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Optimizing Present and Future Therapeutic Choices for Treatment and Management of Chronic Inflammatory Bowel Diseases—2nd Edition

Special Issue Editor

Special Issue Information

Dear Colleagues,

The management of inflammatory bowel diseases (IBDs) has been revolutionized in recent years due to the approval of several new therapeutic options involving new inflammation pathways.

However, we must understand how to choose the correct drug for a patient. The main goal of future IBD research would be to identify new drug-specific biomarkers, which is similar to oncological management.

We invite you to visit our website to access the first volume of this Special Issue, which is available at the following link:

https://www.mdpi.com/journal/jcm/special_issues/X86D52SV7A

This Special Issue, in the Journal of Clinical Medicine, aims to place a spotlight on studies that are able to improve our knowledge of IBDs.

Dr. Lorenzo Bertani
Guest Editor

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Keywords

  • Inflammatory Bowel Diseases(IBD)
  • JAK inhibitors
  • mucosal healing

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Published Papers (1 paper)

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Research

14 pages, 2719 KiB  
Article
Age as a Predictor of Serum Tumor Necrosis Factor Antagonist Drug and Antidrug Antibody Concentrations in Inflammatory Bowel Disease—A Nationwide Cohort Study
by Mohammad Shehab and Fatema Alrashed
J. Clin. Med. 2025, 14(4), 1057; https://doi.org/10.3390/jcm14041057 - 7 Feb 2025
Viewed by 852
Abstract
Background/Objectives: Tumor necrosis factor antagonists (anti-TNFs) have been shown to be an effective treatment for inflammatory bowel disease (IBD). Several factors are associated with anti-TNF treatment failure. This study aims to explore the impact of age on serum concentrations of anti-TNF drugs [...] Read more.
Background/Objectives: Tumor necrosis factor antagonists (anti-TNFs) have been shown to be an effective treatment for inflammatory bowel disease (IBD). Several factors are associated with anti-TNF treatment failure. This study aims to explore the impact of age on serum concentrations of anti-TNF drugs and antidrug antibodies (ADAbs). Methods: We retrospectively reviewed patients’ charts from July 2018 until September 2024 across seven medical centers. Patients with an established diagnosis of IBD receiving infliximab or adalimumab were included. The primary outcome of this study was the effect of age on the anti-TNFs serum drug concentration and ADAb levels. Linear regression was performed to explore the relationship between age and serum anti-TNF drug and ADAb levels. Results: 1093 patients were included in our cohort. In patients receiving infliximab, there was a significant association between older age and increasing ADAbs levels (p = 0.036), whereas in patients treated with adalimumab, there was no significant relationship between older age and ADAb levels (p = 0.771). There was no significant relationship between age and adalimumab serum concentration (p = 0.54). When stratified by age, patients taking infliximab who were >30 years of age developed more ADAbs compared to those aged ≤30 (p = 0.003). Conclusions: Patients older than 30 years of age receiving infliximab monotherapy have higher ADAbs and lower serum drug concentrations than younger patients. There was no statistically significant difference in ADAbs and serum drug concentrations among patients receiving infliximab combination therapy or adalimumab monotherapy. Full article
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