Plant Derived Anti-Cancer Bioactive Molecules
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 1290
Special Issue Editor
Interests: anti-cancer synthetic molecules; glioblastoma multiforme; hematological malignancies; anti-cancer bioactive molecules; apoptosis; cell cycle
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancers represent one of the most common causes of death worldwide. Current drug anti-cancer treatment is multidirectional and involves both synthetic compounds and bioactive ones. Bioactive anti-cancer molecules are compounds derived from natural sources (e.g., plants, microorganisms, animals) and were discovered for the first time thousands of years ago. To date, at least 78 plant-derived compounds, also called phytochemicals, have been found to show anti-cancer activity. These include alkaloids, flavonoids, terpenes, isoflavones, and phenols. Some of these compounds have been successfully used in current treatment regimens and some are still under investigation for use in cancer cell lines. For example, vinca alkaloids like vincristine, vinorelbine, and vinblastine are plant-derived molecules and cell cycle inhibitors that have been used in the chemotherapeutic regimens of both solid and hematological malignancies for many years. The antiproliferative activity of bioactive molecules is also associated with their inhibition of certain intracellular signaling pathways that play a key role in development and maintenance of cancer cells. Moreover, natural molecules, due to their relatively low toxicity compared to synthetic compounds, are currently an attractive therapeutic target in cancer treatment.
This Special Issue of the International Journal of Molecular Sciences is dedicated to all research types, including both original and review articles, exploring new or already known plant-derived anti-cancer compounds with special attention paid to their mechanisms of action in cancer cells and their safety profile.
Dr. Katarzyna Kotwica-Mojzych
Guest Editor
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Keywords
- natural cell cycle inhibitors
- novel anti-cancer bioactive compounds
- bioactive antiapoptotic molecules
- DNA targeting natural molecules
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