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Green Chemical Pesticide Design, Synthesis and Evaluation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 639

Special Issue Editor


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Guest Editor
Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China
Interests: pesticide design and synthesis; nematode control; pesticide science

Special Issue Information

Dear Colleagues,

Green pesticides constitute a crucial safeguard for the implementation of environmentally friendly strategies in the management of crop diseases and pests. The development of these green pesticides, which is based on natural products, represents a significant approach in the discovery of novel pesticides. Despite the numerous natural product pesticides that have been documented, the identification and utilization of those possessing high efficacy and minimal risk are notably constrained. Consequently, the comprehensive investigation of the active constituents within natural product pesticides continues to be a focal point of research in the development of green pesticides.

In this Special Issue, we extend an invitation to researchers to submit articles pertaining to natural products and their derivatives as novel pesticides. This includes the advancement of fungicidal, insecticidal, herbicidal, and nematicidal active natural products, as well as the synthesis of their analogs. Additionally, we welcome research papers that elucidate the mechanisms of action of natural  pesticides.

Prof. Dr. Ranfeng Sun
Guest Editor

Manuscript Submission Information

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Keywords

  • green pesticides
  • natural products
  • action mechanism of pesticides
  • synthesis

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Published Papers (1 paper)

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Research

17 pages, 19509 KiB  
Article
Scaffold Hopping from Dehydrozingerone: Design, Synthesis, and Antifungal Activity of Phenoxyltrifluoromethylpyridines
by Xiaohui Nan, Kaifeng Wang, Xinru Sun, Zhan Hu and Ranfeng Sun
Int. J. Mol. Sci. 2025, 26(11), 5345; https://doi.org/10.3390/ijms26115345 - 2 Jun 2025
Viewed by 461
Abstract
In response to the urgent need for innovative fungicides to ensure food security and safety, a series of twenty-three novel trifluoromethylpyridine compounds were designed and synthesized using a scaffold hopping strategy derived from dehydrozingerone. This approach involved converting the α, β-unsaturated ketone moiety [...] Read more.
In response to the urgent need for innovative fungicides to ensure food security and safety, a series of twenty-three novel trifluoromethylpyridine compounds were designed and synthesized using a scaffold hopping strategy derived from dehydrozingerone. This approach involved converting the α, β-unsaturated ketone moiety into a pyridine ring. Bioassay results indicated that the majority of these compounds exhibited promising in vitro antifungal activity, particularly against Rhizoctonia solani and Colletotrichum musae. Notably, compound 17 showed the highest efficacy and broad-spectrum activity, with median effective concentrations (EC50) ranging from 2.88 to 9.09 μg/mL. Phenoxytrifluoromethylpyridine derivatives, including compound 17, exhibited superior antifungal activity compared to benzyloxytrifluoromethylpyridine derivatives. In vivo tests revealed that both compounds 17 and 23 exhibited moderate control effects against C. musae. The degradation half-lives of compounds 17 and 23 in bananas were determined to be 176.9 h and 94.8 h, respectively, indicating the stability of their structures in the environment. Molecular docking studies indicated that compound 23 interacts with succinate dehydrogenase, offering valuable insights for the structural optimization of compound 23. Full article
(This article belongs to the Special Issue Green Chemical Pesticide Design, Synthesis and Evaluation)
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