Obesity and Malignancies in Women: Searching for New Molecular Links
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 2177
Special Issue Editor
Interests: cancer; breast cancer; obesity; tumor microenvironment; extracellular vesicles; ESR1 mutations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity, with its increasing global incidence, poses a significant risk to health, being linked to many debilitating and fatal diseases, including at least 13 unique cancers that can lead to poor patient outcomes across both sexes. Women are more likely to be overweight or obese and thus more susceptible to obesity-related cancers. Although the strong epidemiological link between cancer and obesity has been widely reported, the molecular mechanisms underlying this association are still under investigation. Among the factors thought to be involved in obesity-related malignancies are alterations in the inflammatory status, changes in hormone and adipokine levels, and oxidative stress. However, the complexity of the obese state and the multiple oncogenic modifications that characterize cancer leave considerable room for further understanding. In addition, it is becoming increasingly important to distinguish between the functional roles of visceral and subcutaneous fat, though new molecular mechanisms may emerge from this knowledge.
The aim of this Special Issue is to provide a deeper understanding of the association between obesity and female cancers, mainly focusing on novel pathophysiological implications or additional molecular mechanisms. Therefore, we welcome the submission of original research and review articles that provide insights into the association between obesity and female malignancies.
Dr. Luca Gelsomino
Guest Editor
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Keywords
- obesity
- female malignancies
- adipokines
- tumor microenvironment
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