Research on Drug Metabolism and Disposition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 3050
Special Issue Editor
Special Issue Information
Dear Colleagues,
A sound understanding of the metabolism and disposition of small-molecule candidate drugs is key to being able to confidently nominate them for clinical development, as well as to their success in the clinic. Current drug design paradigms generate metabolically stable compounds that pose a number of challenges with respect to the characterization of their metabolism. While different chemical series can present with unique challenges, the general metabolic stability of the compounds means reliable in vivo clearance predictions and estimation of enzyme contributions to metabolism can be difficult to make based on in vitro assays. Furthermore, the suitability of classical in vitro sub-cellular systems such as liver microsomes has been placed under the spotlight, as more data show fundamental differences relative to intact cells and in vivo studies. The development of so-called ‘beyond-rule-of-5′ compounds has also seen significant challenges involving the suitability of current in vitro metabolism assays, such as those for assessing protein binding.
The aim of this Special Issue is, therefore, to showcase how novel drug metabolism approaches have been used to overcome these and other challenges. We particularly welcome studies in which a combination of in vitro/in vivo metabolism/biotransformation and modeling are used to unravel complex metabolism.
Dr. Tashinga E. Bapiro
Guest Editor
Manuscript Submission Information
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Keywords
- drug metabolism
- metabolite identification
- biotransformation
- clearance
- bioavailability
- pharmacokinetics
- absorption
- dose prediction
- reaction phenotyping
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