb 2026 | 5 articles | Viewed by 16344 | Submission Open

Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex

(This special issue belongs to the Section Infectious Diseases)

Endodontic and Periodontal Medicine: Systemic Implications of Oral Infections

edited by

Juan J. Segura-Egea

and

Daniel Cabanillas-Balsera

submission deadline 20 Feb 2026 | 10 articles | Viewed by 15925 | Submission Open

Keywords: dentistry; endodontics; apical periodontitis; endodontic medicine; periodontal disease; periodontal medicine; pulpitis; systemic diseases; root canal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Blood Disorders: Diagnosis, Management, and Future Opportunities

edited by

Cristina Panuzzo

and

Barbara Pergolizzi

submission deadline 20 Feb 2026 | 4 articles | Viewed by 13612 | Submission Open

Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)

(This special issue belongs to the Section Hematology)

Pediatric Critical Care: Clinical Recognition, Management, and Outcomes

edited by Janet Hume

submission deadline 20 Feb 2026 | 6 articles | Viewed by 13220 | Submission Open

Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome

(This special issue belongs to the Section Clinical Pediatrics)

Cystic Fibrosis: Diagnosis and Treatment

edited by Corrado Tagliati and Gian Marco Giuseppetti

submission deadline 20 Feb 2026 | 6 articles | Viewed by 12887 | Submission Open

Keywords: cystic fibrosis; diagnosis; treatment; management

(This special issue belongs to the Section Respiratory Medicine)

Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management

edited by

Kornelia Zaręba

Aneta Słabuszewska-Jóźwiak

and Mohamed Ahmed Mostafa Aboellail

submission deadline 20 Feb 2026 | 5 articles | Viewed by 10351 | Submission Open

Keywords: preeclampsia; pregnancy complications; early intervention; diagnosis of pregnancy complications; management of pregnancy complications; sexual dysfunctions in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Orthopedic Surgery: Recent Advances and Prospects

edited by Mitchell K. Ng

submission deadline 20 Feb 2026 | 4 articles | Viewed by 9804 | Submission Open

Keywords: orthopedic surgery; clinical updates; joint reconstruction; spine surgery; trauma; elective surgery; peri-operative management

(This special issue belongs to the Section Orthopedics)

Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition

edited by

Amit Akirov

submission deadline 20 Feb 2026 | 6 articles | Viewed by 9521 | Submission Open

Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis

(This special issue belongs to the Section Endocrinology & Metabolism)

Neuroendocrine Tumors: Challenges and Future Perspectives (Second Edition)

edited by

Anna La Salvia

and

Giuseppe Lamberti

submission deadline 20 Feb 2026 | 5 articles | Viewed by 9223 | Submission Open

Keywords: neuroendocrine tumors; clinical challenges; innovative biomarkers; novel agents; personalized oncology

(This special issue belongs to the Section Oncology)

Navigating Pregnancy and Its Complications: Challenges and Innovations in Maternal–Fetal Medicine

edited by

Nikolaos Machairiotis

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8461 | Submission Open

Keywords: pregnancy; obstetrics; diabetes; high risk; preeclampsia; labor; delivery; hypertension; hemorrhage; embryo; screening

(This special issue belongs to the Section Obstetrics & Gynecology)

Targeted Treatment in Chronic Inflammatory Arthritis

edited by

Cinzia Rotondo

Simone Parisi

and Simone Perniola

submission deadline 20 Feb 2026 | 4 articles | Viewed by 8432 | Submission Open

Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; spondyloarthritis; disease-modifying antirheumatic drugs (DMARDs); personalized medicine; immunomodulatory therapies; patient outcomes; combination therapies

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Updates on Hereditary Hemorrhagic Telangiectasia (HHT) and Other Vascular Diseases

edited by Tamás Major

submission deadline 20 Feb 2026 | 5 articles | Viewed by 6393 | Submission Open

Keywords: hereditary hemorrhagic telangiectasia (HHT); arteriovenous malformations; embolization; VEGF; capillary malformation-arteriovenous malformation

(This special issue belongs to the Section Vascular Medicine)

Optimizing Present and Future Therapeutic Choices for Treatment and Management of Chronic Inflammatory Bowel Diseases—2nd Edition

edited by

Lorenzo Bertani

submission deadline 20 Feb 2026 | 2 articles | Viewed by 6316 | Submission Open

Keywords: Inflammatory Bowel Diseases(IBD); JAK inhibitors; mucosal healing

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Therapeutic Targets with Inflammatory Bowel Diseases

edited by Konstantinos H. Katsanos and

Fotios S. Fousekis

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5774 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Gastrointestinal Diseases: Clinical Challenges and Management

edited by Anusha Shirwaikar Thomas and

Yinghong Wang

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5758 | Submission Open

Keywords: GI bleed; nutrition; obstructive jaundice; drug-induced liver injury; GI motility; clostridium difficile infection; large bowel obstruction; colon cancer prevention and surveillance

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Immunotherapy of Cancer

edited by

Jessica Chacon

and

Shrikanth Gadad

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5756 | Submission Open

Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events

(This special issue belongs to the Section Oncology)

Non-Invasive Respiratory Support: Current Insights and Future Directions

edited by Giovanni Misseri and

Cesare Gregoretti

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5609 | Submission Open

Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine

(This special issue belongs to the Section Respiratory Medicine)

The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention

edited by

Justyna Wyszyńska

and

Piotr Matłosz

submission deadline 20 Feb 2026 | 5 articles | Viewed by 5598 | Submission Open

Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits

(This special issue belongs to the Section Clinical Rehabilitation)

Cardiopulmonary Resuscitation in Emergency Care Units

edited by

Stavros Dimopoulos

and

Christos Kourek

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5155 | Submission Open

Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes

(This special issue belongs to the Section Emergency Medicine)

Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management

edited by

Adrian Boicean

and

Cristian Ichim

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5091 | Submission Open

Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Updates on Lumbar Spine Surgery for Degenerative Diseases

edited by

Se-Jun Park

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5012 | Submission Open

Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes

(This special issue belongs to the Section Orthopedics)

Innovative Approaches to the Challenges of Neurodegenerative Disease

edited by Brian T. Bicknell and

Ann Liebert

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5002 | Submission Open

Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Clinical Neurology)

Interstitial Lung Disease: From Diagnosis to Treatment

edited by

Takeshi Saraya

and Tomohisa Baba

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4714 | Submission Open

Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Gastrointestinal Inflammation

edited by

Ivana Jukic

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4636 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Trends in Cardiomyopathy

edited by Giulia Iannaccone

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3958 | Submission Open

Keywords: cardiomyopathy; genetics; treatment; targeted therapy; prognosis; long-term follow up

(This special issue belongs to the Section Cardiology)

Neurosurgery: Recent Advances and New Perspectives in Skull Base Approaches

edited by Sèbastien Froelich and Matteo De Simone

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3916 | Submission Open

Keywords: skull base; neuroanatomy; tumors; augmented reality; ETOA; EEA; exoscopy; endoscopy; multi-portal approaches

(This special issue belongs to the Section Clinical Neurology)

Intraocular Lenses for Cataract Surgery: Clinical Advances and Perspectives

edited by Choul Yong Park

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3866 | Submission Open

Keywords: cataract surgery; intraocular lens; IOL formula; optic; complication; presbyopia; refractive

(This special issue belongs to the Section Ophthalmology)

Clinical Updates in Trauma and Emergency Medicine

edited by Yong-Soo Cho and Hyun Ho Ryu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3856 | Submission Open

Keywords: emergency medicine; epidemiology; cardiovascular disease

(This special issue belongs to the Section Emergency Medicine)

Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques

edited by Francesco Coppolino and

Vincenzo Pota

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3783 | Submission Open

Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management

(This special issue belongs to the Section Anesthesiology)

Recent Developments in Hearing and Balance Disorders: 2nd Edition

edited by

Juan Carlos Amor-Dorado

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3728 | Submission Open

Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance

(This special issue belongs to the Section Otolaryngology)

Pain Management: Current Challenges and Future Prospects

edited by Gian Marco Petroni

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3708 | Submission Open

Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs

(This special issue belongs to the Section Anesthesiology)

Clinical Progress of Spine Surgery

edited by

Edoardo Mazzucchi

and Gianluca Vadalà

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3336 | Submission Open

Keywords: spine surgery; rehabilitation; robotic surgery; spinal endoscopy; spinal tumor; back pain; minimally invasive surgery; spinal fusion

(This special issue belongs to the Section Clinical Neurology)

Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes

edited by Filippo Carannante and Leandro Siragusa

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3323 | Submission Open

Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology

(This special issue belongs to the Section General Surgery)

Acute Kidney Events in Intensive Care Patients

edited by Kada Klouche

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3173 | Submission Open

Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers

(This special issue belongs to the Section Intensive Care)

New Perspectives in Acute Coronary Syndrome

edited by Makoto Natsumeda

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3071 | Submission Open

Keywords: acute coronary syndrome; PCI; interventional cardiology; coronary imaging; antiplatelet therapy; stentless PCI strategy; CABG; revascularization

(This special issue belongs to the Section Cardiology)

State of the Art in Invasive Vascular Interventions (Second Edition)

edited by

Edit Dósa

and Luca Mezzetto

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3018 | Submission Open

Keywords: coronary artery interventions; non-coronary artery cardiac interventions; open surgical cardiac procedures; endo-vascular interventions; open surgical vascular procedures

(This special issue belongs to the Section Vascular Medicine)

Kidney Transplantation: State of the Art Knowledge

edited by

Georgios Koimtzis

, Georgios Geropoulos and Kyriakos Psarras

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2994 | Submission Open

Keywords: kidney transplantation; end-stage renal disease; immunosuppression; organ donation; graft survival; graft rejection

(This special issue belongs to the Section Nephrology & Urology)

Management of Pregnancy Complications: 2nd Edition

edited by Ariel Many

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2829 | Submission Open

Keywords: high-risk pregnancy; preterm labor; fetal growth restriction; gestational diabetes; twins; hypertensive disorders during pregnancy; preeclampsia; IUGR; prenatal genetics; congenital anomaly detection; cesarean section; complications of labor and delivery

(This special issue belongs to the Section Obstetrics & Gynecology)

Surgical Precision: The Impact of AI and Robotics in General Surgery

edited by Tamara M. H. Gall

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2808 | Submission Open

Keywords: robotic surgery; artificial intelligence in surgery; surgical training; AR in surgery; 3D imaging; surgical navigation

(This special issue belongs to the Section General Surgery)

New Insights in the Diagnosis, Treatment and Monitoring of Anemia, Inflammation and Infection

edited by

Christian Hönemann

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2705 | Submission Open

Keywords: anemia; inflammation; infection; diagnostic tools; therapeutic strategies

(This special issue belongs to the Section Hematology)

Advances in Diagnosis and Therapeutic Strategies for Uveal Melanoma

edited by Yong Qin

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2581 | Submission Open

Keywords: uveal melanoma; immunotherapy; targeted therapy; biomarker; disease management; drug development; drug resistance

(This special issue belongs to the Section Ophthalmology)

Advances in Knee Surgery and Musculoskeletal Rehabilitation: 2nd Edition

edited by

Giulio Maria Marcheggiani Muccioli

and

Giada Lullini

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2571 | Submission Open

Keywords: computer-assisted surgical navigation; smart cutting guides; robotic-assisted surgery; fast-track; telemedicine; tele-rehabilitation; virtual reality

(This special issue belongs to the Section Orthopedics)

Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care

edited by

Peter Radermacher

and Thomas Kapapa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2550 | Submission Open

Keywords: intracranial hypertension; cerebral perfusion pressure; decompressive craniectomy; brain tissue oxygenation; brain tissue microdialysis; blood brain barrier; neuro-critical care

(This special issue belongs to the Section Brain Injury)

Global Expert Views on Clinical Aesthetic Plastic Surgery

edited by

Won Lee

and

Seong Hwan Kim

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2495 | Submission Open

Keywords: aesthetic surgery; cosmetic surgery; dermal fillers; facial plastic surgery; soft tissue fillers; filler complications; ultrasound guided filler injection; hyaluronic acid filler

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice

edited by Ilaria Marcantoni and Michela Casella

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2470 | Submission Open

Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing

(This special issue belongs to the Section Cardiology)

Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia

edited by

Blanca Gonzalez-Sanchez

María Jiménez-Palomares

and

Juan Rodríguez-Mansilla

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2462 | Submission Open

Keywords: cognition; dementia; rehabilitation; exercise; memory; physical activity; Alzheimer’ s disease; non-pharmacological therapies

(This special issue belongs to the Section Clinical Rehabilitation)

Epidemiology of Hyperglycemia in Pregnancy and Its Maternofetal Adverse Outcomes

edited by

Giuseppe Seghieri

submission deadline 20 Feb 2026 | 4 articles | Viewed by 2377 | Submission Open

Keywords: gestational diabetes; diabetes in pregnancy; risk factors; epidemiology; maternofetal adverse outcomes in pregnancies with hypergliycemia; temporal trends

(This special issue belongs to the Section Endocrinology & Metabolism)

Thrombosis: Latest Advances and Prospects

edited by Manila Gaddh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2144 | Submission Open

Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation

(This special issue belongs to the Section Hematology)

Pancreatitis: Current Perspectives on Diagnosis and Management

edited by

Alberto Maringhini

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2088 | Submission Open

Keywords: acute pancreatitis; chronic pancreatitis; pancreatitis; pancreatic cancer; eco-endoscopy; gallstones; biliary stones

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Advances and Future Perspectives of Ischemic Stroke

edited by

Marzia Baldereschi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2054 | Submission Open

Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood– brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke

(This special issue belongs to the Section Clinical Neurology)

Displaying special issue 551-600 on page 12 of 32.

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