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The Role of Extracellular Vesicles in Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 1707

Special Issue Editors


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Guest Editor
Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO-Porto)/Porto Comprehensive Cancer Center (Porto.CCC), Research Center-LAB2, E Bdg 1st Floor, Rua Dr António Bernardino de Almeida, 4200-072 Porto, Portugal
Interests: biochemistry; genetics and epigenetics; molecular biology; extracellular vesicles; medicine pharmacology and biological sciences
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP) & RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal
Interests: biology; genetics and epigenetics; molecular biology; extracellular vesicles and biological sciences; health; nanomedicine; oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The role of extracellular vesicles (EVs) in cancer has attracted significant attention in recent years due to their involvement in various aspects of tumor biology. Extracellular vesicles, including exosomes and microvesicles, are membrane-bound particles that are released by cells and play a critical role in cell communication, transferring bioactive molecules such as proteins, lipids, and nucleic acids. In cancer, EVs are known to influence tumor growth, metastasis, immune evasion, and drug resistance. The intricate interactions between EVs and the tumor microenvironment underscore their potential use as biomarkers for cancer diagnosis and prognosis, as well as their utility as therapeutic targets and delivery vehicles. This Special Issue aims to consolidate current research on the multifaceted roles of EVs in cancer, highlighting a comprehensive overview of their biological functions and clinical implications.

This Special Issue of IJMS welcomes the submission of original research articles, reviews, and short communications that explore the diverse roles of extracellular vesicles in cancer. We aim to cover a broad range of topics including, but not limited to, the molecular mechanisms underlying the biogenesis and release of EVs, the functional role of EVs in tumor progression and metastasis, their interaction with the immune system, and their potential use as biomarkers for early cancer detection and disease monitoring. Additionally, we seek studies on the therapeutic applications of EVs, such as their application in targeted drug delivery and as vehicles for gene therapy. By compiling cutting-edge research from various disciplines, this Special Issue seeks to advance our understanding of EVs in cancer and foster the development of novel diagnostic and therapeutic strategies. Researchers are encouraged to contribute their findings in order to enhance the collective knowledge and clinical management of cancer through the lens of extracellular vesicle biology.

This Special Issue is supervised by Dr. Francisca Dias and, Dr. Ana Luísa Teixeira, assisted by a Topical Advisory Panel Member, Dr. Luis Castro-Sánchez (Universidad de Colima).

Dr. Francisca Dias
Dr. Ana Luísa Teixeira
Guest Editors

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Keywords

  • extracellular vesicles
  • oncobiology
  • tumor microenvironemnt
  • cell communication
  • biomarkers
  • drug resistance
  • drug delivery

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Published Papers (1 paper)

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Review

23 pages, 2304 KiB  
Review
Diagnostic and Therapeutic Utility of Extracellular Vesicles in Ocular Disease
by Vladimir Khristov, Sarah R. Weber, Mireille Caton-Darby, Gregory Campbell and Jeffrey M. Sundstrom
Int. J. Mol. Sci. 2025, 26(2), 836; https://doi.org/10.3390/ijms26020836 - 20 Jan 2025
Viewed by 1161
Abstract
Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, and molecular composition of released EVs correlate to the cells of origin, modulated by the cell’s environment and pathologic [...] Read more.
Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, and molecular composition of released EVs correlate to the cells of origin, modulated by the cell’s environment and pathologic state. The proteins, DNA, RNA, and protein cargo carried by EVs are protected by degradation, with a prominent role in targeted intercellular signaling. These properties make EVs salient targets as both carriers of biomarkers and potential therapeutic delivery vehicles. The majority of EV research has focused on blood, urine, saliva, and cerebrospinal fluid due to easy accessibility. EVs have also been identified and studied in all ocular biofluids, including the vitreous humor, the aqueous humor, and the tear film, and the study of EVs in ocular disease is a new, promising, and underexplored direction with unique challenges and considerations. This review covers recent advances in the diagnostic and therapeutic use of ocular EVs, with a focus on human applications and key preceding in vitro and in vivo animal studies. We also discuss future directions based on the study of EVs in other organ systems and disease sates. Full article
(This article belongs to the Special Issue The Role of Extracellular Vesicles in Cancers)
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