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Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management
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Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 4376

Special Issue Editors

Dr. Kornelia Zaręba

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Guest Editor
Department of Obstetrics and Gynecology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates
Interests: psychosocial aspects of pregnancy; termination of pregnancy; postpartum depression; MRKH; postpartum sexual dysfunctions; obstetrical endocrinology; infertility; endocrinology
Special Issues, Collections and Topics in MDPI journals
Dr. Aneta Słabuszewska-Jóźwiak

E-Mail Website
Guest Editor
1st Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 01-813 Warsaw, Poland
Interests: myomectomy; surgery; minimal invasive gynecological surgery; tumors; cancer
Dr. Mohamed Ahmed Mostafa Aboellail

E-Mail
Guest Editor
Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan
Interests: fetal heart ultrasound; prenatal diagnosis; fetal development; fetal growth restriction; fetal therapies; sonography doppler ultrasound; fetal echocardiography; fetal neurobehavior; fetal medicine

Special Issue Information

Dear Colleagues,

Pregnant women face unique healthcare challenges. As they tend to live longer and conceive later, long-term care issues increasingly affect them from year to year. Consequently, there is a growing need for new research and review manuscripts focused on pregnancy complications. Early intervention, accurate diagnosis, and effective management are crucial in addressing these complications. This Special Issue aims to meet the urgent demand for updated knowledge and practices related to pregnancy complications in order to enhance women's health overall.

The issue will focus on critical areas such as improving diagnostic accuracy, enhancing the quality of prenatal screening, and integrating innovative diagnostic methods into routine clinical practice. Special attention will be given to pre-eclampsia, one of the most common conditions occurring during pregnancy. Additionally, this Special Issue will explore the psychosocial aspects of pregnancy, including psychiatric disorders, abortion, and postpartum women's sexuality, while considering the local laws and culture of different countries.

Potential topics include, but are not limited to, the following:

  1. Pre-eclampsia and chronic hypertension in pregnancy;
  2. Gestational diabetes mellitus;
  3. Postpartum hemorrhage;
  4. Obstetrics emergencies;
  5. Perinatal depression and anxiety;
  6. Psychiatric disorders in pregnancy;
  7. Recurrent miscarriages;
  8. Abortion;
  9. Postpartum women’s sexual dysfunctions.

We eagerly anticipate submissions that provide insightful perspectives, innovative approaches, and significant research findings to advance the evolving field of obstetrics.

Dr. Kornelia Zaręba
Dr. Aneta Słabuszewska-Jóźwiak
Dr. Mohamed Ahmed Mostafa Aboellail
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • preeclampsia
  • pregnancy complications
  • early intervention
  • diagnosis of pregnancy complications
  • management of pregnancy complications
  • sexual dysfunctions in pregnancy

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Published Papers (4 papers)

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10 pages, 225 KB  
Article
First-Trimester Clinical Characteristics and Pregnancy Outcomes in Women with Recurrent Pregnancy Loss
by Cristina Trilla, Judit Platero, Núria Camprubí, Josefina Mora, Cristina Luna, Daniel Oros and Elisa Llurba
J. Clin. Med. 2025, 14(16), 5797; https://doi.org/10.3390/jcm14165797 - 16 Aug 2025
Viewed by 311
Abstract
Objective: To describe first-trimester maternal, biochemical, biophysical, and ultrasound characteristics in women with recurrent pregnancy loss (RPL) compared to women without RPL. Methods: This was a retrospective cohort study analyzing data from 4440 pregnant women, including 142 women with previous RPL. [...] Read more.
Objective: To describe first-trimester maternal, biochemical, biophysical, and ultrasound characteristics in women with recurrent pregnancy loss (RPL) compared to women without RPL. Methods: This was a retrospective cohort study analyzing data from 4440 pregnant women, including 142 women with previous RPL. Maternal and pregnancy characteristics, first-trimester biochemical markers, biophysical assessments, early-onset preeclampsia (EOPE) risk, and perinatal outcomes were compared. Results: Women with RPL were older (37.8 vs. 34.0 years, p < 0.001) and had higher rates of antiphospholipid syndrome (4.9% vs. 0.9%, p < 0.001), other thrombophilias (5.6% vs. 0.8%, p < 0.001), and thyroid disorders (14% vs. 7.5%, p = 0.010) than women without RPL. First-trimester uterine artery pulsatility index (UtA-PI) values, pregnancy-associated plasma protein-A (PAPP-A) levels, mean arterial pressure, and final risk for EOPE were comparable between groups. However, the RPL group had higher rates of very high risk for PE (10.6 vs. 5.1, p = 0.011). Likewise, second-trimester UtA-PI was higher in this group (1.10 vs. 1.01, p = 0.045). Aspirin and low molecular weight heparin prophylaxis were more frequent in women with RPL (23.8% vs. 9.6%, p < 0.001; 14.7% vs. 0.1%, p < 0.001). Regarding perinatal outcomes, we found a higher incidence of second-trimester intrauterine demise in the RPL group (6.4% vs. 1.4%, p = 0.011), with no other differences observed in the remaining outcomes. Conclusions: Women with RPL exhibit distinct maternal characteristics and worse pregnancy outcomes, although first-trimester markers do not seem to significantly differ from findings in women without RPL. These findings underscore the importance of tailored screening and intervention protocols to improve perinatal outcomes in this high-risk population. Full article
(This article belongs to the Special Issue Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management)
14 pages, 498 KB  
Article
The Compounded Risk of Maternal Anemia and Preeclampsia: Neonatal Outcomes and Predictive Modeling in a Low-Resource Tertiary Center
by Victor Bogdan Buciu, Sebastian Ciurescu, Denis Mihai Șerban, Dorin Novacescu, Nicolae Nicoleta, Larisa Tomescu, Elena Lavinia Rusu, Ioan Sas, Mihai Ionac and Veronica-Daniela Chiriac
J. Clin. Med. 2025, 14(14), 5051; https://doi.org/10.3390/jcm14145051 - 16 Jul 2025
Viewed by 362
Abstract
Background: Anemia and preeclampsia are common and independently associated with adverse neonatal outcomes. Their combined effect, however, remains insufficiently explored. This study aims to evaluate the impact of second-trimester maternal anemia on neonatal outcomes in pregnancies complicated by preeclampsia, and to assess [...] Read more.
Background: Anemia and preeclampsia are common and independently associated with adverse neonatal outcomes. Their combined effect, however, remains insufficiently explored. This study aims to evaluate the impact of second-trimester maternal anemia on neonatal outcomes in pregnancies complicated by preeclampsia, and to assess its predictive value for preterm birth and NICU admission. Methods: We conducted a retrospective cohort study including 3517 singleton births from a Romanian tertiary maternity hospital between October 2023 and December 2024. A total of 295 preeclamptic pregnancies were stratified by anemia severity (none, mild, moderate-to-severe) and compared with 428 matched non-preeclamptic anemic pregnancies matched by closest-neighbor selection. Neonatal outcomes included birthweight, gestational age, anthropometric parameters, Apgar score, preterm birth, and NICU admission. Logistic regression and ROC curve analysis were performed using anemia severity as a predictor. Results: Moderate-to-severe anemia in preeclamptic pregnancies was associated with significantly lower birthweight (2618 ± 461 g), shorter gestational age (36.6 ± 2.0 weeks), and higher preterm birth (41.1%) and NICU admission rates (40.0%) were compared to non-anemic counterparts. Each increase in anemia severity conferred 84% higher odds of preterm delivery (OR = 1.84; AUC = 0.63) and a 49% increase in NICU admission (OR = 1.49; AUC = 0.58). Youden’s indices were 0.25 and 0.14, respectively. Conclusions: Maternal anemia is associated with increased neonatal morbidity in preeclamptic pregnancies, with moderate predictive value for preterm birth. These findings support the integration of early anemia screening and risk stratification into hypertensive pregnancy protocols to improve perinatal outcomes. Full article
(This article belongs to the Special Issue Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management)
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16 pages, 921 KB  
Article
The Impact of Maternal Education on Neonatal Outcomes in Preeclamptic Pregnancies from a Low-Resource Settings
by Victor Bogdan Buciu, Denis Mihai Șerban, Sebastian Olariu, Dorin Novacescu, Cosmin Cîtu, Sebastian Ciurescu, Larisa Tomescu, Adrian Claudiu Rațiu, Ioan Sas, Mihai Ionac and Veronica-Daniela Chiriac
J. Clin. Med. 2025, 14(11), 3937; https://doi.org/10.3390/jcm14113937 - 3 Jun 2025
Cited by 1 | Viewed by 870
Abstract
Background/Objective: Preeclampsia is a hypertensive disorder associated with pregnancy that has a significant impact on maternal and neonatal health and has the potential to result in significant perinatal adverse outcomes. Maternal education has been proposed as a protective factor during pregnancy; however, its [...] Read more.
Background/Objective: Preeclampsia is a hypertensive disorder associated with pregnancy that has a significant impact on maternal and neonatal health and has the potential to result in significant perinatal adverse outcomes. Maternal education has been proposed as a protective factor during pregnancy; however, its role in preeclamptic pregnancies remains unclear. This study aimed to explore the relationship between maternal education level, as defined by ISCED classification, and neonatal outcomes (birth weight, gestational age, and APGAR score) in pregnancies complicated by preeclampsia. Methods: A retrospective case-control analysis was conducted on 674 deliveries at a single tertiary center in Western Romania between January 2022 and August 2024. Neonatal outcomes, specifically birth weight, gestational age, and APGAR scores were studied and stratified into three ISCED-based maternal education subgroups. Statistical analyses, including ANOVA, chi-square tests, and logistic regression, were used to analyze the effect of maternal education, with confounders such as maternal age and chronic hypertension being controlled for. Results: Preeclampsia was associated with lower birth weight (p < 0.001), gestational age at birth (p < 0.001), and APGAR scores (p < 0.001) than the control group. Maternal level of education was associated with better neonatal outcomes in the preeclamptic group, with lower odds of fetal growth restriction (OR = 0.68, p = 0.03) and preterm birth; however, the effect was less pronounced in the control group. Conclusions: Maternal education partially mitigates the adverse effects of preeclampsia on neonatal well-being, birth weight, and gestational age at birth. These findings underscore the importance of incorporating maternal education into prenatal care programs to improve perinatal outcomes, with a special focus on high-risk pregnancies. Full article
(This article belongs to the Special Issue Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management)
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22 pages, 3523 KB  
Systematic Review
Sexual Dysfunctions in Breastfeeding Females: Systematic Review and Meta-Analysis
by Darya Smetanina, Shouq Alnuaimi, Afra Alkaabi, Meera Alketbi, Elshimaa Hamam, Hanin Alkindi, Mahra Almheiri, Rouda Albasti, Hajar Almansoori, Mahra Alshehhi, Shamsa Al Awar, Yauhen Statsenko and Kornelia Zaręba
J. Clin. Med. 2025, 14(3), 691; https://doi.org/10.3390/jcm14030691 - 22 Jan 2025
Viewed by 2424
Abstract
Background: The prevalence of sexual dysfunctions varies from 35.5% to over 80% among postpartum women. Controversy exists regarding the risk factors for female sexual dysfunction (FSD) in the postpartum period. It remains unclear whether breastfeeding types contribute to the development of FSDs differently. [...] Read more.
Background: The prevalence of sexual dysfunctions varies from 35.5% to over 80% among postpartum women. Controversy exists regarding the risk factors for female sexual dysfunction (FSD) in the postpartum period. It remains unclear whether breastfeeding types contribute to the development of FSDs differently. Aims: The primary goal of this meta-analysis was to explore the role of baby feeding practices in developing sexual dysfunctions in women. Methods: We conducted a systematic literature search using the biomedical databases Scopus, CINAHL, Embase, the Web of Science, and PubMed/Medline. We looked for peer-reviewed, original studies written in English, Polish, and Arabic and published between January 2000 and June 2023. We included publications that reported scores in sexuality domains assessed with the Female Sexual Dysfunction Index (FSFI) and any sexuality-related issues during postpartum. The FSFI scores were combined in a meta-analysis using the random-effects inverse-variance model. Other findings were synthesized with a narrative review. Results: Eighteen articles met the eligibility criteria for the systematic review and meta-analysis. Sexual dysfunctions were detected in all the women, irrespective of the feeding type. Better overall sexual functioning was reported among women using complementary feeding than among those who breastfed exclusively or used baby bottles: 22.16, 95% CI [21.68; 22.65]; 21.61, 95% CI [20.27; 22.95]; and 20.18, 95% CI: [20.93; 61.30], respectively. Slightly lower scores were reported in all the FSFI subscales in exclusively breastfeeding women compared to those using the complementary method. Conclusions: Breastfeeding females experience difficulties in sexual life during the postpartum period, irrespective of the feeding type. These findings can help in designing preventive measures for tackling postpartum sexual dysfunctions in women. Full article
(This article belongs to the Special Issue Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management)
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