Gene Mutations in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 43
Special Issue Editor
Interests: gastrointestinal tumors; colorectal cancer; pancreatic cancer; cancer of the stomach; head and neck tumors; lung tumors and brain tumors; somatic mutations; circulating tumor DNA (ctDNA)
Special Issue Information
Dear Colleagues,
Current oncological research is based on the knowledge of somatic genetic alterations in the tumor tissue. This knowledge, in addition to providing scientists with an idea of the cause of tumor formation, has the greatest benefit in that it can significantly influence the treatment of a particular tumor, or rather a patient. Specific genetic alterations can predict the patient's prognosis or allow the use of molecularly targeted therapy. A very promising area of modern oncology research is the study of intratumor mutational heterogeneity, whether for understanding the complex functioning of the intratumor environment and its immense diversity or for determining the overall mutational burden in relation to predicting the response to immunotherapy. Another attractive approach is the use of specific genetic alterations to detect circulating tumor DNA (ctDNA), which occurs in the blood of cancer patients. Analysis of this so-called "liquid biopsy" allows non-invasive monitoring of the course of disease practically whenever needed.
This Special Issue welcomes all contributions (original articles and reviews) that support the latest trends in oncogenetic research, particularly those dealing with somatic genetic alterations, intratumor mutational heterogeneity, and liquid biopsy.
Dr. Lucie Benešová
Guest Editor
Manuscript Submission Information
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Keywords
- oncogenetics
- somatic mutations
- intratumor mutational heterogeneity
- tumor mutational burden
- circulating tumor DNA
- liquid biopsy
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