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New Advances in Bioactive Compounds in Health and Disease
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New Advances in Bioactive Compounds in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1793

Special Issue Editor

Dr. Luís Silva

E-Mail Website
Guest Editor
1. SPRINT Sport Physical Activity and Health Research & Innovation Center, Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal
2. CICS/UBI, Universidade da Beira Interior, Covilhã, Portugal
Interests: bioactive compounds; phytochemicals; natural products as health promoters; chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of bioactive compounds, particularly those from medicinal plants, in dietary supplements, nutraceuticals, and pharmaceuticals has received special attention in recent years. This is mainly based on the common belief that they are safer and more effective than synthetic drugs, and also due to their lower price, toxicity, and side effects. Among them, phenolic compounds have been a target of several studies and a hot topic of research. They constitute the largest group of secondary metabolites of plants and are classified as flavonoid (flavonols, flavanols, flavones, flavanones, isoflavones, and anthocyanins) and non-flavonoid compounds (phenolic acids, hydroxycinnamic acids, lignans, stilbenes, and tannins) and exhibit remarkable health-promoting properties, namely, antioxidant, anti-inflammatory, antimutagenic, vasodilator, antidiabetic, and anticancer effects; provide neurological and cardiovascular protection; improve memory; and can be used as additives for beverages, foods, nutraceuticals, pharmaceutical products, and cosmetics.

Dr. Luís Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • phenolic compounds
  • bioactive compounds
  • health-promoting properties
  • human diseases
  • chronic diseases

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Published Papers (2 papers)

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Research

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19 pages, 9200 KiB  
Article
A Novel Butyrate Derivative, Zinc Dibutyroyllysinate, Blunts Microphthalmia-Associated Transcription Factor Expression and Up-Regulates Retinol and Differentiation Pathway mRNAs in a Full-Thickness Human Skin Model
by William R. Swindell, Krzysztof Bojanowski, Geovani Quijas and Ratan K. Chaudhuri
Int. J. Mol. Sci. 2025, 26(6), 2442; https://doi.org/10.3390/ijms26062442 - 9 Mar 2025
Viewed by 753
Abstract
Lysine, butyric acid, and zinc play important roles in skin homeostasis, which involves aging, inflammation, and prevention of skin barrier disruption. This bioactivity spectrum is not replicated by any one topical compound currently in use. Our purpose in this study was to characterize [...] Read more.
Lysine, butyric acid, and zinc play important roles in skin homeostasis, which involves aging, inflammation, and prevention of skin barrier disruption. This bioactivity spectrum is not replicated by any one topical compound currently in use. Our purpose in this study was to characterize a novel compound, zinc dibutyroyllysinate (ZDL), consisting of zinc with lysine and butyric acid moieties. We used RNA-seq to evaluate its effect on gene expression in a full-thickness skin model. We show that lysine alone has minimal effects on gene expression, whereas ZDL had greater transcriptional bioactivity. The effects of ZDL included an increased expression of genes promoting epidermal differentiation and retinol metabolism, along with a decreased expression of microphthalmia-associated transcription factor (MITF) and other melanogenesis genes. These effects were not replicated by an alternative salt compound (i.e., calcium dibutyroyllysinate). ZDL additionally led to a dose-dependent increase in skin fibroblast extracellular matrix proteins, including collagen I, collagen IV, and prolidase. Loss of melanin secretion was also seen in ZDL-treated melanocytes. These results provide an initial characterization of ZDL as a novel topical agent. Our findings support a rationale for the development of ZDL as a skincare ingredient, with potential applications for diverse conditions, involving melanocyte hyperactivity, pigmentation, inflammation, or aging. Full article
(This article belongs to the Special Issue New Advances in Bioactive Compounds in Health and Disease)
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Review

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31 pages, 1776 KiB  
Review
Phenolic Acids from Fruit By-Products as Therapeutic Agents for Metabolic Syndrome: A Review
by Ana R. Nunes, Gilberto Alves, Amílcar Falcão, João A. Lopes and Luís R. Silva
Int. J. Mol. Sci. 2025, 26(8), 3834; https://doi.org/10.3390/ijms26083834 - 18 Apr 2025
Viewed by 575
Abstract
The cultivation and processing of fruits generate a wide range of by-products (e.g., pulp, seeds, pomace, leaves, and stems), which are often underutilized despite being rich sources of phenolic compounds with well-documented bioactive properties. The bioactive potential of these compounds has attracted significant [...] Read more.
The cultivation and processing of fruits generate a wide range of by-products (e.g., pulp, seeds, pomace, leaves, and stems), which are often underutilized despite being rich sources of phenolic compounds with well-documented bioactive properties. The bioactive potential of these compounds has attracted significant interest from both the pharmaceutical and food sectors, offering opportunities for their use in functional foods, dietary supplements, natural medicines, and additives. Among these, phenolic acids have shown promising potential in modulating risk factors associated with metabolic syndrome (MetS), a condition encompassing hypertension, dyslipidemia, hyperglycemia, and abdominal obesity, and contributing significantly to cardiovascular disease. Given the global burden of MetS and the need for novel preventive strategies, numerous studies have investigated the bioactivity of phenolic acids derived from fruit by-products. In this review, we critically examine recent studies regarding the phenolic acid composition of fruit-derived by-products and their biological activity in relation to MetS-related risk factors. This work aims to synthesize current findings, highlight prevailing research trends, and identify existing gaps in the literature to inform future research and promote the sustainable use of fruit by-products in the prevention and management of MetS. Full article
(This article belongs to the Special Issue New Advances in Bioactive Compounds in Health and Disease)
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