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Oxygen Variations, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 155

Special Issue Editors


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Guest Editor
Environmental, Occupational & Ageing Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), Brussels, Belgium
Interests: integrative physiology; oxygen; challenging environments; hyperbaric; hypobaric; hyperoxia; hypoxia; normobaric oxygen paradox
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Guest Editor
National Research Council, Institute of Clinical Physiology, Milan, Italy
Interests: oxidative stress; redox state; inflammation; hypoxia; hyperoxia; extreme environments; normo-hypo-hyperbaric
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For more than a century, the study of human physiology has largely focused on achieving steady states. This emphasis was understandable, as researchers sought reassurance about the validity of measurements and the stability of assessments being performed. In addition, earlier measurement systems were often slow and unstable, requiring lengthy calibration or “warm-up” periods to stabilize readings.

In recent years, however, this has changed. Modern systems are now fast and stable enough to ensure accurate measurements within very short timeframes. This advancement opens the door to new approaches and scientific paradigms, shifting the focus of current and future research toward changes and unsteady states.

With this Special Issue of the International Journal of Molecular Sciences (Biochemistry & Molecular Biology section), we aim to highlight research on oxygen changes, or deltas. We strongly believe that even rapid or minute oxygen variations can act as powerful triggers of adaptive cellular mechanisms. Every change in PO2—whether positive or negative—is of interest. Rather than limiting the discussion to hypoxia or hyperoxia, we encourage studies that investigate deltas and variations across all ranges, including hypoxic, hyperoxic, hypobaric, and hyperbaric conditions.

We welcome original contributions that explore these topics.

Dr. Gerardo Bosco
Prof. Dr. Costantino Balestra
Prof. Dr. Simona Mrakic-Sposta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypoxia
  • hyperoxia
  • normoxia
  • biochemichal response
  • integrative approach
  • normo-hypo-hyperbaric
  • molecular research
  • gene expression
  • adaptive reactions
  • extreme environments

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