Genome Structure, Function and Dynamic Regulation of Cell Fate

Dear Colleagues,

The cell nucleus is a complex system in which simultaneous reactions and functions take place to keep the cell as a well-running individualized, specialized system. The cell nucleus contains chromatin packed in various degrees of density and separated into sub-volumes of territories and sub-chromosomal domains. Between the chromatin, there is enough “free” space for floating RNA, proteins, enzymes, ATPs, ions, water molecules, etc., which are trafficked either actively (using ATP energy) or passively by super- and supra-diffusion to the interaction points where they are required. It seems that this trafficking works somehow automatically and drives the system perfectly. So, genome organization and structure seem to be in an “entanglement” with genome function and molecular dynamics. This “landscape” of genome structure, function, and dynamics represents an advancement in biophysical, biological, and biomedical research. Recent advancements in molecular biology have, on the one hand, revolutionized our understanding of how genetic information is encoded and dynamically regulated. On the other hand, biophysical research has shown that epigenetic pathways impact chromatin organization and vice versa. These complex interactions govern cell function and cell fate decisions. This Special Issue aims to gather cutting-edge research that explores the latest developments in this exciting field. Topics of interest for this Special Issue include, but are not limited to, experimental and theoretical investigations of molecular mechanisms underlying chromatin remodeling, epigenetic regulation, DNA damage response, and transcriptional control in relation to their impact on cellular development, differentiation, and (re)programming or, in general, on cell fate. We invite submissions from researchers across the globe to contribute to this vibrant discussion and propel this field forward.

Prof. Dr. Georg Hildenbrand
Prof. Dr. Michael Hausmann
Guest Editors

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