Metabolic Dysregulation in Cardiovascular Conditions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 2062
Special Issue Editor
Interests: oxidative stress; mitochondria; superoxide dismutase; vascular dysfunction; hypertension
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases are the leading cause of death both globally and in the United States. Metabolic conditions and hypertension are major cardiovascular risk factors. Despite treatment with multiple drugs, 75% of patients do not have their blood pressure under control, potentially due to mechanisms that are not affected by current therapies. Recent studies have shown a link between metabolic conditions and endothelial dysfunction; meanwhile, its molecular mechanism and its causative role remain elusive. Understanding these molecular mechanisms is important for the development of new therapies. Vascular dysfunction plays a key role in the pathogenesis of cardiovascular disease, stroke, and heart failure and the development of cognitive decline and dementia, representing enormous healthcare and economic burdens for the society. Understanding the etiology of these conditions is critical to increase a person’s health span, reducing the morbidity and mortality. Multiple risk factors contribute to vascular dysfunction, including metabolic dysregulation. An old paradigm focused on systemic metabolic disorders; however, recent studies indicate that cell specific metabolic dysregulation in the vasculature promotes pathological conditions independent of systemic metabolic dysregulation. This new paradigm provides novel insights into new pathways such as accelerated vascular aging and the novel role of mitochondrial dysfunction in vascular and cardiac conditions. Recent discoveries of the metabolic mechanisms of microvascular disfunction in the heart and metabolic regulation of neurovascular coupling may lead to paradigm change in how we understand the role of metabolic conditions in cardiovascular disease. The convergent mechanism potentially underlying the interplay of major risk factors is not clear, but mitochondria may represent a common target that can drive both metabolic and redox mechanisms of cardiovascular dysfunction. There are many gaps in knowledge that must be addressed. One of them is related to role of sex and socioeconomic factors in cardiovascular risk, including metabolic mechanisms are yet to be uncovered. In this Special Issue, we will discuss the latest advances in understanding metabolic, epigenetic, hormonal, central and redox mechanisms, as well as the regulation of blood pressure, salt-sensitivity, inflammation, vascular and kidney dysfunctions. The specific roles of mitochondria and other metabolic pathways will be discussed. A deeper understanding of the molecular mechanisms of metabolic alterations and their causative role requires fundamental paradigm changes.
This Special Issue will provide a platform for molecular research on metabolic dysregulation in different cardiovascular conditions. We welcome original papers and reviews on these topics.
Prof. Dr. Sergey Dikalov
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiovascular diseases
- metabolic conditions
- hypertension
- heart failure
- mitochondria
- oxidative stress
- vascular dysfunction
- superoxide dismutase
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
