Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 March 2026) | Viewed by 3613
Special Issue Editor
Interests: Alzheimer's disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pathogenesis of Alzheimer's Disease (AD) remains not completely understood to this day. This is thought to be one important reason as to why no present therapy is able to cure or stop the progression of this disease. Several different pathways are considered as important players in the initiation and/or progression of the disease; the currently most accepted theory is the cascade of pathological mechanisms initiated by soluble or fibrillar forms of Abeta, including increased inflammation, mitochondrial failure, disruption of Ca++ and protein homeostasis, and alterations or loss of synapses, among others. Considering the complexity of AD and the failure or only very limited clinical effects of most single-targeted therapies, it seems to be essential (1) to elucidate further details of and connections to the intricate cellular and molecular mechanisms involved in the pathophysiology of AD and (2) to strive in advancing future therapeutic approaches that target several pathogenic factors of the disease in a stage-dependent manner as much as possible.
This Special Issue by IJMS primarily encourages original research articles and short communications that expand on existing and also present new perspectives and molecular information of the pathophysiology of AD for a more profound understanding of this disease, and/or those which explore therapeutic strategies within the field of neurodegeneration. Review articles covering the most recent discoveries in this area are also welcome.
Dr. Eva Kiss
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- AD
- targeted therapy
- Alzheimer's disease
- neurodegenerative disease
- tau protein
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
