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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Nanoparticle Composites: Functionalization and Application submission deadline 20 Sep 2025 | 1 articles | Viewed by 1199 | Submission Open
Keywords: nanoparticles; nanocomposites; synthesis; functionalization; interface; photocatalysis; antimicrobial nanoparticles; nanomedicine; theoretical modelling; computer simulations
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Diabetic Ischemic Heart Failure
edited by Branko Beleslin
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1197 | Submission Open
Keywords: diabetes; ischemic cardiomyopathy; pathophysiology; diagnostics; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multifunctional Nanocomposites for Bioapplications submission deadline 20 Sep 2025 | 2 articles | Viewed by 1172 | Submission Open
Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli
(This special issue belongs to the Section Molecular Nanoscience)
The Blood–Brain Barrier and Neuroprotection
edited by Aruna Sharma and Hari Shanker Sharma
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1172 | Submission Open
Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Tumor Metastasis and Inhibition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1168 | Submission Open
Keywords: metastasis; epithelial– mesenchymal transition; small-molecule compounds; animal imaging; signal transduction
(This special issue belongs to the Section Molecular Oncology)
The Role of Lipids in Human Health
edited by and Irma Colombo
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1163 | Submission Open
Keywords: lipids; lipidomics; fatty acids; sphingolipids; steroids; metabolism
(This special issue belongs to the Section Biochemistry)
Advances in Molecular Therapeutics for HIV Co-Infections submission deadline 20 Sep 2025 | 1 articles | Viewed by 1140 | Submission Open
Keywords: HIV co-infections; molecular therapeutics; Mtb; ART; immune responses
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Glioma Knowledge: From Genome to Signal Pathways Alterations
edited by and Giuseppina D'Alessandro
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1095 | Submission Open
Keywords: gliomas; signalling pathways; genetic alterations; epigenetics; metabolic alterations; drug resistance; glioma stem cells
(This special issue belongs to the Section Molecular Neurobiology)
The Role of the Endocannabinoid System in Reward- and Addiction-Related Neuroplasticity submission deadline 20 Sep 2025 | 1 articles | Viewed by 1082 | Submission Open
Keywords: endocannabinoid system; neuroplasticity; reward; addiction; biomarker; therapeutic approach
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Diagnosis and Targeted Therapies in Ischemic Stroke
edited by Alicia Aliena-Valero and María Castelló-Ruiz
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1049 | Submission Open
Keywords: ischemic stroke; cerebral protection; repair treatments; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research of Natural Products in Cancer Diseases submission deadline 20 Sep 2025 | Viewed by 1043 | Submission Open
Keywords: cancer; natural products; drug resistance; side effects; bioactive compounds; prevention; treatment; signaling pathways; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Molecular Pathology, Diagnostics, and Therapeutics in Optic Neuropathies
edited by Tsz Kin Ng
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1027 | Submission Open
Keywords: optic neuropathies; glaucoma; optic nerve; retinal ganglion cells; neuroprotection; biomarkers; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insights into Reproductive Toxicology
edited by Maria Cristina Budani
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1016 | Submission Open
Keywords: endocrine disruptors; environmental toxicants; fertility; heavy metals; lifestyle habits; molecular mechanisms; pregnancy; teratology; teratogenic compounds; reproductive toxicology
(This special issue belongs to the Section Molecular Toxicology)
Molecular Research on Apoptosis and Autophagy in Osteosarcoma submission deadline 20 Sep 2025 | 1 articles | Viewed by 1006 | Submission Open
Keywords: apoptosis; autophagy; bioactive molecule; cancer; necroptosis; osteosarcoma; osteoclast; osteoblast
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Bioconjugates and Application
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1001 | Submission Open
Keywords: bioconjugates; targeted therapy; homing moieties; drug delivery; bioconjugates as diagnostic tools; targeted nanoparticles; antibody– drug conjugates; linkage systems
(This special issue belongs to the Section Macromolecules)
Intestinal Microbiome and Its Function
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1000 | Submission Open
Keywords: human microbiome; gut microbiome; microbiota-derived metabolites; SCFAs; gut– organ axis
(This special issue belongs to the Section Molecular Microbiology)
Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 957 | Submission Open
Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies
(This special issue belongs to the Section Molecular Neurobiology)
Personalized Nanomedicine in Oncology
edited by Sajid Ali
submission deadline 20 Sep 2025 | Viewed by 929 | Submission Open
Keywords: drug/gene delivery; biomaterials; stimuli-responsive systems; lipid– polymer nanoparticles; lipodendriplexes; dual delivery; inorganic nanoparticles; targeted delivery system
(This special issue belongs to the Section Molecular Nanoscience)
Mitochondria and Energy Metabolism Reprogramming in Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 905 | Submission Open
Keywords: mitochondrial dysfunctions; energy metabolism; pathophysiological mechanisms; therapeutic targets; physiology of organelle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry
edited by Łukasz Huminiecki
submission deadline 20 Sep 2025 | 1 articles | Viewed by 869 | Submission Open
Keywords: multi-omics; statistics; gene expression analysis
(This special issue belongs to the Section Molecular Informatics)
Nanostructures: From Synthesis, Modification to Biomedical Applications
edited by Kleoniki Giannousi and
submission deadline 20 Sep 2025 | 1 articles | Viewed by 867 | Submission Open
Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors
(This special issue belongs to the Section Molecular Nanoscience)
3D Technology in Biomedicine: Studying Molecular Mechanisms in Health and Disease
edited by Flavia Carton
submission deadline 20 Sep 2025 | 1 articles | Viewed by 855 | Submission Open
Keywords: 3D technologies; biomedicine; molecular biology; in vitro/ex vivo models; regenerative medicine; human diseases
(This special issue belongs to the Section Materials Science)
Advanced Research on Female Reproductive Physiology
edited by Tomoko Fujiwara and
submission deadline 20 Sep 2025 | 1 articles | Viewed by 845 | Submission Open
Keywords: circadian rhythm; diet; hypothalamus; lifestyle habits; ovary; pituitary; preconception care; reproduction function; reproductive behavior; uterus
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Extracellular Vesicles: Functions and Therapeutic Applications
edited by Deepshikha Tewari
submission deadline 20 Sep 2025 | Viewed by 834 | Submission Open
Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases
(This special issue belongs to the Section Molecular Biology)
Role of Glia in Human Health and Disease
edited by and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 813 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
miRNAs in Cancers: From Molecular Biology to Treatment
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 808 | Submission Open
Keywords: cancer; miRNA; epigenetic
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Anti-Cancer Drugs, 2nd Edition submission deadline 20 Sep 2025 | 1 articles | Viewed by 795 | Submission Open
Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance
(This special issue belongs to the Section Molecular Oncology)
Genetic and Epigenetic Insights into Extracellular Vesicles submission deadline 20 Sep 2025 | Viewed by 726 | Submission Open
Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology
(This special issue belongs to the Section Biochemistry)
Recent Research of Protein Structure Prediction and Design submission deadline 20 Sep 2025 | 1 articles | Viewed by 724 | Submission Open
Keywords: protein design; multidomain proteins; AlphaFold2; protein folding; deep learning
(This special issue belongs to the Section Biochemistry)
Host-Pathogen Interactions during Persistent Bacterial Infections, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 709 | Submission Open
Keywords: bacteria; intracellular adaptation; metabolic adaptation; metabolic host reprogramming; host– pathogen interaction; chronic infections; regulation of virulence
(This special issue belongs to the Section Molecular Microbiology)
Cell Biology and Biochemistry Regulation Mediated by Natural Compounds
edited by
submission deadline 20 Sep 2025 | Viewed by 677 | Submission Open
Keywords: cellular targets; natural compounds; nutraceuticals; health-promoting effects; enzymatic activity; cell-based assays; in vivo; nanoencapsulation; delivery of natural compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Research Progresses on Multifaceted Cholinergic Signaling
edited by Taher Darreh-Shori
submission deadline 20 Sep 2025 | Viewed by 669 | Submission Open
Keywords: cholinergic signaling; choline acetyltransferase (ChAT); nicotinic acetylcholine receptors (AChRs); muscarinic acetylcholine receptors (mAChRs); mitochondrial acetylcholine receptors; cholinergic anti-inflammatory pathway; cholinergic signaling in cancer; cholinergic signaling in mitochondria; cholinergic signaling in ALS; cholinergic signaling in dementia; cholinergic signaling in COVID-19
(This special issue belongs to the Section Molecular Neurobiology)
Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond submission deadline 20 Sep 2025 | 1 articles | Viewed by 647 | Submission Open
Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants
(This special issue belongs to the Section Molecular Plant Sciences)
Emerging Topics in Macromolecular Crystallography submission deadline 20 Sep 2025 | 1 articles | Viewed by 647 | Submission Open
Keywords: macromolecular crystallography; structural biology; artificial intelligence; structure determination; molecular mechanism; functions; drug discovery; protein; nucleic acid; carbohydrates
(This special issue belongs to the Section Macromolecules)
Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside submission deadline 20 Sep 2025 | 1 articles | Viewed by 620 | Submission Open
Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology
(This special issue belongs to the Section Molecular Immunology)
Plant Breeding and Genetics: New Findings and Perspectives
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 574 | Submission Open
Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Roles and Function of Extracellular Vesicles in Diseases: 3rd Edition
edited by
submission deadline 20 Sep 2025 | Viewed by 529 | Submission Open
Keywords: extracellular vesicle; exosome; disease; roles and function
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Function of Glial Cells in the Nervous System: 2nd Edition
edited by Krista Minéia Wartchow
submission deadline 20 Sep 2025 | 1 articles | Viewed by 505 | Submission Open
Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches
(This special issue belongs to the Section Molecular Neurobiology)
Nanotechnology and Nanomedicine: Approaches, Challenges and Translation for Tissue Regeneration submission deadline 20 Sep 2025 | 1 articles | Viewed by 503 | Submission Open
Keywords: nanotechnology; bone regeneration; skin regeneration; cardiac tissue regeneration; brain tissue regeneration; drug delivery system; targeted therapy
(This special issue belongs to the Section Molecular Nanoscience)
Role of Natural Products in Human Health and Disease
edited by and Ji Hae Lee
submission deadline 20 Sep 2025 | Viewed by 499 | Submission Open
Keywords: natural substances; phytochemicals; chronic diseases; aging
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Red Blood Cell Dysfunction and Hemodynamic Changes in Inflammation, Infection and Metabolic Disease
edited by Janette Bester
submission deadline 20 Sep 2025 | 1 articles | Viewed by 489 | Submission Open
Keywords: red blood cell; inflammation; infection; metabolic disease; hemodynamics
(This special issue belongs to the Section Molecular Biology)
Lipoproteins—Opportunities for the Development of Nanotherapeutics in Chronic Disease
edited by
submission deadline 20 Sep 2025 | Viewed by 483 | Submission Open
Keywords: lipoproteins; LDL; HDL; nanotherapeutics; chronic disease; targeted therapy; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Advances in Antibiotic Resistance submission deadline 20 Sep 2025 | Viewed by 482 | Submission Open
Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance
(This special issue belongs to the Section Molecular Microbiology)
The Medicinal Mechanism and Application of Biologically Active Compounds in Melanoma
edited by Rosanna Avola and Adriana C. E. Graziano
submission deadline 20 Sep 2025 | Viewed by 476 | Submission Open
Keywords: biologically active compounds; medicinal mechanism; cancer; melanoma; chemoprevention; anticancer effect; immunomodulation; apoptosis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Novel Therapeutic Advances in Pancreatic Cancer
edited by
submission deadline 20 Sep 2025 | Viewed by 464 | Submission Open
Keywords: pancreatic cancer; therapeutic advancements; tumor microenvironment; personalized medicine; biomarkers; liquid biopsy; targeted therapies; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
The Role of Choroid Plexus in Neurological Health
edited by
submission deadline 20 Sep 2025 | Viewed by 460 | Submission Open
Keywords: choroid plexus; cerebrospinal fluid; neurological health; blood– CSF barrier; central nervous system
(This special issue belongs to the Section Molecular Neurobiology)
Chemicals Impacts on the Reproductive System submission deadline 20 Sep 2025 | Viewed by 453 | Submission Open
Keywords: endocrine disruptors; environmental pollution; female reproduction; male reproduction
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Epilepsy and Antiepileptic Drugs, 3rd Edition submission deadline 20 Sep 2025 | Viewed by 446 | Submission Open
Keywords: antiepileptic drugs: classic; novel; second and third generations; antiseizure medications: novel therapeutic options; cannabinoids in epilepsy; animal models of epilepsy: from animals to humans; clinical trials in epilepsy: novel potentially efficacious drugs; interactions between antiepileptic drugs: pharmacodynamic and pharmacokinetic aspects; interactions of antiepileptic drugs with other drugs: pharmacodynamic and pharmacokinetic aspects; adverse effects of antiseizure medication; treatment of epilepsy in specific populations (elderly; childbearing women; children); drug-resistant epilepsy in preclinical conditions; epileptogenesis: all pathophysiological and molecular aspects
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research of Human Fertility
edited by and Byron Asimakopoulos
submission deadline 20 Sep 2025 | Viewed by 438 | Submission Open
Keywords: human reproduction; fertility preservation; ART; infertility; IVF
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs
edited by
submission deadline 20 Sep 2025 | Viewed by 417 | Submission Open
Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation
(This special issue belongs to the Section Molecular Pharmacology)
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