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Recent Advances in Nanomedicines Against Bacterial Infections

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1679

Special Issue Editors


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Guest Editor
1. ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
2. LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
Interests: nanotechnology; polymeric nanoparticles; lipid-based nanoparticles; drug delivery systems; targeted therapy; brain delivery; neurodegenerative disease therapy; effect of compounds on the aggregation and conformation of peptides and proteins; biophysical models; drug–membrane interactions; pharmaceutical and food applications
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
2. ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
Interests: anti-bacterial nucleic acid mimics probes as a new therapeutic approach; delivery mechanisms of nucleic acid mimics in bacteria; nucleic acid mimics

E-Mail Website
Guest Editor
1. LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
2. ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
Interests: drug delivery; targeted therapy; brain delivery; brain cancer; glioblastoma; cancer therapy; neurodegenerative disease therapy; biophysical models; drug–membrane interactions
Special Issues, Collections and Topics in MDPI journals

E-Mail Website1 Website2
Guest Editor
1. LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, R. Dr. Roberto Frias, 4200-465 Porto, Portugal
2. ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
Interests: nanotechnology and interfacial phenomena; effects of fluorinated systems and peptides on the aggregation of amyloid beta peptides; conformational studies of protein and peptide self-organized systems and polymer surfaces; design and production of inorganic and polymeric nanosystems for pharmaceutical and food applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The world is currently experiencing a serious health crisis due to the high morbidity and mortality rates linked to infectious diseases, in particular, caused by bacteria. The increase in antibiotic resistance is still a growing challenge, which hinders the treatment of bacterial infections. Therefore, alternative therapies/strategies are needed due to the lack of effective treatments. In the last years, nanotechnology has emerged as a new strategy to combat bacterial infections and antibiotic-resistant bacteria. Using nanoparticles (NPs) to prevent, treat, or diagnose bacterial infections is one of the most promising approaches since NPs can act directly on bacteria and/or as delivery systems of compounds, improving their therapeutic efficacy.

Thus, this Special Issue focuses on the recent developments in NPs and their current applications in bacterial infections, including their prevention, diagnosis, and treatment. Researchers are welcome to submit their latest findings as original papers and reviews.

Dr. Stephanie Andrade
Dr. Nuno Guimarães
Dr. Maria João Ramalho
Dr. Joana A. Loureiro
Guest Editors

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Keywords

  • nanotechnology
  • nanoparticle
  • nanocarriers
  • nanoantibiotic
  • drug delivery system
  • targeted delivery
  • theranostic
  • infectious diseases
  • antibacterial agent
  • antimicrobial resistance
  • biomedical application

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Published Papers (1 paper)

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Research

20 pages, 2421 KB  
Article
PLGA Nanoparticles Double-Decorated with a TAT Peptide and Folic Acid to Target Staphylococcus aureus
by Stéphanie Andrade, Maria J. Ramalho, João Santos, Sílvio Santos, Luís D. R. Melo, Nuno Guimarães, Maria P. Ferraz, Nuno F. Azevedo, Maria C. Pereira and Joana A. Loureiro
Int. J. Mol. Sci. 2025, 26(21), 10666; https://doi.org/10.3390/ijms262110666 - 1 Nov 2025
Viewed by 560
Abstract
Treating bacterial infections has become increasingly difficult due to the rise in antibiotic-resistant bacterial strains. Strategies involving the targeted delivery of antibiotics have been proposed to minimize the administered antibiotic doses. This study aims to develop the first double-modified nanovehicle capable of increasing [...] Read more.
Treating bacterial infections has become increasingly difficult due to the rise in antibiotic-resistant bacterial strains. Strategies involving the targeted delivery of antibiotics have been proposed to minimize the administered antibiotic doses. This study aims to develop the first double-modified nanovehicle capable of increasing bacterial membranes’ permeability while specifically targeting Staphylococcus aureus, one of the foremost pathogens responsible for global mortality rates. Thus, polymeric NPs composed of poly(lactic-co-glycolic acid) (PLGA) were produced, and their surface was modified with TAT peptide to increase the membranes’ permeability and folic acid (FA) to direct the NPs to S. aureus. The nanosystem showed spherical morphology with sizes of 174 ± 4 nm, a monodisperse population (polydispersity index of 0.08 ± 0.02), and a zeta potential of −2.5 ± 0.1 mV. The NPs remained stable for up to four months during storage. Fluorescence-based flow cytometry analysis proved that the double modification of PLGA NPs increased the interaction of the NPs with S. aureus, with fluorescence increasing from 71 ± 3% to 87 ± 1%. The nanosystem slightly affected the growth curve of S. aureus by extending both the lag time (from 2.5 ± 0.2 to 2.88 ± 0.4 h) and the exponential phase, as evidenced by an increase in the half-maximum growth time (from 3.9 ± 0.2 to 4.4 ± 0.1 h). Furthermore, the nanocarrier showed no toxicity for human dermal fibroblast cells, maintaining a 100% cell viability at the highest concentration tested (100 µM). Therefore, the proposed FA/TAT-functionalized nanocarrier presented promising features to be successfully used as a delivery vehicle of antimicrobials to fight S. aureus. Full article
(This article belongs to the Special Issue Recent Advances in Nanomedicines Against Bacterial Infections)
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