Plant-Derived Natural Substances as Multi-target Therapeutic Modalities in Experimental Models of Non-communicable Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 2110
Special Issue Editor
Interests: antioxidants; antioxidant activity; lipid peroxidation; oxidative stress; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Plants are a rich source of compounds with various therapeutic properties. The traditional medicines of many countries depend on these natural products to treat various ailments. To this day, plant medicines, such as morphine, codeine, galantamine, atropine, etc., are used in hospitals. Numerous secondary metabolites with different structures and pharmacological properties have been identified in plants. Their identification and screening for biological activity are fundamental for the production of pharmaceutical products. Advances in biotechnological sciences, genomics, proteomics, and metabolomics increase the chance and contribution of natural products in the discovery of new drug targets and promising molecules. Plants produce various signaling molecules and secondary metabolites (cytokinins, phenolic acids, flavonoids, alkaloids, terpenoids, phenylpropanoids, etc.) that play a crucial role in their defense mechanisms, while at the same time, they can act as receptor-binding ligands or modulate signaling pathways in the pathogenesis of serious pathological conditions and fatal diseases, such as cancer, diabetes, heart disease, Alzheimer’s disease, etc. However, studies on the safety and toxicological characteristics of these plant sources, extracts, and active compounds are important.
This Special Issue aims to publish and disseminate scientific knowledge in the field of metabolomics and proteomics of biologically and pharmacologically active compounds of plant origin. The focus will be on the influence of pathological processes and signal transduction mechanisms in non-communicable diseases of social importance, with minimal adverse reaction, interaction, and toxic potential risks.
Dr. Rumyana Simeonova
Guest Editor
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Keywords
- cytokinins
- phenolic acids
- flavonoids
- alkaloids
- terpenoids
- phenylpropanoids
- natural products
- toxicological characteristics
- metabolomics and proteomics
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