Molecular Mechanisms and Drug Treatment in Alzheimer’s Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 1053
Special Issue Editors
Interests: intracerebroventricular; mtor; mTOR-I; rapalog; neurological disorders; neurodegeneration; Alzheimer’s disease; DSPE-PEG2000 micelles; micellar liquid formulation; drug stabilization
Special Issue Information
Dear Colleagues,
The understanding of the pathogenic mechanisms of Alzheimer's disease in the last decade is evolving much more rapidly than in the entire century from the discovery to the first decade of the new millennium. New hypotheses are emerging. Moreover, the role of the Immune System is growing, and according to some, it will soon prove to be prevalent and will modify the entire concept of “neurodegenerative diseases”.
The dynamics of Beta-Amyloid and NeuroFibrillary Tangle accumulation, their toxicity for the neuron, the interaction between neuron and glia, and between neurons and the Immune System: these remain the main chapters. It is difficult to predict which of these will offer therapies capable of effectively reaching the patient.
The journal does not deal with clinical trials, but in this Special Issue, all studies preceding this phase, on the understanding of dementia and possible molecular targets in the search for a pharmacological treatment, are welcome.
Dr. Roberto Dominici
Dr. Diego Dolcetta
Guest Editors
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Keywords
- Alzheimer’s disease (AD)
- glia
- immune system
- neurotoxicity
- inflammation
- beta-Amyloid (bA)
- neurofibrillary tangles (NFTs)
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