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Novel Nanoparticle Composites: Functionalization and Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 960

Special Issue Editors


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Guest Editor
Vinča Institute of Nuclear Sciences—National Institute of the Republic of Serbia, University of Belgrade, 11001 Belgrade, Serbia
Interests: energy and environmental applications; antimicrobial properties of metal and metal oxide nanoparticles; photocatalysis; interfacial charge transfer complexes; sensors; green chemistry; inorganic-organic hybrids
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Vinča Institute of Nuclear Sciences—National Institute of the Republic of Serbia, University of Belgrade, 11001 Belgrade, Serbia
Interests: metal and metal oxide nanoparticles; composite nanomaterials; photocatalysis; antimicrobial properties and toxicity of nanoparticles; green synthesis of metal nanoparticles; nanoparticles as a chemical sensor; enzyme immobilization using nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, due to the unique properties of nanoparticles (NPs), ranging in size from a few to a hundred nanometers and possessing a large surface-to-volume ratio, they have received both and fundamental and applicative interest from researchers. The correct functionalization of NPs provides an opportunity to adjust and enhance their properties as desired, broadening their application in diverse fields such as photo-induced catalytic reactions (solar cells, water-splitting reaction, oxidation of organic molecules), sensing, antimicrobial effects and medicine (diagnostic and therapy). An additional significant aspect of functionalization is the potential to manipulate the interface and reducie the toxicity of NPs, thus leading, when possible, to the formation of biocompatible nanocomposites (NCs). Experimental studies accompanied by theoretical modeling are of the utmost importance, providing in-depth insight into the properties of NPs and avoiding a trial-and-error approach.

Thus, this Special Issue intends to highlight recent research results by collecting studies in the form of both full articles and systematic reviews.

The scope of this Special Issue includes, but is not limited to, the following topics:

  • The synthesis and functionalization of various types of materials (metals, semiconductors, oxides, dendrimers);
  • The green synthesis of nanoparticles;
  • The characterization and properties of functionalized nanoparticles;
  • Theoretical modeling and computer simulations;
  • Photo-induced catalytic reactions over functionalized nanoparticles;
  • The antimicrobial ability of functionalized nanoparticles;
  • Application in nanomedicine;
  • Sensing.

Dr. Jovan M. Nedeljković
Dr. Vesna Lazić
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanocomposites
  • synthesis
  • functionalization
  • interface
  • photocatalysis
  • antimicrobial nanoparticles
  • nanomedicine
  • theoretical modelling
  • computer simulations

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Published Papers (1 paper)

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Research

16 pages, 2229 KiB  
Article
Bioactivity Assessment of Functionalized TiO2 Powder with Dihydroquercetin
by Valentina Nikšić, Andrea Pirković, Biljana Spremo-Potparević, Lada Živković, Dijana Topalović, Jovan M. Nedeljković and Vesna Lazić
Int. J. Mol. Sci. 2025, 26(4), 1475; https://doi.org/10.3390/ijms26041475 - 10 Feb 2025
Viewed by 606
Abstract
Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 [...] Read more.
Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1–20 mg/mL), while TiO2/DHQ displayed a significant reduction in cell viability in both cell lines at higher concentrations (≥10 mg/mL). The analysis of reactive oxygen species (ROS) production revealed that TiO2/DHQ significantly reduced ROS levels in both cell types (MRC-5 and HeLa), with HeLa cells showing a more substantial reduction at lower concentrations. Genotoxicity assessment using the comet assay demonstrated that TiO2 induced DNA damage in MRC-5 cells, while TiO2/DHQ did not, indicating that DHQ mitigates the genotoxic potential of TiO2. Furthermore, TiO2/DHQ exhibited antigenotoxic effects by reducing H2O2-induced DNA damage in MRC-5 cells, supporting its protective role against oxidative stress. Preliminary antimicrobial tests revealed that TiO2/DHQ exhibits antimicrobial activity against E. coli under visible-light excitation, while TiO2 does not. These findings suggest that the TiO2-based ICT complex with DHQ with enhanced antioxidant properties can potentially serve as a safe, non-toxic biocide agent. Full article
(This article belongs to the Special Issue Novel Nanoparticle Composites: Functionalization and Application)
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