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Molecular Advances in Ovarian Cancer: 2nd Edition

Special Issue Editor

1. Graduate Institute of Medicine, College of Medicine & Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
2. Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung 807377, Taiwan
Interests: high-risk pregnancies; perinatal medicine; genetic diagnosis; obstetrics and gynecology; endocrinology of reproduction
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Special Issue Information

Dear Colleagues,

Ovarian cancer is the most lethal gynecological malignancy in the world due to the lack of early detection tools and effective therapeutic intervention. Healthcare related to these has been an important issue and remains to be explored. Recent studies have identified that each histotype of ovarian cancer shows different molecular mechanisms of carcinogenesis. This special issue aim to collect paper focused on pathogenesis, tumor microenvironment in Ovarian cancer progression.

Dr. Te-Fu Chan
Guest Editor

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Keywords

  • pathogenesis
  • tumor microenvironment
  • ovarian cancer

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Related Special Issue

Published Papers (1 paper)

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Research

15 pages, 1954 KiB  
Article
Assessment of Molecular Markers in Pediatric Ovarian Tumors: Romanian Single-Center Experience
by Ovidiu Bîcă, Carmen Iulia Ciongradi, Diana Benchia, Ioan Sârbu, Mirabela Alecsa, Alexandra Elena Cristofor, Delia Elena Bîcă and Ludmila Lozneanu
Int. J. Mol. Sci. 2024, 25(12), 6752; https://doi.org/10.3390/ijms25126752 - 19 Jun 2024
Cited by 1 | Viewed by 1092
Abstract
Pediatric ovarian tumors exhibit unique diagnostic and therapeutic challenges. This study evaluates the expression of SALL4 and OCT3/4 biomarkers in pediatric ovarian tumors and their associations with tumor subtype, stage, and clinical outcome. A retrospective analysis was conducted on 64 patients under 18 [...] Read more.
Pediatric ovarian tumors exhibit unique diagnostic and therapeutic challenges. This study evaluates the expression of SALL4 and OCT3/4 biomarkers in pediatric ovarian tumors and their associations with tumor subtype, stage, and clinical outcome. A retrospective analysis was conducted on 64 patients under 18 years old, examining demographic data, tumor characteristics, immunohistochemical staining, and clinical outcomes. Our results show that SALL4 was significantly expressed in adenocarcinoma, dysgerminoma (DSG), mixed germ cell tumors (GCTs), and immature teratoma, while OCT3/4 was highly expressed in DSG and mixed GCTs. Both markers are associated with a higher tumor grade and stage, indicating a more aggressive disease. The SALL4 positivity expression was correlated with high alpha fetoprotein (AFP) and lactate dehydrogenase (LDH) levels, while OCT3/4 positivity significantly predicted the risk of subsequent metastasis. The mean progression-free survival (PFS) was notably shorter in patients with positive markers. These findings underscore the diagnostic and prognostic value of SALL4 and OCT3/4 in pediatric ovarian tumors, aligning with previous research and supporting their use in clinical practice for better disease management and patient outcomes. Full article
(This article belongs to the Special Issue Molecular Advances in Ovarian Cancer: 2nd Edition)
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