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Plant Derived Anti-cancer Bioactive Molecules

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 100

Special Issue Editor

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Guest Editor
Chair of Fundamental Sciences, Department of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland
Interests: anti-cancer synthetic molecules; glioblastoma multiforme; hematological malignancies; anti-cancer bioactive molecules; apoptosis; cell cycle

Special Issue Information

Dear Colleagues,

Cancers represent one of the most common causes of death worldwide. Current drug anti-cancer treatment is multidirectional and involves both synthetic compounds and bioactive ones. Bioactive anti-cancer molecules are compounds derived from natural sources (e.g., plants, microorganisms, animals) and were discovered for the first time thousands of years ago. To date, at least 78 plant-derived compounds, also called phytochemicals, have been found to show anti-cancer activity. These include alkaloids, flavonoids, terpenes, isoflavones, and phenols. Some of these compounds have been successfully used in current treatment regimens and some are still under investigation for use in cancer cell lines. For example, vinca alkaloids like vincristine, vinorelbine, and vinblastine are plant-derived molecules and cell cycle inhibitors that have been used in the chemotherapeutic regimens of both solid and hematological malignancies for many years. The antiproliferative activity of bioactive molecules is also associated with their inhibition of certain intracellular signaling pathways that play a key role in development and maintenance of cancer cells. Moreover, natural molecules, due to their relatively low toxicity compared to synthetic compounds, are currently an attractive therapeutic target in cancer treatment.

This Special Issue of the International Journal of Molecular Sciences is dedicated to all research types, including both original and review articles, exploring new or already known plant-derived anti-cancer compounds with special attention paid to their mechanisms of action in cancer cells and their safety profile.

Dr. Katarzyna Kotwica-Mojzych
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural cell cycle inhibitors
  • novel anti-cancer bioactive compounds
  • bioactive antiapoptotic molecules
  • DNA targeting natural molecules

Published Papers

This special issue is now open for submission.
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